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The map label for this gene is capD [H]

Identifier: 126453946

GI number: 126453946

Start: 3046619

End: 3048532

Strand: Reverse

Name: capD [H]

Synonym: BURPS1106A_3127

Alternate gene names: 126453946

Gene position: 3048532-3046619 (Counterclockwise)

Preceding gene: 126453366

Following gene: 126455322

Centisome position: 76.43

GC content: 65.15

Gene sequence:

>1914_bases
ATGACGCGAGCATTTTGCCCGAAGGCTTCGTGGCTTTCCCTGGGCGCCTTTCTGTTCGATCTGATGGCGGTCGTATGCGC
GTGGCTGATCGCGTATGTGGTCCGGTTCAATGGTGCGATGCCGCCTGAATTCCTGAAAGGCGCCTTCGTCGCGCTCGCAT
GGGTGGTGCCGTTGTATGGCCTGCTGTTTCATGTTTTCGGGTTGTATCGCGGTCTCTGGGTATTTGCGAGCCTGCCGGAT
CTGCTGCGTATCTCGAAGGCCGTGGTGGGCGGCGGCTTGATCGTGATGATCGGCGCGGTGATGCTGCAGCCGGTTCCGAT
CATTCCGCGTTCGGTTCTCGTGCTGTCGCCGATGCTGCTGTTTCTTGCGATGGGTGGTGCACGTGCGCTCTATCGGGCGA
CGAAGGAGTTCTATCTATACGGCGGACTGATCGGGCAGGGCAAGCCCGTGCTGATTCTCGGCGCCGGCAGTGCCGGCGCG
AGCCTCGCCCGTGAACTGTCGCGCTCCGGTGAGTGGCGTCTTGCCGGTCTGCTCGATGACGATCCCGCGAAACACGGGCG
CGAAGTCTACGGCTATAAGGTACTGGGTTCGATCGGCGAAGTCGCAGACTGGGCCGAGGCCGCGAAAGCCGAATACGCGA
TCATCGCGATTCCATCCGCATCGGTCGAAGCGCAACGTCGCTTCGCCACCCTCTGCGTGCGCGCCGGCGTCAGGGCCATG
GTGCTGCCGTCGCTGACCGCATTGATGCCGGGCCAGGGCATTCTGTCGCAGATCCGCCAGATCGATCTCGAAGACCTGCT
CGGCCGCGAGGCCGTGACGATCGACACGCCGCACGTCGAGGCGCTGCTGCGCGGCCGCGTCGTGATGGTGACGGGCGCGG
GCGGCTCGATCGGCTCGGAGCTGTGCCGCCAGATCCTGAAGTTCCAGCCCGCGCAACTGATCGCGTTCGATCTGTCCGAA
TATGCGATGTACCGGCTCACGGAAGAGTTGCGCGAGCGCTTCCCCGATCTGCCCGTCGTGCCGATCATCGGCGATGCGAA
GGATTCGCTGCTGCTCGATCAGGTGATGTCGCGCTATGCGCCGCACATCGTGTTCCATGCGGCCGCGTACAAGCACGTGC
CGTTGATGGAGGAGCTCAACGCATGGCAGGCGCTGCGCAACAACGTGCTCGGCACGTATCGCGTCGCGCGCGCGGCGATT
CGCCACGACGTCAGGCACTTCGTGCTGATCTCGACCGACAAGGCCGTGAACCCGACGAACGTGATGGGCGCGAGCAAGCG
CCTGGCCGAGATGGCTTGCCAGGCGCTGCAGCAGACGAGCGCGCGCACGCAGTTCGAGACGGTGCGCTTCGGCAACGTGC
TCGGCAGCGCCGGCAGCGTGATTCCGAAATTTCAGCAGCAGATCGCCAAGGGCGGCCCGGTGACCGTCACGCATCCGGAA
ATCACGCGCTTCTTCATGACGATTCCCGAGGCGTCGCAACTCGTGCTGCAGGCGTCGAGCATGGGGCAGGGCGGCGAGAT
CTTCATTCTCGACATGGGCGAGCCGGTGAAGATCGTCGATCTCGCGCGCGATCTGATTCGCCTGTACGGCTTCACCGAGG
AGCAGATCCGCATCGAGTTCAGCGGGCTGCGCCCGGGCGAGAAGCTCTATGAGGAACTGCTCGCCGACGACGAGACCACC
ACCCGCACGCCACACCCGAAGCTGCGCACCGCGAAGGCGCGCGAGGTGCCCGATCATCTGCTCGACGAACTGCTGCCGTG
GCTGATGCAGCACCGCGTGCTGAGCGACGATGAAGTGCGGCGCGACTTGCGGCGCTGGGTGCCCGAGTATCAGCCGGCCG
TCGGCCCGACGCTGCAGAGCGTGCCGACCGGCAACGGGCTCGTCGCCGGCATCGGGCGCGAGGCCGGGCGCTGA

Upstream 100 bases:

>100_bases
GATGACTATCGCCGCTTGGGGTTCGATCCTGTTTCTCTTGGGCGTAGCCATCGATGTGTGCTGGAGTCGCTTCCAAATAC
TTACATCAAAATAACGCAAC

Downstream 100 bases:

>100_bases
AGAGCGGGGGCGGCGCGCCAAGCCTGCGCGAGGGGCCGCGCGCGCCACGCGTCGGGCGCGAATGCGCCCGTCCGAAGCCG
CCGAATCGAATGCGCGGGAC

Product: capsular polysaccharide biosynthesis protein

Products: UDPglucoseal [C]

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MTRAFCPKASWLSLGAFLFDLMAVVCAWLIAYVVRFNGAMPPEFLKGAFVALAWVVPLYGLLFHVFGLYRGLWVFASLPD
LLRISKAVVGGGLIVMIGAVMLQPVPIIPRSVLVLSPMLLFLAMGGARALYRATKEFYLYGGLIGQGKPVLILGAGSAGA
SLARELSRSGEWRLAGLLDDDPAKHGREVYGYKVLGSIGEVADWAEAAKAEYAIIAIPSASVEAQRRFATLCVRAGVRAM
VLPSLTALMPGQGILSQIRQIDLEDLLGREAVTIDTPHVEALLRGRVVMVTGAGGSIGSELCRQILKFQPAQLIAFDLSE
YAMYRLTEELRERFPDLPVVPIIGDAKDSLLLDQVMSRYAPHIVFHAAAYKHVPLMEELNAWQALRNNVLGTYRVARAAI
RHDVRHFVLISTDKAVNPTNVMGASKRLAEMACQALQQTSARTQFETVRFGNVLGSAGSVIPKFQQQIAKGGPVTVTHPE
ITRFFMTIPEASQLVLQASSMGQGGEIFILDMGEPVKIVDLARDLIRLYGFTEEQIRIEFSGLRPGEKLYEELLADDETT
TRTPHPKLRTAKAREVPDHLLDELLPWLMQHRVLSDDEVRRDLRRWVPEYQPAVGPTLQSVPTGNGLVAGIGREAGR

Sequences:

>Translated_637_residues
MTRAFCPKASWLSLGAFLFDLMAVVCAWLIAYVVRFNGAMPPEFLKGAFVALAWVVPLYGLLFHVFGLYRGLWVFASLPD
LLRISKAVVGGGLIVMIGAVMLQPVPIIPRSVLVLSPMLLFLAMGGARALYRATKEFYLYGGLIGQGKPVLILGAGSAGA
SLARELSRSGEWRLAGLLDDDPAKHGREVYGYKVLGSIGEVADWAEAAKAEYAIIAIPSASVEAQRRFATLCVRAGVRAM
VLPSLTALMPGQGILSQIRQIDLEDLLGREAVTIDTPHVEALLRGRVVMVTGAGGSIGSELCRQILKFQPAQLIAFDLSE
YAMYRLTEELRERFPDLPVVPIIGDAKDSLLLDQVMSRYAPHIVFHAAAYKHVPLMEELNAWQALRNNVLGTYRVARAAI
RHDVRHFVLISTDKAVNPTNVMGASKRLAEMACQALQQTSARTQFETVRFGNVLGSAGSVIPKFQQQIAKGGPVTVTHPE
ITRFFMTIPEASQLVLQASSMGQGGEIFILDMGEPVKIVDLARDLIRLYGFTEEQIRIEFSGLRPGEKLYEELLADDETT
TRTPHPKLRTAKAREVPDHLLDELLPWLMQHRVLSDDEVRRDLRRWVPEYQPAVGPTLQSVPTGNGLVAGIGREAGR
>Mature_636_residues
TRAFCPKASWLSLGAFLFDLMAVVCAWLIAYVVRFNGAMPPEFLKGAFVALAWVVPLYGLLFHVFGLYRGLWVFASLPDL
LRISKAVVGGGLIVMIGAVMLQPVPIIPRSVLVLSPMLLFLAMGGARALYRATKEFYLYGGLIGQGKPVLILGAGSAGAS
LARELSRSGEWRLAGLLDDDPAKHGREVYGYKVLGSIGEVADWAEAAKAEYAIIAIPSASVEAQRRFATLCVRAGVRAMV
LPSLTALMPGQGILSQIRQIDLEDLLGREAVTIDTPHVEALLRGRVVMVTGAGGSIGSELCRQILKFQPAQLIAFDLSEY
AMYRLTEELRERFPDLPVVPIIGDAKDSLLLDQVMSRYAPHIVFHAAAYKHVPLMEELNAWQALRNNVLGTYRVARAAIR
HDVRHFVLISTDKAVNPTNVMGASKRLAEMACQALQQTSARTQFETVRFGNVLGSAGSVIPKFQQQIAKGGPVTVTHPEI
TRFFMTIPEASQLVLQASSMGQGGEIFILDMGEPVKIVDLARDLIRLYGFTEEQIRIEFSGLRPGEKLYEELLADDETTT
RTPHPKLRTAKAREVPDHLLDELLPWLMQHRVLSDDEVRRDLRRWVPEYQPAVGPTLQSVPTGNGLVAGIGREAGR

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 5.1.3.2 [C]

Molecular weight: Translated: 69910; Mature: 69778

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAFCPKASWLSLGAFLFDLMAVVCAWLIAYVVRFNGAMPPEFLKGAFVALAWVVPLYG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLFHVFGLYRGLWVFASLPDLLRISKAVVGGGLIVMIGAVMLQPVPIIPRSVLVLSPMLL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FLAMGGARALYRATKEFYLYGGLIGQGKPVLILGAGSAGASLARELSRSGEWRLAGLLDD
HHHCCCHHHHHHHHHHHHEECCEECCCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCC
DPAKHGREVYGYKVLGSIGEVADWAEAAKAEYAIIAIPSASVEAQRRFATLCVRAGVRAM
CCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHH
VLPSLTALMPGQGILSQIRQIDLEDLLGREAVTIDTPHVEALLRGRVVMVTGAGGSIGSE
HHHHHHHHCCCHHHHHHHHHCCHHHHCCCCEEEECCHHHHHHHCCCEEEEECCCCCHHHH
LCRQILKFQPAQLIAFDLSEYAMYRLTEELRERFPDLPVVPIIGDAKDSLLLDQVMSRYA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHC
PHIVFHAAAYKHVPLMEELNAWQALRNNVLGTYRVARAAIRHDVRHFVLISTDKAVNPTN
CHHEEHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
VMGASKRLAEMACQALQQTSARTQFETVRFGNVLGSAGSVIPKFQQQIAKGGPVTVTHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECHH
ITRFFMTIPEASQLVLQASSMGQGGEIFILDMGEPVKIVDLARDLIRLYGFTEEQIRIEF
HHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHEEEEE
SGLRPGEKLYEELLADDETTTRTPHPKLRTAKAREVPDHLLDELLPWLMQHRVLSDDEVR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
RDLRRWVPEYQPAVGPTLQSVPTGNGLVAGIGREAGR
HHHHHHCCCCCCCCCCCHHCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TRAFCPKASWLSLGAFLFDLMAVVCAWLIAYVVRFNGAMPPEFLKGAFVALAWVVPLYG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLFHVFGLYRGLWVFASLPDLLRISKAVVGGGLIVMIGAVMLQPVPIIPRSVLVLSPMLL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
FLAMGGARALYRATKEFYLYGGLIGQGKPVLILGAGSAGASLARELSRSGEWRLAGLLDD
HHHCCCHHHHHHHHHHHHEECCEECCCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCC
DPAKHGREVYGYKVLGSIGEVADWAEAAKAEYAIIAIPSASVEAQRRFATLCVRAGVRAM
CCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHH
VLPSLTALMPGQGILSQIRQIDLEDLLGREAVTIDTPHVEALLRGRVVMVTGAGGSIGSE
HHHHHHHHCCCHHHHHHHHHCCHHHHCCCCEEEECCHHHHHHHCCCEEEEECCCCCHHHH
LCRQILKFQPAQLIAFDLSEYAMYRLTEELRERFPDLPVVPIIGDAKDSLLLDQVMSRYA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHC
PHIVFHAAAYKHVPLMEELNAWQALRNNVLGTYRVARAAIRHDVRHFVLISTDKAVNPTN
CHHEEHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
VMGASKRLAEMACQALQQTSARTQFETVRFGNVLGSAGSVIPKFQQQIAKGGPVTVTHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECHH
ITRFFMTIPEASQLVLQASSMGQGGEIFILDMGEPVKIVDLARDLIRLYGFTEEQIRIEF
HHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHEEEEE
SGLRPGEKLYEELLADDETTTRTPHPKLRTAKAREVPDHLLDELLPWLMQHRVLSDDEVR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
RDLRRWVPEYQPAVGPTLQSVPTGNGLVAGIGREAGR
HHHHHHCCCCCCCCCCCHHCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 57600 [C]

Specific activity: 233.3

Km value (mM): 0.256 {UDPgalactose}} 0.225 {UDPgalactose}} 0.2 {UDPgalactose}} 0.18 {UDPgalactose}} 0.16 {UDPgalactose}} 0.14 {UDPgalactose}} 0.048 {UDPgalactose}} 0.026 {UDPgalactose}} [C]

Substrates: UDPglucose [C]

Specific reaction: UDPglucose <==> UDPglucoseal [C]

General reaction: Epimerization (specificity for carbon forming a hexosulose) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]