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The map label for this gene is phhA [H]

Identifier: 126454218

GI number: 126454218

Start: 3979941

End: 3980834

Strand: Direct

Name: phhA [H]

Synonym: BURPS1106A_4075

Alternate gene names: 126454218

Gene position: 3979941-3980834 (Clockwise)

Preceding gene: 126454947

Following gene: 126455335

Centisome position: 99.79

GC content: 67.56

Gene sequence:

>894_bases
ATGTCCACGGTCGTTACCGCGAAACTGAAGGAACAGTTCGACGCGGGCCTCGAAACCCGCGCCGATTTCACCATCGATCA
GCCGCTCGCCCGTTACGGCGACGTCGACCACGCGGTGTGGACGCAGTTGTATACGCGGCAGGCGGCGCTGCTGCGCGGCC
GTGCATGCGACGCGTTCATCGAGGGCCTCGCGCGCATCGGCCTCGCGCCCGATCGCGTGCCGTCGTTCGCCGACGTGAAC
CGGCGGCTCGAGCCCGCAACCGGCTGGCGCATCGTCGCGGTGCCGGGCCTCGTGCCGGACGCCGTTTTCTTCGAGCATCT
CGCGAACCGGCGGTTTCCGGTCACCTGGTGGATGCGCCGCCCGGACCAGCTCGATTATCTACAGGAGCCGGACTGCTTCC
ACGATCTGTTCGGCCACGTGCCGCTGCTGATCGATCCCGTATTCGCCGACTACATGCACGCATACGGCCGCGCGGCGCTT
CGCGTCGCCGACGACGCAAGCGCGCTCGCGCTCCTTGCGCGCCTCTATTGGTATACGGTCGAATTCGGCCTGATTCGCGA
CACGCGCGGCGAAAACGGGCTGCGGATCTACGGCGCGGGCATCGTGTCGAGCAAGGGCGAAACGCTCTACAGCCTCGAAA
GCGCGTCGCCGAACCGGATCGGCTTCGATCTCGAACGCGTGATGCGGACCCGATACCGGATCGACACGTTCCAGAAGACC
TACTTCGTGATCGACGATTTCGCGCAACTCTTCGCGCTCGCCGACCTCGACGCGCGCGCGCTCGCCGCGCGGCTCGCCGG
CGCGCCCGAGCACGCGGCGGGCGCGGTGCTTGACGGCGATCATGTGCTCACGCGCGGCACCGGTGAAGGCTGGGCAGCCG
ATGCAGACGCTTGA

Upstream 100 bases:

>100_bases
CATTTATCAGCACACAATCGCCCATTTTGCGCCCAAACCGCGCGAGCCCCGCTCTACACTTGCATGCATCCCCACCACTG
ATGCGAAGCAGGGCTACCCC

Downstream 100 bases:

>100_bases
CGAACAATTATGGAAGAATGGCCGATACGGCGCGCCGCCGCGCGAATGGGCGCGGCCGCGCCGCTATTGGACGAGGGACG
AAAATGATTCACAAGCTCAC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSTVVTAKLKEQFDAGLETRADFTIDQPLARYGDVDHAVWTQLYTRQAALLRGRACDAFIEGLARIGLAPDRVPSFADVN
RRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAAL
RVADDASALALLARLYWYTVEFGLIRDTRGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTFQKT
YFVIDDFAQLFALADLDARALAARLAGAPEHAAGAVLDGDHVLTRGTGEGWAADADA

Sequences:

>Translated_297_residues
MSTVVTAKLKEQFDAGLETRADFTIDQPLARYGDVDHAVWTQLYTRQAALLRGRACDAFIEGLARIGLAPDRVPSFADVN
RRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAAL
RVADDASALALLARLYWYTVEFGLIRDTRGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTFQKT
YFVIDDFAQLFALADLDARALAARLAGAPEHAAGAVLDGDHVLTRGTGEGWAADADA
>Mature_296_residues
STVVTAKLKEQFDAGLETRADFTIDQPLARYGDVDHAVWTQLYTRQAALLRGRACDAFIEGLARIGLAPDRVPSFADVNR
RLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAALR
VADDASALALLARLYWYTVEFGLIRDTRGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTFQKTY
FVIDDFAQLFALADLDARALAARLAGAPEHAAGAVLDGDHVLTRGTGEGWAADADA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=226, Percent_Identity=36.283185840708, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI88900505, Length=226, Percent_Identity=36.283185840708, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI88900501, Length=226, Percent_Identity=36.283185840708, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557819, Length=227, Percent_Identity=33.0396475770925, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI31795563, Length=229, Percent_Identity=32.7510917030568, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4759248, Length=224, Percent_Identity=32.1428571428571, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531391, Length=225, Percent_Identity=37.3333333333333, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI115533973, Length=236, Percent_Identity=31.7796610169492, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=236, Percent_Identity=31.7796610169492, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=218, Percent_Identity=31.1926605504587, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71980731, Length=150, Percent_Identity=30, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=34.375, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=34.375, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654994, Length=271, Percent_Identity=29.8892988929889, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136774, Length=224, Percent_Identity=29.0178571428571, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17136776, Length=224, Percent_Identity=29.0178571428571, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33095; Mature: 32964

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVVTAKLKEQFDAGLETRADFTIDQPLARYGDVDHAVWTQLYTRQAALLRGRACDAFI
CCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHH
EGLARIGLAPDRVPSFADVNRRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRR
HHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEECCC
PDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAALRVADDASALALLARLYWYTV
CCCCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCHHEEEECCCHHHHHHHHHHHHHHH
EFGLIRDTRGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTFQKT
HHEEEECCCCCCCEEEEEECEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFVIDDFAQLFALADLDARALAARLAGAPEHAAGAVLDGDHVLTRGTGEGWAADADA
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCEECCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
STVVTAKLKEQFDAGLETRADFTIDQPLARYGDVDHAVWTQLYTRQAALLRGRACDAFI
CCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHH
EGLARIGLAPDRVPSFADVNRRLEPATGWRIVAVPGLVPDAVFFEHLANRRFPVTWWMRR
HHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEECCC
PDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGRAALRVADDASALALLARLYWYTV
CCCCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCHHEEEECCCHHHHHHHHHHHHHHH
EFGLIRDTRGENGLRIYGAGIVSSKGETLYSLESASPNRIGFDLERVMRTRYRIDTFQKT
HHEEEECCCCCCCEEEEEECEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
YFVIDDFAQLFALADLDARALAARLAGAPEHAAGAVLDGDHVLTRGTGEGWAADADA
HHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCEECCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]