BacMap

Definition	Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession	NC_009079
Length	2,352,693

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The map label for this gene is fabG [H]

Identifier: 126447223

GI number: 126447223

Start: 377798

End: 378502

Strand: Direct

Name: fabG [H]

Synonym: BMA10247_A0434

Alternate gene names: 126447223

Gene position: 377798-378502 (Clockwise)

Preceding gene: 126446311

Following gene: 126447380

Centisome position: 16.06

GC content: 70.78

Gene sequence:

>705_bases
ATGGCAGTAGAAAAAGTTGCATTGATCACGGCGGCGGGCAAGGGCATGGGCGCGGCGATCGCGCGCGAGCTCGCGTCGGC
CGGCTATCGCGTCGCGCTGATGTCGCCGTCGGGCAGCGCGGTCGCGCTCGCGGGCGAACTGGACGGCCTCGGGCTGCGCG
GTTCGGTGACCGAGGAAGCCGATCTCGACCGGCTCGTGCGCGAGACGCTCGCGCGCTACGGCCGTATCGACGCGGTCGTC
AACAACACCGGCCATCCGCCGAAGGGCGAGCTGCTGTCGATCGCGGACGCGAGCTGGCACGACGCGCTCGATCTGATCCT
GCTGAACGTCGCGGGGCTGATGCGCCGCGTGACGCCGGTCTTTCAGGCACAGGGCGGCGGCGCGGCCGTCAACATCTCGA
GTTTCGCGGCCGTCGCGCCGGAGCAGCCGATGCCGGTGTCGTCGGTGCTGCGCGCGGCGCTCGGCGCCTGGACACGCCTC
TATGCGGAGCGCTACGCGGCCGAGAACATCCGGATGAACGCGGTGCTGCCCGGCTTCGTCGACAGTTGGCCCGAGACGCC
CGGGATCGTCGCGCGCATTCCGGCGGGGCGCTTCGGCAGGACGCGGGAGATCGCGAAGACCGTCGCGTTTCTGCTGTCGG
ACGGCGCGGGGTATGTGACGGGGCAGAGCATTCGCGTCGACGGCGGGATCGTGCGGGCGATGTGA

Upstream 100 bases:

>100_bases
TCGACAGCGGGGGTTGCCGCGCCTAAATTACCACGTCGAACGCCGCAAGAGGCCGCAAACAGCGGCAATGCAGGCTGAAG
AGCATCCGAGGGAGAACGTC

Downstream 100 bases:

>100_bases
CGCCGGCGGCGGAAGCAGTTCGCACGACGCGCCGGGCGGCGCGTGTGGGCCGCCTCGCGCCCGGCGTCGGCCGGGCGCGA
GCGAGCAAAGGCGAGCAAAG

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAVEKVALITAAGKGMGAAIARELASAGYRVALMSPSGSAVALAGELDGLGLRGSVTEEADLDRLVRETLARYGRIDAVV
NNTGHPPKGELLSIADASWHDALDLILLNVAGLMRRVTPVFQAQGGGAAVNISSFAAVAPEQPMPVSSVLRAALGAWTRL
YAERYAAENIRMNAVLPGFVDSWPETPGIVARIPAGRFGRTREIAKTVAFLLSDGAGYVTGQSIRVDGGIVRAM

Sequences:

>Translated_234_residues
MAVEKVALITAAGKGMGAAIARELASAGYRVALMSPSGSAVALAGELDGLGLRGSVTEEADLDRLVRETLARYGRIDAVV
NNTGHPPKGELLSIADASWHDALDLILLNVAGLMRRVTPVFQAQGGGAAVNISSFAAVAPEQPMPVSSVLRAALGAWTRL
YAERYAAENIRMNAVLPGFVDSWPETPGIVARIPAGRFGRTREIAKTVAFLLSDGAGYVTGQSIRVDGGIVRAM
>Mature_233_residues
AVEKVALITAAGKGMGAAIARELASAGYRVALMSPSGSAVALAGELDGLGLRGSVTEEADLDRLVRETLARYGRIDAVVN
NTGHPPKGELLSIADASWHDALDLILLNVAGLMRRVTPVFQAQGGGAAVNISSFAAVAPEQPMPVSSVLRAALGAWTRLY
AERYAAENIRMNAVLPGFVDSWPETPGIVARIPAGRFGRTREIAKTVAFLLSDGAGYVTGQSIRVDGGIVRAM

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=31.9672131147541, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=30.5882352941176, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI40254992, Length=235, Percent_Identity=30.6382978723404, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=29.9180327868852, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=28.2258064516129, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI59889578, Length=226, Percent_Identity=30.9734513274336, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI66933014, Length=192, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=33.1491712707182, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=31.1827956989247, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=26.5873015873016, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI31542939, Length=191, Percent_Identity=28.7958115183246, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=27.8884462151394, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=236, Percent_Identity=32.2033898305085, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=29.5081967213115, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=34, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI87082100, Length=246, Percent_Identity=32.1138211382114, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=31.0204081632653, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786812, Length=243, Percent_Identity=29.2181069958848, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=24.8979591836735, Blast_Score=71, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=31.6872427983539, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=31.9838056680162, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=244, Percent_Identity=31.1475409836066, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=31.3953488372093, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=30.7392996108949, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=29.3436293436293, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=30.6201550387597, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=26.7175572519084, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=31.4393939393939, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=30.4878048780488, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=29.811320754717, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=259, Percent_Identity=30.5019305019305, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=255, Percent_Identity=28.6274509803922, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=203, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=29.2181069958848, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=28.4552845528455, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=28.6290322580645, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=27.8810408921933, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=25.4901960784314, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=206, Percent_Identity=31.5533980582524, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=252, Percent_Identity=26.984126984127, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=26.0536398467433, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=31.404958677686, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=34.2857142857143, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=28.6290322580645, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=28.0487804878049, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=28.6852589641434, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=29.0983606557377, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24643142, Length=236, Percent_Identity=28.3898305084746, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644337, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 24394; Mature: 24263

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEKVALITAAGKGMGAAIARELASAGYRVALMSPSGSAVALAGELDGLGLRGSVTEEA
CCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCHH
DLDRLVRETLARYGRIDAVVNNTGHPPKGELLSIADASWHDALDLILLNVAGLMRRVTPV
HHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FQAQGGGAAVNISSFAAVAPEQPMPVSSVLRAALGAWTRLYAERYAAENIRMNAVLPGFV
HCCCCCCEEEEHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHH
DSWPETPGIVARIPAGRFGRTREIAKTVAFLLSDGAGYVTGQSIRVDGGIVRAM
HCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEECCEEEECCCEEECC
>Mature Secondary Structure 
AVEKVALITAAGKGMGAAIARELASAGYRVALMSPSGSAVALAGELDGLGLRGSVTEEA
CCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCHH
DLDRLVRETLARYGRIDAVVNNTGHPPKGELLSIADASWHDALDLILLNVAGLMRRVTPV
HHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FQAQGGGAAVNISSFAAVAPEQPMPVSSVLRAALGAWTRLYAERYAAENIRMNAVLPGFV
HCCCCCCEEEEHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHH
DSWPETPGIVARIPAGRFGRTREIAKTVAFLLSDGAGYVTGQSIRVDGGIVRAM
HCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEECCEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA