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The map label for this gene is tpx [H]

Identifier: 126451890

GI number: 126451890

Start: 3411279

End: 3411782

Strand: Direct

Name: tpx [H]

Synonym: BURPS1106A_3507

Alternate gene names: 126451890

Gene position: 3411279-3411782 (Clockwise)

Preceding gene: 126454484

Following gene: 126452743

Centisome position: 85.53

GC content: 66.47

Gene sequence:

>504_bases
ATGAGCAAAGTCACGCTGGGTGGCAACCCGATCGACATCGCCGGCACGTTTCCGACGGTCGGCTCGCCGGCCCCCGACTT
CAAGCTGGTCGGCAAGGACCTCGCCGACGTGTCGCTCGCGACCTTCGCGGGCAAGCGCAAGGTGCTGAACATCGTCCCGA
GCCTCGACACGCCGACCTGCGCGGCGTCGACCCGCAAGTTCAACGAAGCGGCGAGCAAGCTCGACAACACGGTCGTCGTC
GTCGTGTCGGCGGATCTGCCGTTTGCCGCAACCCGCTTCTGCACGACGGAAGGCCTCGCGAACGTCATCACCGCGTCGAC
GTTCCGGGGCGGCCGCGCGTTCGCCGACGCGTACGGCGTGAACGTGACAAGCGGCCCGCTCGACGGCTTGGCCGCGCGCG
CGGTCATCGTGATCGACGAAAACGACAAGGTGACGTACACCGAGCTCGTCGGCGAGATCAAGAACGAGCCGAACTACGAT
GCCGCGCTCGCCGCGCTGAAATAA

Upstream 100 bases:

>100_bases
TCGAACTTCCGCGTCCAGATCTTTTATCCGTAACGCGCCGCGACGCGGCGCGCGGCCTCAACCCGTGCGCCGCTGCGGCG
CACACACTTGGAGCACGAAC

Downstream 100 bases:

>100_bases
GCCGCACCGAACGGCCGCTGCGCGCCGCGCCCGCCTGCCGCGCGGCGGACGAAAGGCACGCAGCGGCCGCCCACCTACCC
TCTCTACAGGAACGCACACC

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MSKVTLGGNPIDIAGTFPTVGSPAPDFKLVGKDLADVSLATFAGKRKVLNIVPSLDTPTCAASTRKFNEAASKLDNTVVV
VVSADLPFAATRFCTTEGLANVITASTFRGGRAFADAYGVNVTSGPLDGLAARAVIVIDENDKVTYTELVGEIKNEPNYD
AALAALK

Sequences:

>Translated_167_residues
MSKVTLGGNPIDIAGTFPTVGSPAPDFKLVGKDLADVSLATFAGKRKVLNIVPSLDTPTCAASTRKFNEAASKLDNTVVV
VVSADLPFAATRFCTTEGLANVITASTFRGGRAFADAYGVNVTSGPLDGLAARAVIVIDENDKVTYTELVGEIKNEPNYD
AALAALK
>Mature_166_residues
SKVTLGGNPIDIAGTFPTVGSPAPDFKLVGKDLADVSLATFAGKRKVLNIVPSLDTPTCAASTRKFNEAASKLDNTVVVV
VSADLPFAATRFCTTEGLANVITASTFRGGRAFADAYGVNVTSGPLDGLAARAVIVIDENDKVTYTELVGEIKNEPNYDA
ALAALK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=168, Percent_Identity=61.9047619047619, Blast_Score=208, Evalue=1e-55,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17308; Mature: 17177

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5 ; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVTLGGNPIDIAGTFPTVGSPAPDFKLVGKDLADVSLATFAGKRKVLNIVPSLDTPTC
CCEEECCCCEEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
AASTRKFNEAASKLDNTVVVVVSADLPFAATRFCTTEGLANVITASTFRGGRAFADAYGV
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCC
NVTSGPLDGLAARAVIVIDENDKVTYTELVGEIKNEPNYDAALAALK
CCCCCCCCCCCEEEEEEEECCCCEEHHHHHHHHCCCCCCCCEEEECC
>Mature Secondary Structure 
SKVTLGGNPIDIAGTFPTVGSPAPDFKLVGKDLADVSLATFAGKRKVLNIVPSLDTPTC
CEEECCCCEEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
AASTRKFNEAASKLDNTVVVVVSADLPFAATRFCTTEGLANVITASTFRGGRAFADAYGV
HHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHCCC
NVTSGPLDGLAARAVIVIDENDKVTYTELVGEIKNEPNYDAALAALK
CCCCCCCCCCCEEEEEEEECCCCEEHHHHHHHHCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]