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The map label for this gene is proC [H]

Identifier: 126454190

GI number: 126454190

Start: 3258082

End: 3258894

Strand: Direct

Name: proC [H]

Synonym: BURPS1106A_3334

Alternate gene names: 126454190

Gene position: 3258082-3258894 (Clockwise)

Preceding gene: 126451773

Following gene: 126453625

Centisome position: 81.69

GC content: 73.06

Gene sequence:

>813_bases
ATGAAAATCGCATTCATCGGCGGCGGCAACATGGCGGCCGCGTTGATCGGCGGACTCGTCAAGCGCGGCGTCGACGCGAG
CGGCCTGCTCGCCGTCGACGTCAACGAAGACGCGCGGCAGCGCGCGCAAGCGCAATTCGGCGTGCGCACGGCGGCCGCCG
TCGACGCCACGCTCGCCGGCTACGACGCGATCGTGCTCGCCGTGAAGCCGCAGGTGCTCAAGGACGTCGCGCTCGCGCTC
GCGCCGCATCTGACGACGCAACTCGTCGTGAGCATCGCGGCCGGCATTCGCGGCGCGGACCTGTCGCGCTGGCTCGGCGA
CTACCCGCGCGTCGTGCGCACGATGCCGAACACGCCGGCGCTCGTTGGCCTGGGCGTGACCGGCCTGTCCGCGCTGCCGG
GCGTCGATGCGGCAGGCCGCGATCTCGCGTCGAAAGTGCTCGGCGCGGTCGGCGAGACCGTCTGGTTCGACGACGAATCG
CAGCTCGACGCGGTCACCGCGATCTCGGGCAGCGGCCCCGCGTACGTGTTCTATTTCATCGAGGCGCTGCAGGAAGCGGC
GCGCCAGCTCGGCATGAACGACGAGCAGGGCCGCGCGCTCGCGGTGGCGACGTTCGCGGGCGCCGCGCAGCTCGCGGTGC
AGTCGGGCGAGCCCGCGGGCGTGCTGCGCGAGCGCGTGACGTCCAAGGGCGGCACGACGGCGGCCGCGCTCGCGTCGTTC
GACGCGCAGCACGTGAAGGACGCGATCGTGCGCGGCGTGCTGGCCGCGCAGGCGCGCGCGAGGGAAATGGGCGACGAGCT
CGGCGGCGCCTGA

Upstream 100 bases:

>100_bases
CGCCGAAGGCGCGACAATCGTGCGTATCGGCACCGCGATCTTCGGCGCGCGCGACTACGCGCACTGACCCCTCCCTTCTC
TCTCGACCCTCTCACTCATC

Downstream 100 bases:

>100_bases
GCCTCGGCTGCCCGGACTTCGGCGTTTGGATTTCAGCGTTTGAACCTCGACGCTCGAACTTCGACACTCGAACTTCGGCG
ATCGAGCTGCGGCACTCGAT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKIAFIGGGNMAAALIGGLVKRGVDASGLLAVDVNEDARQRAQAQFGVRTAAAVDATLAGYDAIVLAVKPQVLKDVALAL
APHLTTQLVVSIAAGIRGADLSRWLGDYPRVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDES
QLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPAGVLRERVTSKGGTTAAALASF
DAQHVKDAIVRGVLAAQARAREMGDELGGA

Sequences:

>Translated_270_residues
MKIAFIGGGNMAAALIGGLVKRGVDASGLLAVDVNEDARQRAQAQFGVRTAAAVDATLAGYDAIVLAVKPQVLKDVALAL
APHLTTQLVVSIAAGIRGADLSRWLGDYPRVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDES
QLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPAGVLRERVTSKGGTTAAALASF
DAQHVKDAIVRGVLAAQARAREMGDELGGA
>Mature_270_residues
MKIAFIGGGNMAAALIGGLVKRGVDASGLLAVDVNEDARQRAQAQFGVRTAAAVDATLAGYDAIVLAVKPQVLKDVALAL
APHLTTQLVVSIAAGIRGADLSRWLGDYPRVVRTMPNTPALVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDES
QLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPAGVLRERVTSKGGTTAAALASF
DAQHVKDAIVRGVLAAQARAREMGDELGGA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=32.5757575757576, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=31.3653136531365, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=31.3653136531365, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=28.7822878228782, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=34.2105263157895, Blast_Score=128, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=33.457249070632, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=28.2142857142857, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=226, Percent_Identity=29.2035398230088, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=37.1212121212121, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=31.8840579710145, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=40.2366863905325, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27474; Mature: 27474

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGLVKRGVDASGLLAVDVNEDARQRAQAQFGVRTAAAVDATLAG
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHC
YDAIVLAVKPQVLKDVALALAPHLTTQLVVSIAAGIRGADLSRWLGDYPRVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
LVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDESQLDAVTAISGSGPAYVFYFI
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHEEEECCCCCCHHHHHH
EALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPAGVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEHHCHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHH
DAQHVKDAIVRGVLAAQARAREMGDELGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGLVKRGVDASGLLAVDVNEDARQRAQAQFGVRTAAAVDATLAG
CEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHC
YDAIVLAVKPQVLKDVALALAPHLTTQLVVSIAAGIRGADLSRWLGDYPRVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
LVGLGVTGLSALPGVDAAGRDLASKVLGAVGETVWFDDESQLDAVTAISGSGPAYVFYFI
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHEEEECCCCCCHHHHHH
EALQEAARQLGMNDEQGRALAVATFAGAAQLAVQSGEPAGVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEHHCHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHH
DAQHVKDAIVRGVLAAQARAREMGDELGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]