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The map label for this gene is ywrD [H]

Identifier: 126452986

GI number: 126452986

Start: 723372

End: 725045

Strand: Direct

Name: ywrD [H]

Synonym: BURPS1106A_0744

Alternate gene names: 126452986

Gene position: 723372-725045 (Clockwise)

Preceding gene: 126454740

Following gene: 126454959

Centisome position: 18.14

GC content: 71.09

Gene sequence:

>1674_bases
ATGCCCGCGATGAATCTTCATTCGAACCTGTCCGGCGCGCCGTTCTCGTGGCGCAATCCGTATCCGACGACGCGCGTGCC
GGTGTTCGCGCGCAACGTCGTGTCGACGTCGCATCCGCTCGCCGCGCAGGCGGGGCTCAGGATGCTGTGGAAGGGCGGCA
ACGCCGTCGACGCGGCGATCGCCGCGGCGGCGGCGATCACCGTCGTCGAGCCGGTGTCGTGCGGCCTCGGCGGCGACGCG
TTCGCGCTCGTCTGGGACGGCGCGAAGCTGCATGGCCTGAACGCGTCGGGCGTCGCGCCCGCCGCATGGAGTGTCGACTA
TTTTCGCCGGCGGCACGGCGAGGCGGGCAACGGTCTCGCGCGGCAGCCGGTGCGCGGCTGGGACACGGTGACGGTGCCCG
GCGTGATCGCCGGCTGGGAGGCGCTGCATGCGAAATTCGGCACGCTGCCGTTCGCCGATCTGCTCGAGCCGGCGATCGAG
CTTGCCGAGCGCGGGCACGCGGTGGCCGCGGTGGTCGCGCACAAGTGGGCGGCCGCCGTGCCGGAGCTGAGCGGCCAGCC
GGGCTTCGCTCAAACCTTCATGCCGCACGGCCGCGCGCCCGACGTGAGCGAGCGGGTGCGGCTGCCGGGCCATGCGAGGA
CGCTGCGCACGATCGCGGCCGAAGGCGCGCGCGCGTTCTACGAAGGCAGCCTCGCCGAGTCGATCGCCGCGTTCTTCCGC
GACGGCGGCGGCGCGCTCACCCTCGACGACCTGCGCGCGTACCGCCCCGAGTGGGTCGAGCCGATCGGCAAGGACTTCCG
CGGCTACACGGTGCACGAGATTCCGCCGAACGGCCAGGGGATCGCCGCGCTGATCGCGCTCGGCATCGTCGAGCGCTTCG
GCCTCGACGATTTGCCGCTCGATTCGGCGCAGGCGCAGCATGTGCAGATCGAGGCGATGAAGCTGGCGTTCGCCGACGTC
TATCGCTACGTCGCCGATCCGCGTGCGATGGAACTCACGCCCGCGCAGATGCTCGACGACGCGTACCTCGCCGCGCGCGC
GAAGCTGATCGACCCTCGGCGCGCGACGCATTTCTCGTTCGGCATGCCGCGCGCGGGCGGCACGATCTACCTGTCGGCGG
CCGACGAGCGCGGGATGATGGTGAGCTTCATCCAGTCGAACTACATGGGTTTCGGCTCGGGCCTCGTGGTCCCGGGCACG
GGGATTGCGCTGCAGAACCGCGGCTGCGGGTTCTCGATGGACCCGGCTTCGCCGAACGTCGTCGCGGGCGGCAAGCGGCC
GTTCCACACGATCATTCCGGCGTTCGTCACGCAGCAGGCGGGCAGCGCGCGGCACGCGGTGATGAGCTTCGGCGTGATGG
GCGGCGACATGCAGCCGCAAGGCCATCTGCAGACGATCGTGCGGATGCTCGGCTACGGCCAGCAGCCGCAGGCCGCGTGC
GACGCGCCGCGCTGGAAGGTGAGCCGCTCGTTTACGCTTGATGTCGAGGCCACGTTCGATGCGTCCGTCGTCGAGGCGCT
CGCCGCGCGCGGCCATACGATCCAGGCGATCGACGATCCGTACATGGACTTCGGCTCCGGCCAGTTCATCTGGCGGCTCG
ATCGCGACGAGCCCGACCGCGGCTATGTCGCGGCGAGCGACAGCCGGCGCGACGGCCTCGCGGCCGGCTTCTGA

Upstream 100 bases:

>100_bases
AGACTCGATTCATGTCTTGCGCGCATTCATTCATGTGGCAAATGAATTTGCGGGGACCGCGCGTTCGCGCTGGAATGTCC
GTTTCGAACCTGTTTACAGT

Downstream 100 bases:

>100_bases
CGCATGCCGGCGCGCAATGGATGCGCGTGGTTCGTTGCAGGCGAAACGATATCGAAAGGCATTTCAAAAGAGGCTTTCGA
TATTGCTCGTCTTTTGGAAT

Product: putative gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPAMNLHSNLSGAPFSWRNPYPTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDA
FALVWDGAKLHGLNASGVAPAAWSVDYFRRRHGEAGNGLARQPVRGWDTVTVPGVIAGWEALHAKFGTLPFADLLEPAIE
LAERGHAVAAVVAHKWAAAVPELSGQPGFAQTFMPHGRAPDVSERVRLPGHARTLRTIAAEGARAFYEGSLAESIAAFFR
DGGGALTLDDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPLDSAQAQHVQIEAMKLAFADV
YRYVADPRAMELTPAQMLDDAYLAARAKLIDPRRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGT
GIALQNRGCGFSMDPASPNVVAGGKRPFHTIIPAFVTQQAGSARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAAC
DAPRWKVSRSFTLDVEATFDASVVEALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF

Sequences:

>Translated_557_residues
MPAMNLHSNLSGAPFSWRNPYPTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDA
FALVWDGAKLHGLNASGVAPAAWSVDYFRRRHGEAGNGLARQPVRGWDTVTVPGVIAGWEALHAKFGTLPFADLLEPAIE
LAERGHAVAAVVAHKWAAAVPELSGQPGFAQTFMPHGRAPDVSERVRLPGHARTLRTIAAEGARAFYEGSLAESIAAFFR
DGGGALTLDDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPLDSAQAQHVQIEAMKLAFADV
YRYVADPRAMELTPAQMLDDAYLAARAKLIDPRRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGT
GIALQNRGCGFSMDPASPNVVAGGKRPFHTIIPAFVTQQAGSARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAAC
DAPRWKVSRSFTLDVEATFDASVVEALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF
>Mature_556_residues
PAMNLHSNLSGAPFSWRNPYPTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGGDAF
ALVWDGAKLHGLNASGVAPAAWSVDYFRRRHGEAGNGLARQPVRGWDTVTVPGVIAGWEALHAKFGTLPFADLLEPAIEL
AERGHAVAAVVAHKWAAAVPELSGQPGFAQTFMPHGRAPDVSERVRLPGHARTLRTIAAEGARAFYEGSLAESIAAFFRD
GGGALTLDDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPLDSAQAQHVQIEAMKLAFADVY
RYVADPRAMELTPAQMLDDAYLAARAKLIDPRRATHFSFGMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGTG
IALQNRGCGFSMDPASPNVVAGGKRPFHTIIPAFVTQQAGSARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACD
APRWKVSRSFTLDVEATFDASVVEALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDRGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=556, Percent_Identity=29.8561151079137, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI73915090, Length=556, Percent_Identity=29.8561151079137, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI73915096, Length=556, Percent_Identity=29.8561151079137, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI73915094, Length=556, Percent_Identity=29.8561151079137, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI113429324, Length=559, Percent_Identity=28.2647584973166, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI113429326, Length=564, Percent_Identity=27.8368794326241, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI153266885, Length=554, Percent_Identity=25.9927797833935, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI153266901, Length=555, Percent_Identity=26.1261261261261, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI109148539, Length=521, Percent_Identity=28.4069097888676, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI153266907, Length=552, Percent_Identity=25, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789856, Length=553, Percent_Identity=29.8372513562387, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI72000294, Length=513, Percent_Identity=25.9259259259259, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI212646519, Length=513, Percent_Identity=25.9259259259259, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17542894, Length=559, Percent_Identity=25.2236135957066, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17506189, Length=535, Percent_Identity=24.4859813084112, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=514, Percent_Identity=25.6809338521401, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=514, Percent_Identity=25.6809338521401, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24642670, Length=569, Percent_Identity=26.5377855887522, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24642666, Length=569, Percent_Identity=26.5377855887522, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45551474, Length=569, Percent_Identity=26.5377855887522, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161077878, Length=569, Percent_Identity=26.5377855887522, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161077880, Length=569, Percent_Identity=26.5377855887522, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI18859893, Length=530, Percent_Identity=27.5471698113208, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18859741, Length=524, Percent_Identity=27.2900763358779, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI161077496, Length=516, Percent_Identity=26.7441860465116, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59468; Mature: 59337

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMNLHSNLSGAPFSWRNPYPTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAI
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCEEECCCCHHHHHH
AAAAAITVVEPVSCGLGGDAFALVWDGAKLHGLNASGVAPAAWSVDYFRRRHGEAGNGLA
HHHHHHHEECCCCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCC
RQPVRGWDTVTVPGVIAGWEALHAKFGTLPFADLLEPAIELAERGHAVAAVVAHKWAAAV
CCCCCCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
PELSGQPGFAQTFMPHGRAPDVSERVRLPGHARTLRTIAAEGARAFYEGSLAESIAAFFR
CCCCCCCCCHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DGGGALTLDDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPL
CCCCEEEHHHHHHCCCHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC
DSAQAQHVQIEAMKLAFADVYRYVADPRAMELTPAQMLDDAYLAARAKLIDPRRATHFSF
CCCCCCEEEHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCEEEC
GMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGCGFSMDPASPNV
CCCCCCCEEEEEECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCE
VAGGKRPFHTIIPAFVTQQAGSARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAAC
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHH
DAPRWKVSRSFTLDVEATFDASVVEALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDR
CCCCEEECCEEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEECCCCCCC
GYVAASDSRRDGLAAGF
CEEEECCCCCCCCCCCC
>Mature Secondary Structure 
PAMNLHSNLSGAPFSWRNPYPTTRVPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAAI
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCEEECCCCHHHHHH
AAAAAITVVEPVSCGLGGDAFALVWDGAKLHGLNASGVAPAAWSVDYFRRRHGEAGNGLA
HHHHHHHEECCCCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCC
RQPVRGWDTVTVPGVIAGWEALHAKFGTLPFADLLEPAIELAERGHAVAAVVAHKWAAAV
CCCCCCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
PELSGQPGFAQTFMPHGRAPDVSERVRLPGHARTLRTIAAEGARAFYEGSLAESIAAFFR
CCCCCCCCCHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DGGGALTLDDLRAYRPEWVEPIGKDFRGYTVHEIPPNGQGIAALIALGIVERFGLDDLPL
CCCCEEEHHHHHHCCCHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC
DSAQAQHVQIEAMKLAFADVYRYVADPRAMELTPAQMLDDAYLAARAKLIDPRRATHFSF
CCCCCCEEEHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCEEEC
GMPRAGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGCGFSMDPASPNV
CCCCCCCEEEEEECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCE
VAGGKRPFHTIIPAFVTQQAGSARHAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAAC
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHH
DAPRWKVSRSFTLDVEATFDASVVEALAARGHTIQAIDDPYMDFGSGQFIWRLDRDEPDR
CCCCEEECCEEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEECCCCCCC
GYVAASDSRRDGLAAGF
CEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]