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The map label for this gene is hemH [H]

Identifier: 126454237

GI number: 126454237

Start: 3232905

End: 3234008

Strand: Reverse

Name: hemH [H]

Synonym: BURPS1106A_3316

Alternate gene names: 126454237

Gene position: 3234008-3232905 (Counterclockwise)

Preceding gene: 126455393

Following gene: 126452935

Centisome position: 81.08

GC content: 69.2

Gene sequence:

>1104_bases
GTGTCGTTCGATTCGGTGCCCCGGCACGCTCTTTCCATGCGTTTTGACCTCGAACCGCCGTCGCACGCGTCGGCCGCCCA
CCGCGTCGCCGTGCTGCTCGTCAATCTCGGCACGCCCGACGCGCCGACGCCGCGCGCGGTGCGCCGCTATCTGGCGCAGT
TCCTGTCCGACCCGCGCGTCGTCGAGATTCCGCAGCTCGTCTGGCAGGTGATCCTGCGCACGCTGATCCTGCCGCTGCGC
GGCCGCGCGTCCGCGAAGAAATACGCGGCTGTCTGGCTGCCGGAAGGCTCGCCGCTGCGCGTTTATACGGAGCGCCAGGT
CGAGAGCGTGAAACCGCTCTTTGCGGCGAACGGCTACCGGGTGATCGTCGATTACGCGATGCGCTACGGCACGCCGAGCA
TCGCCGACGTGCTCGCGCAACTGAAGCGCGCGGGCGCCGAGCGCGTGCTGCTGCTGCCGATGTATCCGCAATATTCGTCA
TCGACGACGGCCACCGCGTTCGACGCGGCGTTCGCCGCGCTCGGCCGGATGCGCAACCAGCCGGAGGTCCGCACGGTGCG
CCACTACGCGGATCACCCGGCCTATATCCACGCGCTCGCCGAGCAGGTCCGCCAGTATTGGGCGGCGCATGGCCGGCCGG
CTTTCGATGCGGGCGACAAGCTCGTGCTGAGCTTTCACGGCGTGCCCAAGCGCACGCTCGACCTCGGCGATCCTTACCAT
GACCAGTGCCAGCAGACAGCCGCGCTGTTGATGTCCGCGCTCGGCCTGACGACGTTCGAGTGCCGGGTCACGTTCCAGTC
GCGCTTCGGCAAGGCCGAGTGGCTGCAGCCCTACACGGCGCCCACCCTCAAGGAGCTCGGCGCGGCGGGCGTGCGGCGCG
CCGACGTGTTCTGCCCGGGCTTCACGGCCGACTGCCTCGAGACGATCGAGGAGATCGGCATCGAAGTGCGCGACGAGTTC
GTGCACGGCGGCGGCAAGGAGTTTCACCGGATTCCGTGCCTGAATGCGTCGCCCGCGTGGATCGCCGCGCTCGGCGAGAT
CGCCGCGGAAAACCTGCAAGGCTGGCCGGTGCGCGTCGCGATGGCGCCGGAAGCCGTGAGCTGA

Upstream 100 bases:

>100_bases
TTCCGCTCGGGCTACGTCATCGCCATCGTGCCGGCCCGCCGGGCGCCGTGCAATCGGCCGGACGGCCGACTGGTGGTGCC
CGGCCGCCCCGCTATAATGA

Downstream 100 bases:

>100_bases
TCGCGATGAACTTCAAGATTTCGACCGAACCCGGCGCGCGGCTGCGCATCGACAAATGGCTCTGGGCCGCGCGCTTCTTC
AAGACCCGCTCGCTCGCGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSFDSVPRHALSMRFDLEPPSHASAAHRVAVLLVNLGTPDAPTPRAVRRYLAQFLSDPRVVEIPQLVWQVILRTLILPLR
GRASAKKYAAVWLPEGSPLRVYTERQVESVKPLFAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSS
STTATAFDAAFAALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSFHGVPKRTLDLGDPYH
DQCQQTAALLMSALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGIEVRDEF
VHGGGKEFHRIPCLNASPAWIAALGEIAAENLQGWPVRVAMAPEAVS

Sequences:

>Translated_367_residues
MSFDSVPRHALSMRFDLEPPSHASAAHRVAVLLVNLGTPDAPTPRAVRRYLAQFLSDPRVVEIPQLVWQVILRTLILPLR
GRASAKKYAAVWLPEGSPLRVYTERQVESVKPLFAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSS
STTATAFDAAFAALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSFHGVPKRTLDLGDPYH
DQCQQTAALLMSALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGIEVRDEF
VHGGGKEFHRIPCLNASPAWIAALGEIAAENLQGWPVRVAMAPEAVS
>Mature_366_residues
SFDSVPRHALSMRFDLEPPSHASAAHRVAVLLVNLGTPDAPTPRAVRRYLAQFLSDPRVVEIPQLVWQVILRTLILPLRG
RASAKKYAAVWLPEGSPLRVYTERQVESVKPLFAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSSS
TTATAFDAAFAALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSFHGVPKRTLDLGDPYHD
QCQQTAALLMSALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGIEVRDEFV
HGGGKEFHRIPCLNASPAWIAALGEIAAENLQGWPVRVAMAPEAVS

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=25.6505576208178, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=25.6505576208178, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.6521739130435, Blast_Score=278, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6324750, Length=357, Percent_Identity=23.249299719888, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=26.5486725663717, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24651774, Length=268, Percent_Identity=26.4925373134328, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 40571; Mature: 40440

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDSVPRHALSMRFDLEPPSHASAAHRVAVLLVNLGTPDAPTPRAVRRYLAQFLSDPRV
CCCCHHCHHHHHEEECCCCCCCHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
VEIPQLVWQVILRTLILPLRGRASAKKYAAVWLPEGSPLRVYTERQVESVKPLFAANGYR
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHCHHHHCCCCE
VIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSSSTTATAFDAAFAALGRMRNQ
EEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
PEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSFHGVPKRTLDLGDPYH
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHH
DQCQQTAALLMSALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPG
HHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCC
FTADCLETIEEIGIEVRDEFVHGGGKEFHRIPCLNASPAWIAALGEIAAENLQGWPVRVA
CCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEE
MAPEAVS
ECCCCCC
>Mature Secondary Structure 
SFDSVPRHALSMRFDLEPPSHASAAHRVAVLLVNLGTPDAPTPRAVRRYLAQFLSDPRV
CCCHHCHHHHHEEECCCCCCCHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCE
VEIPQLVWQVILRTLILPLRGRASAKKYAAVWLPEGSPLRVYTERQVESVKPLFAANGYR
EHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHCHHHHCCCCE
VIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSSSTTATAFDAAFAALGRMRNQ
EEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
PEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDAGDKLVLSFHGVPKRTLDLGDPYH
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHH
DQCQQTAALLMSALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPG
HHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCC
FTADCLETIEEIGIEVRDEFVHGGGKEFHRIPCLNASPAWIAALGEIAAENLQGWPVRVA
CCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEE
MAPEAVS
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA