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The map label for this gene is mrcA [H]

Identifier: 126453856

GI number: 126453856

Start: 2373876

End: 2376398

Strand: Reverse

Name: mrcA [H]

Synonym: BURPS1106A_2411

Alternate gene names: 126453856

Gene position: 2376398-2373876 (Counterclockwise)

Preceding gene: 126454478

Following gene: 126455348

Centisome position: 59.58

GC content: 67.9

Gene sequence:

>2523_bases
ATGCCTATTATCAAACGACCGCCTTCCTCCCGCGCCACGAACGAGCACCATTATTCGCTGCGACGCTCGCCGGCCGGCGC
CTATTACACCGATGACGACGATGATGACGAGCGCGCGCCGCGCCGCACGGGCCGCGACGGCGGCTCGCGCACGTTCGGCT
CGCGCGTCGCGCTGTGGTTCGCCGGGCTCTTCGCGACGCTGCTCGTCGTCGGCGCGCTGATCGTAGGCTATGCGCTGGTG
GTGATGGGGCCGCAACTGCCGTCGCTCGACGCGCTCACGAATTACCAGCCGAAGGTGCCGCTGCGCGTGTACAGCGCGGA
CCACGTGCTGCTCGGCGAATTCGGCGAGGAGCGCCGCAGCCTCGTGCGCTTCGCGGACATCCCCGACGTGATGAAGAAGG
CGGTGCTCGCGATCGAGGATTATCGCTTCTACGAGCACGGCGGCGTGGATTTCGTCGGCATCCTGCGCGCGGGTGTGGCC
GATCTGCTGCATGGCGGCGCGCGGCAGGGCGCGAGCACGATCACGATGCAGGTCGCGCGCAACTTCTTCCTGTCGAGCGA
GAAGACGTACACGCGCAAGATCTACGAGATGCTGCTCGCGTACAAGATCGAAAAGGCGCTGACGAAGGACCAGATCCTCG
AGCTGTACATGAACCAGATCTATCTGGGCCAGCGCGCGTACGGCTTCGCGGCCGCCGCGCGCGTGTATTTCGGCAAGGAC
CTGAAGGACGTCACGCTCGCCGAGGCCGCGATGCTCGCGGGGCTGCCGAAGGCGCCGTCCGCGTACAACCCGGTCGTCAA
CCCGAAGCGCGCGAAGGTGCGTCAGGAGTACATCCTGAAGCGGATGCTGGAGATCGGCTACATCACGCAGCAGCAGTACG
ATCAGGCGGTGAAGGAGGAAATCCACGTGCGCACGCCGGGTAACCAGTACGCGGTGCACGGCGAGTACGTCGCCGAAATG
GTGCGGCAGATGATGTATGCGCAGTACAAGGACGAAACCTACACGCGCGGCCTGACCGTCACGACGACGATCAACGCGGC
CGACCAGGAAGCCGCGTACCAGGCGGTGCGCCGCGGGATCATGGATTACGAGCGCCGCCACGGCTATCGCGGGCCGGAAG
GCTTCGTCGCGCTGCCGCCCGCCGGCGACGAGCGCGACGAGGCGATCGACGACGCGCTCGCGGATCATCCCGACAACGGC
GATCTGCAGTCGGCCGTCGTGCTCGCCGTCTCGCCGACGGCGGTCGACGTGCAGTTCGTCGGCGGCGCGACGGCGACGAT
CAACGGCGCCGGGCTGCGTTTCGCGGCCGGTGCGTTGAGCGCGCGCGCGTCGGCCGCGCTGAAGATCAAGCCGGGTTCGA
TCGTGCGCGTGATGAAGGACGCGAGGAGCGCATGGCAGATCGTGCAGTTGCCGCAGGTCGAGGGCGCGCTCGTCGCGGTC
GCGCCGCAGGACGGCGCGATCCGCTCGCTCGTCGGCGGCTTCGATTTCAACAAGAGCAAGTTCAACCACGTGACGCAGGC
ATGGCGGCAGCCGGGCTCGTCGTTCAAGCCGTTCATCTATTCGGCGTCGCTCGAAAAGGGCCTCGGGCCCGCGACGATCA
TCAACGACGCGCCGCTCTATTTCCCGCCGAGCGTGCCGGGCGGCCAGCCGTGGGAGCCGAAGGACGACGATCAGCCGGAC
GGCCCGATGCCGATGCGCACCGCGCTGCAGCGCTCGAAGAACCTCGTGTCGATCCGGATTCTGGCGTCGATCGGCACGTC
GTATGCGCAGGACTACGTGACGCAGCGCTTCGGCTTCGATCCCGCGAAGACGCCGCCGTATCTGCCGATGGCGCTCGGCG
CGGGCCTCGTCACGCCGCTGCAGCTCGCGGCGGGCTACGCGGTGTTCGCCAACGGCGGCTTCAAGGTCGATCCGTATCTG
ATCGCCGAAGTCGACGACGCGCGCGGGCAGGCGCTGCAAAAGGCGCAGCCGGTGGTCGCGGGCGCGAGCGCGACGCGCAC
GATCGACGCGCGCAACGCCTACGTGATGAACAGCCTGCTGCACACCGTCGCGACGGCGGGCACGGGCGCCGGCACGAACG
CGCTCGGCCGTGGCGACCTGCAGGGCAAGACCGGCACGACGAACGAGGCGAAGGACGGCTGGTTCGCCGGCTATCAGCAG
TCGCTCGTCGCCGTTGCATGGATGGGCTTCGATCAGCCGAAGAGTCTCGGCAGCCGTGAATTCGGCGCGCAGCTCGCGTT
GCCGATCTGGGTGAATTACATGCGCACCGCGCTCAACGGCGTGCCGGAGCAGCAGATGGCGATGCCGGACGGGCTGACGA
CGATCGACGGCGAGCTGTATTACGCGGATCGCACGCCGGGCGCGGGCTTCGTCGCGAGCGTCGATTTCAATCCGGCCGCG
AGCCCGACCGTGAGCGCGAACGATGCGCTCGGCTCGGCGGGCGCGGCGGGCCTGACGCCGCCGCCCGTGACGCCGGAGGA
GAAGCGGCAGATCATCGACATGTTCGAAGGCAACAAGCCTTGA

Upstream 100 bases:

>100_bases
GGAACCGTCGACGTGATACGCTCCACGACGCTACGTCCATCGATTCCATGCACGCGTTCAGCGCGTGCTCGAGGCGCGCC
TCGTGCGCCGCCCATCCGAC

Downstream 100 bases:

>100_bases
TCGGCGATCGGCGATGCGGATCGCATGACGAGGAAACGGGCGCCGGCGGCGCTCGTTTTTTTTGCCGGCGCGGTTTGGTG
GGCGGCGTCGGCGCTGCCTG

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 840; Mature: 839

Protein sequence:

>840_residues
MPIIKRPPSSRATNEHHYSLRRSPAGAYYTDDDDDDERAPRRTGRDGGSRTFGSRVALWFAGLFATLLVVGALIVGYALV
VMGPQLPSLDALTNYQPKVPLRVYSADHVLLGEFGEERRSLVRFADIPDVMKKAVLAIEDYRFYEHGGVDFVGILRAGVA
DLLHGGARQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYKIEKALTKDQILELYMNQIYLGQRAYGFAAAARVYFGKD
LKDVTLAEAAMLAGLPKAPSAYNPVVNPKRAKVRQEYILKRMLEIGYITQQQYDQAVKEEIHVRTPGNQYAVHGEYVAEM
VRQMMYAQYKDETYTRGLTVTTTINAADQEAAYQAVRRGIMDYERRHGYRGPEGFVALPPAGDERDEAIDDALADHPDNG
DLQSAVVLAVSPTAVDVQFVGGATATINGAGLRFAAGALSARASAALKIKPGSIVRVMKDARSAWQIVQLPQVEGALVAV
APQDGAIRSLVGGFDFNKSKFNHVTQAWRQPGSSFKPFIYSASLEKGLGPATIINDAPLYFPPSVPGGQPWEPKDDDQPD
GPMPMRTALQRSKNLVSIRILASIGTSYAQDYVTQRFGFDPAKTPPYLPMALGAGLVTPLQLAAGYAVFANGGFKVDPYL
IAEVDDARGQALQKAQPVVAGASATRTIDARNAYVMNSLLHTVATAGTGAGTNALGRGDLQGKTGTTNEAKDGWFAGYQQ
SLVAVAWMGFDQPKSLGSREFGAQLALPIWVNYMRTALNGVPEQQMAMPDGLTTIDGELYYADRTPGAGFVASVDFNPAA
SPTVSANDALGSAGAAGLTPPPVTPEEKRQIIDMFEGNKP

Sequences:

>Translated_840_residues
MPIIKRPPSSRATNEHHYSLRRSPAGAYYTDDDDDDERAPRRTGRDGGSRTFGSRVALWFAGLFATLLVVGALIVGYALV
VMGPQLPSLDALTNYQPKVPLRVYSADHVLLGEFGEERRSLVRFADIPDVMKKAVLAIEDYRFYEHGGVDFVGILRAGVA
DLLHGGARQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYKIEKALTKDQILELYMNQIYLGQRAYGFAAAARVYFGKD
LKDVTLAEAAMLAGLPKAPSAYNPVVNPKRAKVRQEYILKRMLEIGYITQQQYDQAVKEEIHVRTPGNQYAVHGEYVAEM
VRQMMYAQYKDETYTRGLTVTTTINAADQEAAYQAVRRGIMDYERRHGYRGPEGFVALPPAGDERDEAIDDALADHPDNG
DLQSAVVLAVSPTAVDVQFVGGATATINGAGLRFAAGALSARASAALKIKPGSIVRVMKDARSAWQIVQLPQVEGALVAV
APQDGAIRSLVGGFDFNKSKFNHVTQAWRQPGSSFKPFIYSASLEKGLGPATIINDAPLYFPPSVPGGQPWEPKDDDQPD
GPMPMRTALQRSKNLVSIRILASIGTSYAQDYVTQRFGFDPAKTPPYLPMALGAGLVTPLQLAAGYAVFANGGFKVDPYL
IAEVDDARGQALQKAQPVVAGASATRTIDARNAYVMNSLLHTVATAGTGAGTNALGRGDLQGKTGTTNEAKDGWFAGYQQ
SLVAVAWMGFDQPKSLGSREFGAQLALPIWVNYMRTALNGVPEQQMAMPDGLTTIDGELYYADRTPGAGFVASVDFNPAA
SPTVSANDALGSAGAAGLTPPPVTPEEKRQIIDMFEGNKP
>Mature_839_residues
PIIKRPPSSRATNEHHYSLRRSPAGAYYTDDDDDDERAPRRTGRDGGSRTFGSRVALWFAGLFATLLVVGALIVGYALVV
MGPQLPSLDALTNYQPKVPLRVYSADHVLLGEFGEERRSLVRFADIPDVMKKAVLAIEDYRFYEHGGVDFVGILRAGVAD
LLHGGARQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYKIEKALTKDQILELYMNQIYLGQRAYGFAAAARVYFGKDL
KDVTLAEAAMLAGLPKAPSAYNPVVNPKRAKVRQEYILKRMLEIGYITQQQYDQAVKEEIHVRTPGNQYAVHGEYVAEMV
RQMMYAQYKDETYTRGLTVTTTINAADQEAAYQAVRRGIMDYERRHGYRGPEGFVALPPAGDERDEAIDDALADHPDNGD
LQSAVVLAVSPTAVDVQFVGGATATINGAGLRFAAGALSARASAALKIKPGSIVRVMKDARSAWQIVQLPQVEGALVAVA
PQDGAIRSLVGGFDFNKSKFNHVTQAWRQPGSSFKPFIYSASLEKGLGPATIINDAPLYFPPSVPGGQPWEPKDDDQPDG
PMPMRTALQRSKNLVSIRILASIGTSYAQDYVTQRFGFDPAKTPPYLPMALGAGLVTPLQLAAGYAVFANGGFKVDPYLI
AEVDDARGQALQKAQPVVAGASATRTIDARNAYVMNSLLHTVATAGTGAGTNALGRGDLQGKTGTTNEAKDGWFAGYQQS
LVAVAWMGFDQPKSLGSREFGAQLALPIWVNYMRTALNGVPEQQMAMPDGLTTIDGELYYADRTPGAGFVASVDFNPAAS
PTVSANDALGSAGAAGLTPPPVTPEEKRQIIDMFEGNKP

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=814, Percent_Identity=39.6805896805897, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI1786343, Length=249, Percent_Identity=36.9477911646586, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1788867, Length=229, Percent_Identity=32.3144104803493, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1789601, Length=172, Percent_Identity=34.3023255813954, Blast_Score=93, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 90876; Mature: 90745

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIKRPPSSRATNEHHYSLRRSPAGAYYTDDDDDDERAPRRTGRDGGSRTFGSRVALWF
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCHHCCCCCCCCHHHHHHHHHH
AGLFATLLVVGALIVGYALVVMGPQLPSLDALTNYQPKVPLRVYSADHVLLGEFGEERRS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEECCCEEEECHHHHHHHH
LVRFADIPDVMKKAVLAIEDYRFYEHGGVDFVGILRAGVADLLHGGARQGASTITMQVAR
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
NFFLSSEKTYTRKIYEMLLAYKIEKALTKDQILELYMNQIYLGQRAYGFAAAARVYFGKD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
LKDVTLAEAAMLAGLPKAPSAYNPVVNPKRAKVRQEYILKRMLEIGYITQQQYDQAVKEE
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHVRTPGNQYAVHGEYVAEMVRQMMYAQYKDETYTRGLTVTTTINAADQEAAYQAVRRGI
EEEECCCCCEEECHHHHHHHHHHHHHHHHCCCHHHCCEEEEEEECCCHHHHHHHHHHHHH
MDYERRHGYRGPEGFVALPPAGDERDEAIDDALADHPDNGDLQSAVVLAVSPTAVDVQFV
HHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEE
GGATATINGAGLRFAAGALSARASAALKIKPGSIVRVMKDARSAWQIVQLPQVEGALVAV
CCCEEEECCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCEEEE
APQDGAIRSLVGGFDFNKSKFNHVTQAWRQPGSSFKPFIYSASLEKGLGPATIINDAPLY
ECCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHCCCCEEEECCCCCE
FPPSVPGGQPWEPKDDDQPDGPMPMRTALQRSKNLVSIRILASIGTSYAQDYVTQRFGFD
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEHHHHCHHHHHHHHHHHCCCC
PAKTPPYLPMALGAGLVTPLQLAAGYAVFANGGFKVDPYLIAEVDDARGQALQKAQPVVA
CCCCCCCCHHHHCCCHHHHHHHHCCEEEEECCCEEECCEEEEECCCHHHHHHHHCCCCEE
GASATRTIDARNAYVMNSLLHTVATAGTGAGTNALGRGDLQGKTGTTNEAKDGWFAGYQQ
CCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
SLVAVAWMGFDQPKSLGSREFGAQLALPIWVNYMRTALNGVPEQQMAMPDGLTTIDGELY
HHHHHHHCCCCCCHHCCCHHHCCEEEHHHHHHHHHHHHCCCCHHHHCCCCCCEEECCEEE
YADRTPGAGFVASVDFNPAASPTVSANDALGSAGAAGLTPPPVTPEEKRQIIDMFEGNKP
EECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PIIKRPPSSRATNEHHYSLRRSPAGAYYTDDDDDDERAPRRTGRDGGSRTFGSRVALWF
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHCCHHCCCCCCCCHHHHHHHHHH
AGLFATLLVVGALIVGYALVVMGPQLPSLDALTNYQPKVPLRVYSADHVLLGEFGEERRS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEECCCEEEECHHHHHHHH
LVRFADIPDVMKKAVLAIEDYRFYEHGGVDFVGILRAGVADLLHGGARQGASTITMQVAR
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
NFFLSSEKTYTRKIYEMLLAYKIEKALTKDQILELYMNQIYLGQRAYGFAAAARVYFGKD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
LKDVTLAEAAMLAGLPKAPSAYNPVVNPKRAKVRQEYILKRMLEIGYITQQQYDQAVKEE
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHVRTPGNQYAVHGEYVAEMVRQMMYAQYKDETYTRGLTVTTTINAADQEAAYQAVRRGI
EEEECCCCCEEECHHHHHHHHHHHHHHHHCCCHHHCCEEEEEEECCCHHHHHHHHHHHHH
MDYERRHGYRGPEGFVALPPAGDERDEAIDDALADHPDNGDLQSAVVLAVSPTAVDVQFV
HHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEE
GGATATINGAGLRFAAGALSARASAALKIKPGSIVRVMKDARSAWQIVQLPQVEGALVAV
CCCEEEECCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCEEEE
APQDGAIRSLVGGFDFNKSKFNHVTQAWRQPGSSFKPFIYSASLEKGLGPATIINDAPLY
ECCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHCCCCEEEECCCCCE
FPPSVPGGQPWEPKDDDQPDGPMPMRTALQRSKNLVSIRILASIGTSYAQDYVTQRFGFD
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEHHHHCHHHHHHHHHHHCCCC
PAKTPPYLPMALGAGLVTPLQLAAGYAVFANGGFKVDPYLIAEVDDARGQALQKAQPVVA
CCCCCCCCHHHHCCCHHHHHHHHCCEEEEECCCEEECCEEEEECCCHHHHHHHHCCCCEE
GASATRTIDARNAYVMNSLLHTVATAGTGAGTNALGRGDLQGKTGTTNEAKDGWFAGYQQ
CCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
SLVAVAWMGFDQPKSLGSREFGAQLALPIWVNYMRTALNGVPEQQMAMPDGLTTIDGELY
HHHHHHHCCCCCCHHCCCHHHCCEEEHHHHHHHHHHHHCCCCHHHHCCCCCCEEECCEEE
YADRTPGAGFVASVDFNPAASPTVSANDALGSAGAAGLTPPPVTPEEKRQIIDMFEGNKP
EECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA