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The map label for this gene is yicE [H]

Identifier: 126453470

GI number: 126453470

Start: 1209992

End: 1211380

Strand: Reverse

Name: yicE [H]

Synonym: BURPS1106A_1231

Alternate gene names: 126453470

Gene position: 1211380-1209992 (Counterclockwise)

Preceding gene: 126451783

Following gene: 126452180

Centisome position: 30.37

GC content: 69.11

Gene sequence:

>1389_bases
ATGCAACCCGCCCCCCTCGCCCGCCCCGCTTCCCACGGCGCCGACGCCGCCGAATCCGCGCACGATCTCGTCTACGGCCC
CGACGAGCGCCCCGCGCCGATGATCGCCTGCGTCGCCGCGCTCCAGCATCTGCTCGCGATCCTCGTGCCGATCGTCACGC
CCGGCCTGCTGATCTGCCAGGCGCTCGGCGTATCGAGCCGCGACACGACGCTGATCGTGTCGATGTCGCTCGTGATCTCC
GGCATCGCGACCTTCGTCCAGTGCAGGCGCTTCGGCCCGCTCGGCGCGGGCCTGCTGATCGTCCAGGGCACGAGCTTCAA
CTTCGTCGGGCCGCTGATCGCGGGCGGCAGCCTGATGGTCAAGCAGGGCACGCCGGTCGAAACCGTGATGGCCGCGATCT
TCGGCGTCGTCATCGCCGGCTCGTTCGTCGAGATGGCCGTGTCGCGCATCCTGCCTTTCGTGAAGCGCCTGATCACCCCG
CTCGTCACCGGCGTCGTGGTGCTGCTGATCGGCCTCACGCTCATCAAGGTCGGCCTCGTCAGCATGGGCGGCGGCTATGG
CGCGATCGCCAAGGGCAGCTTCGGCAGCGCCCAGAACCTGACGCTGTCGGGGCTCGTGCTCGGCGCCATCATCGTGCTCA
ATCGCGTGCCCATCGTCTGGGTGCGCAGCACCGCGCTCGTCATCGCGCTCGCGATCGGCTATCTCGCGGCCGCCGCGATG
GGCCGTCTCGATTTCACCGGCGCGCGCGAGGCCGCGCTGTTCCAGATCCCGACGCCGCTGCACTTCGGCCTGGGCTTCTC
GTGGGCGCTGTTCGTGCCGATGCTGATCATCTATCTCGTCACGTCGCTCGAGGCGATCGGCGATGTCACGGCCACGAGCA
AGATCTCGCGGCAACCCGTCGAGGGGCCGCTGTGGATGCGGCGCATCAAGGGCGGCGTGCTCGTCAACGGCGCGAACTCG
CTGCTCGCCGGCGTCTTCAATACGTTCCCCAGCTCGGTCTTCGCGCAGAACAACGGCGTGATCCAGCTCACCGGCATCGC
GAGCCGCCATGTCGGCATCTGGATCGCGGGCATGCTCGTGCTGCTCGGGCTCTTCCCCGTCGTCGCGGGCGTCCTGCAAG
CGGTACCCGAGCCCGTGCTCGGCGGCGCGGCGATGGTGATGTTCGGCGCGGTGGCCGCGTCCGGCATCAATATCCTCGCC
GGCATCCGGCTCGATCGCCGCGCGCTGCTGATCATCGCGGTGTCGCTCGCGCTCGGCCTGGGCGTGTCGCAGGTGCCGGA
GATCCTGACGAACCTGCCGCACGCGCTCGGGAACGTGCTCGAATCGGGCGTCGCGACGGGCGGCATCTGCGCGCTCGTGA
TGAACTGGTTCCTGCCCGAGAAGCAATGA

Upstream 100 bases:

>100_bases
CGTCGAACACGCGCGCGGCCAATCCGCGCACCCGCGACGGCAGGCCGCCACCGCCGCTTCCGTTAAAATCCCGCCTTTCC
ACCGCACCGGCCCTTTCGCG

Downstream 100 bases:

>100_bases
AGCGGCGGCAATACGCGTGCCGCGCGCTCAGGACCGATGTCCCGAAATCGGCCCGGCTTCGCCGGTCAGGTTGAAGATGC
TGTCGAGCCACGCAAGAAAG

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQPAPLARPASHGADAAESAHDLVYGPDERPAPMIACVAALQHLLAILVPIVTPGLLICQALGVSSRDTTLIVSMSLVIS
GIATFVQCRRFGPLGAGLLIVQGTSFNFVGPLIAGGSLMVKQGTPVETVMAAIFGVVIAGSFVEMAVSRILPFVKRLITP
LVTGVVVLLIGLTLIKVGLVSMGGGYGAIAKGSFGSAQNLTLSGLVLGAIIVLNRVPIVWVRSTALVIALAIGYLAAAAM
GRLDFTGAREAALFQIPTPLHFGLGFSWALFVPMLIIYLVTSLEAIGDVTATSKISRQPVEGPLWMRRIKGGVLVNGANS
LLAGVFNTFPSSVFAQNNGVIQLTGIASRHVGIWIAGMLVLLGLFPVVAGVLQAVPEPVLGGAAMVMFGAVAASGINILA
GIRLDRRALLIIAVSLALGLGVSQVPEILTNLPHALGNVLESGVATGGICALVMNWFLPEKQ

Sequences:

>Translated_462_residues
MQPAPLARPASHGADAAESAHDLVYGPDERPAPMIACVAALQHLLAILVPIVTPGLLICQALGVSSRDTTLIVSMSLVIS
GIATFVQCRRFGPLGAGLLIVQGTSFNFVGPLIAGGSLMVKQGTPVETVMAAIFGVVIAGSFVEMAVSRILPFVKRLITP
LVTGVVVLLIGLTLIKVGLVSMGGGYGAIAKGSFGSAQNLTLSGLVLGAIIVLNRVPIVWVRSTALVIALAIGYLAAAAM
GRLDFTGAREAALFQIPTPLHFGLGFSWALFVPMLIIYLVTSLEAIGDVTATSKISRQPVEGPLWMRRIKGGVLVNGANS
LLAGVFNTFPSSVFAQNNGVIQLTGIASRHVGIWIAGMLVLLGLFPVVAGVLQAVPEPVLGGAAMVMFGAVAASGINILA
GIRLDRRALLIIAVSLALGLGVSQVPEILTNLPHALGNVLESGVATGGICALVMNWFLPEKQ
>Mature_462_residues
MQPAPLARPASHGADAAESAHDLVYGPDERPAPMIACVAALQHLLAILVPIVTPGLLICQALGVSSRDTTLIVSMSLVIS
GIATFVQCRRFGPLGAGLLIVQGTSFNFVGPLIAGGSLMVKQGTPVETVMAAIFGVVIAGSFVEMAVSRILPFVKRLITP
LVTGVVVLLIGLTLIKVGLVSMGGGYGAIAKGSFGSAQNLTLSGLVLGAIIVLNRVPIVWVRSTALVIALAIGYLAAAAM
GRLDFTGAREAALFQIPTPLHFGLGFSWALFVPMLIIYLVTSLEAIGDVTATSKISRQPVEGPLWMRRIKGGVLVNGANS
LLAGVFNTFPSSVFAQNNGVIQLTGIASRHVGIWIAGMLVLLGLFPVVAGVLQAVPEPVLGGAAMVMFGAVAASGINILA
GIRLDRRALLIIAVSLALGLGVSQVPEILTNLPHALGNVLESGVATGGICALVMNWFLPEKQ

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=493, Percent_Identity=22.7180527383367, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI40316845, Length=493, Percent_Identity=22.7180527383367, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI44680145, Length=474, Percent_Identity=23.4177215189873, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI44680143, Length=478, Percent_Identity=23.2217573221757, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790087, Length=449, Percent_Identity=54.56570155902, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI87082178, Length=446, Percent_Identity=43.7219730941704, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI87082181, Length=458, Percent_Identity=29.9126637554585, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=25.8454106280193, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081818, Length=474, Percent_Identity=25.1054852320675, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=500, Percent_Identity=24, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47612; Mature: 47612

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00879 ODR_DC_2_2 ; PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPAPLARPASHGADAAESAHDLVYGPDERPAPMIACVAALQHLLAILVPIVTPGLLICQ
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALGVSSRDTTLIVSMSLVISGIATFVQCRRFGPLGAGLLIVQGTSFNFVGPLIAGGSLMV
HHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCEEE
KQGTPVETVMAAIFGVVIAGSFVEMAVSRILPFVKRLITPLVTGVVVLLIGLTLIKVGLV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMGGGYGAIAKGSFGSAQNLTLSGLVLGAIIVLNRVPIVWVRSTALVIALAIGYLAAAAM
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHH
GRLDFTGAREAALFQIPTPLHFGLGFSWALFVPMLIIYLVTSLEAIGDVTATSKISRQPV
CCCCCCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCC
EGPLWMRRIKGGVLVNGANSLLAGVFNTFPSSVFAQNNGVIQLTGIASRHVGIWIAGMLV
CCHHHHHHHCCCEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
LLGLFPVVAGVLQAVPEPVLGGAAMVMFGAVAASGINILAGIRLDRRALLIIAVSLALGL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHEECCCCCHHHHHHHHHHHHHHC
GVSQVPEILTNLPHALGNVLESGVATGGICALVMNWFLPEKQ
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQPAPLARPASHGADAAESAHDLVYGPDERPAPMIACVAALQHLLAILVPIVTPGLLICQ
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALGVSSRDTTLIVSMSLVISGIATFVQCRRFGPLGAGLLIVQGTSFNFVGPLIAGGSLMV
HHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCEEE
KQGTPVETVMAAIFGVVIAGSFVEMAVSRILPFVKRLITPLVTGVVVLLIGLTLIKVGLV
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMGGGYGAIAKGSFGSAQNLTLSGLVLGAIIVLNRVPIVWVRSTALVIALAIGYLAAAAM
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHH
GRLDFTGAREAALFQIPTPLHFGLGFSWALFVPMLIIYLVTSLEAIGDVTATSKISRQPV
CCCCCCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCC
EGPLWMRRIKGGVLVNGANSLLAGVFNTFPSSVFAQNNGVIQLTGIASRHVGIWIAGMLV
CCHHHHHHHCCCEEEECHHHHHHHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHH
LLGLFPVVAGVLQAVPEPVLGGAAMVMFGAVAASGINILAGIRLDRRALLIIAVSLALGL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHEECCCCCHHHHHHHHHHHHHHC
GVSQVPEILTNLPHALGNVLESGVATGGICALVMNWFLPEKQ
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]