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The map label for this gene is yhcA [H]

Identifier: 126446888

GI number: 126446888

Start: 548240

End: 549646

Strand: Reverse

Name: yhcA [H]

Synonym: BMA10247_A0603

Alternate gene names: 126446888

Gene position: 549646-548240 (Counterclockwise)

Preceding gene: 126446242

Following gene: 126447548

Centisome position: 23.36

GC content: 71.93

Gene sequence:

>1407_bases
TTGGCCGCCATGTCCGCTCGCTCACGCATCGCCGCTGTCTATCTGCTCGGCTTCTCGATCGACCTCGCGAACATGTTCGC
GATCAACGCCGCGTATCCGGCGCTGCAGCGCGCGCTGCGCGCGTCGGTCGCGCAGCTCGCGTGGGTCGGCAACATCTACA
TGCTCGGGCTCACGGTCGTGATTCCGCTCGGCGCTTGGCTTGCGCACCGGTTCGGCGAGCGCAGGCTGCTCACGGCGTCG
CTGCTCGTGTTCGCGCTCGGCAGCGCCGGCGCGGCGAGCGCGCCGTCGATCGGCGCGCTGCTCGCGTCGCGGCTCGTGCA
GGGGCTCGGCGGCGGTTTGCTGATTCCCGTCGGCCAAGCGATGACCTATCGCGCCTATCCGCGCGAAGCGCGCGCCCGCC
TCACGTCGATCGTGATGATGGTCGCGCTGCTCGTTCCCGCGGCCTCGCCCGCGCTCGGCGGCGTGATCGTCGACCATGCA
TCGTGGCGCGTGGTGTTCTGGAGCATGCTCGCGCTCGCCGCGTCGACGTGCACGCTCGCGCTCGCATGGCTGCCCGCCGA
CGTCGCGCGCGACGCGCCTCGCACGCTCGACGCGGCGGGCCTCGGCCTGAGCGCGGCCGCGCTCGTCGCGTTGCTGCTCG
GCCTCGCGTTCGCGAGCCGGCGCGGCGCGGGCGCGCCGGCGATCGCGATGCTCGCGCTCGCATGCACCGCCGGCGTCGCG
TATGTCCGGCACGCGCGCCGCTCGAGCGCGCCATTGCTCGATCTCGCGCTGCTCTCGCAGCCGCTCCTGCGTGCCGGCGT
CGTTATTTATCTGTGCGTGCCCGGCATTTTCACCGGCGTGAATCTGATCGCGTCGCTCTTTCTGCAAAACGCGCTGGGGC
TCGGCGCGACGCAGGTCGGCGCGCTGATGGTGCCGTGGGCCGCCGCGTCGTTCGCCGCGATCGCGACGACGCGGCGCGCG
TTCCCCGCGGTCGGCGCGCGGCCGCTGCTCGCATGCGGCGTTGTAGCCGACTGCATCGGCATCGCGCTGCTCGCGACGCC
GCTCGCGGCGCACGAGGCAGGCCGCGTGCTCGCCTACGTCGCGATGGGTTTCGGCGCGAGCCTCTGCACGAGCACGTCGC
AAACCGCCGCGTTTCTCGATGTGCCTGCCGACCGGATGGGCGAAGCGAGCGCGCTATGGAACATCAATCGCCAATTGAGC
TTCTGCCTGGGCGTCGCCGTGCTCGGCGGCATGCTCAATTTCCTGCTGGCAGCCGGCGGCGGCGACGCGCCGCTCGCGTA
TCGCCGCTGCTTCGCGTTCGGCGCGCTGCTGACCCTGCTGCCGCTGCCGCTCGTCGCACGGCTCGGCTCGCGTCGCGCCG
CGGTCTCGCCGGCCGTTTCCGTGGACGCCCAATCGAATCGAACATGA

Upstream 100 bases:

>100_bases
TCGCGCCCTCGATTGTCAAAATTTTTCGATCAGTCTATCCGGGCAATCGGGCTGACGGCCCCGGATCGCGGACTTTACAC
TACGTCACCCGATGTCACCG

Downstream 100 bases:

>100_bases
ACGAACCGAACCCGTATTTTCAGGAAGTCGTCGACGCGCACGTCGACATCGAACGATGGCTGTCAGGCCGGGCCGAACAC
GGCCGGCTGCCCGCGTTGCT

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALRASVAQLAWVGNIYMLGLTVVIPLGAWLAHRFGERRLLTAS
LLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHA
SWRVVFWSMLALAASTCTLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTAGVA
YVRHARRSSAPLLDLALLSQPLLRAGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATTRRA
FPAVGARPLLACGVVADCIGIALLATPLAAHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLS
FCLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT

Sequences:

>Translated_468_residues
MAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALRASVAQLAWVGNIYMLGLTVVIPLGAWLAHRFGERRLLTAS
LLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHA
SWRVVFWSMLALAASTCTLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTAGVA
YVRHARRSSAPLLDLALLSQPLLRAGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATTRRA
FPAVGARPLLACGVVADCIGIALLATPLAAHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLS
FCLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT
>Mature_467_residues
AAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALRASVAQLAWVGNIYMLGLTVVIPLGAWLAHRFGERRLLTASL
LVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQAMTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHAS
WRVVFWSMLALAASTCTLALAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTAGVAY
VRHARRSSAPLLDLALLSQPLLRAGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVGALMVPWAAASFAAIATTRRAF
PAVGARPLLACGVVADCIGIALLATPLAAHEAGRVLAYVAMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLSF
CLGVAVLGGMLNFLLAAGGGDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=425, Percent_Identity=26.5882352941176, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788710, Length=406, Percent_Identity=25.8620689655172, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081983, Length=393, Percent_Identity=26.4631043256997, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=411, Percent_Identity=26.2773722627737, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789042, Length=278, Percent_Identity=25.8992805755396, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47918; Mature: 47787

Theoretical pI: Translated: 11.00; Mature: 11.00

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALRASVAQLAWVGNIYMLGLTVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPLGAWLAHRFGERRLLTASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQA
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
MTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHASWRVVFWSMLALAASTCTLA
CEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
LAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTAGVA
HHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
YVRHARRSSAPLLDLALLSQPLLRAGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVG
HHHHHHHCCCCHHHHHHHHHHHHHHCHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALMVPWAAASFAAIATTRRAFPAVGARPLLACGVVADCIGIALLATPLAAHEAGRVLAYV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLSFCLGVAVLGGMLNFLLAAGG
HHHCCHHHHCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEECCCCCCC
>Mature Secondary Structure 
AAMSARSRIAAVYLLGFSIDLANMFAINAAYPALQRALRASVAQLAWVGNIYMLGLTVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPLGAWLAHRFGERRLLTASLLVFALGSAGAASAPSIGALLASRLVQGLGGGLLIPVGQA
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
MTYRAYPREARARLTSIVMMVALLVPAASPALGGVIVDHASWRVVFWSMLALAASTCTLA
CEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
LAWLPADVARDAPRTLDAAGLGLSAAALVALLLGLAFASRRGAGAPAIAMLALACTAGVA
HHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
YVRHARRSSAPLLDLALLSQPLLRAGVVIYLCVPGIFTGVNLIASLFLQNALGLGATQVG
HHHHHHHCCCCHHHHHHHHHHHHHHCHHHEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ALMVPWAAASFAAIATTRRAFPAVGARPLLACGVVADCIGIALLATPLAAHEAGRVLAYV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGFGASLCTSTSQTAAFLDVPADRMGEASALWNINRQLSFCLGVAVLGGMLNFLLAAGG
HHHCCHHHHCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDAPLAYRRCFAFGALLTLLPLPLVARLGSRRAAVSPAVSVDAQSNRT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]