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The map label for this gene is fumC [H]

Identifier: 126454162

GI number: 126454162

Start: 2835001

End: 2836896

Strand: Direct

Name: fumC [H]

Synonym: BURPS1106A_2886

Alternate gene names: 126454162

Gene position: 2835001-2836896 (Clockwise)

Preceding gene: 126454795

Following gene: 126452597

Centisome position: 71.08

GC content: 68.09

Gene sequence:

>1896_bases
GTGGCAACGGTCCGCGCGATCGCTCATGCGCGCCGCAAGTCAGTCTCCGATCATTCATTTTTGCCGAAAGGCGTCGAGCG
CAGTATGACGACGGTCGATTCGCCGCGTGACGCGAACGGCCCCCCTCGCTTCGCCGCCAGCGGGTTCGCCACGCCCCGCC
GCCCCGATGACACCGATGACACTGGCGACGCCGACGAAACGGCCGCCACCGTCCCACATCGAACACGCGCGCTCACAACG
CCGCCCCGACGAAAAACGATCGCCGCGCCACGTATCGATGCTCGCACCCGCCGCGATCGCCCCGCTCGTCGCGCTACGCA
TGCGCGCCGCGCGCTCGCCGATTTCCGCGCCCCCGCGCCGCCCATCGCACGCGGCACGACACGAAATCGCGCGCGGCGCT
ATGCTTGCCCATCAGTGGATGCCGTCGCGAGAACGGCTCCGTCCCCGCATGCGCATCGCGCCGCGCCCGCGCGGCGTCCC
CCGTCATCTGAAGGAGCAATCATGAGCGAAGCAGTACGGATGGAACGCGACACGTTCGGCGAAATCGCCGTGCCGGCCGC
CCGGCTATGGGGCGCGCAGACGCAGCGCTCGCTGCAGAACTTCAAGATCTCGACCGAGAAGCAGTCGCCCGAACTGATCC
ACGCGCTCGCGCTGATCAAGCGCGCGGCCGCCGCCGTCAATCTCGAGCTCGGCGTGCTCGCGCAGGACAAGGCGAACGCG
ATCGTCGCCGCCGCCGACGAGATCATCGCCGGCCGTCACGCCGACGAATTCCCGCTCGCCGTCTGGCAAACGGGTTCGGG
CACGCAGACCAACATGAACCTCAACGAGGTGATCGCGAACCGCGCGAGCGAGCTGCTCGGCGGCGAGCGCGGCGAAAGCC
GCGCCGTGCATCCAAACGATGACGTCAATCGCGGCCAGTCGTCGAACGACGTGTTCCCGACCGCGATGCACATCGCCGCC
GCGCGTGCGATCGTCGACCATCTGCTGCCCGCGCTGCGCACGCTGCGCGCGACACTCGACGCGAAGGCCGCCGCGTTCGC
CGACATCGTGAAGATCGGCCGCACGCACCTGCAGGACGCGACGCCGCTCACGCTCGGCCAGGAATTCTCCGGCTACGTCG
CGCAGCTCGATCAGGGCATCCGTCACGTCGAGGCGGCGCTGCCTCATCTGTACGAGCTCGCGCAAGGCGGCACCGCGGTC
GGCACGGGCCTGAACGCGCATCCGAAGTTCGCGGCGGGCGTTGCGGCCGAGATCGGCCGGCTCACCGGCCTGCCGTTCGT
CAGCGCACCGAACAAATTCGAAGTGATGGCCGCTGCCGACGCGCTCGTGTTCGCGCACGGCGCGCTGAAGACGGTCGCCG
CGAGCCTGATGAAGATCGCGAACGACATCCGCTGGCTCGCGAGCGGGCCGCGCTGCGGGCTCGGCGAGCTGTCGATTCCG
GAAAACGAGCCGGGCAGCTCGATCATGCCGGGCAAGGTCAATCCGACGCAATCCGAAGCGGTGACGATGCTGTGCTGCCA
GGTGTTCGGCAATGACGTCGCGGTGAACTTCGGCGGCGCGAGCGGCAATTTCGAGCTGAACGTGTTTCGGCCGATGATCG
CGCACAACGTGCTGCAATCGGTGCGGCTGCTCGCGGACGGCGCACGGGGCTTCAACGATCATTGCGCGGTCGGCATCGAG
CCGAATCGCGCGCGCATCGACGCGCTGCTGAACGAATCGCTGATGCTCGTGACGGCGCTCAATCCGCACATCGGCTACGA
CAAGGCCGCGCAGATCGCGAAGAAGGCGCACAAGGAAGGCACCACGCTCAAAGCCGCCGCGCTTGCGCTCGGTTACGTGA
CCGATGCGCAGTTCGACGAATGGGTGCGGCCGGAGCATATGGTCGGCAACCGCTGA

Upstream 100 bases:

>100_bases
GCTTAGGCTTTTGGGCTTTTTTAGCGGATAGCCGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTAGCCGTTAG
CGAGTATGCACGCAAGCATC

Downstream 100 bases:

>100_bases
CGCCGACGCGGCGCACGAGCGACGCGGCCGGCCTCTCTTACGCGCGCCGAAGCGCCGAAGCGCCGGAGCACGTCGGCGCG
CCCCGGTGAACGCAGATCGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MATVRAIAHARRKSVSDHSFLPKGVERSMTTVDSPRDANGPPRFAASGFATPRRPDDTDDTGDADETAATVPHRTRALTT
PPRRKTIAAPRIDARTRRDRPARRATHARRALADFRAPAPPIARGTTRNRARRYACPSVDAVARTAPSPHAHRAAPARRP
PSSEGAIMSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANA
IVAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPNDDVNRGQSSNDVFPTAMHIAA
ARAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAV
GTGLNAHPKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIP
ENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGARGFNDHCAVGIE
PNRARIDALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR

Sequences:

>Translated_631_residues
MATVRAIAHARRKSVSDHSFLPKGVERSMTTVDSPRDANGPPRFAASGFATPRRPDDTDDTGDADETAATVPHRTRALTT
PPRRKTIAAPRIDARTRRDRPARRATHARRALADFRAPAPPIARGTTRNRARRYACPSVDAVARTAPSPHAHRAAPARRP
PSSEGAIMSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANA
IVAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPNDDVNRGQSSNDVFPTAMHIAA
ARAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAV
GTGLNAHPKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIP
ENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGARGFNDHCAVGIE
PNRARIDALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR
>Mature_630_residues
ATVRAIAHARRKSVSDHSFLPKGVERSMTTVDSPRDANGPPRFAASGFATPRRPDDTDDTGDADETAATVPHRTRALTTP
PRRKTIAAPRIDARTRRDRPARRATHARRALADFRAPAPPIARGTTRNRARRYACPSVDAVARTAPSPHAHRAAPARRPP
SSEGAIMSEAVRMERDTFGEIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANAI
VAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPNDDVNRGQSSNDVFPTAMHIAAA
RAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVG
TGLNAHPKFAAGVAAEIGRLTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIPE
NEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQSVRLLADGARGFNDHCAVGIEP
NRARIDALLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYVTDAQFDEWVRPEHMVGNR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=478, Percent_Identity=62.1338912133891, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=48.4848484848485, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=74.2919389978213, Blast_Score=706, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=38.7931034482759, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=64.1304347826087, Blast_Score=603, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=67.5925925925926, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=59.4827586206897, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=61.6379310344828, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=61.6379310344828, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=59.6529284164859, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=60.0867678958785, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=52.9284164859002, Blast_Score=492, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 67356; Mature: 67225

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVRAIAHARRKSVSDHSFLPKGVERSMTTVDSPRDANGPPRFAASGFATPRRPDDTDD
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TGDADETAATVPHRTRALTTPPRRKTIAAPRIDARTRRDRPARRATHARRALADFRAPAP
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCC
PIARGTTRNRARRYACPSVDAVARTAPSPHAHRAAPARRPPSSEGAIMSEAVRMERDTFG
CCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
EIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANA
CHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCE
IVAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPND
EEEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
DVNRGQSSNDVFPTAMHIAAARAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAHPKFAAGVAAEIGR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHH
LTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIP
HCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHH
VRLLADGARGFNDHCAVGIEPNRARIDALLNESLMLVTALNPHIGYDKAAQIAKKAHKEG
HHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCC
TTLKAAALALGYVTDAQFDEWVRPEHMVGNR
CHHHHHHHHHHHHCCCCHHHHCCCHHHCCCC
>Mature Secondary Structure 
ATVRAIAHARRKSVSDHSFLPKGVERSMTTVDSPRDANGPPRFAASGFATPRRPDDTDD
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TGDADETAATVPHRTRALTTPPRRKTIAAPRIDARTRRDRPARRATHARRALADFRAPAP
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCC
PIARGTTRNRARRYACPSVDAVARTAPSPHAHRAAPARRPPSSEGAIMSEAVRMERDTFG
CCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
EIAVPAARLWGAQTQRSLQNFKISTEKQSPELIHALALIKRAAAAVNLELGVLAQDKANA
CHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCE
IVAAADEIIAGRHADEFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGESRAVHPND
EEEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
DVNRGQSSNDVFPTAMHIAAARAIVDHLLPALRTLRATLDAKAAAFADIVKIGRTHLQDA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPLTLGQEFSGYVAQLDQGIRHVEAALPHLYELAQGGTAVGTGLNAHPKFAAGVAAEIGR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHH
LTGLPFVSAPNKFEVMAAADALVFAHGALKTVAASLMKIANDIRWLASGPRCGLGELSIP
HCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNFGGASGNFELNVFRPMIAHNVLQS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHH
VRLLADGARGFNDHCAVGIEPNRARIDALLNESLMLVTALNPHIGYDKAAQIAKKAHKEG
HHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCC
TTLKAAALALGYVTDAQFDEWVRPEHMVGNR
CHHHHHHHHHHHHCCCCHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]