Click here to switch to the map view.

The map label for this gene is ybhO [H]

Identifier: 126454347

GI number: 126454347

Start: 667050

End: 668324

Strand: Direct

Name: ybhO [H]

Synonym: BURPS1106A_0693

Alternate gene names: 126454347

Gene position: 667050-668324 (Clockwise)

Preceding gene: 126453806

Following gene: 126453041

Centisome position: 16.72

GC content: 69.73

Gene sequence:

>1275_bases
ATGAGTGGCGAGACCCGGCACCGCCTCGCGCAACTGCGCCAGATGTTCCTGCAGGAGCGCGGCTCCGCGTCGCGGCTCGC
GTTCACGTCCGGCAACGCGGTGCGCCTCTGCGACGGCGGCGCGGCGTTCTTTCCGGCGCTGATCGAACGGATCGACGCCG
CGCGCGAGCGCGTCGCGCTCGAAACCTACATCTTCTGCGACGACGCCGTCGGCCGCGCGGTGTCCGACGCGCTCGTCCGC
GCGGCCGCGCGCGGCGTTCACGTGCGCGTCATCACCGATGGAATCGGCACCGAGCGCCTGCCGCTTTTCGGCACCTGGCC
GGACGCGGGCGTCGAGCACCGGATCTACAATCCCTATCTGTTCGGCCGCTTCGGTTTTTCGCGCACGCACCGCAAGCTCG
CGGTGATCGACGACGCCTGCGCGTTCTGCGGCGGCATCAACATCGTCGACGATTTCGAGCAGAACGGCGAGCGCCTGCCG
CATCCGCGCTGGGACTTCGCGGTCGAACTGGCCGGGCCCGCCGTCGCCGACGTGCGCGCCGCGTTCGAGGTGCAGTGGCA
CCGGATCGCCGCCGGCCACAAGCGCTACGCGCAATATCTGCCGCATGACGTCGATGGTCCCGCGTTCGCCGCGCGCTTTC
GCCGCTGGATGCGCAGCCACCGCTGGGTGAAGGCGGGCGCGCTGCGCGTCGTGACCGAGCCGAGCGTGGCGTTCGTCGCG
CGCGACAATATCGTGAACCGCCGGGCGATCGAGAAGGCGTATCTCGCGGCGATCGGCCGCGCGCGCCAGTCGATCCTGCT
CGCTAACCCTTACTTCATGCCGGGGCGCAAGCTGCGGCGCGCGCTCGCCGGCGCGGCGCGCCGCGGCGTCGACGTGCGGA
TCCTGCTCGGGCGCAACGAGTTCGCGTCGCTCGATATGGCGGTGCCGTTCCTATATCATGCATTGCTGCGCTCGGGCGTG
CGCGTTGCCGAATACGACAAGACGATGCTGCACGGCAAGGTCGCGGTGATCGACGATCATTGGGCGACCGTCGGCTCGTC
GAATCTGGATGCGCTCAGCCTGATGCTGAACAACGAGGCGAACGTCGTGCTCGTGCGCCACCGCGAGGAGACGGCCGCGC
TGCGCGACGCGATCGCGGCGGCGTTCGCCGACGGCCGCGAGATCGACCCGGCGCTCTACGCGGCGCGGCCCGCCGCCGAG
CGGTTTCTGAACTGGTTCGCGTACAACGCGTACCGGAGTGCGATGAAGCTGCTGACGGTCGGCGGATACGACTAA

Upstream 100 bases:

>100_bases
ATCTGTGGCTGCCTTATCGCGAAGCGGCCGCGCGCTGCTATTCGCCGTCGAACGCCGAGGCGATCCTGCAGTTGCCCGAG
CGCCTCGCGTCGCGCGCCGC

Downstream 100 bases:

>100_bases
GCATTCGCTTACACATGCGGCGCGCCGCGGCCTGCACAGGGCCTCCTCCAAAGGCGCGCGACCCTGCAAAATAGCGGGGG
CGGTTAGAAACCGATTTCTA

Product: cardiolipin synthetase ybhO

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSGETRHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVR
AAARGVHVRVITDGIGTERLPLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDACAFCGGINIVDDFEQNGERLP
HPRWDFAVELAGPAVADVRAAFEVQWHRIAAGHKRYAQYLPHDVDGPAFAARFRRWMRSHRWVKAGALRVVTEPSVAFVA
RDNIVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGV
RVAEYDKTMLHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAAAFADGREIDPALYAARPAAE
RFLNWFAYNAYRSAMKLLTVGGYD

Sequences:

>Translated_424_residues
MSGETRHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVR
AAARGVHVRVITDGIGTERLPLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDACAFCGGINIVDDFEQNGERLP
HPRWDFAVELAGPAVADVRAAFEVQWHRIAAGHKRYAQYLPHDVDGPAFAARFRRWMRSHRWVKAGALRVVTEPSVAFVA
RDNIVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGV
RVAEYDKTMLHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAAAFADGREIDPALYAARPAAE
RFLNWFAYNAYRSAMKLLTVGGYD
>Mature_423_residues
SGETRHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVALETYIFCDDAVGRAVSDALVRA
AARGVHVRVITDGIGTERLPLFGTWPDAGVEHRIYNPYLFGRFGFSRTHRKLAVIDDACAFCGGINIVDDFEQNGERLPH
PRWDFAVELAGPAVADVRAAFEVQWHRIAAGHKRYAQYLPHDVDGPAFAARFRRWMRSHRWVKAGALRVVTEPSVAFVAR
DNIVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNEFASLDMAVPFLYHALLRSGVR
VAEYDKTMLHGKVAVIDDHWATVGSSNLDALSLMLNNEANVVLVRHREETAALRDAIAAAFADGREIDPALYAARPAAER
FLNWFAYNAYRSAMKLLTVGGYD

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=380, Percent_Identity=38.1578947368421, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1787502, Length=401, Percent_Identity=27.930174563591, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081826, Length=417, Percent_Identity=27.8177458033573, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 47187; Mature: 47055

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGETRHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVAL
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHEE
ETYIFCDDAVGRAVSDALVRAAARGVHVRVITDGIGTERLPLFGTWPDAGVEHRIYNPYL
EEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCCCCCCEECCCEE
FGRFGFSRTHRKLAVIDDACAFCGGINIVDDFEQNGERLPHPRWDFAVELAGPAVADVRA
EEECCCCHHCCEEEEEHHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHH
AFEVQWHRIAAGHKRYAQYLPHDVDGPAFAARFRRWMRSHRWVKAGALRVVTEPSVAFVA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNIVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNE
CCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCC
FASLDMAVPFLYHALLRSGVRVAEYDKTMLHGKVAVIDDHWATVGSSNLDALSLMLNNEA
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCEEEEEECCHHHCCCCCCCEEEEEECCCC
NVVLVRHREETAALRDAIAAAFADGREIDPALYAARPAAERFLNWFAYNAYRSAMKLLTV
CEEEEEECHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
GGYD
CCCC
>Mature Secondary Structure 
SGETRHRLAQLRQMFLQERGSASRLAFTSGNAVRLCDGGAAFFPALIERIDAARERVAL
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHEE
ETYIFCDDAVGRAVSDALVRAAARGVHVRVITDGIGTERLPLFGTWPDAGVEHRIYNPYL
EEEEEECHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCCCCCCEECCCEE
FGRFGFSRTHRKLAVIDDACAFCGGINIVDDFEQNGERLPHPRWDFAVELAGPAVADVRA
EEECCCCHHCCEEEEEHHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHH
AFEVQWHRIAAGHKRYAQYLPHDVDGPAFAARFRRWMRSHRWVKAGALRVVTEPSVAFVA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNIVNRRAIEKAYLAAIGRARQSILLANPYFMPGRKLRRALAGAARRGVDVRILLGRNE
CCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCC
FASLDMAVPFLYHALLRSGVRVAEYDKTMLHGKVAVIDDHWATVGSSNLDALSLMLNNEA
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCEEEEEECCHHHCCCCCCCEEEEEECCCC
NVVLVRHREETAALRDAIAAAFADGREIDPALYAARPAAERFLNWFAYNAYRSAMKLLTV
CEEEEEECHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
GGYD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]