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The map label for this gene is dacC [H]

Identifier: 126454122

GI number: 126454122

Start: 422571

End: 423884

Strand: Direct

Name: dacC [H]

Synonym: BURPS1106A_0458

Alternate gene names: 126454122

Gene position: 422571-423884 (Clockwise)

Preceding gene: 126453148

Following gene: 126452552

Centisome position: 10.59

GC content: 67.5

Gene sequence:

>1314_bases
ATGCGTCTGTCTTCCCTCGGCCTCACGTCACTCGCTTCCTCCACCGCCATTGCCGTCGCCGCGCGTAACGTCGCGCTCGG
CATCGTGCTGCCCGCCGCGCTCGTGTCGACGATCGCCGTCGCGCAGGCGAAGCCCGCCGCCAAGGCGAAGCATGCGGCCG
CGCCGGCCGCCGCCGCCGCGCCGACGGGCGCGCCCGCCACGTACGTGCCGGGCGCCGTGCCGCCGCCGGGCGTGAACGCG
CGCTCGTGGGTGCTCGTCGATGCGTCGAGCAATCAGGTGCTCGCCTCCGGCAACGCCGACGAGCGTGTCGAGCCCGCGTC
GCTCACGAAGCTGATGACGGCCTACCTCGTGTTCGAGGCGCTCGACGCGAAGAAGATCACGATGGAGCAGATCGTCACGC
CGAGCGAGGCGGTGCGCCGCGTCGGCCGCGACGAATCGCGGATGTTCATCGAGGCGAACAAGCCCGTGAGCGTGCACGAT
CTCGTCTACGGGATGATCATCCAGTCGGGCAACGACGCGGCGATCGCGCTCGCCGAGCTCGTCGGCGGCAGCGAAGCGCA
GTTCGTCAACATGATGAACGCTGAAGCGCAGCGCCTCGGGATGAAGAGCACGCACTTCGCCGACGTGAACGGCATGCCCG
ACCCGAATCACTACACGACGGCGGGCGACCTCGCGAAGCTGTCGACGCATCTGATCCGCGACTATCCGGATTACTACAAC
ATCTTCTCGGTCAAGGAATTCACGTACAACAACATCAAGCAGCCGAACCGCAACCGGCTGCTGTGGCTCGATCCGACCGT
CGACGGCCTGAAGACCGGCCACACGCAGGCGGCGGGCTACTGCCTGATCGCGTCGGCGAAGCGCGCGCTGCCGGGCGCGG
CGGACGCGACGCGCCGCCTCGTCACCGTGATGATGGGCGAGACCAAGGAGAGCGACCGCGTGCAGGACAGCATGAAGATG
CTGAACTACGGCTACACCGCGTTCGATTCGGTGCGCCTGTACAAGGCCGGCCAGCCGATCGGCACGCCGCGCGTCTACAA
GGGCAAGAGCAACAACGTGCAGGTCGGCGTGAAGAAGGACCAGTTCATCACCGTGCCGCGCGGCCTGGCGGACAAGGTGA
AGCCGGAAGTCGCGCTGAACGCGCCGCTCATCGCGCCGCTCGCGGACGGCCAGGTGGTGGGCTCGGTGAAGCTCGTCGCC
GACGGCAAGACGGTGGCGGAATTCCCGGTCGTCGCGCTGCAGCCGGTGCCGGAAGCGGGCCTGCTCGGCCGCATCTGGGA
TTCGATCCTGCTGATGTTCAGCAAAAAGAAGTAA

Upstream 100 bases:

>100_bases
CGAGCCTTCGTTCCCCGACATGCCGCCGCAACGCCGCCGACCGGCCCTTCAACCGCGCGCTCCGTGCGCGCTGCAATTTC
TGCCATCAGCCTGAATCGAT

Downstream 100 bases:

>100_bases
GCTGTCCGCTCGCGTCGAGCGCGGCGCCGGCCTCGCCGGCGCCGCGGGCTTTCGCTTTCCGTCACGATTTTCGCCGTCCG
TTCAACGCCATGAATCAAGC

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRLSSLGLTSLASSTAIAVAARNVALGIVLPAALVSTIAVAQAKPAAKAKHAAAPAAAAAPTGAPATYVPGAVPPPGVNA
RSWVLVDASSNQVLASGNADERVEPASLTKLMTAYLVFEALDAKKITMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHD
LVYGMIIQSGNDAAIALAELVGGSEAQFVNMMNAEAQRLGMKSTHFADVNGMPDPNHYTTAGDLAKLSTHLIRDYPDYYN
IFSVKEFTYNNIKQPNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRALPGAADATRRLVTVMMGETKESDRVQDSMKM
LNYGYTAFDSVRLYKAGQPIGTPRVYKGKSNNVQVGVKKDQFITVPRGLADKVKPEVALNAPLIAPLADGQVVGSVKLVA
DGKTVAEFPVVALQPVPEAGLLGRIWDSILLMFSKKK

Sequences:

>Translated_437_residues
MRLSSLGLTSLASSTAIAVAARNVALGIVLPAALVSTIAVAQAKPAAKAKHAAAPAAAAAPTGAPATYVPGAVPPPGVNA
RSWVLVDASSNQVLASGNADERVEPASLTKLMTAYLVFEALDAKKITMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHD
LVYGMIIQSGNDAAIALAELVGGSEAQFVNMMNAEAQRLGMKSTHFADVNGMPDPNHYTTAGDLAKLSTHLIRDYPDYYN
IFSVKEFTYNNIKQPNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRALPGAADATRRLVTVMMGETKESDRVQDSMKM
LNYGYTAFDSVRLYKAGQPIGTPRVYKGKSNNVQVGVKKDQFITVPRGLADKVKPEVALNAPLIAPLADGQVVGSVKLVA
DGKTVAEFPVVALQPVPEAGLLGRIWDSILLMFSKKK
>Mature_437_residues
MRLSSLGLTSLASSTAIAVAARNVALGIVLPAALVSTIAVAQAKPAAKAKHAAAPAAAAAPTGAPATYVPGAVPPPGVNA
RSWVLVDASSNQVLASGNADERVEPASLTKLMTAYLVFEALDAKKITMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHD
LVYGMIIQSGNDAAIALAELVGGSEAQFVNMMNAEAQRLGMKSTHFADVNGMPDPNHYTTAGDLAKLSTHLIRDYPDYYN
IFSVKEFTYNNIKQPNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRALPGAADATRRLVTVMMGETKESDRVQDSMKM
LNYGYTAFDSVRLYKAGQPIGTPRVYKGKSNNVQVGVKKDQFITVPRGLADKVKPEVALNAPLIAPLADGQVVGSVKLVA
DGKTVAEFPVVALQPVPEAGLLGRIWDSILLMFSKKK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=369, Percent_Identity=42.2764227642276, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1786851, Length=384, Percent_Identity=40.1041666666667, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082022, Length=380, Percent_Identity=39.4736842105263, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI87082054, Length=221, Percent_Identity=32.579185520362, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 46450; Mature: 46450

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSSLGLTSLASSTAIAVAARNVALGIVLPAALVSTIAVAQAKPAAKAKHAAAPAAAAA
CCCCCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHCC
PTGAPATYVPGAVPPPGVNARSWVLVDASSNQVLASGNADERVEPASLTKLMTAYLVFEA
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LDAKKITMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHDLVYGMIIQSGNDAAIALAEL
HCCCHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHEEHEEECCCCHHEEHHHH
VGGSEAQFVNMMNAEAQRLGMKSTHFADVNGMPDPNHYTTAGDLAKLSTHLIRDYPDYYN
HCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHC
IFSVKEFTYNNIKQPNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRALPGAADATRRL
EEEEEEHHHCCCCCCCCCEEEEECCCCCCHHCCCCCCCCEEEEECHHHCCCCCHHHHHHH
VTVMMGETKESDRVQDSMKMLNYGYTAFDSVRLYKAGQPIGTPRVYKGKSNNVQVGVKKD
HHHHHCCCCCHHHHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCEEECCCCCEEEEECCC
QFITVPRGLADKVKPEVALNAPLIAPLADGQVVGSVKLVADGKTVAEFPVVALQPVPEAG
CEEECCCCCHHHCCCCEEECCCEEEECCCCEEEEEEEEEECCCCHHHCCEEEECCCCCCC
LLGRIWDSILLMFSKKK
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLSSLGLTSLASSTAIAVAARNVALGIVLPAALVSTIAVAQAKPAAKAKHAAAPAAAAA
CCCCCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHCC
PTGAPATYVPGAVPPPGVNARSWVLVDASSNQVLASGNADERVEPASLTKLMTAYLVFEA
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LDAKKITMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHDLVYGMIIQSGNDAAIALAEL
HCCCHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHEEHEEECCCCHHEEHHHH
VGGSEAQFVNMMNAEAQRLGMKSTHFADVNGMPDPNHYTTAGDLAKLSTHLIRDYPDYYN
HCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHC
IFSVKEFTYNNIKQPNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRALPGAADATRRL
EEEEEEHHHCCCCCCCCCEEEEECCCCCCHHCCCCCCCCEEEEECHHHCCCCCHHHHHHH
VTVMMGETKESDRVQDSMKMLNYGYTAFDSVRLYKAGQPIGTPRVYKGKSNNVQVGVKKD
HHHHHCCCCCHHHHHHHHHHHHCCCCHHCCEEEEECCCCCCCCCEEECCCCCEEEEECCC
QFITVPRGLADKVKPEVALNAPLIAPLADGQVVGSVKLVADGKTVAEFPVVALQPVPEAG
CEEECCCCCHHHCCCCEEECCCEEEECCCCEEEEEEEEEECCCCHHHCCEEEECCCCCCC
LLGRIWDSILLMFSKKK
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]