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The map label for this gene is aceA [H]

Identifier: 126453955

GI number: 126453955

Start: 2482622

End: 2483929

Strand: Direct

Name: aceA [H]

Synonym: BURPS1106A_2524

Alternate gene names: 126453955

Gene position: 2482622-2483929 (Clockwise)

Preceding gene: 126453899

Following gene: 126453426

Centisome position: 62.25

GC content: 64.91

Gene sequence:

>1308_bases
ATGTCGCGTCAACAACAGGCTCAGGAACTGCAAAAGCAATGGGAAACCGACCCGCGCTGGAAGGGCATCAAGCGCGCGTT
CACCGCTGAGGACGTCGTGCGCCTGCGCGGCTCGATCCAGCAAGAGCACACGCTCGCGAAGCGCGGCGCGGAAAAGCTCT
GGACGCTCATCAACAACGAGCCGTTCGTCAACGCACTCGGCGCGCTGACGGGCAACCAGGCGATGCAGCAGGTCAAGGCC
GGCCTCAAGGCGATCTATCTGTCGGGCTGGCAAGTCGCGGGCGACGCGAACGTCGCGGGCGAAATGTATCCGGACCAGTC
GCTGTACCCGGCGAACTCGGTGCCGCTCGTCGTCAAGCGCATCAACAACACGCTCACGCGCGCCGATCAGATCCAGTGGT
CGGAAGGCAAGAACCCCGGCGACGAAGGCTATGTCGACTTCTTCGCGCCGATCGTCGCCGACGCGGAAGCCGGCTTCGGC
GGCGTGCTGAACGCGTTCGAACTGATGAAGGCGATGATCGAGGCGGGCGCGTCGGGCGTTCACTTCGAAGACCAGCTCGC
CTCGGTCAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTCGTGCCGACCCGCGAGGCGGTCGCGAAGCTGACGGCCGCGC
GTCTCGCCGCCGACGTGATGGGCACGCCGACCGTGCTGGTCGCGCGCACCGACGCCGAAGCGGCCGACCTGATCACGTCC
GACATCGACGACAACGACAAGCCGTACCTGACGGGCGAGCGCACGGTCGAAGGCTTCTTCCGCACGAAGCCGGGCCTCGA
GCAGGCGATCTCGCGCGGCCTCGCCTATGCGCCGTACGCCGACCTGATCTGGTGCGAAACCGGCAAGCCGGATCTCGAAT
ACGCGAAGAAGTTCGCGGAAGCGATCCACAAGCAGTTCCCGGGCAAGCTGCTGTCGTACAACTGCTCGCCGTCGTTCAAC
TGGAAGAAGAACCTCGACGACGCGACGATCGCGAAGTTCCAGAAGGAACTCGGCGCGATGGGCTACAAGTTCCAGTTCAT
CACGCTCGCCGGCTTCCATGCGCTGAACTACTCGATGTTCAACCTCGCGCACGGCTACGCCCGCACGCAGATGAGCGCGT
TCGTCGAACTGCAGCAAGCCGAGTTCGCGGCGGCCGACAAGGGCTTCACCGCGGTCAAGCACCAGCGTGAAGTCGGCACC
GGCTACTTCGACGCGGTGACGCAGACGGTCGAGCGCGAAGCGTCGACGACCGCGCTGCACGGCTCGACCGAAGACGAACA
GTTCTTCGACGGCCAGAAAGTCGCCTGA

Upstream 100 bases:

>100_bases
GACTTCACGAACGAAACCGCCGAATCCCAATCGCGCCGTCCGTTTCGCCCAGTCAAAGATTTCTTCTCTTCAGGCAACGA
CCACTCAAGGAGTACGCATC

Downstream 100 bases:

>100_bases
GCTCCGGCAGGCGCAGGCACGCCGCGCGCGGCCATGAGCCGCCGCGGCGCGCGACCCGGCAAGACCAAGACCATATCGGG
GAGCACTCGCCTGCGGCGCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFG
GVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAEAADLITS
DIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA

Sequences:

>Translated_435_residues
MSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFG
GVLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAEAADLITS
DIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA
>Mature_434_residues
SRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNEPFVNALGALTGNQAMQQVKAG
LKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGG
VLNAFELMKAMIEAGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAEAADLITSD
IDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAEAIHKQFPGKLLSYNCSPSFNW
KKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTG
YFDAVTQTVEREASTTALHGSTEDEQFFDGQKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=69.9769053117783, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=268, Percent_Identity=27.2388059701493, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71982926, Length=418, Percent_Identity=63.8755980861244, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17561814, Length=418, Percent_Identity=63.8755980861244, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320908, Length=294, Percent_Identity=36.734693877551, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325263, Length=256, Percent_Identity=33.203125, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47775; Mature: 47644

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNE
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGGVLNAFELMKAMIEAGASGV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
DIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKLLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
NLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGQKVA
CCCCCHHHCCCCCCC
>Mature Secondary Structure 
SRQQQAQELQKQWETDPRWKGIKRAFTAEDVVRLRGSIQQEHTLAKRGAEKLWTLINNE
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGGVLNAFELMKAMIEAGASGV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTREAVAKLTAARLAADVMGTPTVLVARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
DIDDNDKPYLTGERTVEGFFRTKPGLEQAISRGLAYAPYADLIWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKLLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
NLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGQKVA
CCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]