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The map label for this gene is fabI1 [H]

Identifier: 126447912

GI number: 126447912

Start: 1441886

End: 1442647

Strand: Reverse

Name: fabI1 [H]

Synonym: BMA10247_A1486

Alternate gene names: 126447912

Gene position: 1442647-1441886 (Counterclockwise)

Preceding gene: 126445655

Following gene: 126446549

Centisome position: 61.32

GC content: 69.16

Gene sequence:

>762_bases
ATGCGACTTCAGCACAAGCGTGGCCTCATCATCGGCATTGCAAACGAAAACAGCATCGCGTTCGGCTGCGCGCGGGTCAT
GCGCGAGCAGGGCGCCGAGCTCGCGCTCACTTACTTGAACGAAAAGGCCGAGCCCTATGTCCGTCCGCTCGCGCAGCGTC
TGGACAGCCGGCTCGTCGTGCCGTGCGACGTGCGCGAGCCCGGCCGGCTCGAGGACGTGTTCGCGCGCATCGCGCAGGAA
TGGGGGCAGCTCGACTTCGTGCTGCACTCGATCGCATACGCGCCGAAGGAGGACCTGCATCGCCGCGTGACCGACTGCTC
GCAGGCGGGCTTCGCGATGGCGATGGACGTGTCGTGCCATTCGTTCATTCGCGTCGCGCGCCTGGCCGAGCCGCTGATGA
CGAACGGCGGCTGCCTGCTGACCGTCACGTTCTACGGTGCCGAGCGGGCTGTCGAGGACTACAACCTGATGGGCCCGGTG
AAGGCGGCGCTCGAGGGCTCGGTGCGCTATCTCGCCGCCGAGCTCGGGCCGCGGCGCATCCGCGTGCACGCGCTGTCGCC
CGGGCCGCTGAAGACGCGCGCCGCGTCCGGCATCGACCGCTTCGACGCGCTGCTCGAACGCGTGCGCGAGCGCACGCCCG
GGCATCGCCTCGTCGACATCGACGACGTCGGCCATGTCGCCGCGTTCCTCGCGAGCGACGATGCGGCCGCGCTGACGGGC
AACGTCGAGTACATCGACGGCGGCTATCACGTCGTCGGCTGA

Upstream 100 bases:

>100_bases
CATACGGCGCGTGAATGCGCCGTATGCACGCATCCTCGTGCGATCCGAATCTCCGAATCGCGCCGCATGCCCCGTCGAAC
GACTCCCGAAGGAGATCCCA

Downstream 100 bases:

>100_bases
CGGCGGCAAGGGGGGGCTAGGGGGGTTAGGGCGGCTAGGGCGGCTAGGGCGGCAAGGGCAGCAAAGGCAGCAAGGGAGGT
GGACGTAGCATGAGCGGCAG

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVVPCDVREPGRLEDVFARIAQE
WGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCHSFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPV
KAALEGSVRYLAAELGPRRIRVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
NVEYIDGGYHVVG

Sequences:

>Translated_253_residues
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVVPCDVREPGRLEDVFARIAQE
WGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCHSFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPV
KAALEGSVRYLAAELGPRRIRVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
NVEYIDGGYHVVG
>Mature_253_residues
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVVPCDVREPGRLEDVFARIAQE
WGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCHSFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPV
KAALEGSVRYLAAELGPRRIRVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
NVEYIDGGYHVVG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=201, Percent_Identity=27.363184079602, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=27.7992277992278, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=25.0996015936255, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787545, Length=250, Percent_Identity=42.4, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=27.734375, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=25.8823529411765, Blast_Score=69, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=239, Percent_Identity=24.2677824267782, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=24.3137254901961, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27824; Mature: 27824

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVV
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHCCCCCHHHHHHHHHHCCCEEE
PCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCH
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEHHHH
SFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRI
HHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEE
RVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
EEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEEC
NVEYIDGGYHVVG
CEEEECCCEEECC
>Mature Secondary Structure
MRLQHKRGLIIGIANENSIAFGCARVMREQGAELALTYLNEKAEPYVRPLAQRLDSRLVV
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEHHCCCCCHHHHHHHHHHCCCEEE
PCDVREPGRLEDVFARIAQEWGQLDFVLHSIAYAPKEDLHRRVTDCSQAGFAMAMDVSCH
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEHHHH
SFIRVARLAEPLMTNGGCLLTVTFYGAERAVEDYNLMGPVKAALEGSVRYLAAELGPRRI
HHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEE
RVHALSPGPLKTRAASGIDRFDALLERVRERTPGHRLVDIDDVGHVAAFLASDDAAALTG
EEEEECCCCCCHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEEC
NVEYIDGGYHVVG
CEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]