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The map label for this gene is gnd [H]

Identifier: 126447314

GI number: 126447314

Start: 417693

End: 419108

Strand: Direct

Name: gnd [H]

Synonym: BMA10247_A0469

Alternate gene names: 126447314

Gene position: 417693-419108 (Clockwise)

Preceding gene: 126447635

Following gene: 126446555

Centisome position: 17.75

GC content: 66.81

Gene sequence:

>1416_bases
ATGGGCAAACAAGCAATCGGTGTGGTCGGTCTCGCGGTGATGGGGCGCAATCTGGCCTTGAATATCGAAAGCCGTGGCTA
TGCGGTGTCGGTCTACAACCGCAGCCGCGAGAAGACCGACGAACTGATCGCCGAATTTCCCGATCGCAAGCTCGTGCCGG
CCCATACGCTCGAGGCGTTCGTCGCGTCGCTCGAGACGCCGCGGCGCATCCTCCTGATGGTGAAGGCGGGCGAAGCGACC
GACGCGACGATCGCGGCGCTCAAGCCGCTGCTCGACAAGGGCGACGTGCTGATCGACGGCGGCAACACGCATTTCACCGA
CACGATTCGCCGCAACCAGGAGCTCGCGCAGGCGGGGCTGCATTTCATCGGCACGGGCGTGTCGGGGGGCGAGGAGGGCG
CACTGCGCGGGCCGTCGATCATGCCGGGCGGCCAGCGCGACGCCTACGATCTCGTCGAGCCGATCCTCGAGCAGATCGCC
GCGAAGGCGCCGGCGGACGGGGAGCCGTGCGTCGCGTACATGGGGCCGGACGGCGCGGGCCATTACGTGAAGATGGTCCA
CAACGGGATCGAGTACGGCGACATGCAACTGATCGCCGAGAGCTACGCGGTGCTCAAGCAGGTCGCGGGCCTGACGAACG
ACGAGCTGGGCGCGGTCTACGCCGAATGGAACCAGGGCGAACTCGACAGCTACCTGATCGAGATCACCGCGAAGATCTTC
GGCAAGAAGGACGACGAAACGGGCGAGCATCTCGTCGACGTGATCCTCGACCGCGCCGCGCAGAAGGGCACCGGCAAGTG
GACGAGCCAGAACGCGCTCGACCTCGGCGTGCCGTTGCCGCTCATCACCGAATCGGTGTTCGCGCGCGTGCTGTCGTCGC
TGAAGGCGCAGCGCGTCGCGGCGAGCGAGGTGTTGAGCGGGCCGTCGCCCGCGCCGCTCGAAGGCGATCGCGCCGCGTTC
GTCGAGTCGGTGCGCCGCGCGCTGTATCTGTCGAAGGTGATCTCGTACGCGCAGGGCTTCGCGCAGCTCGATACGGCGTC
GAAGGAATACGGCTGGAACCTCGATCTCGGCACGATCGCGAAGATCTTCCGCGCGGGCTGCATTATCCGCGCGCGTTTCC
TGCAGAAGATCACCGATGCGTATGCGAAGAACGCCGCGCTCGCGAACCTGCTGCTCGACCCGTATTTCCAGGACATCGCG
GCGAACTATCAGTCCGCGCTGCGCGACGTCGTGATCGCCGCGGTGAAGGCGGGCGTGCCCGTGCCGGCGTTCGCGTCGGC
GGTCGCGTACTTCGACAGCTACCGGTCCGCGCGCCTGCCCGCGAACCTCGTGCAGGCGCAGCGCGATTTCTTCGGCGCGC
ATACGTTCGAGCGCACGGACAAGCCGGGCAGTTTCCACGCGAGTTGGGCCGAGTGA

Upstream 100 bases:

>100_bases
CGTCTTTCATTCGCGGCGCGCTCGCGTGGTTTCCCTTATCCTTGCGCCTATGCGCGCGACCCCGGTGGGTCGCGCCCTGT
TTTTTCCGGAGAATTGAACA

Downstream 100 bases:

>100_bases
CCGCCGAGCGCGGCAATTGTTGCGCTCACCTACGTTATTAGTAGGGTTTTTCTAGGGATGTAACGGCGATTGTTATCGGT
CGCGAAACAGTGTTTTCGTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MGKQAIGVVGLAVMGRNLALNIESRGYAVSVYNRSREKTDELIAEFPDRKLVPAHTLEAFVASLETPRRILLMVKAGEAT
DATIAALKPLLDKGDVLIDGGNTHFTDTIRRNQELAQAGLHFIGTGVSGGEEGALRGPSIMPGGQRDAYDLVEPILEQIA
AKAPADGEPCVAYMGPDGAGHYVKMVHNGIEYGDMQLIAESYAVLKQVAGLTNDELGAVYAEWNQGELDSYLIEITAKIF
GKKDDETGEHLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKAQRVAASEVLSGPSPAPLEGDRAAF
VESVRRALYLSKVISYAQGFAQLDTASKEYGWNLDLGTIAKIFRAGCIIRARFLQKITDAYAKNAALANLLLDPYFQDIA
ANYQSALRDVVIAAVKAGVPVPAFASAVAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHASWAE

Sequences:

>Translated_471_residues
MGKQAIGVVGLAVMGRNLALNIESRGYAVSVYNRSREKTDELIAEFPDRKLVPAHTLEAFVASLETPRRILLMVKAGEAT
DATIAALKPLLDKGDVLIDGGNTHFTDTIRRNQELAQAGLHFIGTGVSGGEEGALRGPSIMPGGQRDAYDLVEPILEQIA
AKAPADGEPCVAYMGPDGAGHYVKMVHNGIEYGDMQLIAESYAVLKQVAGLTNDELGAVYAEWNQGELDSYLIEITAKIF
GKKDDETGEHLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKAQRVAASEVLSGPSPAPLEGDRAAF
VESVRRALYLSKVISYAQGFAQLDTASKEYGWNLDLGTIAKIFRAGCIIRARFLQKITDAYAKNAALANLLLDPYFQDIA
ANYQSALRDVVIAAVKAGVPVPAFASAVAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHASWAE
>Mature_470_residues
GKQAIGVVGLAVMGRNLALNIESRGYAVSVYNRSREKTDELIAEFPDRKLVPAHTLEAFVASLETPRRILLMVKAGEATD
ATIAALKPLLDKGDVLIDGGNTHFTDTIRRNQELAQAGLHFIGTGVSGGEEGALRGPSIMPGGQRDAYDLVEPILEQIAA
KAPADGEPCVAYMGPDGAGHYVKMVHNGIEYGDMQLIAESYAVLKQVAGLTNDELGAVYAEWNQGELDSYLIEITAKIFG
KKDDETGEHLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKAQRVAASEVLSGPSPAPLEGDRAAFV
ESVRRALYLSKVISYAQGFAQLDTASKEYGWNLDLGTIAKIFRAGCIIRARFLQKITDAYAKNAALANLLLDPYFQDIAA
NYQSALRDVVIAAVKAGVPVPAFASAVAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHASWAE

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=52.0169851380042, Blast_Score=487, Evalue=1e-137,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=72.2814498933902, Blast_Score=698, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=50.7399577167019, Blast_Score=489, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321695, Length=463, Percent_Identity=51.4038876889849, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321977, Length=453, Percent_Identity=52.5386313465784, Blast_Score=468, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24639279, Length=466, Percent_Identity=51.0729613733906, Blast_Score=461, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 50716; Mature: 50585

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKQAIGVVGLAVMGRNLALNIESRGYAVSVYNRSREKTDELIAEFPDRKLVPAHTLEAF
CCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHH
VASLETPRRILLMVKAGEATDATIAALKPLLDKGDVLIDGGNTHFTDTIRRNQELAQAGL
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCH
HFIGTGVSGGEEGALRGPSIMPGGQRDAYDLVEPILEQIAAKAPADGEPCVAYMGPDGAG
HHEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYAVLKQVAGLTNDELGAVYAEWNQGELDSYLIEITAKIF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
GKKDDETGEHLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKAQRVA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASEVLSGPSPAPLEGDRAAFVESVRRALYLSKVISYAQGFAQLDTASKEYGWNLDLGTIA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHH
KIFRAGCIIRARFLQKITDAYAKNAALANLLLDPYFQDIAANYQSALRDVVIAAVKAGVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPAFASAVAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHASWAE
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKQAIGVVGLAVMGRNLALNIESRGYAVSVYNRSREKTDELIAEFPDRKLVPAHTLEAF
CCHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHH
VASLETPRRILLMVKAGEATDATIAALKPLLDKGDVLIDGGNTHFTDTIRRNQELAQAGL
HHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCH
HFIGTGVSGGEEGALRGPSIMPGGQRDAYDLVEPILEQIAAKAPADGEPCVAYMGPDGAG
HHEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYAVLKQVAGLTNDELGAVYAEWNQGELDSYLIEITAKIF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
GKKDDETGEHLVDVILDRAAQKGTGKWTSQNALDLGVPLPLITESVFARVLSSLKAQRVA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASEVLSGPSPAPLEGDRAAFVESVRRALYLSKVISYAQGFAQLDTASKEYGWNLDLGTIA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHH
KIFRAGCIIRARFLQKITDAYAKNAALANLLLDPYFQDIAANYQSALRDVVIAAVKAGVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VPAFASAVAYFDSYRSARLPANLVQAQRDFFGAHTFERTDKPGSFHASWAE
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]