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The map label for this gene is hemL [H]

Identifier: 126452611

GI number: 126452611

Start: 2993799

End: 2995082

Strand: Direct

Name: hemL [H]

Synonym: BURPS1106A_3064

Alternate gene names: 126452611

Gene position: 2993799-2995082 (Clockwise)

Preceding gene: 126451465

Following gene: 126453712

Centisome position: 75.06

GC content: 70.64

Gene sequence:

>1284_bases
ATGTCGAACAATCAAACTCTCTTCGAACGCGCCCAGCGAATCATCCCGGGCGGCGTCAATTCGCCGGTGCGGGCGTTCCG
CTCGGTCGGCGGCACGCCGCGCTTCGTCGCGCGTGCGCAGGGCGCGTACTTCTGGGACGCGGACGGCAAGCGCTACATCG
ACTACATCGGCTCGTGGGGGCCGATGATCGTCGGCCACGTGCACCCGGACGTGCTCGCGGCCGTGCAGCGCGTGCTCGCC
GACGGCTTCTCGTTCGGCGCGCCCACCGAAGCCGAAATCGAGATCGCCGAGGAGATCTGCAAGCTCGTGCCGTCGATCGA
GCAGGTGCGGATGGTGTCGAGCGGCACCGAAGCGACGATGAGCGCGCTGCGCCTCGCGCGCGGCTTCACCGGCCGCAGCC
GGATCGTCAAGTTCGAGGGCTGCTATCACGGCCATGCGGACAGCCTGCTCGTGAAGGCAGGCTCGGGCCTGCTCACGTTC
GGCAATCCGACCTCGGCGGGCGTGCCGGCCGACGTCGCGAAGCACACGACCGTGCTCGAGTACAACAACGTCGCGGCGCT
CGAGGAAGCGTTCGCCGCGTTCGGCGGCGAGATCGCCGCGGTGATCGTCGAGCCCGTCGCGGGCAACATGAACCTCGTGC
GCGGCACGCCGGAGTTCCTGAACGCGCTGCGCGCGCTCACCGCGAAGCACGGCGCCGTGCTGATCTTCGACGAAGTGATG
TGCGGCTTTCGCGTCGCGCTCGGCGGCGCGCAGCAGCACTACGGGATCACGCCGGATCTGACCTGCCTCGGCAAGGTGAT
CGGCGGCGGCATGCCGGCCGCCGCGTTCGGCGGCCGTGGCGACATCATGTCGCACCTCGCGCCGCTCGGCGGCGTCTATC
AGGCGGGCACGCTGTCGGGCAACCCGGTCGCGGTCGCGGCGGGCCTCGCGACGCTGCGGCTGATCCAGGCGCCGGGCTTT
CACGATGCGCTCGCCGACAAGACCCGGCGGCTCGCCGACGGCCTCGCCGCCGAGGCGCGCGCGGCGGGCGTGCCGTTCTC
GGCCGACGCGATCGGCGGGATGTTCGGCCTCTACTTCACCGAGCAGGTGCCCGCGAGCTTCGCCGACGTGACGAAGAGCG
ACATCGAGCGCTTCAACCGCTTCTTCCATCTGATGCTCGACACCGGCGTGTACTTCGCGCCCTCCGCGTACGAAGCGGGC
TTCGTGTCGAGCGCGCACGACGACGCGACGCTCGACGCGACGCTCGACGCCGCCCGCCGCGCGTTCGCCGCGCTGCGTGC
CTGA

Upstream 100 bases:

>100_bases
ACCCGTCGCGCGCGTCTCCGGTACAATCAGTCGGATCGATACGCGCGACGCGAGCCGCGGCGCTTCGCCGCTCGCGCGCA
CTCTCTCGCAGGTCCAATTC

Downstream 100 bases:

>100_bases
CCGGCCGCACGACTGACAGGACGAACCGATGTTCTCGGAAAGCGACTTCACCCACATGCAGCGCGCGCTCGCGCTCGCCG
CGCGCGGGATGTACACGACG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSNNQTLFERAQRIIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVM
CGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGF
HDALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDTGVYFAPSAYEAG
FVSSAHDDATLDATLDAARRAFAALRA

Sequences:

>Translated_427_residues
MSNNQTLFERAQRIIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVM
CGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGF
HDALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDTGVYFAPSAYEAG
FVSSAHDDATLDATLDAARRAFAALRA
>Mature_426_residues
SNNQTLFERAQRIIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWGPMIVGHVHPDVLAAVQRVLAD
GFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
NPTSAGVPADVAKHTTVLEYNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVMC
GFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIQAPGFH
DALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFTEQVPASFADVTKSDIERFNRFFHLMLDTGVYFAPSAYEAGF
VSSAHDDATLDATLDAARRAFAALRA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=303, Percent_Identity=28.3828382838284, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI284507298, Length=220, Percent_Identity=28.1818181818182, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=60.7981220657277, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=31.0679611650485, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=29.903536977492, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787560, Length=359, Percent_Identity=30.9192200557103, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788044, Length=330, Percent_Identity=30.6060606060606, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693181, Length=341, Percent_Identity=30.4985337243402, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786991, Length=382, Percent_Identity=28.5340314136126, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=363, Percent_Identity=25.8953168044077, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=336, Percent_Identity=26.4880952380952, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=328, Percent_Identity=24.390243902439, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144274, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=335, Percent_Identity=27.4626865671642, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=350, Percent_Identity=24.5714285714286, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357415, Length=320, Percent_Identity=25.9375, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356575, Length=348, Percent_Identity=27.0114942528736, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 44841; Mature: 44709

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNQTLFERAQRIIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWG
CCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCCCEEECCCCCHHHHHHCCCC
PMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVM
ECCHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEHHHH
CGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSG
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHCCCCHHHHHHHHHCCCCEECCCCCC
NPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFT
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EQVPASFADVTKSDIERFNRFFHLMLDTGVYFAPSAYEAGFVSSAHDDATLDATLDAARR
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
AFAALRA
HHHHHCC
>Mature Secondary Structure 
SNNQTLFERAQRIIPGGVNSPVRAFRSVGGTPRFVARAQGAYFWDADGKRYIDYIGSWG
CCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCCCEEECCCCCHHHHHHCCCC
PMIVGHVHPDVLAAVQRVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADVAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFAAFGGEIAAVIVEPVAGNMNLVRGTPEFLNALRALTAKHGAVLIFDEVM
ECCHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEHHHH
CGFRVALGGAQQHYGITPDLTCLGKVIGGGMPAAAFGGRGDIMSHLAPLGGVYQAGTLSG
HHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHCCCCHHHHHHHHHCCCCEECCCCCC
NPVAVAAGLATLRLIQAPGFHDALADKTRRLADGLAAEARAAGVPFSADAIGGMFGLYFT
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EQVPASFADVTKSDIERFNRFFHLMLDTGVYFAPSAYEAGFVSSAHDDATLDATLDAARR
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
AFAALRA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA