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The map label for this gene is hemK [H]

Identifier: 126452796

GI number: 126452796

Start: 3518750

End: 3519607

Strand: Direct

Name: hemK [H]

Synonym: BURPS1106A_3615

Alternate gene names: 126452796

Gene position: 3518750-3519607 (Clockwise)

Preceding gene: 126454756

Following gene: 126451940

Centisome position: 88.22

GC content: 73.78

Gene sequence:

>858_bases
ATGAACACGACGAAACCCTCGCCCGCCACCGCCGCCGAGCTGCTGCGCGCGTCGCCGCTCGATGCGCTCGACGCGCGCAT
CCTGCTCGCGCACGCGCTCGGCTGGAGCCGCACGCAGTTGATCACGCGCGCCGACGAACCGCTCGACGCGGCCGCGCGCG
CGCGCTATCTGGCGCTTCAGGCGCGCCGCGCGGCGGGCGAGCCCATCGCGCAGCTCACCGGCGCGCGCGAGTTCTTCGGT
CTCGAATTCGACATCACGCCGGACGTGCTGATCCCGCGCCCGGAGACGGAGCTGCTCGTCGAGACGGCGCTCGACGCGAT
CGACGGCATCGCATCGCCATGCGTGCTCGATCTCGGCACGGGCAGCGGCGCGATCGCGGTGTCGATCGCATCCGAGCGGC
CCGACGCGCGCGTGTGGGCGCTCGAGCGCTCGGTCGCCGCGCTCGACGTCGCGCGCCGCAACGCACGCAAGCTGCTCGAT
CCGGCGCGCGCGGGCGGCCCGCTGCGGTTTCTCGAAAGCGACTGGTACGCGGCGCTCGATCCGGGCCTGCGCTTTCACGT
CGTCGTCAGCAACCCGCCGTACATCGCGCGGCACGATCCGCACCTCGCCGAAGGCGACCTGCGCTTCGAGCCGCGCGGCG
CGCTCACCGACGAGAACGACGGGCTTGCCGCGATCCGCACGATCGTTGCGGGCGCGCATGCGTTCGTCGCGCCCGGCGGC
GCGCTGTGGCTCGAACACGGTTACGATCAGGCGGCCGCGGTGCGCGCGCTCCTCGACGCGGCAGGCTTCGCCGACGTCGA
ATCGCGCGCGGATCTCGCGTCGATCGAGCGCGCGAGCGGCGGGCGCCTGCCCGGCTGA

Upstream 100 bases:

>100_bases
GCGCTCGTGAGCGAGCACCAGGCCGAGCTGCTCGCCTCGCTCGGCGACGCCGAATGACGCCGCCCGCCCCTCGCACGCTC
ACTCGCGTTCGCGCCACCCG

Downstream 100 bases:

>100_bases
CACGCCGCCCGACGCCCGCCGGCCCAGGTGAAATCCAGTATCATTTCTTTTCTCACGCCCAGCTACAGCAAGGTCAGTCA
TGGACACCCAACAACGCATC

Product: protein hemK

Products: NA

Alternate protein names: M.XfaHemK2P [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNTTKPSPATAAELLRASPLDALDARILLAHALGWSRTQLITRADEPLDAAARARYLALQARRAAGEPIAQLTGAREFFG
LEFDITPDVLIPRPETELLVETALDAIDGIASPCVLDLGTGSGAIAVSIASERPDARVWALERSVAALDVARRNARKLLD
PARAGGPLRFLESDWYAALDPGLRFHVVVSNPPYIARHDPHLAEGDLRFEPRGALTDENDGLAAIRTIVAGAHAFVAPGG
ALWLEHGYDQAAAVRALLDAAGFADVESRADLASIERASGGRLPG

Sequences:

>Translated_285_residues
MNTTKPSPATAAELLRASPLDALDARILLAHALGWSRTQLITRADEPLDAAARARYLALQARRAAGEPIAQLTGAREFFG
LEFDITPDVLIPRPETELLVETALDAIDGIASPCVLDLGTGSGAIAVSIASERPDARVWALERSVAALDVARRNARKLLD
PARAGGPLRFLESDWYAALDPGLRFHVVVSNPPYIARHDPHLAEGDLRFEPRGALTDENDGLAAIRTIVAGAHAFVAPGG
ALWLEHGYDQAAAVRALLDAAGFADVESRADLASIERASGGRLPG
>Mature_285_residues
MNTTKPSPATAAELLRASPLDALDARILLAHALGWSRTQLITRADEPLDAAARARYLALQARRAAGEPIAQLTGAREFFG
LEFDITPDVLIPRPETELLVETALDAIDGIASPCVLDLGTGSGAIAVSIASERPDARVWALERSVAALDVARRNARKLLD
PARAGGPLRFLESDWYAALDPGLRFHVVVSNPPYIARHDPHLAEGDLRFEPRGALTDENDGLAAIRTIVAGAHAFVAPGG
ALWLEHGYDQAAAVRALLDAAGFADVESRADLASIERASGGRLPG

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=242, Percent_Identity=30.5785123966942, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787463, Length=269, Percent_Identity=44.9814126394052, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI87082085, Length=203, Percent_Identity=32.0197044334975, Blast_Score=80, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24582226, Length=269, Percent_Identity=27.1375464684015, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 30220; Mature: 30220

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTKPSPATAAELLRASPLDALDARILLAHALGWSRTQLITRADEPLDAAARARYLALQ
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHH
ARRAAGEPIAQLTGAREFFGLEFDITPDVLIPRPETELLVETALDAIDGIASPCVLDLGT
HHHHCCCCHHHHHCCHHHCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEECC
GSGAIAVSIASERPDARVWALERSVAALDVARRNARKLLDPARAGGPLRFLESDWYAALD
CCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEECCCCCEEEC
PGLRFHVVVSNPPYIARHDPHLAEGDLRFEPRGALTDENDGLAAIRTIVAGAHAFVAPGG
CCCEEEEEECCCCEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCHHEECCCC
ALWLEHGYDQAAAVRALLDAAGFADVESRADLASIERASGGRLPG
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNTTKPSPATAAELLRASPLDALDARILLAHALGWSRTQLITRADEPLDAAARARYLALQ
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHH
ARRAAGEPIAQLTGAREFFGLEFDITPDVLIPRPETELLVETALDAIDGIASPCVLDLGT
HHHHCCCCHHHHHCCHHHCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEECC
GSGAIAVSIASERPDARVWALERSVAALDVARRNARKLLDPARAGGPLRFLESDWYAALD
CCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEECCCCCEEEC
PGLRFHVVVSNPPYIARHDPHLAEGDLRFEPRGALTDENDGLAAIRTIVAGAHAFVAPGG
CCCEEEEEECCCCEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCHHEECCCC
ALWLEHGYDQAAAVRALLDAAGFADVESRADLASIERASGGRLPG
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]