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The map label for this gene is hpaH [H]

Identifier: 126446912

GI number: 126446912

Start: 1462559

End: 1463362

Strand: Reverse

Name: hpaH [H]

Synonym: BMA10247_A1508

Alternate gene names: 126446912

Gene position: 1463362-1462559 (Counterclockwise)

Preceding gene: 126446238

Following gene: 126447904

Centisome position: 62.2

GC content: 67.41

Gene sequence:

>804_bases
ATGCTAGATTCCGCCACCATCCAGTTGCTCGCCCGCCGGTTGCACGTCGCGGAGCGCGAGCGCAGGCAGATCCGCCAGAT
CTCGCTCGATTACCCGGAAATCACGATCGACGACGCGTACGCGATCCAGCGCACGTGGGTCGACATGAAGCTCGCCGAAG
GGCGCGTGCTGAAGGGGCACAAGATCGGCCTCACGTCGAAGGCGATGCAGTCGTCGTCGCAGATCGACGAGCCCGACTTC
GGCGCGCTGCTCGACGACATGTTCTTCGAGGACGGCGCGACGATTCCGACGCGCCGCTTCATCGTGCCGCGCGTCGAGGT
CGAGCTCGCGTTCGTGCTCGGCAAGCCGCTCAAGGGGCCGGACTGCACGGTGTTCGACGTGTACGACGCGGTCGACTACG
TGGTGCCCGCGCTCGAGATCATCGATGCGCGCAGCCAGTCGATCGATCCGGACACGAAGCGCCCGCGCAAGGTGTTCGAC
ACGATCGCCGACAACGCGGCGAACGCGGGCGTCGTGCTCGGCGGGCGGCCCGTGCGCCCGATGGACGTCGATCTGCGCTG
GGTCGCGGCGATCATGTCGCGCAACGGCGTCGTCGAGGAAACGGGCGTCGCCGCCGGCGTGCTGAACCATCCGGCGAACG
GCGTCGCGTGGCTCGCGAACCGGCTCGCCCGCTTCGACGTGTCGCTCGACGCGGGCGAGATCATCCTCGGCGGATCGTTC
ACGCGGCCGTGCGCGGCGAAGAGCGGCGATACGTTCAACGTCGATTACGGCCCGCTCGGCGCGATTCATTGCCATTTCGA
ATGA

Upstream 100 bases:

>100_bases
ATGGAGCTCGCCGAGTTCAGCGAGACGGGCTCGTACAAGCACAACAACATCCACGCACGCTACAAGCGCGGCGCGTGAGC
TCACCCCGACAACGAAGACC

Downstream 100 bases:

>100_bases
CGGTGAGCGATGCGCATTCCTGAGAATACGTTCAAGGCCGCGCTTGCGCGCGGGCACGCGCAGATCGGGCTGTGGCTCGG
ACTCGCGAATCCCTATGCGG

Product: 2-oxo-hepta-3-ene-1,7-dioic acid hydratase

Products: H2O; 2-oxopent-4-enoate [C]

Alternate protein names: OHED hydratase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MLDSATIQLLARRLHVAERERRQIRQISLDYPEITIDDAYAIQRTWVDMKLAEGRVLKGHKIGLTSKAMQSSSQIDEPDF
GALLDDMFFEDGATIPTRRFIVPRVEVELAFVLGKPLKGPDCTVFDVYDAVDYVVPALEIIDARSQSIDPDTKRPRKVFD
TIADNAANAGVVLGGRPVRPMDVDLRWVAAIMSRNGVVEETGVAAGVLNHPANGVAWLANRLARFDVSLDAGEIILGGSF
TRPCAAKSGDTFNVDYGPLGAIHCHFE

Sequences:

>Translated_267_residues
MLDSATIQLLARRLHVAERERRQIRQISLDYPEITIDDAYAIQRTWVDMKLAEGRVLKGHKIGLTSKAMQSSSQIDEPDF
GALLDDMFFEDGATIPTRRFIVPRVEVELAFVLGKPLKGPDCTVFDVYDAVDYVVPALEIIDARSQSIDPDTKRPRKVFD
TIADNAANAGVVLGGRPVRPMDVDLRWVAAIMSRNGVVEETGVAAGVLNHPANGVAWLANRLARFDVSLDAGEIILGGSF
TRPCAAKSGDTFNVDYGPLGAIHCHFE
>Mature_267_residues
MLDSATIQLLARRLHVAERERRQIRQISLDYPEITIDDAYAIQRTWVDMKLAEGRVLKGHKIGLTSKAMQSSSQIDEPDF
GALLDDMFFEDGATIPTRRFIVPRVEVELAFVLGKPLKGPDCTVFDVYDAVDYVVPALEIIDARSQSIDPDTKRPRKVFD
TIADNAANAGVVLGGRPVRPMDVDLRWVAAIMSRNGVVEETGVAAGVLNHPANGVAWLANRLARFDVSLDAGEIILGGSF
TRPCAAKSGDTFNVDYGPLGAIHCHFE

Specific function: Transforms 2-oxo-hept-3-ene-1,7-dioate (OHED) into 2,4- dihydoxy-hept-2-ene-1,7-dioic acid (HHED) [H]

COG id: COG3971

COG function: function code Q; 2-keto-4-pentenoate hydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hydratase/decarboxylase family [H]

Homologues:

Organism=Escherichia coli, GI87081722, Length=236, Percent_Identity=36.4406779661017, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234
- InterPro:   IPR012690 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 29304; Mature: 29304

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSATIQLLARRLHVAERERRQIRQISLDYPEITIDDAYAIQRTWVDMKLAEGRVLKGH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHEEEECCCEEECCC
KIGLTSKAMQSSSQIDEPDFGALLDDMFFEDGATIPTRRFIVPRVEVELAFVLGKPLKGP
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECEEEEEEEEEECCCCCCC
DCTVFDVYDAVDYVVPALEIIDARSQSIDPDTKRPRKVFDTIADNAANAGVVLGGRPVRP
CCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCC
MDVDLRWVAAIMSRNGVVEETGVAAGVLNHPANGVAWLANRLARFDVSLDAGEIILGGSF
CCCCHHHHHHHHHCCCCEECCCCHHHHHCCCCCHHHHHHHHHHHEEEECCCCCEEECCCC
TRPCAAKSGDTFNVDYGPLGAIHCHFE
CCCCCCCCCCEEEECCCCCEEEEEECC
>Mature Secondary Structure
MLDSATIQLLARRLHVAERERRQIRQISLDYPEITIDDAYAIQRTWVDMKLAEGRVLKGH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHEEEECCCEEECCC
KIGLTSKAMQSSSQIDEPDFGALLDDMFFEDGATIPTRRFIVPRVEVELAFVLGKPLKGP
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECEEEEEEEEEECCCCCCC
DCTVFDVYDAVDYVVPALEIIDARSQSIDPDTKRPRKVFDTIADNAANAGVVLGGRPVRP
CCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCC
MDVDLRWVAAIMSRNGVVEETGVAAGVLNHPANGVAWLANRLARFDVSLDAGEIILGGSF
CCCCHHHHHHHHHCCCCEECCCCHHHHHCCCCCHHHHHHHHHHHEEEECCCCCEEECCCC
TRPCAAKSGDTFNVDYGPLGAIHCHFE
CCCCCCCCCCEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxy-2-ketovalerate [C]

Specific reaction: 4-hydroxy-2-ketovalerate = H2O + 2-oxopent-4-enoate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7737515 [H]