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The map label for this gene is rfbD [H]

Identifier: 126454004

GI number: 126454004

Start: 3060584

End: 3061480

Strand: Reverse

Name: rfbD [H]

Synonym: BURPS1106A_3138

Alternate gene names: 126454004

Gene position: 3061480-3060584 (Counterclockwise)

Preceding gene: 126452584

Following gene: 126455168

Centisome position: 76.76

GC content: 63.1

Gene sequence:

>897_bases
ATGAAGATTTTGGTGACGGGGGCAAACGGCCAAGTGGGCTGGGAACTCGCTCGGAGTCTGGCGGTATTGGGGCAAGTTGT
CCCGCTCACGCGTGAGCAGGCCGATCTCGGCCGCCCCGAAACGCTTGCTCGAATTGTTGAGGACGCGAAGCCGGATGTCG
TCGTCAATGCTGCGGCATATACGGCGGTCGATGCTGCGGAAACCGATGGTGCTGCAGCGAATGTGATCAACGGTGAGGCG
GTAGGTGTGCTGGCCGCCGCGACGAAGCGTGTCGGCGGCTTGTTCGTTCATTACTCGACGGACTACGTTTTTGACGGCAC
CAAGCCGTCGCCATACATCGAGACGGATCCGACGTGTCCCGTCAATGCCTACGGCGCCAGCAAGTTGCTGGGAGAGTTGG
CGGTTGCGGAGACCGGCGGCGACTGGCTGACGTTTCGCACCACGTGGGTGTTCGCCGCACGCGGCAAGAACTTCCTGCGA
ACGATGCTTCGTCTTGCCAAGGAGCGCGAAGAGATGAAGATCGTGGCCGATCAGTTCGGCGCGCCGACCTGGGCGCGATC
GATTGCTGACGGCACGGCCCACGCGCTCACGACCGCGATGCGTGAACGCGCGGCAGGCGCGTTCACGTCCGGCGTCTATC
ACATGACATCCGCGGGGCAGACTTCATGGCACGGTTTCGCGGACGCGATCATCGCATCCTGGCGAGCGGCTCCGGGGGCG
GCACCGCTCGCCGTCAGCCGGATCGTGCCGATTCCGGCGAGCGCCTATCCCGTGCCGGCACAGCGCCCGGCAAACTCGGT
ACTGTCGAACAAGGCGCTGAAAGAGCGTTTCGGTATCGAACTGCCTGATTGGCGGTATGCAGTAGGGCTGTGCGTCAACG
ATCTGCTTTCCCAATGA

Upstream 100 bases:

>100_bases
GCGACAAGCAAATCGGTATCGAATGGCCGATTGATCGGGAGCCGCTTGTTGCTGCAAAGGATGCCGCGGGCAAGGCGATT
AGCGAAGCCGAGGTCTATGC

Downstream 100 bases:

>100_bases
GATAAGAGAAGCAACGGCTTCACGCGATGTCGATAATTAGTGTTTTTACCTCTGCTCCGGGAGATCTCGTAAGCTCGGTC
GCGCGGAACGCTTCGCTCAT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKILVTGANGQVGWELARSLAVLGQVVPLTREQADLGRPETLARIVEDAKPDVVVNAAAYTAVDAAETDGAAANVINGEA
VGVLAAATKRVGGLFVHYSTDYVFDGTKPSPYIETDPTCPVNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLR
TMLRLAKEREEMKIVADQFGAPTWARSIADGTAHALTTAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIIASWRAAPGA
APLAVSRIVPIPASAYPVPAQRPANSVLSNKALKERFGIELPDWRYAVGLCVNDLLSQ

Sequences:

>Translated_298_residues
MKILVTGANGQVGWELARSLAVLGQVVPLTREQADLGRPETLARIVEDAKPDVVVNAAAYTAVDAAETDGAAANVINGEA
VGVLAAATKRVGGLFVHYSTDYVFDGTKPSPYIETDPTCPVNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLR
TMLRLAKEREEMKIVADQFGAPTWARSIADGTAHALTTAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIIASWRAAPGA
APLAVSRIVPIPASAYPVPAQRPANSVLSNKALKERFGIELPDWRYAVGLCVNDLLSQ
>Mature_298_residues
MKILVTGANGQVGWELARSLAVLGQVVPLTREQADLGRPETLARIVEDAKPDVVVNAAAYTAVDAAETDGAAANVINGEA
VGVLAAATKRVGGLFVHYSTDYVFDGTKPSPYIETDPTCPVNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLR
TMLRLAKEREEMKIVADQFGAPTWARSIADGTAHALTTAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIIASWRAAPGA
APLAVSRIVPIPASAYPVPAQRPANSVLSNKALKERFGIELPDWRYAVGLCVNDLLSQ

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=292, Percent_Identity=28.4246575342466, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI11034825, Length=292, Percent_Identity=28.4246575342466, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788352, Length=301, Percent_Identity=44.5182724252492, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31613; Mature: 31613

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGANGQVGWELARSLAVLGQVVPLTREQADLGRPETLARIVEDAKPDVVVNAAAY
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCEEEEHHHH
TAVDAAETDGAAANVINGEAVGVLAAATKRVGGLFVHYSTDYVFDGTKPSPYIETDPTCP
HEECCCCCCCCEEECCCCCHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCCCCCCCCCC
VNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLRTMLRLAKEREEMKIVADQFG
CCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
APTWARSIADGTAHALTTAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIIASWRAAPGA
CCHHHHHHHCCHHHHHHHHHHHHHCCHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCC
APLAVSRIVPIPASAYPVPAQRPANSVLSNKALKERFGIELPDWRYAVGLCVNDLLSQ
CCHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKILVTGANGQVGWELARSLAVLGQVVPLTREQADLGRPETLARIVEDAKPDVVVNAAAY
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCCEEEEHHHH
TAVDAAETDGAAANVINGEAVGVLAAATKRVGGLFVHYSTDYVFDGTKPSPYIETDPTCP
HEECCCCCCCCEEECCCCCHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCCCCCCCCCC
VNAYGASKLLGELAVAETGGDWLTFRTTWVFAARGKNFLRTMLRLAKEREEMKIVADQFG
CCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
APTWARSIADGTAHALTTAMRERAAGAFTSGVYHMTSAGQTSWHGFADAIIASWRAAPGA
CCHHHHHHHCCHHHHHHHHHHHHHCCHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCC
APLAVSRIVPIPASAYPVPAQRPANSVLSNKALKERFGIELPDWRYAVGLCVNDLLSQ
CCHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]