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The map label for this gene is ytnA [H]

Identifier: 126452964

GI number: 126452964

Start: 3770092

End: 3771498

Strand: Direct

Name: ytnA [H]

Synonym: BURPS1106A_3874

Alternate gene names: 126452964

Gene position: 3770092-3771498 (Clockwise)

Preceding gene: 126453152

Following gene: 126455054

Centisome position: 94.53

GC content: 64.39

Gene sequence:

>1407_bases
ATGCAGAAAGGACATTCGGAAACCGACCTACACCGAGGGCTGGGGCAACGGCAGATGCGCCTGATCGCGCTCGGCGCGGC
GATCGGCGTCGGGCTCTTTCTCGGCTCGGCCAACGCGATCAAGATGGCGGGCCCCGGCATCATCCTGTCGTACATCATCG
GCGGCGCGGTGATCTTCGTGATCATGCGCGCGCTCGGCGAGATGGCCGTGCACGAGCCGGTTGCCGGCTCGTTCAGCCGC
TACGCGCGCAACTACCTCGGGCCGCTCGCCGGTTACCTGACGGGCTGGAACTACTGGTTCCTCTGGCTCGTCACCTGCAT
CGCCGAGATCACGGCGGTCGGCATCTACATGGGCATCTGGTTCCCTGACGTGCCGCGCTGGATCTGGGCGCTCGCCGCGC
TGGCGACGATGGGATCGGTGAACCTGCTCACCGTGAAGGCGTATGGCGAATTCGAATTCTGGTTCGCGCTGATCAAAGTG
GTGACGATCGTCGTGATGATCGCAGTGGGCATCGCGATGATCGCGTTCGGCATCGGCAATCATGGCGTGCCGATGGGCAT
CTCGAACCTGTGGGCGCACGGCGGCTTCTTCCCGAACGGCGCGCAAGGCGTGCTGATGTCGATGCAGATGGTGATGTTCG
CGTACCTCGGCGTCGAGATGATCGGGCTGACGGCGGGCGAAGCGGCAAATCCGCAGAAGACGATTCCGGGCGCGATCAAC
TCGGTGTTCTGGCGCATTCTGCTCTTCTACGGCGGCGCGCTCTTCGTGATTCTGTCGATCTACCCGTGGAACGAGATCGG
CACGCAGGGCAGCCCGTTCGTGATGACGTTCGAGCGGCTCGGCATCAAGACGGCGGCGGGCATCATCAACTTCGTCGTGC
TGACGGCGGCGCTTTCGTCATGCAACGGCGGCATCTTCAGCACGGGGCGGATGCTGTACAACCTCGCGCAGCAGGGCCAT
GCGCCGCGCACGTTCGGCGAGACGACGGCGAGCGGCGTGCCGCGCCGGGCGATTCTGGTTTCGATGGCGGCGCTGCTCGT
GGGCGTGCTGTTGAACTACCTGGTGCCGGAGAAAGTGTTCGTCTGGGTGACGTCGATCTCGACATTCGGGGCGATCTGGA
CATGGGGTGTCATTCTCGTCACGCAGATGAAGTTTCGCGCGAGCCTCGCGCCGGCGGAAGAGCGGGCGCTGCGGTTCCGG
ATGCCGTTCTGGCCGTACGCGTCCTGGGTCGCGCTCGCGTTTCTGGTGCTCGTGATCGGATTGATGGCCTATTTTCCGGA
TACGCGGATCGCGCTTTATGTCGGGCCGGCCTGGCTCGTGTTGCTCGTGGTGCTGTATTTCGTGTTGAAGCTCGAGCCGG
AGGGTGGCAAGGCTGCGGGGCTGGAGCGCAGGTACGGGCGCGGGTGA

Upstream 100 bases:

>100_bases
CTCCCGCTCGCCGTCATCGAGACGACGCGGGACATGCGCGCGTCGCACCACGCCGACGCCCGCGCCGCCATTTTTCACAA
ACTTCAAAGGAGACATCCCG

Downstream 100 bases:

>100_bases
TTGATTCGCGAGGGAGCGGCGCGACGCGGATCTCGGCGGCCAGCCTGTTCGGGCCGTCCGGCGGTTCGGCGGGCCGCGCC
GCTCGCTCGGGAGCGAGCAG

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MQKGHSETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSR
YARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKV
VTIVVMIAVGIAMIAFGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAANPQKTIPGAIN
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGH
APRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVTQMKFRASLAPAEERALRFR
MPFWPYASWVALAFLVLVIGLMAYFPDTRIALYVGPAWLVLLVVLYFVLKLEPEGGKAAGLERRYGRG

Sequences:

>Translated_468_residues
MQKGHSETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSR
YARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKV
VTIVVMIAVGIAMIAFGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAANPQKTIPGAIN
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGH
APRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVTQMKFRASLAPAEERALRFR
MPFWPYASWVALAFLVLVIGLMAYFPDTRIALYVGPAWLVLLVVLYFVLKLEPEGGKAAGLERRYGRG
>Mature_468_residues
MQKGHSETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFVIMRALGEMAVHEPVAGSFSR
YARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKV
VTIVVMIAVGIAMIAFGIGNHGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAANPQKTIPGAIN
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGH
APRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVFVWVTSISTFGAIWTWGVILVTQMKFRASLAPAEERALRFR
MPFWPYASWVALAFLVLVIGLMAYFPDTRIALYVGPAWLVLLVVLYFVLKLEPEGGKAAGLERRYGRG

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=342, Percent_Identity=25.1461988304094, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI258614005, Length=410, Percent_Identity=23.6585365853659, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI258614003, Length=410, Percent_Identity=23.6585365853659, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI258645169, Length=410, Percent_Identity=23.6585365853659, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786602, Length=440, Percent_Identity=56.5909090909091, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=49.8915401301518, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=44.6188340807175, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1786302, Length=458, Percent_Identity=44.3231441048035, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1790653, Length=444, Percent_Identity=42.3423423423423, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI87081915, Length=444, Percent_Identity=42.7927927927928, Blast_Score=345, Evalue=5e-96,
Organism=Escherichia coli, GI87081708, Length=464, Percent_Identity=36.8534482758621, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.6589327146172, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1788480, Length=469, Percent_Identity=36.2473347547974, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87081869, Length=286, Percent_Identity=23.7762237762238, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532491, Length=426, Percent_Identity=21.1267605633803, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=469, Percent_Identity=33.0490405117271, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=33.1818181818182, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324924, Length=486, Percent_Identity=32.9218106995885, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6322892, Length=442, Percent_Identity=32.3529411764706, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=444, Percent_Identity=32.2072072072072, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=28.8557213930348, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=443, Percent_Identity=29.1196388261851, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=443, Percent_Identity=27.765237020316, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320717, Length=445, Percent_Identity=27.1910112359551, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=31.5, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=27.0676691729323, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=438, Percent_Identity=26.4840182648402, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=399, Percent_Identity=26.0651629072682, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=439, Percent_Identity=27.1070615034169, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6319608, Length=456, Percent_Identity=26.3157894736842, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=391, Percent_Identity=26.0869565217391, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324981, Length=390, Percent_Identity=25.6410256410256, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=26.3366336633663, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667468, Length=370, Percent_Identity=25.9459459459459, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221512776, Length=375, Percent_Identity=20.2666666666667, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666159, Length=375, Percent_Identity=20.2666666666667, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077963, Length=342, Percent_Identity=24.2690058479532, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50890; Mature: 50890

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKGHSETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFV
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
IMRALGEMAVHEPVAGSFSRYARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKVVTIVVMIAVGIAMIAFGIGN
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAANPQKTIPGAIN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHH
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSS
HHHHHHHHHHCCHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHH
CNGGIFSTGRMLYNLAQQGHAPRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVF
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VWVTSISTFGAIWTWGVILVTQMKFRASLAPAEERALRFRMPFWPYASWVALAFLVLVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHH
LMAYFPDTRIALYVGPAWLVLLVVLYFVLKLEPEGGKAAGLERRYGRG
HHHHCCCCCEEEEECHHHHHHHHHHHHHHEECCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MQKGHSETDLHRGLGQRQMRLIALGAAIGVGLFLGSANAIKMAGPGIILSYIIGGAVIFV
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
IMRALGEMAVHEPVAGSFSRYARNYLGPLAGYLTGWNYWFLWLVTCIAEITAVGIYMGIW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFALIKVVTIVVMIAVGIAMIAFGIGN
CCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGVPMGISNLWAHGGFFPNGAQGVLMSMQMVMFAYLGVEMIGLTAGEAANPQKTIPGAIN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHH
SVFWRILLFYGGALFVILSIYPWNEIGTQGSPFVMTFERLGIKTAAGIINFVVLTAALSS
HHHHHHHHHHCCHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHH
CNGGIFSTGRMLYNLAQQGHAPRTFGETTASGVPRRAILVSMAALLVGVLLNYLVPEKVF
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VWVTSISTFGAIWTWGVILVTQMKFRASLAPAEERALRFRMPFWPYASWVALAFLVLVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHH
LMAYFPDTRIALYVGPAWLVLLVVLYFVLKLEPEGGKAAGLERRYGRG
HHHHCCCCCEEEEECHHHHHHHHHHHHHHEECCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]