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The map label for this gene is mdh [H]

Identifier: 126452408

GI number: 126452408

Start: 2091137

End: 2092384

Strand: Reverse

Name: mdh [H]

Synonym: BURPS1106A_2097

Alternate gene names: 126452408

Gene position: 2092384-2091137 (Counterclockwise)

Preceding gene: 126451725

Following gene: 126451740

Centisome position: 52.46

GC content: 66.59

Gene sequence:

>1248_bases
ATGGATCGTGCATTTTCGTTTCCCGGCATTACGGGCGGCTCAACACGAGACGCACCGACACAACCAGGAGACGACATGAG
TAATCTGAGCAGCGCGGAGCGCACCGACAGCTTCTTCATTCCCCGCGTGACCCTGATCGGCCCGGGCTGCGCGCGCGAGA
CGGGCGCGCGCGCCAAATCGCTGGGCGCGAAAAAGGCGCTCATCGTGACCGACGCGGGCTTGCACAAGATGGGGGTGTCC
GAGATCGTCGCGGGCCATATCCGCGAAGCGGGGCTTCAGGCCGCGATCTTTCCCGGCGCGCAGCCCAATCCGACCGACGT
CAACGTTCACGACGGCGTTGAACTCTATCGGCGGGAAGGGTGCGATTTCATCGTGTCGCTCGGCGGCGGCTCGTCGCACG
ACTGCGCGAAGGGCATCGGGCTCGTCACCGCCGGCGGCGGACATATCCGCGACTACGAAGGCATCGACAAATCGACGGTG
CCGATGACGCCGTTGATTTCGATCAACACGACGGCGGGCACGGCGGCGGAGATGACGCGCTTTTGCATCATCACGAATTC
CAGCAATCACGTGAAGATGGCGATCGTCGACTGGCGTTGCACGCCGCTCATCGCGATCGACGACCCGAGCCTGATGGTGG
CGATGCCGCCCGCGCTGACGGCCGCAACCGGCATGGACGCGCTCACGCACGCGGTGGAGGCCTACGTTTCCACCGCCGCG
ACGCCGATCACCGACGCCTGCGCCGAAAAGGCGATCGCGTTGATCGGCGAATGGCTGCCGAAGGCCGTCGCGAACGGCGA
ATCGATGCAGGCGCGCGCGGCGATGTGCTACGCGCAGTACCTCGCCGGGATGGCGTTCAACAATGCGTCGCTCGGCTATG
TGCACGCGATGGCGCACCAGCTCGGCGGGTTCTACAACCTTCCGCACGGGGTCTGCAACGCGATCCTGCTGCCGCACGTG
TGCGAGTTCAACCTGATCGCCGCGCCCGAGCGTTTCGCCGCCATCGCGCCGCTGCTCGGCGTCAGGACGGCGGGCATGAG
CACCCCCGATGCCGCCCGCGCCGCCATTGCGGCGATCCGCGCGCTCTCGGCGTCGATCGGCATCCCGTCGGGCCTGGCCG
CGCTCGGCGTGAAGGCTGAAGACCATGAGGTGATGGCCGGCAACGCGCAGAAAGATGCGTGCATGCTGACCAATCCGCGC
AAGGCGACGCTCGCGCAGGTCATCGCGATCTTCGCGGCGGCGATGTGA

Upstream 100 bases:

>100_bases
CCGATCGCTCCGAAATGGAGCAGCATGTGCCTAATTCGAACAGGCGTTGCGCGGCGCGCGGCGGGCCGTTCATCAGCGCG
CGGCCTTCCGGCGGGATGGT

Downstream 100 bases:

>100_bases
GCGCCGCGGCCGCCATGCCGCGCGTGCGCGGATAGCGCATTGAACGCACATCGAGCGCGTATCGGGCAAGGGCGGCGGGT
CGTTGGAAGCCGTCATCGCG

Product: EutG protein

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDRAFSFPGITGGSTRDAPTQPGDDMSNLSSAERTDSFFIPRVTLIGPGCARETGARAKSLGAKKALIVTDAGLHKMGVS
EIVAGHIREAGLQAAIFPGAQPNPTDVNVHDGVELYRREGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTV
PMTPLISINTTAGTAAEMTRFCIITNSSNHVKMAIVDWRCTPLIAIDDPSLMVAMPPALTAATGMDALTHAVEAYVSTAA
TPITDACAEKAIALIGEWLPKAVANGESMQARAAMCYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHV
CEFNLIAAPERFAAIAPLLGVRTAGMSTPDAARAAIAAIRALSASIGIPSGLAALGVKAEDHEVMAGNAQKDACMLTNPR
KATLAQVIAIFAAAM

Sequences:

>Translated_415_residues
MDRAFSFPGITGGSTRDAPTQPGDDMSNLSSAERTDSFFIPRVTLIGPGCARETGARAKSLGAKKALIVTDAGLHKMGVS
EIVAGHIREAGLQAAIFPGAQPNPTDVNVHDGVELYRREGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTV
PMTPLISINTTAGTAAEMTRFCIITNSSNHVKMAIVDWRCTPLIAIDDPSLMVAMPPALTAATGMDALTHAVEAYVSTAA
TPITDACAEKAIALIGEWLPKAVANGESMQARAAMCYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHV
CEFNLIAAPERFAAIAPLLGVRTAGMSTPDAARAAIAAIRALSASIGIPSGLAALGVKAEDHEVMAGNAQKDACMLTNPR
KATLAQVIAIFAAAM
>Mature_415_residues
MDRAFSFPGITGGSTRDAPTQPGDDMSNLSSAERTDSFFIPRVTLIGPGCARETGARAKSLGAKKALIVTDAGLHKMGVS
EIVAGHIREAGLQAAIFPGAQPNPTDVNVHDGVELYRREGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTV
PMTPLISINTTAGTAAEMTRFCIITNSSNHVKMAIVDWRCTPLIAIDDPSLMVAMPPALTAATGMDALTHAVEAYVSTAA
TPITDACAEKAIALIGEWLPKAVANGESMQARAAMCYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHV
CEFNLIAAPERFAAIAPLLGVRTAGMSTPDAARAAIAAIRALSASIGIPSGLAALGVKAEDHEVMAGNAQKDACMLTNPR
KATLAQVIAIFAAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=426, Percent_Identity=27.2300469483568, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=57.5197889182058, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1789163, Length=358, Percent_Identity=43.0167597765363, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI87082107, Length=390, Percent_Identity=37.4358974358974, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1787493, Length=381, Percent_Identity=32.2834645669291, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789386, Length=359, Percent_Identity=26.1838440111421, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=385, Percent_Identity=24.4155844155844, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=379, Percent_Identity=52.2427440633245, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24657991, Length=409, Percent_Identity=25.9168704156479, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 42925; Mature: 42925

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRAFSFPGITGGSTRDAPTQPGDDMSNLSSAERTDSFFIPRVTLIGPGCARETGARAKS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCEEEEECCCCCHHHCCHHHH
LGAKKALIVTDAGLHKMGVSEIVAGHIREAGLQAAIFPGAQPNPTDVNVHDGVELYRREG
CCCCEEEEEECCCCHHHCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHCCHHHHHHCC
CDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTVPMTPLISINTTAGTAAEMTR
CEEEEECCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEE
FCIITNSSNHVKMAIVDWRCTPLIAIDDPSLMVAMPPALTAATGMDALTHAVEAYVSTAA
EEEEECCCCEEEEEEEEECCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
TPITDACAEKAIALIGEWLPKAVANGESMQARAAMCYAQYLAGMAFNNASLGYVHAMAHQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHH
LGGFYNLPHGVCNAILLPHVCEFNLIAAPERFAAIAPLLGVRTAGMSTPDAARAAIAAIR
HCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALSASIGIPSGLAALGVKAEDHEVMAGNAQKDACMLTNPRKATLAQVIAIFAAAM
HHHHHCCCCCCHHHHCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRAFSFPGITGGSTRDAPTQPGDDMSNLSSAERTDSFFIPRVTLIGPGCARETGARAKS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCEEEEECCCCCHHHCCHHHH
LGAKKALIVTDAGLHKMGVSEIVAGHIREAGLQAAIFPGAQPNPTDVNVHDGVELYRREG
CCCCEEEEEECCCCHHHCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHCCHHHHHHCC
CDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSTVPMTPLISINTTAGTAAEMTR
CEEEEECCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHCEE
FCIITNSSNHVKMAIVDWRCTPLIAIDDPSLMVAMPPALTAATGMDALTHAVEAYVSTAA
EEEEECCCCEEEEEEEEECCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
TPITDACAEKAIALIGEWLPKAVANGESMQARAAMCYAQYLAGMAFNNASLGYVHAMAHQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHH
LGGFYNLPHGVCNAILLPHVCEFNLIAAPERFAAIAPLLGVRTAGMSTPDAARAAIAAIR
HCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALSASIGIPSGLAALGVKAEDHEVMAGNAQKDACMLTNPRKATLAQVIAIFAAAM
HHHHHCCCCCCHHHHCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]