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The map label for this gene is aptA [C]

Identifier: 126453446

GI number: 126453446

Start: 3022179

End: 3023507

Strand: Reverse

Name: aptA [C]

Synonym: BURPS1106A_3101

Alternate gene names: 126453446

Gene position: 3023507-3022179 (Counterclockwise)

Preceding gene: 126452713

Following gene: 126454505

Centisome position: 75.81

GC content: 69.07

Gene sequence:

>1329_bases
ATGACCGAGCACGTTTCGCAGACCCCCGATCTCTCCGCGTTCTGGATGCCGTTCACCGCGAACCGGCAGTTCAAGGAAGC
GCCGCGCCTGCTCGTCGCGGCGAAGGGGATGTACTACACGTCGCACGACGGCCGGCGCATTCTCGACGGCACCGCGGGCC
TCTGGTGCGTGAACGCGGGGCACGGGCGCGACGAGATCGTCGCCGCGGTGCGGGCGCAGGCCGAGGAGATGGATTTCGCG
CCGACGTTCCAGATGGGGCACCCGAAGGCGTTCGAGGCCGCGACGAAGATCGCGCGCCACACGCCGGGCGACCTGAAACA
CATCTTCTTCACGAATTCCGGCTCGGAGGCGGTCGACACCGCGCTGAAGATCGCGCTCGCGTATCACCGCGCGCGCGGCG
AAGGGCAGCGCACGCGCTTCATCGGCCGCGAGCGCGGCTATCACGGCGTCGGCTTCGGCGGCATCTCGGTGGGCGGCATC
GCGCCGAACCGCAACGCGTATTCGGGCGCGCTGCTGCCGTCGGTCGACCATCTGCCGCATACGCTGAACCTGAAGGAGGC
CGCGTTCTCGAAGGGGCAGCCCGCGTGGGGCGCGCAGCTGGCGGACGAACTGGAGCGGCTCGTCGCGCTGCACGACGCAT
CGACGATCGCCGCGGTGATCGTCGAGCCCGTCGCCGGCTCGACGGGCGTGCTGATCCCGCCGCGAGGCTATCTCGAACGC
TTGCGCGAACTGTGCGACAAGCACGGCATCCTGCTGATCTTCGACGAAGTGATCACCGGTTGGGGGCGGCTCGGCGCGCC
GTTCGCGGCGCAGTTCTTCGGCGTGACGCCCGATCTGCTGACGATGGCCAAAGGCACGAACAACGCGGCGGTGCCGATGG
GCGCGGTGGCGGCGAGCGGCGCGATTCACGACGCGATCGTCGGCGGCGCGCCGGCCGGCATCGAGCTGTTTCACGGCTAC
ACGTATTCGGGGCACCCGCTCGCGGCGGCGGCCGCCGTCGCGACGATCGATCTGTACGAACGCGAAGGGCTCCTCACGCG
CGCCGCGCGGATCGCGCCGATCTTCGAGCGCGAGATCCACAAGCTGAAGGACGCGCGCCACGTGATCGACGTGCGCAATC
TCGGCCTCGTCGGCGGCGTCGAGTTGAAGCCGCGTGACGGCAAGCCGGGCGCGCGCGCCTACGAAGTCTTCGTCAAGTGC
TTCGAGAAGGGCGCGATGATCCGCTACACGGGCGACATCCTCGCGTTCTCGCCGCCCCTCATCGTCGAGGAGGCGCAGAT
CGTCGAGCTGTTCTCGATCGTCGCGCAGGCGCTGAAGGAAACGGAGTAG

Upstream 100 bases:

>100_bases
AGGCGAATTCCCATCGATGCGGCGCGTTGCGCACCGCACCCGTCAGCGCGCATCGCGCCGCGTTCCAGACATCGTTCGAT
CGATCTCCGAGGAGACTTCC

Downstream 100 bases:

>100_bases
GCGGAGCGCGGCAAACGGGCGCCGCGCTCAGGGAAACGGGCGGCGCGCCCGGGCGAAGCGGCGCGCGTCGCGCGCGCCGC
CGCGATGCGCGCTCAGTAGC

Product: omega amino acid--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVRAQAEEMDFA
PTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGI
APNRNAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAQLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPRGYLER
LRELCDKHGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVGGAPAGIELFHGY
TYSGHPLAAAAAVATIDLYEREGLLTRAARIAPIFEREIHKLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKC
FEKGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE

Sequences:

>Translated_442_residues
MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVRAQAEEMDFA
PTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGI
APNRNAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAQLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPRGYLER
LRELCDKHGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVGGAPAGIELFHGY
TYSGHPLAAAAAVATIDLYEREGLLTRAARIAPIFEREIHKLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKC
FEKGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE
>Mature_441_residues
TEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAGHGRDEIVAAVRAQAEEMDFAP
TFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDTALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIA
PNRNAYSGALLPSVDHLPHTLNLKEAAFSKGQPAWGAQLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPRGYLERL
RELCDKHGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTNNAAVPMGAVAASGAIHDAIVGGAPAGIELFHGYT
YSGHPLAAAAAVATIDLYEREGLLTRAARIAPIFEREIHKLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKCF
EKGAMIRYTGDILAFSPPLIVEEAQIVELFSIVAQALKETE

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=426, Percent_Identity=27.9342723004695, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=27.5626423690205, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=27.7522935779816, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=29.3939393939394, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=27.8195488721804, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI13994255, Length=376, Percent_Identity=28.4574468085106, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=27.1844660194175, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786991, Length=433, Percent_Identity=32.3325635103926, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=30.9692671394799, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI145693181, Length=309, Percent_Identity=33.0097087378641, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1789759, Length=416, Percent_Identity=31.0096153846154, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787560, Length=411, Percent_Identity=31.3868613138686, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=29.4840294840295, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=29.483282674772, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=29.1284403669725, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=427, Percent_Identity=25.9953161592506, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=27.4599542334096, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=241, Percent_Identity=30.7053941908714, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=25.2900232018561, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=495, Percent_Identity=26.6666666666667, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=25.4950495049505, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21357415, Length=415, Percent_Identity=26.2650602409639, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=28.9532293986637, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=28.6353467561521, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356575, Length=372, Percent_Identity=30.1075268817204, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47513; Mature: 47382

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAG
CCCCCCCCCCCCEEEECCCCCCCHHHCCCEEEEECCEEEECCCCCEEECCCCCEEEEECC
HGRDEIVAAVRAQAEEMDFAPTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIAPNRNAYSGALLPSVDHLPH
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHCCCC
TLNLKEAAFSKGQPAWGAQLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPRGYLER
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHEEEHEEECCCCCCCEEECCHHHHHH
LRELCDKHGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTNNAAVPMGAVAASG
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHCC
AIHDAIVGGAPAGIELFHGYTYSGHPLAAAAAVATIDLYEREGLLTRAARIAPIFEREIH
CHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKCFEKGAMIRYTGDILAFSPPL
HHHHHHHHHHHHCCCEECCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEECCCC
IVEEAQIVELFSIVAQALKETE
EECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEHVSQTPDLSAFWMPFTANRQFKEAPRLLVAAKGMYYTSHDGRRILDGTAGLWCVNAG
CCCCCCCCCCCEEEECCCCCCCHHHCCCEEEEECCEEEECCCCCEEECCCCCEEEEECC
HGRDEIVAAVRAQAEEMDFAPTFQMGHPKAFEAATKIARHTPGDLKHIFFTNSGSEAVDT
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHH
ALKIALAYHRARGEGQRTRFIGRERGYHGVGFGGISVGGIAPNRNAYSGALLPSVDHLPH
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHCCCC
TLNLKEAAFSKGQPAWGAQLADELERLVALHDASTIAAVIVEPVAGSTGVLIPPRGYLER
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHEEEHEEECCCCCCCEEECCHHHHHH
LRELCDKHGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTNNAAVPMGAVAASG
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHCC
AIHDAIVGGAPAGIELFHGYTYSGHPLAAAAAVATIDLYEREGLLTRAARIAPIFEREIH
CHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KLKDARHVIDVRNLGLVGGVELKPRDGKPGARAYEVFVKCFEKGAMIRYTGDILAFSPPL
HHHHHHHHHHHHCCCEECCEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEECCCC
IVEEAQIVELFSIVAQALKETE
EECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]