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The map label for this gene is groEL [H]

Identifier: 126452878

GI number: 126452878

Start: 3073525

End: 3075165

Strand: Reverse

Name: groEL [H]

Synonym: BURPS1106A_3153

Alternate gene names: 126452878

Gene position: 3075165-3073525 (Counterclockwise)

Preceding gene: 126453024

Following gene: 126453658

Centisome position: 77.1

GC content: 64.05

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTCGTATTCGGCGATTCCGCACGCGCGAAGATGGTCGAAGGCGTGAACATTCTCGCCAACGCTGT
GAAGGTCACGCTGGGTCCGAAGGGCCGCAACGTGGTGCTCGAGCGCAGCTTCGGCGGCCCGACGGTCACGAAGGACGGTG
TGTCGGTCGCGAAGGAAATCGAGCTGAAGGACAAGCTCCAGAACATGGGCGCGCAGATGGTCAAGGAAGTCGCTTCCAAG
ACCAGCGACAACGCCGGCGACGGCACGACGACGGCCACCGTCCTCGCGCAATCGATCGTCCGCGAAGGCATGAAGTACGT
CGCATCGGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACAAGGCAGTCGCCGCGGCAGTCGAAGAGCTGAAGAAGA
TCAGCAAGCCGTGCACGACGAACAAGGAAATCGCGCAAGTCGGCGCGATCTCGGCGAACAGCGATTCGTCGATCGGCGAT
CGCATCGCTGAAGCGATGGACAAGGTCGGCAAGGAAGGCGTGATCACCGTCGAAGACGGCAAGTCGCTCGCCGACGAGCT
CGACGTCGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGACAAGCAAGTCGCCG
TCCTCGAGAACCCGTTCGTGCTGCTGCACGACAAGAAGGTGTCGAACATCCGCGACCTGCTGCCGGTGCTCGAGCAAGTC
GCGAAGGCTGGCCGTCCGCTGCTGATCATCGCCGAAGACGTCGAAGGCGAAGCGCTCGCAACGCTGGTCGTCAACAACAT
CCGCGGCATCCTGAAGACCGTTGCGGTCAAGGCACCGGGCTTCGGCGATCGTCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACGGGCGGCCAGGTCATCGCGGAAGAAACCGGCCTCACGCTCGAGAAGGCAACGCTGGCAGAACTGGGCCAGGCG
AAGCGCATCGAAGTGGGCAAGGAAAACACGACGATCATCGACGGCGCGGGCGAAGCCGTGAACATCGAAGCGCGCGTCAA
GCAAATCCGCACGCAAATCGAAGAAGCGACGTCGGACTACGACCGTGAAAAGCTGCAAGAGCGCGTGGCCAAGCTGGCAG
GCGGCGTGGCGGTGATCAAGGTCGGCGCTGCGACCGAAGTCGAAATGAAGGAAAAGAAGGCACGTGTCGAGGACGCGCTG
CACGCCACCCGCGCTGCCGTTGAAGAAGGCATCGTCCCGGGCGGCGGCGTCGCGCTGATCCGCGCACGCACCGCGATCGC
GAGCCTGACCGGCGTGAACGCCGACCAGAACGCCGGCATCAAGATCGTGCTGCGCGCGATGGAAGAGCCGCTGCGCCAGA
TCGTCACGAACGGCGGCGAAGAAGCGAGCGTCGTGGTGGCGGCAGTTGCTGCGGGCAAGGGCAACTACGGCTACAACGCG
GCGACGGGCGAGTACGTCGACATGGTCGAAGCCGGCGTCGTCGATCCGACGAAGGTCACCCGTACCGCGCTGCAGAACGC
GGCTTCGGTCGCCGGCCTGCTGCTGACGACGGACGCAGCCGTTGCCGAACTGCCGAAGGAAGACGCTCCGATGCCGGGCG
GCATGCCGGGCGGCATGGGCGGCATGGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
AACTGCTCGTGATGCGCGAAGAAGACATCATGGCCGTGGTCAACGCTAAGTAAGCGTTCGCCAACGGATCACAATCTCAG
AGAATTCAAGGAGTTAGAAG

Downstream 100 bases:

>100_bases
TTGGCTTGACGCCGATTGCATCGAAGGACGCGCGGCAACGCGCGTTCTCCCAAACGAAAACACCCGCAGCGATGCGGGTG
TTTTCGTTTGGGGCGGCGGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALIRARTAIASLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Sequences:

>Translated_546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALIRARTAIASLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM
>Mature_545_residues
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDR
IAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAK
RIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVPGGGVALIRARTAIASLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNAA
TGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.9772727272727, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.9772727272727, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI24307939, Length=363, Percent_Identity=23.9669421487603, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI5453607, Length=553, Percent_Identity=22.7848101265823, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=75.992438563327, Blast_Score=797, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.930056710775, Blast_Score=553, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=218, Percent_Identity=51.8348623853211, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI25144674, Length=548, Percent_Identity=22.2627737226277, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147750, Length=131, Percent_Identity=35.1145038167939, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.4714828897338, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322446, Length=577, Percent_Identity=22.1837088388215, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=375, Percent_Identity=24.2666666666667, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=567, Percent_Identity=22.5749559082892, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.1821631878558, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.1821631878558, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.6641366223909, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.6641366223909, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.6641366223909, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=44, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=37.218045112782, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=37.218045112782, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI17647245, Length=576, Percent_Identity=23.0902777777778, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24652903, Length=549, Percent_Identity=23.4972677595628, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57146; Mature: 57015

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
RARTAIASLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC
>Mature Secondary Structure 
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
RARTAIASLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA