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The map label for this gene is degP [H]

Identifier: 126453300

GI number: 126453300

Start: 833854

End: 835341

Strand: Direct

Name: degP [H]

Synonym: BURPS1106A_0853

Alternate gene names: 126453300

Gene position: 833854-835341 (Clockwise)

Preceding gene: 126454420

Following gene: 126453104

Centisome position: 20.91

GC content: 68.28

Gene sequence:

>1488_bases
ATGACTACCCGAATCCTTGCACGTGGCGCAGTTGCCGTGGCTGTCGCCGCGGCGTTGTCGGCAGGCTATGTGGCGGGCAC
CCGCCGGGCGGAGCCGCAGATCATCACGCCGGCGGTCGCCGCGCTGATGCCGGCCGAGGCGGCCGCGAAGACGGGCATCC
CCGATTTTTCCGGGCTGGTCGAGACCTACGGGCCGGCCGTCGTGAACATCAGCGCGAAGCACGTCGTGCAGCGCGCCGCG
CAGCGTCGCGCGGCACCGCAGTTGCCGATCGACCCGGACGATCCGTTCTATCAATTCTTCCGACATTTCTACGGGCAGAT
TCCCGGGATGGGCGGCGGCCGCCAGCCGCAGCCGGACGACCAGCCGAGCACGAGCCTCGGCTCCGGCTTCATCATCAGCG
CCGACGGGTATATCCTGACTAACGCGCACGTGATCGACGGTGCGAACGTCGTGACCGTGAAGCTCACCGACAAGCGCGAG
TACAAGGCGAAGGTCGTCGGCGCCGACAAGCAGTCCGACGTCGCGGTGCTGAAGATCGACGCTTCGGGCCTGCCGATCGT
GAAGATCGGCGATCCGGCGCAGAGCAAGGTCGGCCAGTGGGTCGTCGCGATCGGCTCGCCGTACGGGTTCGACAACACGG
TCACCTCGGGCATCATCAGCGCGAAGTCGCGTGCGTTGCCCGACGAGAACTACACGCCGTTCATCCAGACCGACGTGCCC
GTGAACCCCGGCAACTCGGGCGGCCCGCTGTTCAACCTGAACGGCGAGGTGATCGGCATCAACTCGATGATCTACTCGCA
GACGGGCGGCTTCCAGGGGCTGTCGTTCGCGATCCCGATCAACGAGGCGATGAAGGTGAAGGACGAGCTCGTGAAGACGG
GCCACGTGAGCCGCGGCCGGCTCGGCGTCGCCGTGCAGGGGCTCAATCAGACGCTCGCGAGTTCGTTCGGCTTGCAAAAG
CCCGACGGCGCGCTCGTCAGCTCGGTCGATCCGAAGGGGCCGGCCGCGAAGGCCGGGCTGCAGCCGGGCGACGTGATCCT
CGCGGTCGACGGCGTGCCGGTTCAGGATTCGTCGACGCTGCCCGCGCAGATCGCGGGCATGAAGCCGGGCACGAAGGCCG
ATCTGCAGATCTGGCGCGACAAGTCGAGGAAGACGGTATCGGTGACGCTCGCGTCGCTCGCCGACGATCAGGCGAAGGCG
GGCGCCGACGAGCCCGTCGAGCAGGGGCGGCTCGGCGTCGCGGTGCGCCCGCTGTCGCCGCGCGAGCGCAACGGCTCGTC
TCTCACGCACGGTCTGGTCGTCCAGCAATCGGCGGGGCCCGCCGCGAGCGCGGGCATCCAGCCCGGCGACGTGATTCTCG
CGGTGAACGGGCGGCCCGTCACGAGCGCCGAACAATTGCGCGACGCGGTCAAGCGCGCGGGCAACAGTCTTGCGCTGCTG
ATCCAGCGTGACGATGCCCAGATTTTCGTGCCGGTCGATCTGGGCTGA

Upstream 100 bases:

>100_bases
CCCGTCGCTTGCTCGTTCCGTTTATCGGTGCCGAAGCCGATTAAGCCTGCTTTAAGCCAGGGTCGTTACGCTTTAAGCCA
TTAGATGAGGAGAGCGATCG

Downstream 100 bases:

>100_bases
GCCGGTCGCGCCCGGCGCGCCGGGCGAGCCGGCGCGCCGGCCACACGGCCGCCGGCATCGCGGCGGCCTGCCGCGCTGCG
CGGGCGGACGCCGCCCATCG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MTTRILARGAVAVAVAAALSAGYVAGTRRAEPQIITPAVAALMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVQRAA
QRRAAPQLPIDPDDPFYQFFRHFYGQIPGMGGGRQPQPDDQPSTSLGSGFIISADGYILTNAHVIDGANVVTVKLTDKRE
YKAKVVGADKQSDVAVLKIDASGLPIVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVP
VNPGNSGGPLFNLNGEVIGINSMIYSQTGGFQGLSFAIPINEAMKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQK
PDGALVSSVDPKGPAAKAGLQPGDVILAVDGVPVQDSSTLPAQIAGMKPGTKADLQIWRDKSRKTVSVTLASLADDQAKA
GADEPVEQGRLGVAVRPLSPRERNGSSLTHGLVVQQSAGPAASAGIQPGDVILAVNGRPVTSAEQLRDAVKRAGNSLALL
IQRDDAQIFVPVDLG

Sequences:

>Translated_495_residues
MTTRILARGAVAVAVAAALSAGYVAGTRRAEPQIITPAVAALMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVQRAA
QRRAAPQLPIDPDDPFYQFFRHFYGQIPGMGGGRQPQPDDQPSTSLGSGFIISADGYILTNAHVIDGANVVTVKLTDKRE
YKAKVVGADKQSDVAVLKIDASGLPIVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVP
VNPGNSGGPLFNLNGEVIGINSMIYSQTGGFQGLSFAIPINEAMKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQK
PDGALVSSVDPKGPAAKAGLQPGDVILAVDGVPVQDSSTLPAQIAGMKPGTKADLQIWRDKSRKTVSVTLASLADDQAKA
GADEPVEQGRLGVAVRPLSPRERNGSSLTHGLVVQQSAGPAASAGIQPGDVILAVNGRPVTSAEQLRDAVKRAGNSLALL
IQRDDAQIFVPVDLG
>Mature_494_residues
TTRILARGAVAVAVAAALSAGYVAGTRRAEPQIITPAVAALMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVQRAAQ
RRAAPQLPIDPDDPFYQFFRHFYGQIPGMGGGRQPQPDDQPSTSLGSGFIISADGYILTNAHVIDGANVVTVKLTDKREY
KAKVVGADKQSDVAVLKIDASGLPIVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPV
NPGNSGGPLFNLNGEVIGINSMIYSQTGGFQGLSFAIPINEAMKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQKP
DGALVSSVDPKGPAAKAGLQPGDVILAVDGVPVQDSSTLPAQIAGMKPGTKADLQIWRDKSRKTVSVTLASLADDQAKAG
ADEPVEQGRLGVAVRPLSPRERNGSSLTHGLVVQQSAGPAASAGIQPGDVILAVNGRPVTSAEQLRDAVKRAGNSLALLI
QRDDAQIFVPVDLG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=241, Percent_Identity=38.1742738589212, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI22129776, Length=265, Percent_Identity=36.9811320754717, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI7019477, Length=294, Percent_Identity=36.0544217687075, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI24308541, Length=251, Percent_Identity=35.0597609561753, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1786356, Length=371, Percent_Identity=40.4312668463612, Blast_Score=248, Evalue=9e-67,
Organism=Escherichia coli, GI1789629, Length=491, Percent_Identity=35.8452138492872, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789630, Length=271, Percent_Identity=39.4833948339483, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24646839, Length=295, Percent_Identity=35.2542372881356, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51299; Mature: 51168

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRILARGAVAVAVAAALSAGYVAGTRRAEPQIITPAVAALMPAEAAAKTGIPDFSGLV
CCCEEECCCHHHHHHHHHHHCCCEECCCCCCCCEECHHHHHHCCHHHHHHCCCCCHHHHH
ETYGPAVVNISAKHVVQRAAQRRAAPQLPIDPDDPFYQFFRHFYGQIPGMGGGRQPQPDD
HHCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
QPSTSLGSGFIISADGYILTNAHVIDGANVVTVKLTDKREYKAKVVGADKQSDVAVLKID
CCCCCCCCCEEEECCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEC
ASGLPIVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVP
CCCCCEEEECCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCC
VNPGNSGGPLFNLNGEVIGINSMIYSQTGGFQGLSFAIPINEAMKVKDELVKTGHVSRGR
CCCCCCCCCEEECCCCEEEECCEEEECCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCE
LGVAVQGLNQTLASSFGLQKPDGALVSSVDPKGPAAKAGLQPGDVILAVDGVPVQDSSTL
EEEEEECHHHHHHHHCCCCCCCCCEEECCCCCCCCHHCCCCCCCEEEEECCCCCCCCCCC
PAQIAGMKPGTKADLQIWRDKSRKTVSVTLASLADDQAKAGADEPVEQGRLGVAVRPLSP
CCEEECCCCCCCCHHHHHHCCCCEEEEEEEEHHCCHHHHCCCCCCHHCCCCCEEEECCCC
RERNGSSLTHGLVVQQSAGPAASAGIQPGDVILAVNGRPVTSAEQLRDAVKRAGNSLALL
CCCCCCCCEEEEEEECCCCCCHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEE
IQRDDAQIFVPVDLG
EEECCCEEEEEECCC
>Mature Secondary Structure 
TTRILARGAVAVAVAAALSAGYVAGTRRAEPQIITPAVAALMPAEAAAKTGIPDFSGLV
CCEEECCCHHHHHHHHHHHCCCEECCCCCCCCEECHHHHHHCCHHHHHHCCCCCHHHHH
ETYGPAVVNISAKHVVQRAAQRRAAPQLPIDPDDPFYQFFRHFYGQIPGMGGGRQPQPDD
HHCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
QPSTSLGSGFIISADGYILTNAHVIDGANVVTVKLTDKREYKAKVVGADKQSDVAVLKID
CCCCCCCCCEEEECCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEC
ASGLPIVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVP
CCCCCEEEECCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCC
VNPGNSGGPLFNLNGEVIGINSMIYSQTGGFQGLSFAIPINEAMKVKDELVKTGHVSRGR
CCCCCCCCCEEECCCCEEEECCEEEECCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCE
LGVAVQGLNQTLASSFGLQKPDGALVSSVDPKGPAAKAGLQPGDVILAVDGVPVQDSSTL
EEEEEECHHHHHHHHCCCCCCCCCEEECCCCCCCCHHCCCCCCCEEEEECCCCCCCCCCC
PAQIAGMKPGTKADLQIWRDKSRKTVSVTLASLADDQAKAGADEPVEQGRLGVAVRPLSP
CCEEECCCCCCCCHHHHHHCCCCEEEEEEEEHHCCHHHHCCCCCCHHCCCCCEEEECCCC
RERNGSSLTHGLVVQQSAGPAASAGIQPGDVILAVNGRPVTSAEQLRDAVKRAGNSLALL
CCCCCCCCEEEEEEECCCCCCHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEE
IQRDDAQIFVPVDLG
EEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]