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The map label for this gene is folP [H]

Identifier: 126451770

GI number: 126451770

Start: 1470037

End: 1470927

Strand: Direct

Name: folP [H]

Synonym: BURPS1106A_1513

Alternate gene names: 126451770

Gene position: 1470037-1470927 (Clockwise)

Preceding gene: 126452144

Following gene: 126454506

Centisome position: 36.86

GC content: 70.15

Gene sequence:

>891_bases
GTGTCCAGTTCCGATTCCGTTTTTCCCGTTCCCGCGCCGCTGCAATGCGGCCGTTTCACCTTGACCTTCGAGCGCCCCCT
CGTGATGGGGATCCTCAACGTCACCCCCGATTCGTTCTCCGACGGCGGCCGTTACGTCGCCCGTGACGCCGCGCTCGCGC
AGGCGGAGCGGATGCTTGCCGAAGGCGCGGACATCCTCGACATCGGCGGCGAATCGACGCGCCCCGGCGCGCCGCCCGTG
CCGCTTAACGAGGAGCTCGAGCGCGTGATTCCGCTCGTCGAGGCGCTGCGCGGCCGGAACGTGCCGCTGTCGATCGACAC
GTACAAGCCCGCCGTGATGCGCGCGTCGCTCGCCGCGGGCGTCGATCTGATCAACGATATCTGGGGGCTGCGGCAGCCGG
GCGCGATCGACGCGGTGCGCGACAGCGCGTGCGGCCTCTGCGTGATGCACATGCTCGGCGAGCCGCGGACGATGCAGGTG
CATGCGCCCGAGTATCGCGACGTGATCGACGACGTGCGCGCGTTTCTCGCCGAGCGCGCCGATGCGCTCGTGCAGGCGGG
CATCGATGCCCGACGTATCAGCGTCGATCCGGGGTTCGGTTTCGGCAAGTCGGTGATAGAACACAACTATGCGCTGCTTG
CGCATTTGCCGAGGACCGCGCCCGCGCGGCCCGACGGGCGCGCGTATCCGATCCTCGCCGGCATGTCGCGCAAGTCGATG
CTGGGCGCGGTGATCGGCAGACCCGCGCCCGAGCGCATCGCGGCGAGCGTCGCGGCGGCGGTCTGCGCGGCCGAGCGGGG
GGCGGCGATCGTGCGCGTGCACGACGTCGCGGCGACCGTCGACGCATTGAAAGTATGGAGCGCCGTGCGCGATGCCGCGC
GGCGAGCATAA

Upstream 100 bases:

>100_bases
TGGGTTCACGGGCTGGTGTGGCTGTCACACCGGCCCGTTTTGCTTTGTTATCAGACGCTTTTCGTCGCTTCCCACTGCGT
TCGATCCGACGCTTCCGCTC

Downstream 100 bases:

>100_bases
GTCGAAACAAGGAGGAAGGTTCTACATGGGACGTCGTTATTTCGGCACGGACGGCATTCGCGGCAAGGTCGGCGACGCGC
CGATCACGCCCGATTTCGTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSSSDSVFPVPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLAEGADILDIGGESTRPGAPPV
PLNEELERVIPLVEALRGRNVPLSIDTYKPAVMRASLAAGVDLINDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQV
HAPEYRDVIDDVRAFLAERADALVQAGIDARRISVDPGFGFGKSVIEHNYALLAHLPRTAPARPDGRAYPILAGMSRKSM
LGAVIGRPAPERIAASVAAAVCAAERGAAIVRVHDVAATVDALKVWSAVRDAARRA

Sequences:

>Translated_296_residues
MSSSDSVFPVPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLAEGADILDIGGESTRPGAPPV
PLNEELERVIPLVEALRGRNVPLSIDTYKPAVMRASLAAGVDLINDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQV
HAPEYRDVIDDVRAFLAERADALVQAGIDARRISVDPGFGFGKSVIEHNYALLAHLPRTAPARPDGRAYPILAGMSRKSM
LGAVIGRPAPERIAASVAAAVCAAERGAAIVRVHDVAATVDALKVWSAVRDAARRA
>Mature_295_residues
SSSDSVFPVPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLAEGADILDIGGESTRPGAPPVP
LNEELERVIPLVEALRGRNVPLSIDTYKPAVMRASLAAGVDLINDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQVH
APEYRDVIDDVRAFLAERADALVQAGIDARRISVDPGFGFGKSVIEHNYALLAHLPRTAPARPDGRAYPILAGMSRKSML
GAVIGRPAPERIAASVAAAVCAAERGAAIVRVHDVAATVDALKVWSAVRDAARRA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=48.5401459854015, Blast_Score=244, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324073, Length=315, Percent_Identity=28.8888888888889, Blast_Score=112, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31472; Mature: 31340

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSDSVFPVPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLA
CCCCCCEECCCCCCCCCCEEEEECCCCEEHEECCCCCCCCCCCCEEHHHHHHHHHHHHHH
EGADILDIGGESTRPGAPPVPLNEELERVIPLVEALRGRNVPLSIDTYKPAVMRASLAAG
CCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHH
VDLINDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQVHAPEYRDVIDDVRAFLAERA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
DALVQAGIDARRISVDPGFGFGKSVIEHNYALLAHLPRTAPARPDGRAYPILAGMSRKSM
HHHHHCCCCCEEEECCCCCCCHHHHHHCCHHHEEECCCCCCCCCCCCCCEEEECCCHHHH
LGAVIGRPAPERIAASVAAAVCAAERGAAIVRVHDVAATVDALKVWSAVRDAARRA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSDSVFPVPAPLQCGRFTLTFERPLVMGILNVTPDSFSDGGRYVARDAALAQAERMLA
CCCCCEECCCCCCCCCCEEEEECCCCEEHEECCCCCCCCCCCCEEHHHHHHHHHHHHHH
EGADILDIGGESTRPGAPPVPLNEELERVIPLVEALRGRNVPLSIDTYKPAVMRASLAAG
CCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHH
VDLINDIWGLRQPGAIDAVRDSACGLCVMHMLGEPRTMQVHAPEYRDVIDDVRAFLAERA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
DALVQAGIDARRISVDPGFGFGKSVIEHNYALLAHLPRTAPARPDGRAYPILAGMSRKSM
HHHHHCCCCCEEEECCCCCCCHHHHHHCCHHHEEECCCCCCCCCCCCCCEEEECCCHHHH
LGAVIGRPAPERIAASVAAAVCAAERGAAIVRVHDVAATVDALKVWSAVRDAARRA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]