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The map label for this gene is sdhA [H]

Identifier: 126447504

GI number: 126447504

Start: 450791

End: 452566

Strand: Direct

Name: sdhA [H]

Synonym: BMA10247_A0501

Alternate gene names: 126447504

Gene position: 450791-452566 (Clockwise)

Preceding gene: 126445800

Following gene: 126446741

Centisome position: 19.16

GC content: 66.1

Gene sequence:

>1776_bases
ATGGCTGCAATCAAAACTTCCCTGCCGCGTCGCAAGTTCGACGTGGTGATCGTCGGCGCGGGCGGCTCGGGGATGCGCGC
GTCGCTGCAACTGTCGCGCGCGGGCCTCTCCGTATGCGTGCTCTCGAAGGTGTTCCCGACCCGTTCGCACACGGTCGCCG
CGCAAGGCGGGATCGGCGCGTCGCTCGGCAACATGAGCGAAGACAACTGGCACTACCACTTCTACGACACGATCAAGGGC
TCCGACTGGCTCGGCGATCAGGACGCGATCGAGTTCATGTGCCGCGAGGCGCCGAACGTCGTGTACGAGCTCGAGCACTT
CGGCATGCCGTTCGACCGTAACGCGGACGGCACGATCTACCAGCGTCCGTTCGGCGGCCACACGGCCAACTACGGCGAGA
AGCCGGTCCAGCGCGCGTGCGCGGCGGCCGACCGTACCGGCCACGCGCTGCTGCACACGCTGTATCAGCAAAACGTCGCG
GCGAAGACGCAGTTCTTCGTCGAATGGATGGCACTCGACCTGATCCGCGACGCGGACGGCGACGTGCTCGGCGTGACGGC
CCTCGAAATGGAAACGGGCGACGTCTACATCCTCGAAGGCAAGACCACGCTGTTCGCCACGGGCGGCGCGGGCCGGATCT
TCGCGGCGTCGACCAACGCGTTCATCAATACCGGCGACGGCCTCGGCATGGCCGCGCGTTCGGGCATCGCGCTGCAGGAC
ATGGAATTCTGGCAATTCCACCCGACGGGCGTCGCGGGCGCGGGCGTGCTGATCACCGAAGGCGTGCGCGGCGAAGGCGG
CATTCTGCGCAACGCGAACGGCGAGCGCTTCATGGAGCGCTACGCGCCGACGCTGAAGGATCTGGCGCCGCGCGATTTCG
TGTCGCGCTCGATGGACCAGGAAATCAAGGAAGGCCGCGGCGTGGGCCCGAACAAGGACCACGTGCTGCTCGACCTGTCG
CACATCGGCGCCGAGACGATCATGAAGCGTCTGCCGTCGATCCGCGAAATCGCGCTGAAGTTCGCGAACGTCGACTGCAT
CAAGGAACCGATTCCCGTCGTGCCGACGATCCACTACCAGATGGGCGGCATCCCGACCAACATCCACGGCCAGGTGGTGG
GCACGTCGCGCGATCACAAGGAGCCGATCAACGGCTTCTATGCGGTGGGCGAATGCTCGTGCGTGTCCGTGCACGGCGCG
AACCGCCTCGGCACGAACTCGCTGCTCGACCTCGTCGTGTTTGGTCGCGCGGCCGGCAACCACATCGTCGAGCACGTGAA
GAACCAGCGCGATCACAAGCCGCTGCCGGCCGACGCCGCCGACTTCTCGCTGTCGCGCCTCGCGAAGCTCGAGAAGTCGA
CCTCGGGCGAGTACACGCAGGACATCGCCAACGACATCCGCGCGACGATGCAAAAGCATGCCGGCGTGTTCCGCACGTCC
GCGCTGCTCAAGGAAGGCGTCGAGCAAATGGCGGGCCTGAAGGAGCGCGCCGCCGCCGTCCACCTGAAGGACAAGTCGAA
GGTGTTCAACACCGCGCGCGTCGAAGCGCTCGAACTGGCGAACCTGATCGAGGTCGCGCGCGCGACGATGGTGTCGGCGG
AAGCGCGCAAGGAAAGCCGCGGCGCGCACGCGCACAGCGATTACGAGCACCGCGACGACGAGAACTGGCTGCGTCACACG
CTGTGGTACAGCGAAGGCGATCGCCTCGACTACAAGCCCGTCCAAATGAAGCCGCTGACGGTCGAGTCCGTGCCGCCGAA
GGCGCGTACGTTCTAA

Upstream 100 bases:

>100_bases
AAGCCCGTCGGTGTGCGCCTGCTGCTGCAATCGCTGACGATCGTCTGGCTGCTCGCGTGCGCGGGCTACGCTGCGCAGAT
TCTCTGGAGAGTTTAAAAGA

Downstream 100 bases:

>100_bases
GCCAGCGCAAAGGAATCTGAAATGGCCAAACGCATTTTCGAAATCTACCGCTACGATCCGGACAAGGACGCCGCGCCGCG
CATGCAGACGTACGAGCTGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MAAIKTSLPRRKFDVVIVGAGGSGMRASLQLSRAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVA
AKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARSGIALQD
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLS
HIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGA
NRLGTNSLLDLVVFGRAAGNHIVEHVKNQRDHKPLPADAADFSLSRLAKLEKSTSGEYTQDIANDIRATMQKHAGVFRTS
ALLKEGVEQMAGLKERAAAVHLKDKSKVFNTARVEALELANLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHT
LWYSEGDRLDYKPVQMKPLTVESVPPKARTF

Sequences:

>Translated_591_residues
MAAIKTSLPRRKFDVVIVGAGGSGMRASLQLSRAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVA
AKTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARSGIALQD
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLS
HIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGA
NRLGTNSLLDLVVFGRAAGNHIVEHVKNQRDHKPLPADAADFSLSRLAKLEKSTSGEYTQDIANDIRATMQKHAGVFRTS
ALLKEGVEQMAGLKERAAAVHLKDKSKVFNTARVEALELANLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHT
LWYSEGDRLDYKPVQMKPLTVESVPPKARTF
>Mature_590_residues
AAIKTSLPRRKFDVVIVGAGGSGMRASLQLSRAGLSVCVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKGS
DWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAA
KTQFFVEWMALDLIRDADGDVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARSGIALQDM
EFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGVGPNKDHVLLDLSH
IGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQMGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGAN
RLGTNSLLDLVVFGRAAGNHIVEHVKNQRDHKPLPADAADFSLSRLAKLEKSTSGEYTQDIANDIRATMQKHAGVFRTSA
LLKEGVEQMAGLKERAAAVHLKDKSKVFNTARVEALELANLIEVARATMVSAEARKESRGAHAHSDYEHRDDENWLRHTL
WYSEGDRLDYKPVQMKPLTVESVPPKARTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=586, Percent_Identity=50.8532423208191, Blast_Score=577, Evalue=1e-165,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=55.4607508532423, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1790597, Length=574, Percent_Identity=40.7665505226481, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788928, Length=556, Percent_Identity=32.0143884892086, Blast_Score=231, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=50.4258943781942, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17505833, Length=588, Percent_Identity=50.8503401360544, Blast_Score=572, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=51.6949152542373, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=52.0338983050847, Blast_Score=588, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6320788, Length=482, Percent_Identity=25.7261410788382, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=51.6556291390728, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=51.6556291390728, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=51.6556291390728, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24663005, Length=614, Percent_Identity=47.8827361563518, Blast_Score=541, Evalue=1e-154,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64621; Mature: 64490

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIKTSLPRRKFDVVIVGAGGSGMRASLQLSRAGLSVCVLSKVFPTRSHTVAAQGGIGA
CCCCCCCCCCCEEEEEEEECCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAAKTQFFVEWMALDLIRDADG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARSGIALQD
CEEEEEEEEEECCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCHHHHCCCEEEC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCEEEEEE
MGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGN
CCCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCH
HIVEHVKNQRDHKPLPADAADFSLSRLAKLEKSTSGEYTQDIANDIRATMQKHAGVFRTS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHH
ALLKEGVEQMAGLKERAAAVHLKDKSKVFNTARVEALELANLIEVARATMVSAEARKESR
HHHHHHHHHHHCHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAHSDYEHRDDENWLRHTLWYSEGDRLDYKPVQMKPLTVESVPPKARTF
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCCCCCCC
>Mature Secondary Structure 
AAIKTSLPRRKFDVVIVGAGGSGMRASLQLSRAGLSVCVLSKVFPTRSHTVAAQGGIGA
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPNVVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQQNVAAKTQFFVEWMALDLIRDADG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DVLGVTALEMETGDVYILEGKTTLFATGGAGRIFAASTNAFINTGDGLGMAARSGIALQD
CEEEEEEEEEECCCEEEEECCEEEEEECCCCEEEEEECCCEEECCCCCCHHHHCCCEEEC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNANGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGVGPNKDHVLLDLSHIGAETIMKRLPSIREIALKFANVDCIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCEEEEEE
MGGIPTNIHGQVVGTSRDHKEPINGFYAVGECSCVSVHGANRLGTNSLLDLVVFGRAAGN
CCCCCCCCCCEEEECCCCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCH
HIVEHVKNQRDHKPLPADAADFSLSRLAKLEKSTSGEYTQDIANDIRATMQKHAGVFRTS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHH
ALLKEGVEQMAGLKERAAAVHLKDKSKVFNTARVEALELANLIEVARATMVSAEARKESR
HHHHHHHHHHHCHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAHSDYEHRDDENWLRHTLWYSEGDRLDYKPVQMKPLTVESVPPKARTF
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]