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The map label for this gene is hbd [H]

Identifier: 126447137

GI number: 126447137

Start: 1879083

End: 1880129

Strand: Reverse

Name: hbd [H]

Synonym: BMA10247_A1957

Alternate gene names: 126447137

Gene position: 1880129-1879083 (Counterclockwise)

Preceding gene: 126446578

Following gene: 126447670

Centisome position: 79.91

GC content: 68.58

Gene sequence:

>1047_bases
GTGGCGAAGGCGGCCGGGCGCGCATGCGTCGCGCCGGCGCGGCTCCTTCGTATGCCGTTCTCGTTCAAGGATCGAAAGTA
CATGGCTGTCATCACCAAAATCGACACGTTCGCCGCGATCGGCGCGGGCGTCATCGGCAGCGGCTGGGTTGCGCGCGCGC
TCGCGAACGGGCTCGACGTGCTCGCGTGGGATCCCGCCGAAGATGCGGAAATGCAGTTGCGCGCGAACGTCGAGAACGCA
TGGCCCGCGCTCGAGCGCGCCGGCCTGGCGCCTGGCGCGTCGCCGGCACGCCTGCATTTCGTGCCGACGATCGAGGCGTG
CGTCGCCGACGCGGATTTCGTGCAGGAAAGCGCGCCCGAGCGCGAGGCGCTGAAGCTCGAACTGCACGAGCGGATCAGTC
GCGCGGCGAAGCCCGATGCGATCATCGCGTCGTCGACGTCGGGCCTGTTGCCGACGGATTTCTACGCGCGCGCGCATCGT
CCCGAGCGCTGCATCGTCGGGCATCCGTTCAATCCGGTCTATCTGCTGCCGCTCGTCGAAGTGCTGGGCGGCGAGCGCAC
CGCGCCCGACACCGTCGACGCGGCGCTCGGCATCTATCGCGCGCTCGGCATGCGGCCGCTGCGCGTGCGCAAGGAAGTGC
CGGGCTTCATCGCCGATCGCCTGCTCGAAGCGCTGTGGCGCGAGGCGCTGCACCTCGTCGACGAAGGCGTCGCGACGACG
GGCGAGATCGACGATGCGATCCGTTTCGGCGCGGGCATCCGCTGGTCGTTCATGGGCACGTTCCTCACGTATACACTGGC
GGGCGGCGAGGCCGGCATGCGTCACTTCATGCAGCAGTTCGGTCCCGCGCTGGAGCTGCCGTGGACCAAGCTCGTCGCGC
CGAAGCTGACCGATGCGCTGATCGACCGCGTCGTCGAGGGCACCGCCGAGCAGCAAGGACCCCGAAGCATCAAGGCGCTC
GAACGCTATCGGGACGAATGCATCACCGAAGTGATCGCGGCGATCGCCGCAGTGAAGGCGCGCCACGGCATGCGCTACGA
GGATTGA

Upstream 100 bases:

>100_bases
CAAGCTCGGCCTGCCGCCGCGCGGCGAGCGGCCGCTCGAGCGGCGCGCGATGACCGAATACGTATAGCGCGACCGCGCCG
CGCATCGACGGCCGCGCAAC

Downstream 100 bases:

>100_bases
CGATGACGACGGCCGGGATGCAAGCGACCGAACTGACGATTCACCGCGACACGGTGCGCGCGGAATGGGTGGATTACAAC
GGCCACCTGCGCGACGCGTT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAKAAGRACVAPARLLRMPFSFKDRKYMAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEDAEMQLRANVENA
WPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHR
PERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATT
GEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKAL
ERYRDECITEVIAAIAAVKARHGMRYED

Sequences:

>Translated_348_residues
MAKAAGRACVAPARLLRMPFSFKDRKYMAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEDAEMQLRANVENA
WPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHR
PERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATT
GEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKAL
ERYRDECITEVIAAIAAVKARHGMRYED
>Mature_347_residues
AKAAGRACVAPARLLRMPFSFKDRKYMAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEDAEMQLRANVENAW
PALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRP
ERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATTG
EIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKALE
RYRDECITEVIAAIAAVKARHGMRYED

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=303, Percent_Identity=30.6930693069307, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI296179429, Length=222, Percent_Identity=31.981981981982, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI296179427, Length=219, Percent_Identity=30.1369863013699, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI68989263, Length=266, Percent_Identity=24.812030075188, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI261878539, Length=266, Percent_Identity=24.812030075188, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787661, Length=226, Percent_Identity=29.2035398230088, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788682, Length=143, Percent_Identity=31.4685314685315, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790281, Length=122, Percent_Identity=29.5081967213115, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193203623, Length=272, Percent_Identity=29.0441176470588, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI115533614, Length=273, Percent_Identity=28.9377289377289, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17549919, Length=234, Percent_Identity=30.3418803418803, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17553560, Length=232, Percent_Identity=28.448275862069, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17563036, Length=227, Percent_Identity=25.9911894273128, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=216, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=216, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=213, Percent_Identity=29.5774647887324, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=223, Percent_Identity=28.2511210762332, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549573, Length=305, Percent_Identity=27.2131147540984, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI20129993, Length=247, Percent_Identity=27.1255060728745, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921000, Length=212, Percent_Identity=27.3584905660377, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=212, Percent_Identity=27.3584905660377, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583079, Length=212, Percent_Identity=27.3584905660377, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 37935; Mature: 37804

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAAGRACVAPARLLRMPFSFKDRKYMAVITKIDTFAAIGAGVIGSGWVARALANGLDV
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHCHHHHHHHHHCCCCE
LAWDPAEDAEMQLRANVENAWPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPE
EEECCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCCHHHHHHCCCH
REALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRPERCIVGHPFNPVYLLPLVE
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCEEEECCCCCCHHHHHHHH
VLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATT
HHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDAL
CCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
IDRVVEGTAEQQGPRSIKALERYRDECITEVIAAIAAVKARHGMRYED
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKAAGRACVAPARLLRMPFSFKDRKYMAVITKIDTFAAIGAGVIGSGWVARALANGLDV
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHCHHHHHHHHHCCCCE
LAWDPAEDAEMQLRANVENAWPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPE
EEECCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHCCHHHHHHCCCH
REALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRPERCIVGHPFNPVYLLPLVE
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCEEEECCCCCCHHHHHHHH
VLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATT
HHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDAL
CCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
IDRVVEGTAEQQGPRSIKALERYRDECITEVIAAIAAVKARHGMRYED
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]