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The map label for this gene is metC [H]

Identifier: 126454483

GI number: 126454483

Start: 2181667

End: 2182851

Strand: Reverse

Name: metC [H]

Synonym: BURPS1106A_2195

Alternate gene names: 126454483

Gene position: 2182851-2181667 (Counterclockwise)

Preceding gene: 126452275

Following gene: 126452591

Centisome position: 54.73

GC content: 66.92

Gene sequence:

>1185_bases
ATGACCGCATCCATTCCCAAGCGCGCGTTGCAGACGCGCGTCGTCCAGCCGGACGATCGCATTCCCGCCGGTTTCGAATC
GTTCGTCGTGCCCGTCGCGCGGGCGTCGACGGTCGTGTTTCCCGATCTCGCGACGATGCGCAATCTCGACTGGCGCCAGG
ACGGCCAATGGCGCTACGGGCTGCACGCGACGCCGACGTCGCTCGCGCTCGCGCAGCGGCTCGCCGAGATCGAGGGCGGC
GCGCACGCGCTGTTGCAGCCGTCGGGGCTCTGCGCGATCACGAACGTGTATTTCGGTCTCGTCAAGGAAGGCGACGATGT
GCTGATTCCGGACAATGCGTACGGGCCGAACGGCGATTTCGGCAAATGGCTGGCGAAGGATTTCGGTATCACCGCGCGCT
TCTACGATCCGATGATCGGCGCGGGCATCGCCGATCTGATCCAGCCGAACACGCGCATCGTCTGGCTCGAGGCGCCCGGC
TCGGTGACGATGGAAGTGCCCGACGTGCGGGCGATCACGGCGGTCGCACGCGCACGCGGCATCGTCACGGCGATCGACAA
CACGTATTCGGCGGGCCTTGCGTTCAAGCCGTTCGAGCACGGGGTCGACATCTCGGTGCAGGCGCTGACCAAGTACCAGT
CGGGCGGCAGCGACGTGCTGATGGGCGCGACGATCACCGCCGACGGCGAACTGCATGCGAAGCTCAAGCTCGCGCGGATG
CGGCTCGGCATCGGCGTGTCGGCCGACGACTGTTCGCTCGTGCTGCGCGGTCTGCCGAGCATGCAGGCGCGTTTCGACGC
GCACAGCCGCAGCGCCCTGTCGCTCGCGCGCTGGCTGAAGACGCGCGCGGAGATCGCAACGGTGCTGCATCCGCAACTGC
CCGATTGTCCGGGCCACGATACGTTCATGCGCGACTTCACGGGCGCGGGCGGGCTGTTCTCGGTCGTGTTCGACGAGCGC
TACGATGCCGCACAGGTCGATCGCTTCGTCGAGGCGCTCGAACTGTTCGCGATCGGCTGGAGCTGGGGCGGCGCATGCAG
CCTTGCGATGCCGTACGACGTGCAGTCGATGCGCACGGGCAAGTGGCCGCATCGCGGCACGCTGGTGCGTTTCTATGTCG
GTCTCGAAGACGAGGCCGATTTGCGCGCGGATATCGAGCGCGCATTGACGTCGGCGCTCGCATAA

Upstream 100 bases:

>100_bases
CGGCCGCGCCGATTGTACCGGGCCAAACGCGCGGAATCAGGCTAAGCTAGCCGGATTCCAATCTTTTCGGGGCTCCGTCT
CGCGTCGAGCCCGCCCAGTC

Downstream 100 bases:

>100_bases
CGCGCGCGAGATCGGCGGCGCGGACAGTGGTGGCGCATCGGTGCGCCGCACGCGGGCCGTGCAGCGCGCTCGTGCATGGA
TCGAGCGACGAGTGAGCGGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYGLHATPTSLALAQRLAEIEGG
AHALLQPSGLCAITNVYFGLVKEGDDVLIPDNAYGPNGDFGKWLAKDFGITARFYDPMIGAGIADLIQPNTRIVWLEAPG
SVTMEVPDVRAITAVARARGIVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADGELHAKLKLARM
RLGIGVSADDCSLVLRGLPSMQARFDAHSRSALSLARWLKTRAEIATVLHPQLPDCPGHDTFMRDFTGAGGLFSVVFDER
YDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADIERALTSALA

Sequences:

>Translated_394_residues
MTASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYGLHATPTSLALAQRLAEIEGG
AHALLQPSGLCAITNVYFGLVKEGDDVLIPDNAYGPNGDFGKWLAKDFGITARFYDPMIGAGIADLIQPNTRIVWLEAPG
SVTMEVPDVRAITAVARARGIVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADGELHAKLKLARM
RLGIGVSADDCSLVLRGLPSMQARFDAHSRSALSLARWLKTRAEIATVLHPQLPDCPGHDTFMRDFTGAGGLFSVVFDER
YDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADIERALTSALA
>Mature_393_residues
TASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYGLHATPTSLALAQRLAEIEGGA
HALLQPSGLCAITNVYFGLVKEGDDVLIPDNAYGPNGDFGKWLAKDFGITARFYDPMIGAGIADLIQPNTRIVWLEAPGS
VTMEVPDVRAITAVARARGIVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADGELHAKLKLARMR
LGIGVSADDCSLVLRGLPSMQARFDAHSRSALSLARWLKTRAEIATVLHPQLPDCPGHDTFMRDFTGAGGLFSVVFDERY
DAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTGKWPHRGTLVRFYVGLEDEADLRADIERALTSALA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=298, Percent_Identity=30.2013422818792, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI299473759, Length=240, Percent_Identity=30.4166666666667, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI25453487, Length=297, Percent_Identity=27.6094276094276, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1789383, Length=362, Percent_Identity=38.121546961326, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1790375, Length=375, Percent_Identity=29.3333333333333, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560056, Length=357, Percent_Identity=32.4929971988796, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=357, Percent_Identity=31.3725490196078, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71980708, Length=394, Percent_Identity=28.4263959390863, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321170, Length=329, Percent_Identity=37.6899696048632, Blast_Score=228, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6319307, Length=351, Percent_Identity=27.3504273504274, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=26.7942583732057, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321904, Length=353, Percent_Identity=26.628895184136, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321254, Length=387, Percent_Identity=25.5813953488372, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922554, Length=389, Percent_Identity=31.6195372750643, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42780; Mature: 42649

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYG
CCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHCCCCCCCCCEEEC
LHATPTSLALAQRLAEIEGGAHALLQPSGLCAITNVYFGLVKEGDDVLIPDNAYGPNGDF
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEHHHHHHHHEECCCCEEECCCCCCCCCCH
GKWLAKDFGITARFYDPMIGAGIADLIQPNTRIVWLEAPGSVTMEVPDVRAITAVARARG
HHHHHHHHCCEEEECCCHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
IVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADGELHAKLKLARM
EEEEECCCCCCCEEECCHHCCCCEEEEEEHHHCCCCCCEEEEEEEECCCCCHHHHEEEHH
RLGIGVSADDCSLVLRGLPSMQARFDAHSRSALSLARWLKTRAEIATVLHPQLPDCPGHD
HHCCCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TFMRDFTGAGGLFSVVFDERYDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTG
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHCCC
KWPHRGTLVRFYVGLEDEADLRADIERALTSALA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TASIPKRALQTRVVQPDDRIPAGFESFVVPVARASTVVFPDLATMRNLDWRQDGQWRYG
CCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHCCCCCCCCCEEEC
LHATPTSLALAQRLAEIEGGAHALLQPSGLCAITNVYFGLVKEGDDVLIPDNAYGPNGDF
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEHHHHHHHHEECCCCEEECCCCCCCCCCH
GKWLAKDFGITARFYDPMIGAGIADLIQPNTRIVWLEAPGSVTMEVPDVRAITAVARARG
HHHHHHHHCCEEEECCCHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
IVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADGELHAKLKLARM
EEEEECCCCCCCEEECCHHCCCCEEEEEEHHHCCCCCCEEEEEEEECCCCCHHHHEEEHH
RLGIGVSADDCSLVLRGLPSMQARFDAHSRSALSLARWLKTRAEIATVLHPQLPDCPGHD
HHCCCCCCHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TFMRDFTGAGGLFSVVFDERYDAAQVDRFVEALELFAIGWSWGGACSLAMPYDVQSMRTG
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHCCC
KWPHRGTLVRFYVGLEDEADLRADIERALTSALA
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]