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The map label for this gene is yeaE [H]

Identifier: 126452797

GI number: 126452797

Start: 931317

End: 932162

Strand: Direct

Name: yeaE [H]

Synonym: BURPS1106A_0952

Alternate gene names: 126452797

Gene position: 931317-932162 (Clockwise)

Preceding gene: 126454629

Following gene: 126453124

Centisome position: 23.35

GC content: 69.03

Gene sequence:

>846_bases
ATGACCAGCAGGCTCGAAACCGTCGCGCTGCCCGGCGGCGAACGCGTACCGAAGCTCGGGCAGGGCACCTGGGAAATGGG
CGAGCGGCCCGCGAAGCGCGCAGCCGAGATCGCCGCGCTGCGCGAGGGCGTCGATCTCGGCATGACGCTCATCGATACCG
CGGAGATGTACGGCGACGGCGTGACCGAGACGCTTGTCGGCGACGCGCTCGCCGACGTGCGCGAGCGCTTGTTCATCGTC
AGCAAGGTGCTGCCGCATCATGCGAGCCGCGGCGGTGTCGTCGCCGCATGCGAGGCGACGCTCAAGCGCTTGCGCACCGA
TCGCGTGGATCTGTATTTGCTGCACTGGCGCGGCTCGATTCCGCTCGCGGAGACGATCGCGGGCTTCGAGGCGCTGCGCG
ACGCGGGCAAGATCCGCTACTGGGGCGTCAGCAATTTCGATGTCGACGACATGGAGGCGCTCGTCGCCGAAGCGGGCGGC
GCCGTCTGCGCGACCGACCAGATCCTCTACAACCTCGCGCGCCGCGGCCCGGAGTTCGATTTGCTGCCGTGGCTCGCGCG
GCGCGAGATGCCGGCGATGGCGTACAGCCCGATCGATCACATGCGATTGCCCAAGCGCACCGCGCTCGACGAGATCGCGC
GCGAGCGCGGCGTATCGCCGACGCGCGTCGCGCTTGCGTGGGTGCTCGGGCAGCCGAACGTGCTGGCGATTCCGAAGGCG
GGCAGCATCGAGCACGTGCGCGACAATCGCGCGGCGCTCGATCTCGTGCTCGGCGAAGAAGAGCTCGCACGGCTCGACGC
GCAGTTCAAATCGCCGCGGGGGAAGCGGCCGCTTGAAATGCTGTAG

Upstream 100 bases:

>100_bases
GCGCGAGGCGGCCCGGCGCGCGCCGAATCGCTACACTGACGCTTCAACCGCGGGCCTCGCGCAACCGCGTGCCGCGCCCG
CCTATGTGACGAGGAACGAT

Downstream 100 bases:

>100_bases
CGCGTGCGGCGCGGCGAGGTGAGACGGGCTCGGGCGAGCGGCGGCTCGCGAAACGCGCGGGCGGTGTCTCGCGGATCGCC
GATCGGTTCGTGCGAAGGCG

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTSRLETVALPGGERVPKLGQGTWEMGERPAKRAAEIAALREGVDLGMTLIDTAEMYGDGVTETLVGDALADVRERLFIV
SKVLPHHASRGGVVAACEATLKRLRTDRVDLYLLHWRGSIPLAETIAGFEALRDAGKIRYWGVSNFDVDDMEALVAEAGG
AVCATDQILYNLARRGPEFDLLPWLARREMPAMAYSPIDHMRLPKRTALDEIARERGVSPTRVALAWVLGQPNVLAIPKA
GSIEHVRDNRAALDLVLGEEELARLDAQFKSPRGKRPLEML

Sequences:

>Translated_281_residues
MTSRLETVALPGGERVPKLGQGTWEMGERPAKRAAEIAALREGVDLGMTLIDTAEMYGDGVTETLVGDALADVRERLFIV
SKVLPHHASRGGVVAACEATLKRLRTDRVDLYLLHWRGSIPLAETIAGFEALRDAGKIRYWGVSNFDVDDMEALVAEAGG
AVCATDQILYNLARRGPEFDLLPWLARREMPAMAYSPIDHMRLPKRTALDEIARERGVSPTRVALAWVLGQPNVLAIPKA
GSIEHVRDNRAALDLVLGEEELARLDAQFKSPRGKRPLEML
>Mature_280_residues
TSRLETVALPGGERVPKLGQGTWEMGERPAKRAAEIAALREGVDLGMTLIDTAEMYGDGVTETLVGDALADVRERLFIVS
KVLPHHASRGGVVAACEATLKRLRTDRVDLYLLHWRGSIPLAETIAGFEALRDAGKIRYWGVSNFDVDDMEALVAEAGGA
VCATDQILYNLARRGPEFDLLPWLARREMPAMAYSPIDHMRLPKRTALDEIARERGVSPTRVALAWVLGQPNVLAIPKAG
SIEHVRDNRAALDLVLGEEELARLDAQFKSPRGKRPLEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=290, Percent_Identity=28.6206896551724, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI24497577, Length=310, Percent_Identity=29.3548387096774, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI5174391, Length=310, Percent_Identity=29.3548387096774, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI5453543, Length=310, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI45446745, Length=310, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4503285, Length=310, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI310109920, Length=310, Percent_Identity=27.4193548387097, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI24497585, Length=307, Percent_Identity=27.3615635179153, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI223468663, Length=295, Percent_Identity=26.4406779661017, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI24497583, Length=310, Percent_Identity=26.7741935483871, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI5174695, Length=307, Percent_Identity=24.7557003257329, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4502049, Length=303, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI223718702, Length=187, Percent_Identity=30.4812834224599, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=49.4661921708185, Blast_Score=284, Evalue=5e-78,
Organism=Escherichia coli, GI1786400, Length=273, Percent_Identity=27.4725274725275, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI87081735, Length=311, Percent_Identity=27.6527331189711, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787674, Length=283, Percent_Identity=29.6819787985866, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788070, Length=303, Percent_Identity=27.3927392739274, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082198, Length=279, Percent_Identity=27.2401433691756, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789199, Length=325, Percent_Identity=29.8461538461538, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI48994888, Length=291, Percent_Identity=29.8969072164948, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=309, Percent_Identity=25.5663430420712, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=26.7148014440433, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17561298, Length=289, Percent_Identity=28.3737024221453, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17564128, Length=309, Percent_Identity=27.831715210356, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17566692, Length=164, Percent_Identity=33.5365853658537, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71998625, Length=289, Percent_Identity=24.5674740484429, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537077, Length=309, Percent_Identity=25.2427184466019, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537075, Length=303, Percent_Identity=24.7524752475248, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324694, Length=284, Percent_Identity=27.8169014084507, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644950, Length=305, Percent_Identity=27.2131147540984, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45553081, Length=297, Percent_Identity=26.5993265993266, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24657054, Length=313, Percent_Identity=26.1980830670927, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129731, Length=308, Percent_Identity=25.6493506493506, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646159, Length=261, Percent_Identity=28.3524904214559, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24662789, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30881; Mature: 30750

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRLETVALPGGERVPKLGQGTWEMGERPAKRAAEIAALREGVDLGMTLIDTAEMYGDG
CCCCCCEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCHHHCHHHHHHHHHHCCC
VTETLVGDALADVRERLFIVSKVLPHHASRGGVVAACEATLKRLRTDRVDLYLLHWRGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCEEEEEEECCCC
PLAETIAGFEALRDAGKIRYWGVSNFDVDDMEALVAEAGGAVCATDQILYNLARRGPEFD
CHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCC
LLPWLARREMPAMAYSPIDHMRLPKRTALDEIARERGVSPTRVALAWVLGQPNVLAIPKA
HHHHHHHHCCCCHHCCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHEECCCCEEEECCC
GSIEHVRDNRAALDLVLGEEELARLDAQFKSPRGKRPLEML
CCHHHHHCCHHHEEEEECHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TSRLETVALPGGERVPKLGQGTWEMGERPAKRAAEIAALREGVDLGMTLIDTAEMYGDG
CCCCCEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCHHHCHHHHHHHHHHCCC
VTETLVGDALADVRERLFIVSKVLPHHASRGGVVAACEATLKRLRTDRVDLYLLHWRGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCEEEEEEECCCC
PLAETIAGFEALRDAGKIRYWGVSNFDVDDMEALVAEAGGAVCATDQILYNLARRGPEFD
CHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCC
LLPWLARREMPAMAYSPIDHMRLPKRTALDEIARERGVSPTRVALAWVLGQPNVLAIPKA
HHHHHHHHCCCCHHCCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHEECCCCEEEECCC
GSIEHVRDNRAALDLVLGEEELARLDAQFKSPRGKRPLEML
CCHHHHHCCHHHEEEEECHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]