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The map label for this gene is lysA [H]

Identifier: 126453755

GI number: 126453755

Start: 3678660

End: 3679931

Strand: Direct

Name: lysA [H]

Synonym: BURPS1106A_3766

Alternate gene names: 126453755

Gene position: 3678660-3679931 (Clockwise)

Preceding gene: 126453170

Following gene: 126454410

Centisome position: 92.23

GC content: 68.71

Gene sequence:

>1272_bases
ATGACTCAAGCTGCATTCGACTACGTCGACGGCGCGCTCCACGCCGAGCGCGTGAGCACCGTCGAGCTCGCCGAGCGTTT
CGGCACCCCGCTCTTCGTCTATTCGCGCGCCGCGCTCACCGCGGCCTACGAGGCCTACGCGAAAGCCTGCGCCGGCCGCC
GCGCGTCGATTCACGTCGCCGTGAAGGCGAACAGCAACCTCGGCGTGCTGAACGTGTTCGCGCGTCTCGGCGCGGGCTTC
GACATCGTGTCGGGCGGCGAGCTCGCGCGCGTGCTCGCGGCGGGCGGCCGCGCGCGGGACGTCGTGTTCTCGGGCGTCGG
CAAGAGCGCCGACGAAATGCGCGTCGCACTCGAAGCAGGCGTGAAGTGCTTCAACGTCGAATCGATCCCGGAGCTCGACC
GGCTGAACGCCGTCGCGGCATCGCTCGGCAAGCGCGCGCCCGTGTCGCTGCGGGTGAATCCGGACGTCGACCCGAAGACG
CATCCGTACATCTCGACGGGGCTGAAGGCAAACAAGTTCGGTATCGCGTTCGACGACGCGCGCGCGACGTACCGCGCGGC
CGCCGCGCTGCCGAACCTCGAAGTCGTCGGCATCGACTGCCACATCGGCTCGCAGATCACCGAGCTGAGCCCGTACCTCG
ACGCGATCGACAAGCTGCTCGATCTCGTCGAGCGGATCGAGGCGGACGGCGTGCAGATCCATCACGTCGACGTCGGCGGA
GGGCTCGGCATCACGTATGACGACGAAACGCCGCCCGACATCGGCGCCTACGTGCGCGCGGTGCTCGCGCGCATCGATGC
GCGCGGCCACGGCCAGCGCGAAATCTGGTTCGAGCCGGGCCGCTCGCTGACGGGCAACGCCGGCATTCTGCTCACGCGCG
TCGAATTCCTGAAGCAGGGCGAAGAGAAGAACTTCGCGATCGTCGACGCGGCGATGAACGACCTCGCGCGCCCCGCGATG
TACCAGGCGTTTCACGCGATCGTGCCGGTTGCGCCGCGCACGGACGTCGCGGCCGCGGTGTACGACATCGTCGGTCCCGT
CTGCGAGAGCGGCGACTGGCTTGGGCGCGAGCGCTCGCTCGCGATCGCGCCCGGCGATCTGCTCGCGATCCGCTCGGCGG
GCGCGTATGGCTTCACGATGAGCTCGAACTACAATACGCGGCCGCGCGCGGCGGAAGTGATCGTCGATGGCGCGAACGCG
CATCTGGTACGGCCGCGCGAGACGGTCGAAAGCCTGTTCGAGCACGAAACGATCCTGCCCGAAGGCCGGTAA

Upstream 100 bases:

>100_bases
GCCGACGCGCCGCTCACGCTGTCGCCCGACCTGTCGACGCAACGCACGCCGAAGGCCGCGCCCGCGTCCGGCGCTTCCTC
CGCCCAATGACCGATCCTGC

Downstream 100 bases:

>100_bases
GCGCCGGCACGCGGCGCTCGCACGACGCATCGGCAACCGCCGGCAATTCGATCATTCGACAAACCGGCGGGCCCGATCAA
AAAAGGCGATGTCCAACAAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTQAAFDYVDGALHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAM
YQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANA
HLVRPRETVESLFEHETILPEGR

Sequences:

>Translated_423_residues
MTQAAFDYVDGALHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGF
DIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKT
HPYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAM
YQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANA
HLVRPRETVESLFEHETILPEGR
>Mature_422_residues
TQAAFDYVDGALHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVAVKANSNLGVLNVFARLGAGFD
IVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAGVKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTH
PYISTGLKANKFGIAFDDARATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGGG
LGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQGEEKNFAIVDAAMNDLARPAMY
QAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSLAIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAH
LVRPRETVESLFEHETILPEGR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=23.7142857142857, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789203, Length=430, Percent_Identity=32.7906976744186, Blast_Score=157, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24586474, Length=389, Percent_Identity=28.0205655526992, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24586472, Length=342, Percent_Identity=27.1929824561404, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45192; Mature: 45060

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAAFDYVDGALHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVA
CCCCHHHHHHCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
VKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDA
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCH
RATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQG
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHCC
EEKNFAIVDAAMNDLARPAMYQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSL
CCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
AIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAHLVRPRETVESLFEHETILP
EECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCCC
EGR
CCC
>Mature Secondary Structure 
TQAAFDYVDGALHAERVSTVELAERFGTPLFVYSRAALTAAYEAYAKACAGRRASIHVA
CCCHHHHHHCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEE
VKANSNLGVLNVFARLGAGFDIVSGGELARVLAAGGRARDVVFSGVGKSADEMRVALEAG
EEECCCCCHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHC
VKCFNVESIPELDRLNAVAASLGKRAPVSLRVNPDVDPKTHPYISTGLKANKFGIAFDDA
CEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCH
RATYRAAAALPNLEVVGIDCHIGSQITELSPYLDAIDKLLDLVERIEADGVQIHHVDVGG
HHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GLGITYDDETPPDIGAYVRAVLARIDARGHGQREIWFEPGRSLTGNAGILLTRVEFLKQG
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEHHHHHHHHCC
EEKNFAIVDAAMNDLARPAMYQAFHAIVPVAPRTDVAAAVYDIVGPVCESGDWLGRERSL
CCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
AIAPGDLLAIRSAGAYGFTMSSNYNTRPRAAEVIVDGANAHLVRPRETVESLFEHETILP
EECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHHCCCCCC
EGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]