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The map label for this gene is dctA [H]

Identifier: 126453978

GI number: 126453978

Start: 1801873

End: 1803180

Strand: Reverse

Name: dctA [H]

Synonym: BURPS1106A_1845

Alternate gene names: 126453978

Gene position: 1803180-1801873 (Counterclockwise)

Preceding gene: 126454393

Following gene: 126452196

Centisome position: 45.21

GC content: 65.44

Gene sequence:

>1308_bases
ATGAAGAAAAGACGCAACATCACCTCGTACATCGTGATTGCGATGATCCTCGGCATCGCGGTTGGCTACGGCTGCCACAG
CGCGTTTCCGGATCCGGCGATCGCGAAGGAAATCGCCGGCTACGTCTCGCTGCTGTCCGACGTGTTCCTGCGTCTCATCA
AGATGATCATCGCGCCGCTCGTGTTCGCGACGCTGACGGTCGGCATCGCGCACATGGGCGACACCGGCGCCGTCGGCCGC
GTCGGCGTGAAGGCGCTCGGCTGGTTCTTCATCGCGTCGTTCACCTCGCTGCTGCTCGGCCTGCTCGCCGCCACGCTCCT
GCAGCCGGGCAGTCACCTGAGCCTGCCGCTGCCCGCCACCGACGCCGCCGTCAACCTGAAGACGAGCGCGTTCACACTGA
AGGACTTCGTGATCCATCTGGTGCCGAAGTCGATCGCCGAGGCGATGGCGAACAACGAGATCCTGCAGATCGTCGTGTTC
TCGATCTTCTTCGGCACGGCGCTGTCCGCGCTCGGCGACGCCGGCAAGCGCCTGACCGGCGTGATCGAGGATCTCGCGCA
AGTGATGCTGAAGGTCACGGGCGCGGTGATGTGGTTCGCCCCCGTCGCGGTGTTCGCGGCGCTCGCCTCGACGATCACGA
CGGAAGGACTCGGCATCCTGCTCACGTTCGCGAAGTTCATGGGCAGCTTCTACATCGCGCTCGCGCTGCTGTGGGGCGTG
CTCACGCTCGCGGGGCTCGTGTTCCTCGGCAAGCGCACGTTCACGCTGATCCGCCTGATTCGCGAGCCGTTCCTGCTGTC
GTTCGCGACCGCGAGCTCGGAGGCCGCGTACCCGAAACTGCTCGACGCGCTCGACCGCTTCGGCGTGAATCGCAAGATTT
CGAGCTTCGTGCTGCCGATCGGCTATTCGTTCAACCTCGACGGCTCGATGATGTACTGCACGTTCGCGGTGCTGTTCATC
GCGCAGGTATACGGCGTTCACCTGCCGCTCGGCACGCAGATCACGATGCTGTTGCTGCTGATGCTCACGTCGAAGGGCAT
GGCGGGCGTGCCGCGCGCGTCGCTCGTCGTGATCGCGGCGACACTCAACCAGTTCCACCTGCCCGAAGCGGGCCTGCTGC
TGATCATGGGCGTCGACATGTTCCTCGACATGGGCCGTTCGGCGACCAATGCGGTCGGCAATTCGATCGCGGCCGCCGTC
GTCGCGAAGTGGGAGGGCCAGCTCGACGCCCCGCGCGACGATGCCGACTCCGATTCCGACAGCGGCGACGCATCGCGCGG
ATCGCCGCGGATCACGCAGCGCGTGTAG

Upstream 100 bases:

>100_bases
ACCGGAAGGCGCGCGAACAGCTCAGATTTCCAGTCCACTGCTTGCACGCCGGCGAGCCGCGCCGTCATTCGCAACACCTG
CCGCGCAATTTGGACTCCTC

Downstream 100 bases:

>100_bases
CGCGCGGCCGAGCCGGGGCGGCGCTCGTTCGCCCGCGCCTCAGCCTCGCGGTAAGGCGCTCGCCCGGACGCGCTCCGCTC
GCGCGAGCAGGTTCTCGCCG

Product: dicarboxylate/amino acid:cation (Na+ or H+) symporter (DAACS) family protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKKRRNITSYIVIAMILGIAVGYGCHSAFPDPAIAKEIAGYVSLLSDVFLRLIKMIIAPLVFATLTVGIAHMGDTGAVGR
VGVKALGWFFIASFTSLLLGLLAATLLQPGSHLSLPLPATDAAVNLKTSAFTLKDFVIHLVPKSIAEAMANNEILQIVVF
SIFFGTALSALGDAGKRLTGVIEDLAQVMLKVTGAVMWFAPVAVFAALASTITTEGLGILLTFAKFMGSFYIALALLWGV
LTLAGLVFLGKRTFTLIRLIREPFLLSFATASSEAAYPKLLDALDRFGVNRKISSFVLPIGYSFNLDGSMMYCTFAVLFI
AQVYGVHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLNQFHLPEAGLLLIMGVDMFLDMGRSATNAVGNSIAAAV
VAKWEGQLDAPRDDADSDSDSGDASRGSPRITQRV

Sequences:

>Translated_435_residues
MKKRRNITSYIVIAMILGIAVGYGCHSAFPDPAIAKEIAGYVSLLSDVFLRLIKMIIAPLVFATLTVGIAHMGDTGAVGR
VGVKALGWFFIASFTSLLLGLLAATLLQPGSHLSLPLPATDAAVNLKTSAFTLKDFVIHLVPKSIAEAMANNEILQIVVF
SIFFGTALSALGDAGKRLTGVIEDLAQVMLKVTGAVMWFAPVAVFAALASTITTEGLGILLTFAKFMGSFYIALALLWGV
LTLAGLVFLGKRTFTLIRLIREPFLLSFATASSEAAYPKLLDALDRFGVNRKISSFVLPIGYSFNLDGSMMYCTFAVLFI
AQVYGVHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLNQFHLPEAGLLLIMGVDMFLDMGRSATNAVGNSIAAAV
VAKWEGQLDAPRDDADSDSDSGDASRGSPRITQRV
>Mature_435_residues
MKKRRNITSYIVIAMILGIAVGYGCHSAFPDPAIAKEIAGYVSLLSDVFLRLIKMIIAPLVFATLTVGIAHMGDTGAVGR
VGVKALGWFFIASFTSLLLGLLAATLLQPGSHLSLPLPATDAAVNLKTSAFTLKDFVIHLVPKSIAEAMANNEILQIVVF
SIFFGTALSALGDAGKRLTGVIEDLAQVMLKVTGAVMWFAPVAVFAALASTITTEGLGILLTFAKFMGSFYIALALLWGV
LTLAGLVFLGKRTFTLIRLIREPFLLSFATASSEAAYPKLLDALDRFGVNRKISSFVLPIGYSFNLDGSMMYCTFAVLFI
AQVYGVHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLNQFHLPEAGLLLIMGVDMFLDMGRSATNAVGNSIAAAV
VAKWEGQLDAPRDDADSDSDSGDASRGSPRITQRV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=482, Percent_Identity=25.9336099585062, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI21314632, Length=441, Percent_Identity=27.2108843537415, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI40254478, Length=449, Percent_Identity=24.0534521158129, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4827012, Length=256, Percent_Identity=33.203125, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI5032093, Length=384, Percent_Identity=28.3854166666667, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI194239697, Length=283, Percent_Identity=30.0353356890459, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468566, Length=279, Percent_Identity=28.3154121863799, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=29.520295202952, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI66773030, Length=415, Percent_Identity=23.1325301204819, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI262359914, Length=414, Percent_Identity=24.1545893719807, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI301601644, Length=196, Percent_Identity=28.0612244897959, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1789947, Length=385, Percent_Identity=41.038961038961, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=38.1067961165049, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1788024, Length=421, Percent_Identity=23.7529691211401, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789473, Length=242, Percent_Identity=25.6198347107438, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=440, Percent_Identity=25.4545454545455, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71996953, Length=477, Percent_Identity=27.4633123689727, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71983099, Length=419, Percent_Identity=25.2983293556086, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=419, Percent_Identity=25.2983293556086, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=477, Percent_Identity=24.7379454926625, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=445, Percent_Identity=22.4719101123595, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=23.5, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24583025, Length=399, Percent_Identity=26.0651629072682, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17137668, Length=399, Percent_Identity=26.0651629072682, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583023, Length=399, Percent_Identity=26.0651629072682, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360481, Length=432, Percent_Identity=27.0833333333333, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281360483, Length=432, Percent_Identity=27.0833333333333, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17137666, Length=432, Percent_Identity=27.0833333333333, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46215; Mature: 46215

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCHHCCC
>Mature Secondary Structure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CCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA