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The map label for this gene is bioA [C]

Identifier: 126447562

GI number: 126447562

Start: 1415130

End: 1416530

Strand: Reverse

Name: bioA [C]

Synonym: BMA10247_A1454

Alternate gene names: 126447562

Gene position: 1416530-1415130 (Counterclockwise)

Preceding gene: 126445950

Following gene: 126445674

Centisome position: 60.21

GC content: 69.52

Gene sequence:

>1401_bases
ATGCGCAACATCTTCATTCACTCGCGCATCGCCGCGCCGACCGACATGAACGCTCCGACCGAACCGACCGCCCCCGACAC
GACCGTGCGCACCGATGCCGAGTGGCTCGACGCGCACTGGATGCCGTTCACGGCGAACCGCCAGTTCAAGCGCGACCCGC
GCATCATCGTCGAAGGCAAGGGCGCCTATTACACGGCGGCCGACGGCCGCCAGATCTTCGACGGCCTGTCCGGCCTCTGG
TGCTGCGGGCTCGGCCACGGCCGCGCCGAGATCTCGGATGCGGTCGCGCGCCAGGTCGCGCGGCTCGACTATTCGCCGGC
GTTCCAGTTCGGTCATCCGCAGTCGTTCGAGCTCGCGAACCGGATCAAGGCGATGACGCCCGCCGGCCTCGACTACGTGT
TCTTCACGGGTTCGGGCTCGGAGGCGGCCGACACGTCGCTCAAGCTCGCGCGCGCGTACTGGCGCGCGAAGGGCAAGGGC
ACGAAGACGCGCCTGATCGGCCGCGAGAAGGGCTATCACGGCGTGAACTTCGGCGGCATCTCGGTCGGCGGGATCGGGCC
GAACCGCAAGCTGTTCGGCCAGGGCATCGACGCCGACTTCCTGCCGCACACGCAACTGCCCGAGAACCGGTTCTCGCGCG
GTCTGCCCGAGCGCGGCGCCGAGCTCGCCGAGCGCCTGCTCGATCTGATCGCGCTGCACGACGCGTCGAACATCGCGGCG
GTGATCGTCGAGCCGTTCTCCGGCTCGGCGGGCGTCGTCGTGCCGCCGAAGGGCTATCTGCAGCGGCTGCGCGAGATCTG
CACCGCGCACGACATCCTGCTGATCTTCGACGAGGTCATCACGGGCTTCGGCCGCACGGGCGCGATGACGGGCGCCGAAG
CGTTCGGCGTCGTGCCGGACATCATGAACGTCGCGAAGCAGGTGACCAACGGCGCGCAGCCGCTCGGCGCGGTGATCGCG
AGCAAGGACGTCTACGACGCGTTCATGGCGGCGGGCGGCCCCGACTACATGCTCGAATTTTCGCACGGCTACACGTATTC
CGCGCATCCCGTCGCGTGCGCGGCGGGCGTCGCCGCGCTCGACCTGCTCGTCAAGGAGGACGCGCTCGGCCGCGTGCGCG
AGCTCGCGCCGTATTTCGAGGCGGCCGTGCACGGCCTGAAGGGCGTGCGCCACGTCGCCGACATCCGCAACTGCGGGCTG
GCCGCGGGCCTCACGATCGAGCATGCGCCGGGCGAGCCCGCGCGGCGTCCGTACGAGATCGCGATGCATTGCTGGAAGAA
CGGCTTCTACGTGCGCTACGGCGGCGACACGATCCAGCTCGCGCCGCCGTTCATCGCCGAGAAGCGCGAGATCGACAGTC
TGATCGGCGCGCTCAACGACGCGCTGCTCGCCACCGACTGA

Upstream 100 bases:

>100_bases
CTGGCCGAGGAGCGCACGGCTCTTCGGTTTTCTTGCTTGCATAAATGCTCAAGTAAACATTGATATTGCGATATTCAAAA
GACTATTCGCCGACTCGACA

Downstream 100 bases:

>100_bases
CGGCGCGGCCGCGCGCGCCGGGCGGCGGCCGAATCGGCTTGCGCCGTGCGCCGGAGCCGCGCGGCAGGCATGCGTTCGGC
GCCGGCGCGGCGGACCCGGC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MRNIFIHSRIAAPTDMNAPTEPTAPDTTVRTDAEWLDAHWMPFTANRQFKRDPRIIVEGKGAYYTAADGRQIFDGLSGLW
CCGLGHGRAEISDAVARQVARLDYSPAFQFGHPQSFELANRIKAMTPAGLDYVFFTGSGSEAADTSLKLARAYWRAKGKG
TKTRLIGREKGYHGVNFGGISVGGIGPNRKLFGQGIDADFLPHTQLPENRFSRGLPERGAELAERLLDLIALHDASNIAA
VIVEPFSGSAGVVVPPKGYLQRLREICTAHDILLIFDEVITGFGRTGAMTGAEAFGVVPDIMNVAKQVTNGAQPLGAVIA
SKDVYDAFMAAGGPDYMLEFSHGYTYSAHPVACAAGVAALDLLVKEDALGRVRELAPYFEAAVHGLKGVRHVADIRNCGL
AAGLTIEHAPGEPARRPYEIAMHCWKNGFYVRYGGDTIQLAPPFIAEKREIDSLIGALNDALLATD

Sequences:

>Translated_466_residues
MRNIFIHSRIAAPTDMNAPTEPTAPDTTVRTDAEWLDAHWMPFTANRQFKRDPRIIVEGKGAYYTAADGRQIFDGLSGLW
CCGLGHGRAEISDAVARQVARLDYSPAFQFGHPQSFELANRIKAMTPAGLDYVFFTGSGSEAADTSLKLARAYWRAKGKG
TKTRLIGREKGYHGVNFGGISVGGIGPNRKLFGQGIDADFLPHTQLPENRFSRGLPERGAELAERLLDLIALHDASNIAA
VIVEPFSGSAGVVVPPKGYLQRLREICTAHDILLIFDEVITGFGRTGAMTGAEAFGVVPDIMNVAKQVTNGAQPLGAVIA
SKDVYDAFMAAGGPDYMLEFSHGYTYSAHPVACAAGVAALDLLVKEDALGRVRELAPYFEAAVHGLKGVRHVADIRNCGL
AAGLTIEHAPGEPARRPYEIAMHCWKNGFYVRYGGDTIQLAPPFIAEKREIDSLIGALNDALLATD
>Mature_466_residues
MRNIFIHSRIAAPTDMNAPTEPTAPDTTVRTDAEWLDAHWMPFTANRQFKRDPRIIVEGKGAYYTAADGRQIFDGLSGLW
CCGLGHGRAEISDAVARQVARLDYSPAFQFGHPQSFELANRIKAMTPAGLDYVFFTGSGSEAADTSLKLARAYWRAKGKG
TKTRLIGREKGYHGVNFGGISVGGIGPNRKLFGQGIDADFLPHTQLPENRFSRGLPERGAELAERLLDLIALHDASNIAA
VIVEPFSGSAGVVVPPKGYLQRLREICTAHDILLIFDEVITGFGRTGAMTGAEAFGVVPDIMNVAKQVTNGAQPLGAVIA
SKDVYDAFMAAGGPDYMLEFSHGYTYSAHPVACAAGVAALDLLVKEDALGRVRELAPYFEAAVHGLKGVRHVADIRNCGL
AAGLTIEHAPGEPARRPYEIAMHCWKNGFYVRYGGDTIQLAPPFIAEKREIDSLIGALNDALLATD

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=418, Percent_Identity=28.9473684210526, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI37574042, Length=380, Percent_Identity=29.2105263157895, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI226442705, Length=380, Percent_Identity=29.2105263157895, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI13994255, Length=443, Percent_Identity=25.9593679458239, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442709, Length=345, Percent_Identity=29.5652173913043, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=29.607250755287, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=26.2755102040816, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1786991, Length=413, Percent_Identity=30.5084745762712, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI145693181, Length=417, Percent_Identity=29.0167865707434, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=29.5566502463054, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789759, Length=422, Percent_Identity=27.4881516587678, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789016, Length=347, Percent_Identity=27.6657060518732, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786349, Length=324, Percent_Identity=30.2469135802469, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=432, Percent_Identity=27.0833333333333, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=25.7831325301205, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=25.9174311926606, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=231, Percent_Identity=29.8701298701299, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=426, Percent_Identity=26.056338028169, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324386, Length=435, Percent_Identity=25.9770114942529, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=425, Percent_Identity=24.9411764705882, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=341, Percent_Identity=24.3401759530792, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357415, Length=418, Percent_Identity=27.511961722488, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI161085790, Length=444, Percent_Identity=27.027027027027, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=27.4599542334096, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=27.4553571428571, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 50268; Mature: 50268

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIFIHSRIAAPTDMNAPTEPTAPDTTVRTDAEWLDAHWMPFTANRQFKRDPRIIVEGK
CCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCCCCCCCCCEEEEECC
GAYYTAADGRQIFDGLSGLWCCGLGHGRAEISDAVARQVARLDYSPAFQFGHPQSFELAN
CCEEECCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
RIKAMTPAGLDYVFFTGSGSEAADTSLKLARAYWRAKGKGTKTRLIGREKGYHGVNFGGI
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCE
SVGGIGPNRKLFGQGIDADFLPHTQLPENRFSRGLPERGAELAERLLDLIALHDASNIAA
EECCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEE
VIVEPFSGSAGVVVPPKGYLQRLREICTAHDILLIFDEVITGFGRTGAMTGAEAFGVVPD
EEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHH
IMNVAKQVTNGAQPLGAVIASKDVYDAFMAAGGPDYMLEFSHGYTYSAHPVACAAGVAAL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
DLLVKEDALGRVRELAPYFEAAVHGLKGVRHVADIRNCGLAAGLTIEHAPGEPARRPYEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEECCCCCCCCCHHHH
AMHCWKNGFYVRYGGDTIQLAPPFIAEKREIDSLIGALNDALLATD
HHHHHCCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRNIFIHSRIAAPTDMNAPTEPTAPDTTVRTDAEWLDAHWMPFTANRQFKRDPRIIVEGK
CCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCCCCCCCCCEEEEECC
GAYYTAADGRQIFDGLSGLWCCGLGHGRAEISDAVARQVARLDYSPAFQFGHPQSFELAN
CCEEECCCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
RIKAMTPAGLDYVFFTGSGSEAADTSLKLARAYWRAKGKGTKTRLIGREKGYHGVNFGGI
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCE
SVGGIGPNRKLFGQGIDADFLPHTQLPENRFSRGLPERGAELAERLLDLIALHDASNIAA
EECCCCCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEE
VIVEPFSGSAGVVVPPKGYLQRLREICTAHDILLIFDEVITGFGRTGAMTGAEAFGVVPD
EEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHH
IMNVAKQVTNGAQPLGAVIASKDVYDAFMAAGGPDYMLEFSHGYTYSAHPVACAAGVAAL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHH
DLLVKEDALGRVRELAPYFEAAVHGLKGVRHVADIRNCGLAAGLTIEHAPGEPARRPYEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEECCCCCCCCCHHHH
AMHCWKNGFYVRYGGDTIQLAPPFIAEKREIDSLIGALNDALLATD
HHHHHCCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]