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The map label for this gene is mntH [H]

Identifier: 126453069

GI number: 126453069

Start: 2165549

End: 2166856

Strand: Direct

Name: mntH [H]

Synonym: BURPS1106A_2180

Alternate gene names: 126453069

Gene position: 2165549-2166856 (Clockwise)

Preceding gene: 126455357

Following gene: 126453703

Centisome position: 54.3

GC content: 73.32

Gene sequence:

>1308_bases
ATGAACAGTCGCCCGCTTGCCGCCCGCAGCCCGTCGTCGCGCCGCCCGTCCGCTTCCGGCGGGCCGGGCGGCGGCCGCCG
CTGGGCCGCGTTCGTCGGCGCGGGCGTGCTCGTCGCGGTCGGCTACATGGACCCCGGCAACTGGGCGACCGCGCTCGCGG
GCGGCGCGGGCTACGGCTACACGCTCCTCGGCGTCGTGATCGCCGCGAGCCTGATGGCGATGCTGCTGCAATGGCTCGCC
GCGCGGATCGGCGTCGTGTCCGGGCGCGACCTCGCGCAACTGTGCCGCGAGCGCTTCGACCCGCGCGCGACCGTGCTGCT
GTGGATTGCCGCCGAAATCGCGATCGTCGCGTGCGACGTCGCCGAAGTCGTCGGCGCGGCGGTCGCGCTGCAGATGCTGC
TCGGCGTGTCGCTGAGCACGGGCGTGCTCGTGTCGGCGGTGGGCACGCTCGCGATGCTCGCGCTCGAGCGGCACGGCCGG
CGCACGCTCGAGGCGGCGATCGCATCGCTGATCTTCTTCGTCGGCCTGTGCTTCGTGATCGAGGTCGCGCTCGCGCAGCC
CGACTGGCACGCGGCGCTCGCCGGCGCCGCGCCGTCGCCGCGGCTGCTGCGCGAGCCCGGCATGCTGTGGCTCGCGGCCG
GCATCCTCGGCGCGACCGTGATGCCGCACAACCTCTACCTGCACTCGATGCTGGTCAAGCATCACGCGAGCGCGCGCGAC
GAGCCGTCGATCCGCCGCGCGCTGTTCGGCGTCAATCTCGACACGTTCGTGTCGCTCGGATTCGCGTTCGTGATCAACGC
GGCGCTTCTCATCGTCGCGGCGGCAGTGTTCCACGCGAGCGGCCACGACGACGTCACCGATCTCGCCGACGCGCACCGGC
TGATCGCGCCGCTCGTCGGCAATCGCTGGGCGGGCCCGCTGTTCGCGGCCGCCTTGCTCGCATGCGGGCTGTCGGCAACG
GTGACGGGCACGCTCGCCGGCCAGGCGATCATGGAAGGGTTCCTGAAGCTGACGCTGCCGCGCTGGCAGCGCGCGCTCCT
CACCCGCGCGCTCGCGATCGGCCCCGCGCTCGCCGCGGTCGGCCTGTTCGGGCAGCACGGATCGAATCAACTGCTCGTCG
CGAGCCAGGTCGTGCTGAGCCTGCAATTGCCGCTCGCGATGGTGCCGCTCGTCGTGTTCGCGTCGAGCCGCGCGCTGATG
GGGCGCTGGCGGGTCCGCGGCCTGCCGCTCGCGGCCGCATGGATGTGTGCCGCGGCGATCGTGGCGCTGAACGGCGCGCT
CGTCTGGCAGGTGGTTGCGGCGGGGTGA

Upstream 100 bases:

>100_bases
GCCCGTTCGTCGTTCCGGGTAGGAGGACGCGCGCCCGCCCGTCCGAACGCCGCGCCCGCCGCCCGGCCGTGCACGGCAAA
CCGTTGGCCGAACCGCCGCC

Downstream 100 bases:

>100_bases
GCGGGTGACGATCGTCGCGATGGGGGCGATCGGCGCCGGCCCGGTGCGGCGCAACGCAACGGGGCGCGACGGCCATTCCG
CCGTTCGATTGAAAAACCGC

Product: manganese/iron transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNSRPLAARSPSSRRPSASGGPGGGRRWAAFVGAGVLVAVGYMDPGNWATALAGGAGYGYTLLGVVIAASLMAMLLQWLA
ARIGVVSGRDLAQLCRERFDPRATVLLWIAAEIAIVACDVAEVVGAAVALQMLLGVSLSTGVLVSAVGTLAMLALERHGR
RTLEAAIASLIFFVGLCFVIEVALAQPDWHAALAGAAPSPRLLREPGMLWLAAGILGATVMPHNLYLHSMLVKHHASARD
EPSIRRALFGVNLDTFVSLGFAFVINAALLIVAAAVFHASGHDDVTDLADAHRLIAPLVGNRWAGPLFAAALLACGLSAT
VTGTLAGQAIMEGFLKLTLPRWQRALLTRALAIGPALAAVGLFGQHGSNQLLVASQVVLSLQLPLAMVPLVVFASSRALM
GRWRVRGLPLAAAWMCAAAIVALNGALVWQVVAAG

Sequences:

>Translated_435_residues
MNSRPLAARSPSSRRPSASGGPGGGRRWAAFVGAGVLVAVGYMDPGNWATALAGGAGYGYTLLGVVIAASLMAMLLQWLA
ARIGVVSGRDLAQLCRERFDPRATVLLWIAAEIAIVACDVAEVVGAAVALQMLLGVSLSTGVLVSAVGTLAMLALERHGR
RTLEAAIASLIFFVGLCFVIEVALAQPDWHAALAGAAPSPRLLREPGMLWLAAGILGATVMPHNLYLHSMLVKHHASARD
EPSIRRALFGVNLDTFVSLGFAFVINAALLIVAAAVFHASGHDDVTDLADAHRLIAPLVGNRWAGPLFAAALLACGLSAT
VTGTLAGQAIMEGFLKLTLPRWQRALLTRALAIGPALAAVGLFGQHGSNQLLVASQVVLSLQLPLAMVPLVVFASSRALM
GRWRVRGLPLAAAWMCAAAIVALNGALVWQVVAAG
>Mature_435_residues
MNSRPLAARSPSSRRPSASGGPGGGRRWAAFVGAGVLVAVGYMDPGNWATALAGGAGYGYTLLGVVIAASLMAMLLQWLA
ARIGVVSGRDLAQLCRERFDPRATVLLWIAAEIAIVACDVAEVVGAAVALQMLLGVSLSTGVLVSAVGTLAMLALERHGR
RTLEAAIASLIFFVGLCFVIEVALAQPDWHAALAGAAPSPRLLREPGMLWLAAGILGATVMPHNLYLHSMLVKHHASARD
EPSIRRALFGVNLDTFVSLGFAFVINAALLIVAAAVFHASGHDDVTDLADAHRLIAPLVGNRWAGPLFAAALLACGLSAT
VTGTLAGQAIMEGFLKLTLPRWQRALLTRALAIGPALAAVGLFGQHGSNQLLVASQVVLSLQLPLAMVPLVVFASSRALM
GRWRVRGLPLAAAWMCAAAIVALNGALVWQVVAAG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI295293167, Length=417, Percent_Identity=36.21103117506, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI295293178, Length=417, Percent_Identity=36.21103117506, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI295293175, Length=417, Percent_Identity=36.21103117506, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI295293173, Length=417, Percent_Identity=36.21103117506, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI10835169, Length=417, Percent_Identity=36.21103117506, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI295293171, Length=465, Percent_Identity=33.9784946236559, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI295293169, Length=465, Percent_Identity=33.9784946236559, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI109255241, Length=421, Percent_Identity=35.3919239904988, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI1788736, Length=423, Percent_Identity=38.0614657210402, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193210616, Length=429, Percent_Identity=31.9347319347319, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17569473, Length=377, Percent_Identity=35.0132625994695, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71999499, Length=443, Percent_Identity=31.3769751693002, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71993856, Length=210, Percent_Identity=36.6666666666667, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323062, Length=395, Percent_Identity=37.9746835443038, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321841, Length=427, Percent_Identity=36.0655737704918, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324450, Length=418, Percent_Identity=32.2966507177034, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24648607, Length=417, Percent_Identity=34.5323741007194, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281362176, Length=417, Percent_Identity=34.5323741007194, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24648609, Length=417, Percent_Identity=34.5323741007194, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI45553443, Length=417, Percent_Identity=34.5323741007194, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45111; Mature: 45111

Theoretical pI: Translated: 10.57; Mature: 10.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRPLAARSPSSRRPSASGGPGGGRRWAAFVGAGVLVAVGYMDPGNWATALAGGAGYGY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHEEEECCCCCCHHHHHCCCCCCHH
TLLGVVIAASLMAMLLQWLAARIGVVSGRDLAQLCRERFDPRATVLLWIAAEIAIVACDV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AEVVGAAVALQMLLGVSLSTGVLVSAVGTLAMLALERHGRRTLEAAIASLIFFVGLCFVI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
EVALAQPDWHAALAGAAPSPRLLREPGMLWLAAGILGATVMPHNLYLHSMLVKHHASARD
HHHHCCCCHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
EPSIRRALFGVNLDTFVSLGFAFVINAALLIVAAAVFHASGHDDVTDLADAHRLIAPLVG
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
NRWAGPLFAAALLACGLSATVTGTLAGQAIMEGFLKLTLPRWQRALLTRALAIGPALAAV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFGQHGSNQLLVASQVVLSLQLPLAMVPLVVFASSRALMGRWRVRGLPLAAAWMCAAAI
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHH
VALNGALVWQVVAAG
HHHCCHHHHHEEECC
>Mature Secondary Structure
MNSRPLAARSPSSRRPSASGGPGGGRRWAAFVGAGVLVAVGYMDPGNWATALAGGAGYGY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHEEEECCCCCCHHHHHCCCCCCHH
TLLGVVIAASLMAMLLQWLAARIGVVSGRDLAQLCRERFDPRATVLLWIAAEIAIVACDV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AEVVGAAVALQMLLGVSLSTGVLVSAVGTLAMLALERHGRRTLEAAIASLIFFVGLCFVI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
EVALAQPDWHAALAGAAPSPRLLREPGMLWLAAGILGATVMPHNLYLHSMLVKHHASARD
HHHHCCCCHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
EPSIRRALFGVNLDTFVSLGFAFVINAALLIVAAAVFHASGHDDVTDLADAHRLIAPLVG
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
NRWAGPLFAAALLACGLSATVTGTLAGQAIMEGFLKLTLPRWQRALLTRALAIGPALAAV
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFGQHGSNQLLVASQVVLSLQLPLAMVPLVVFASSRALMGRWRVRGLPLAAAWMCAAAI
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHH
VALNGALVWQVVAAG
HHHCCHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]