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The map label for this gene is dmlR [H]

Identifier: 126453911

GI number: 126453911

Start: 2278812

End: 2279723

Strand: Reverse

Name: dmlR [H]

Synonym: BURPS1106A_2298

Alternate gene names: 126453911

Gene position: 2279723-2278812 (Counterclockwise)

Preceding gene: 126453403

Following gene: 126454831

Centisome position: 57.16

GC content: 68.64

Gene sequence:

>912_bases
ATGGACCGGTACAAGCAGATCGAAACCTTCGTGCGGGTAGCCGATGCGGGCAGCCTCGCGGCGGCCGCGCTCGAGGAGGG
CGTGTCGCCCGTCGTGCTCGGGCGGCGGATCGACGCGCTCGAAAAGCGCCTAGGCGTGAAGCTGATGTACCGGTCGACGC
GGCGGCTCGTGGTGAGCGAGGACGGCGCCGCGTTCCTCGAGCGCTGCCGGGGGCTCCTGACCGAATGGGCGCAAGCGGAG
AACGAGGTCGTCGCGGGGCGCCGCGCGGTGGGCGGGCATCTGATCGTGTCGGCGCCCGCCGCGTTCGGGCGCAAGCATGT
CGCGCCGCTCGCGCCCGCGTTCGTCGCGGACAAGCCCGACTTGCAAATGTCGTTCAATCTGACCGACCGTGTCGTCGATC
TCGTGCGCGAGGGCTACGATCTGTCGATCCGGATCGGCGGCGCGGTCGATCCGAATTTCGTCGCGGTGAAGCTCGCGTCG
AACCGGCGCGTGGTGTGCGGCACGCCCGAGTATTTTCGCCGGCACGGCCGGCCGAGGACGCTCGACGATCTCGCGAGCCA
CAACTGCCTCGCGTTCAACCTGCAGGGCGGCCAGAACCGCGGCTGGTATTTTCGGCGCAACGGCAAGCTCGTGACGATGC
GCGTATCGGGCACGCTCGACTGCAACGACGGCGAACTCCTGCATCGCTGGGTGTCGGAGGGGCTCGGGCTCGGTTGGCGC
TCGACGTGGGAGATCGCGCAGCAGCTCGCGCGCGGCGAGCTCGAGACGGTGCTCGACGAGTACGCGCTGCCCGATTACGA
CATCCTCGCCGTCTATCCGCAGCAGCGCTACGTGCCCGCGCGCGTGCGCTATTTCATCGACTATCTGCGCGACGTCTATG
CGCGGCCGGGGTATTGGGAAGGAGCCGAGTGA

Upstream 100 bases:

>100_bases
CAGGAAAGGTTTGATAAGATCCTGTCGAGTCGCTTATTTCGAGACTAAAAGTATCGAATGCCGGGCGTGCGCGGCGGCCC
CGGCGCAGAGGAGACAGCGG

Downstream 100 bases:

>100_bases
GCGCGCTGGGCGCCGCGCGCGCGTTTCTTCGCGCGCGGCGCCAGTTCGCCAGTTCGCCAGTTCGCCAGTTCGCCAGTTCG
CCAGTTCGCCAGTTCGCCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MDRYKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLTEWAQAE
NEVVAGRRAVGGHLIVSAPAAFGRKHVAPLAPAFVADKPDLQMSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLAS
NRRVVCGTPEYFRRHGRPRTLDDLASHNCLAFNLQGGQNRGWYFRRNGKLVTMRVSGTLDCNDGELLHRWVSEGLGLGWR
STWEIAQQLARGELETVLDEYALPDYDILAVYPQQRYVPARVRYFIDYLRDVYARPGYWEGAE

Sequences:

>Translated_303_residues
MDRYKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLTEWAQAE
NEVVAGRRAVGGHLIVSAPAAFGRKHVAPLAPAFVADKPDLQMSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLAS
NRRVVCGTPEYFRRHGRPRTLDDLASHNCLAFNLQGGQNRGWYFRRNGKLVTMRVSGTLDCNDGELLHRWVSEGLGLGWR
STWEIAQQLARGELETVLDEYALPDYDILAVYPQQRYVPARVRYFIDYLRDVYARPGYWEGAE
>Mature_303_residues
MDRYKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLTEWAQAE
NEVVAGRRAVGGHLIVSAPAAFGRKHVAPLAPAFVADKPDLQMSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLAS
NRRVVCGTPEYFRRHGRPRTLDDLASHNCLAFNLQGGQNRGWYFRRNGKLVTMRVSGTLDCNDGELLHRWVSEGLGLGWR
STWEIAQQLARGELETVLDEYALPDYDILAVYPQQRYVPARVRYFIDYLRDVYARPGYWEGAE

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=288, Percent_Identity=36.8055555555556, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1789440, Length=285, Percent_Identity=31.5789473684211, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1786401, Length=295, Percent_Identity=31.864406779661, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1787128, Length=283, Percent_Identity=29.6819787985866, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789639, Length=297, Percent_Identity=26.5993265993266, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI145693193, Length=296, Percent_Identity=27.3648648648649, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787589, Length=286, Percent_Identity=25.5244755244755, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790011, Length=303, Percent_Identity=20.7920792079208, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34029; Mature: 34029

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRYKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCEEEEEECCCEEEEEC
DGAAFLERCRGLLTEWAQAENEVVAGRRAVGGHLIVSAPAAFGRKHVAPLAPAFVADKPD
CCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCC
LQMSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLASNRRVVCGTPEYFRRHGRPRT
CEEEECHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCEEEECCHHHHHHCCCCCC
LDDLASHNCLAFNLQGGQNRGWYFRRNGKLVTMRVSGTLDCNDGELLHRWVSEGLGLGWR
HHHHHCCCEEEEEECCCCCCCEEEEECCEEEEEEECCEEECCCHHHHHHHHHHHCCCCCC
STWEIAQQLARGELETVLDEYALPDYDILAVYPQQRYVPARVRYFIDYLRDVYARPGYWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
GAE
CCC
>Mature Secondary Structure
MDRYKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCEEEEEECCCEEEEEC
DGAAFLERCRGLLTEWAQAENEVVAGRRAVGGHLIVSAPAAFGRKHVAPLAPAFVADKPD
CCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEECCHHHCCCCCCCCCCHHHCCCCC
LQMSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLASNRRVVCGTPEYFRRHGRPRT
CEEEECHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCEEEECCHHHHHHCCCCCC
LDDLASHNCLAFNLQGGQNRGWYFRRNGKLVTMRVSGTLDCNDGELLHRWVSEGLGLGWR
HHHHHCCCEEEEEECCCCCCCEEEEECCEEEEEEECCEEECCCHHHHHHHHHHHCCCCCC
STWEIAQQLARGELETVLDEYALPDYDILAVYPQQRYVPARVRYFIDYLRDVYARPGYWE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
GAE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]