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The map label for this gene is ispB [H]

Identifier: 126451455

GI number: 126451455

Start: 3431150

End: 3432148

Strand: Direct

Name: ispB [H]

Synonym: BURPS1106A_3527

Alternate gene names: 126451455

Gene position: 3431150-3432148 (Clockwise)

Preceding gene: 126454047

Following gene: 126453893

Centisome position: 86.03

GC content: 63.36

Gene sequence:

>999_bases
ATGATCATGTCGTCGACTGCCACCCCTTCCCTCAGCGCCGCCCACCTGCTCGCACCGATCGCAAGCGACATGGAGCAGGT
GAATCGCGTCATTCGGCAAAGCCTCGCGTCCGACGTGCTGCTGATCAATCAGATCGCCGAGTACATCATCGGCGCGGGCG
GCAAACGGCTGCGGCCGGCGCTTCTTCTGCTCGTCGCGGGCGCGCTCGGCGAAAACACGAACCAGAAGCACGTGCTCGCG
GCCGTCGTCGAATTCATCCATACGGCGACGCTGCTGCACGACGACGTCGTCGACGAATCCGAGCTGCGGCGCGGCCGCAA
GACTGCGAACGCACTGTTCGGCAATGCGGCGAGCGTGCTTGTCGGCGATTACCTCTATTCGCGCTCGTTCGAGATGATGG
TGGGCGTCGGCAAGATGCGCGTGATGGAAATCCTGTCCGAAGCGACGACGATCATCTCCGAAGGCGAAGTGCTGCAATTG
CTGAACATGCACGATGCGGACGTCGACGAAGCCCGCTACATGCAGGTGATCCGCTATAAGACCGCGAAGCTGTTCGAAGC
GGCCGCGCGGCTCGGCGCGGTGCTCGCCGGCGCCGACGCGCCGACGGAAGCCGCCGCGGCCGAGTACGGCCGCCGGATCG
GCACCGCGTTCCAGATCATGGACGACTGGCTCGACTATGCGGGCACCGCCGAATCGATGGGCAAGAACGCCGGCGACGAC
CTGCGCGAAGGCAAGCCGACGCTGCCGCTCATCTATCTGATCGAGCGCGGCACGCCCGAGCAGTCGACACTCGCGCGCGA
AGCGATCGAGCACGGCGGTACCGATCGCTTCGACACGATTTTCGACGCGATCACGCGTTCGGGCGCGCTCGACCATACGC
TCGAATGCGCTCGCCAAGAAGCGCAGGCGGCCGCAGCAGCAATTTCTTCATTTCCCTCTTCCAATTTCAAAGAGAGCCTG
CTAGAATTATGCTCTTACTCGACGTCACGTCAGTCTTGA

Upstream 100 bases:

>100_bases
CGCGGACATCGGCCGAACGGCCTAAAAACGCGCGATGACGTCGCACGACGGCCCGGCTTGACGGCGATTCGCCTTATAAT
CCGCGGCACTACCCATTTCC

Downstream 100 bases:

>100_bases
TCTAGACCGAAGCGACGAATCAGTACGAATCGAGTTCAAATCGGGGTGTAGCTTAGCCTGGTAGAGCGCTACGTTCGGGA
CGTAGAGGCCGGAGGTTCGA

Product: octaprenyl-diphosphate synthase

Products: NA

Alternate protein names: All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MIMSSTATPSLSAAHLLAPIASDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGENTNQKHVLA
AVVEFIHTATLLHDDVVDESELRRGRKTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQL
LNMHDADVDEARYMQVIRYKTAKLFEAAARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAESMGKNAGDD
LREGKPTLPLIYLIERGTPEQSTLAREAIEHGGTDRFDTIFDAITRSGALDHTLECARQEAQAAAAAISSFPSSNFKESL
LELCSYSTSRQS

Sequences:

>Translated_332_residues
MIMSSTATPSLSAAHLLAPIASDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGENTNQKHVLA
AVVEFIHTATLLHDDVVDESELRRGRKTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQL
LNMHDADVDEARYMQVIRYKTAKLFEAAARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAESMGKNAGDD
LREGKPTLPLIYLIERGTPEQSTLAREAIEHGGTDRFDTIFDAITRSGALDHTLECARQEAQAAAAAISSFPSSNFKESL
LELCSYSTSRQS
>Mature_332_residues
MIMSSTATPSLSAAHLLAPIASDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPALLLLVAGALGENTNQKHVLA
AVVEFIHTATLLHDDVVDESELRRGRKTANALFGNAASVLVGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQL
LNMHDADVDEARYMQVIRYKTAKLFEAAARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAESMGKNAGDD
LREGKPTLPLIYLIERGTPEQSTLAREAIEHGGTDRFDTIFDAITRSGALDHTLECARQEAQAAAAAISSFPSSNFKESL
LELCSYSTSRQS

Specific function: Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=308, Percent_Identity=29.2207792207792, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4758430, Length=209, Percent_Identity=24.4019138755981, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI83700220, Length=209, Percent_Identity=24.4019138755981, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789578, Length=311, Percent_Identity=51.1254019292604, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1786623, Length=243, Percent_Identity=32.5102880658436, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=321, Percent_Identity=31.4641744548287, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319475, Length=242, Percent_Identity=30.1652892561983, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325188, Length=236, Percent_Identity=24.5762711864407, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651612, Length=287, Percent_Identity=31.7073170731707, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281365769, Length=334, Percent_Identity=25.1497005988024, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24660002, Length=334, Percent_Identity=25.1497005988024, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.90 [H]

Molecular weight: Translated: 35826; Mature: 35826

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMSSTATPSLSAAHLLAPIASDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLLLVAGALGENTNQKHVLAAVVEFIHTATLLHDDVVDESELRRGRKTANALFGNAASVL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
VGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLLNMHDADVDEARYMQVIRYK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHH
TAKLFEAAARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAESMGKNAGDD
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
LREGKPTLPLIYLIERGTPEQSTLAREAIEHGGTDRFDTIFDAITRSGALDHTLECARQE
HHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
AQAAAAAISSFPSSNFKESLLELCSYSTSRQS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIMSSTATPSLSAAHLLAPIASDMEQVNRVIRQSLASDVLLINQIAEYIIGAGGKRLRPA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
LLLLVAGALGENTNQKHVLAAVVEFIHTATLLHDDVVDESELRRGRKTANALFGNAASVL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
VGDYLYSRSFEMMVGVGKMRVMEILSEATTIISEGEVLQLLNMHDADVDEARYMQVIRYK
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHH
TAKLFEAAARLGAVLAGADAPTEAAAAEYGRRIGTAFQIMDDWLDYAGTAESMGKNAGDD
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
LREGKPTLPLIYLIERGTPEQSTLAREAIEHGGTDRFDTIFDAITRSGALDHTLECARQE
HHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
AQAAAAAISSFPSSNFKESLLELCSYSTSRQS
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8312607; 9278503; 2670911; 8037730 [H]