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The map label for this gene is speE [H]

Identifier: 126454202

GI number: 126454202

Start: 3377157

End: 3378014

Strand: Direct

Name: speE [H]

Synonym: BURPS1106A_3470

Alternate gene names: 126454202

Gene position: 3377157-3378014 (Clockwise)

Preceding gene: 126453381

Following gene: 126451733

Centisome position: 84.67

GC content: 69.46

Gene sequence:

>858_bases
TTGAGCACCACCCTCCTCTTTCACCCGACTCCCGACGTCGCGTACGGCTTTCCGAACGCCCGGCGGCTCGCGCGCATCGA
ATCCGAGTATCAGGAGATCGAGGTCTGGGAAACATCGCTGCTCGGGCGGCTCTTCACGCTCGACGGCCGGCCGATGACGT
CGGTCGGCGACGAGTTCGTCTATCACGAATGCATGACGCATCCGGCCGCGCTCGCGCACCCGGCGCCGAAAAAAGCGCTC
GTGCTCGGCGGCGGCGACGGCGGCGCCGCGCGCCAGCTGCTGCGGCATCCGTGCATCGAGCGGATCGTCGTCGCGGAGCT
CGATGCGGCTGTCGTCGACATGGCGCGCCGCTTTCTCGGCGACGTGCATCAGGGCGCGCTCGACGATCCGCGCGTCGAGC
TCGCGATCGGCGACGCCGCGCGCTACGTCGACCACGCGTGCGAGCACTTCGATCTCGCGGTGTTCGACCTGACGCCGCCC
GACTCGCCCGCGGCGGGCCTCTATACGCCCGCGTTCTACACGCGCCTGAAGCGCATCCTGACGCCGCAGGGCGCGGTGTC
GCTGCATCTGGGCTCGCCGCTTTATCACGGAGCGCGCATCGCCGCGCTGCTCGCCGGGCTGCGCGAGCGCTTCGCGGTCG
TCGCGCCGCTTTGCGCGCACGTGCCGCTGTACGGCTCGCCTTGGCTGATGGCGATCGCGAGCGACACGCTCGACGCGGCT
TCGCTGTTCTCGCACGACATCGACGCGCGGCTCGCCGAGCGGCACATCGAAGGCCTGCGCTTCTACGACGCGAAGCTGCA
TTCCGCACTCTTCACGCTGCCGCACGCGCTGCGCGATACTCTCGGCATGCATCGCTAA

Upstream 100 bases:

>100_bases
GGCCTTGTCGGAATCCGCCCGCGCGCGCGGTTTCTCGGCCCTCCTCCCACCCTCTATAATTCAGACCATCGGAACCGCCC
GCCCAGCCGCGCCCGCCGCC

Downstream 100 bases:

>100_bases
GTTCGGCGAAGCATCCGCCTTTCCCGCAGGAGAACCCGCATGACCGACCCACGGCCGGCCGACGTGCCCTGGTTGACCCC
TTATCTGACGGTGCGCAGCG

Product: spermidine synthase

Products: NA

Alternate protein names: Putrescine aminopropyltransferase; PAPT; SPDSY [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSTTLLFHPTPDVAYGFPNARRLARIESEYQEIEVWETSLLGRLFTLDGRPMTSVGDEFVYHECMTHPAALAHPAPKKAL
VLGGGDGGAARQLLRHPCIERIVVAELDAAVVDMARRFLGDVHQGALDDPRVELAIGDAARYVDHACEHFDLAVFDLTPP
DSPAAGLYTPAFYTRLKRILTPQGAVSLHLGSPLYHGARIAALLAGLRERFAVVAPLCAHVPLYGSPWLMAIASDTLDAA
SLFSHDIDARLAERHIEGLRFYDAKLHSALFTLPHALRDTLGMHR

Sequences:

>Translated_285_residues
MSTTLLFHPTPDVAYGFPNARRLARIESEYQEIEVWETSLLGRLFTLDGRPMTSVGDEFVYHECMTHPAALAHPAPKKAL
VLGGGDGGAARQLLRHPCIERIVVAELDAAVVDMARRFLGDVHQGALDDPRVELAIGDAARYVDHACEHFDLAVFDLTPP
DSPAAGLYTPAFYTRLKRILTPQGAVSLHLGSPLYHGARIAALLAGLRERFAVVAPLCAHVPLYGSPWLMAIASDTLDAA
SLFSHDIDARLAERHIEGLRFYDAKLHSALFTLPHALRDTLGMHR
>Mature_284_residues
STTLLFHPTPDVAYGFPNARRLARIESEYQEIEVWETSLLGRLFTLDGRPMTSVGDEFVYHECMTHPAALAHPAPKKALV
LGGGDGGAARQLLRHPCIERIVVAELDAAVVDMARRFLGDVHQGALDDPRVELAIGDAARYVDHACEHFDLAVFDLTPPD
SPAAGLYTPAFYTRLKRILTPQGAVSLHLGSPLYHGARIAALLAGLRERFAVVAPLCAHVPLYGSPWLMAIASDTLDAAS
LFSHDIDARLAERHIEGLRFYDAKLHSALFTLPHALRDTLGMHR

Specific function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor [H]

COG id: COG0421

COG function: function code E; Spermidine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the spermidine/spermine synthase family [H]

Homologues:

Organism=Homo sapiens, GI63253298, Length=256, Percent_Identity=26.953125, Blast_Score=121, Evalue=6e-28,
Organism=Escherichia coli, GI1786312, Length=284, Percent_Identity=33.4507042253521, Blast_Score=158, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25154106, Length=278, Percent_Identity=31.294964028777, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI212645616, Length=323, Percent_Identity=26.9349845201238, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323175, Length=253, Percent_Identity=29.2490118577075, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6325326, Length=251, Percent_Identity=29.0836653386454, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24645443, Length=273, Percent_Identity=30.4029304029304, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21355941, Length=212, Percent_Identity=31.6037735849057, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001045 [H]

Pfam domain/function: PF01564 Spermine_synth [H]

EC number: =2.5.1.16 [H]

Molecular weight: Translated: 31224; Mature: 31093

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS51006 SPERMIDINE_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLLFHPTPDVAYGFPNARRLARIESEYQEIEVWETSLLGRLFTLDGRPMTSVGDEFV
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHH
YHECMTHPAALAHPAPKKALVLGGGDGGAARQLLRHPCIERIVVAELDAAVVDMARRFLG
HHHHHCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVHQGALDDPRVELAIGDAARYVDHACEHFDLAVFDLTPPDSPAAGLYTPAFYTRLKRIL
HHHCCCCCCCCEEEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHH
TPQGAVSLHLGSPLYHGARIAALLAGLRERFAVVAPLCAHVPLYGSPWLMAIASDTLDAA
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHCCHHHH
SLFSHDIDARLAERHIEGLRFYDAKLHSALFTLPHALRDTLGMHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLLFHPTPDVAYGFPNARRLARIESEYQEIEVWETSLLGRLFTLDGRPMTSVGDEFV
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHH
YHECMTHPAALAHPAPKKALVLGGGDGGAARQLLRHPCIERIVVAELDAAVVDMARRFLG
HHHHHCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVHQGALDDPRVELAIGDAARYVDHACEHFDLAVFDLTPPDSPAAGLYTPAFYTRLKRIL
HHHCCCCCCCCEEEEECHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHH
TPQGAVSLHLGSPLYHGARIAALLAGLRERFAVVAPLCAHVPLYGSPWLMAIASDTLDAA
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHCCHHHH
SLFSHDIDARLAERHIEGLRFYDAKLHSALFTLPHALRDTLGMHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]