Click here to switch to the map view.

The map label for this gene is yvaG [H]

Identifier: 126447442

GI number: 126447442

Start: 1438342

End: 1439136

Strand: Direct

Name: yvaG [H]

Synonym: BMA10247_A1482

Alternate gene names: 126447442

Gene position: 1438342-1439136 (Clockwise)

Preceding gene: 126445739

Following gene: 126446588

Centisome position: 61.14

GC content: 68.93

Gene sequence:

>795_bases
ATGCACATCGACCTCACCGGCAAGACCGCCCTCGTGACCGCCTCGACCGCCGGCATCGGCCTCGCGATCGCCGAGGGACT
CGCGCGCGCCGGCGCGCAGTTGTTCATCAACGGCCGCAGCGACGCGTCCGTCAAGGCGGCGCTCGCGCACCTGCGCGTCA
CCGCGCCCGGCGCGCACGCGCAAGGCGTCGTCGCCGATCTGTCGGACGCTGACGGCGCGCGGCGCGTGATCGACGCCGCG
CCGTCGGCCGACATTCTCGTCAACAACGCGGGCATCTACGGCCCGAAGCCGTTCTTCGACATCGACGACGCCGAATGGGA
ACATTTCTTCCAGGTGAACGTGATGTCGGGCGTGCGGCTCGCGCGCCATTATCTGAAGGGGATGCTCGAGCGCGACTGGG
GGCGCGTCGTCTTCATCTCGTCGGAATCGGCGCTCAATGTCCCGGCCGACATGATCCATTACGGCTTCACGAAAACCGCG
CAATTGTCGATCTCGCGCGGGCTCGCCAAGCTCGCGGCCGGCAGCCGCGTGACGGTGAACGCGGTGCTGCCCGGCCCGAC
GATGTCCGACGGCGTGAAGGCGATGCTCAAGGCGACGGCCGACGCCGAGCACACGAGCATCGAGCAGGCGGGGGTCGATT
TCGTGCGCACGCACCGCTCGAGCTCGATCATCCAGCGGCCGGCGACTTGCGACGAAGTCGCGAACCTCGTCGTCTACGTG
TGCTCGCCGCAGTCGTCGGCGACGACGGGCGCGGCGTTGCGCGTCGACGGCGGCGTCGTAGACACGATCGCCTGA

Upstream 100 bases:

>100_bases
CTCGCCCGACTGCCGACTTCGCGGCTTTCGTCTAAGCTAGTCGCTCGCGTCCGCCGCCGCCGCGCGGCGGATCGTTCTCT
CCTTTTTGCGGAGTCTGCCC

Downstream 100 bases:

>100_bases
CGAACCGAACGGCCGGCGCGTTCGGCGCCGGCTCATCCCGCCTGGCTCGAACGAGCCACAAGAGCCACAAGAGCCACAAG
AGCCGCAAGAGCCGCAAGGG

Product: D-beta-hydroxybutyrate dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAA
PSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTA
QLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
CSPQSSATTGAALRVDGGVVDTIA

Sequences:

>Translated_264_residues
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAA
PSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTA
QLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
CSPQSSATTGAALRVDGGVVDTIA
>Mature_264_residues
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHAQGVVADLSDADGARRVIDAA
PSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRLARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTA
QLSISRGLAKLAAGSRVTVNAVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
CSPQSSATTGAALRVDGGVVDTIA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=30.9160305343511, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=31.2741312741313, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=242, Percent_Identity=30.5785123966942, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=32.7956989247312, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=25.0980392156863, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI126723750, Length=265, Percent_Identity=27.9245283018868, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI31542939, Length=264, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=24.1379310344828, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=265, Percent_Identity=29.0566037735849, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=30.5660377358491, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=29.4776119402985, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790717, Length=266, Percent_Identity=27.4436090225564, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=28.957528957529, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=29.4573643410853, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=29.1828793774319, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789208, Length=272, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=29.8850574712644, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=29.811320754717, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=28.4090909090909, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=261, Percent_Identity=31.0344827586207, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=29.6875, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=265, Percent_Identity=28.6792452830189, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=267, Percent_Identity=26.5917602996255, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=28.3018867924528, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=28.6764705882353, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=30.5263157894737, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=29.0566037735849, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=269, Percent_Identity=23.7918215613383, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=25.9541984732824, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=170, Percent_Identity=30, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=31.7829457364341, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355319, Length=263, Percent_Identity=29.6577946768061, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=25.7692307692308, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=28.6821705426357, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=28.2352941176471, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=27.5193798449612, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=27.3764258555133, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27549; Mature: 27549

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHA
CEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEEEECCCCCC
QGVVADLSDADGARRVIDAAPSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRL
CCEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHH
ARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTAQLSISRGLAKLAAGSRVTVN
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCCEEEEE
AVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
EEECCCCHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCCHHHHCCCCCHHHHCCEEEEE
CSPQSSATTGAALRVDGGVVDTIA
ECCCCCCCCCEEEEECCCEEECCC
>Mature Secondary Structure
MHIDLTGKTALVTASTAGIGLAIAEGLARAGAQLFINGRSDASVKAALAHLRVTAPGAHA
CEEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHEEEECCCCCC
QGVVADLSDADGARRVIDAAPSADILVNNAGIYGPKPFFDIDDAEWEHFFQVNVMSGVRL
CCEEEECCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHH
ARHYLKGMLERDWGRVVFISSESALNVPADMIHYGFTKTAQLSISRGLAKLAAGSRVTVN
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCCEEEEE
AVLPGPTMSDGVKAMLKATADAEHTSIEQAGVDFVRTHRSSSIIQRPATCDEVANLVVYV
EEECCCCHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCCHHHHCCCCCHHHHCCEEEEE
CSPQSSATTGAALRVDGGVVDTIA
ECCCCCCCCCEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]