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The map label for this gene is ethA [H]

Identifier: 126446870

GI number: 126446870

Start: 100078

End: 101676

Strand: Reverse

Name: ethA [H]

Synonym: BMA10247_A0119

Alternate gene names: 126446870

Gene position: 101676-100078 (Counterclockwise)

Preceding gene: 126447405

Following gene: 126446929

Centisome position: 4.32

GC content: 68.67

Gene sequence:

>1599_bases
ATGAGTTCGACGACAGACTGGAACGCCGCGCGCGCGCTCGACGAACGCGCGCCGCAAGCGGCGGCGGGCGGCCACGCCCG
CGCCAAGACCGACTTCGACGTGCTGATCGTCGGCGCGGGCCTGTCGGGCATCGGCGCCGCTTACTACCTGCGCGAGCGCT
GCCCGGACGCGACGTACGCGATCCTCGAAGGCCGCGAGACGATGGGCGGCACGTGGGACCTGTTCCGCTATCCGGGCGTG
CGTTCGGACTCCGACATGTTCACGCTCGGCTTCAGCTTCCGGCCGTGGCACAGCGACAAGGCGATCTCCGACGGCCAGAC
GATCCTCGACTACATCCGGGACACCGCGCGCGCATACGGCATCGACAAGACGATCCGCTTCGGCCACAAGGTGACGGCCG
CGAGCTGGGATTCGACGAGCGCGCGCTGGACCGTGCGCGTGCAGCGCGCGACGGGCGACGCGCGGCACGATGAAGCCGTC
TATACGTGCCGCTTCCTCTATATGTGCAGCGGCTACTACGACTACGAAGAAGGCCATGCGCCGAGCTGGCCGGACATGGA
CGCGTACCAGGGCCGCATCGTGCATCCGCAGCACTGGCCGAGCGATCTCGATTACAAGGACAAGCGCGTCGTCGTGATCG
GCAGCGGCGCGACCGCGGTCACGCTCGTGCCCTCGATGGCGGCCGACGCGCGCCACGTGACGATGCTGCAGCGCTCGCCG
ACCTACATCGTGTCGCTGCCCGCGCGCGACGCGATCGCGAACGCGCTGCGCCGCTGGCTGCCGTCGGGGCTCGCGCACCG
GCTCGTGCGGCTGAAGAACGTGCTGCTGACGATGTACTTCTACAACCTCGCGCGCCGCCGCCCGGACGCGACGAAGAAGT
TCATCGTCCGCGCGGCGGGCAAGCAGCTCGGCCCGCAGTTCGACGTCAACAAGCACCTGACGCCGCGCTACAAGCCGTGG
GACCAACGCGTCTGCCTCGTGCCGAACGGCGATCTGTTCAAGGCGATCCGCGCGGGACGCGCGTCGATCGCCACCGACGA
GATCGAGCGCTTCACCCCGGGCGGCCTGCGCCTGAAGAGCGGCCAGCGCCTCGAGGCCGACGTGATCGTCACCGCGACGG
GCCTGAAGCTGAAGATGCTGGGCGGCGCGGCCGTGACGGTCGACGGCAAGCCCGTCGATCTGTCGCAGACCGTGTCGTAC
AAGGGGATGATGTACAGCGGCGTGCCGAACCTCGCGTCGTCGTTCGGCTATACGAACGCATCGTGGACGCTGAAGGCCGA
GCTGATCGCGCAATACGTGTGCCGGCTGCTCGAGCACATGCGCACGCACGGCTACGACGTCTGCGTGCCGCGGCTCGCGC
CCGGCAGCATGGAGCTCGAACCCGTCGTCGATCTGACGTCGGGCTATATCCAGCGCGCCGCCGGCGTGCTGCCGAAGCAG
GGCACGAAAAAGCCGTGGAAGTCCTACCAGAACTACGCGCGCGATTTCGCCACATTCAGGTTCGGCCCGCTCGCCGACGG
CGCGATGCAGTTCGAGCGCCGCCGCCCGGCGCTCGCCGAACGTGACGACACCCGTCAGCCCGCCTACGAAGGAAGGTGA

Upstream 100 bases:

>100_bases
TCGTGCTGCGCTTCGTGCGCAAGTCGCGCGAGCGCAACCTCGCGCGCCAGCCGGCCGCGGCGCGGCCCACCCCGCCCTCC
TCCATCAGCAAGGATCCCGC

Downstream 100 bases:

>100_bases
TCCCGATGATAGCCAAGCTGTTCCACTTTCTCGTCTATGCATTCGTCGCGCTCTTCGCGTTCACGCAGTACACCGCGTAT
CGCATCCGGAAGATGTTCCC

Product: FAD-dependent oxidoreductase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSSTTDWNAARALDERAPQAAAGGHARAKTDFDVLIVGAGLSGIGAAYYLRERCPDATYAILEGRETMGGTWDLFRYPGV
RSDSDMFTLGFSFRPWHSDKAISDGQTILDYIRDTARAYGIDKTIRFGHKVTAASWDSTSARWTVRVQRATGDARHDEAV
YTCRFLYMCSGYYDYEEGHAPSWPDMDAYQGRIVHPQHWPSDLDYKDKRVVVIGSGATAVTLVPSMAADARHVTMLQRSP
TYIVSLPARDAIANALRRWLPSGLAHRLVRLKNVLLTMYFYNLARRRPDATKKFIVRAAGKQLGPQFDVNKHLTPRYKPW
DQRVCLVPNGDLFKAIRAGRASIATDEIERFTPGGLRLKSGQRLEADVIVTATGLKLKMLGGAAVTVDGKPVDLSQTVSY
KGMMYSGVPNLASSFGYTNASWTLKAELIAQYVCRLLEHMRTHGYDVCVPRLAPGSMELEPVVDLTSGYIQRAAGVLPKQ
GTKKPWKSYQNYARDFATFRFGPLADGAMQFERRRPALAERDDTRQPAYEGR

Sequences:

>Translated_532_residues
MSSTTDWNAARALDERAPQAAAGGHARAKTDFDVLIVGAGLSGIGAAYYLRERCPDATYAILEGRETMGGTWDLFRYPGV
RSDSDMFTLGFSFRPWHSDKAISDGQTILDYIRDTARAYGIDKTIRFGHKVTAASWDSTSARWTVRVQRATGDARHDEAV
YTCRFLYMCSGYYDYEEGHAPSWPDMDAYQGRIVHPQHWPSDLDYKDKRVVVIGSGATAVTLVPSMAADARHVTMLQRSP
TYIVSLPARDAIANALRRWLPSGLAHRLVRLKNVLLTMYFYNLARRRPDATKKFIVRAAGKQLGPQFDVNKHLTPRYKPW
DQRVCLVPNGDLFKAIRAGRASIATDEIERFTPGGLRLKSGQRLEADVIVTATGLKLKMLGGAAVTVDGKPVDLSQTVSY
KGMMYSGVPNLASSFGYTNASWTLKAELIAQYVCRLLEHMRTHGYDVCVPRLAPGSMELEPVVDLTSGYIQRAAGVLPKQ
GTKKPWKSYQNYARDFATFRFGPLADGAMQFERRRPALAERDDTRQPAYEGR
>Mature_531_residues
SSTTDWNAARALDERAPQAAAGGHARAKTDFDVLIVGAGLSGIGAAYYLRERCPDATYAILEGRETMGGTWDLFRYPGVR
SDSDMFTLGFSFRPWHSDKAISDGQTILDYIRDTARAYGIDKTIRFGHKVTAASWDSTSARWTVRVQRATGDARHDEAVY
TCRFLYMCSGYYDYEEGHAPSWPDMDAYQGRIVHPQHWPSDLDYKDKRVVVIGSGATAVTLVPSMAADARHVTMLQRSPT
YIVSLPARDAIANALRRWLPSGLAHRLVRLKNVLLTMYFYNLARRRPDATKKFIVRAAGKQLGPQFDVNKHLTPRYKPWD
QRVCLVPNGDLFKAIRAGRASIATDEIERFTPGGLRLKSGQRLEADVIVTATGLKLKMLGGAAVTVDGKPVDLSQTVSYK
GMMYSGVPNLASSFGYTNASWTLKAELIAQYVCRLLEHMRTHGYDVCVPRLAPGSMELEPVVDLTSGYIQRAAGVLPKQG
TKKPWKSYQNYARDFATFRFGPLADGAMQFERRRPALAERDDTRQPAYEGR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17561948, Length=383, Percent_Identity=22.4543080939948, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25150462, Length=380, Percent_Identity=22.6315789473684, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145785, Length=355, Percent_Identity=22.8169014084507, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 59333; Mature: 59202

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTTDWNAARALDERAPQAAAGGHARAKTDFDVLIVGAGLSGIGAAYYLRERCPDATYA
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
ILEGRETMGGTWDLFRYPGVRSDSDMFTLGFSFRPWHSDKAISDGQTILDYIRDTARAYG
EEECCCCCCCCEEHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
IDKTIRFGHKVTAASWDSTSARWTVRVQRATGDARHDEAVYTCRFLYMCSGYYDYEEGHA
CCHHHHCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PSWPDMDAYQGRIVHPQHWPSDLDYKDKRVVVIGSGATAVTLVPSMAADARHVTMLQRSP
CCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCEEEEEECHHHCCCHHEEEEECCC
TYIVSLPARDAIANALRRWLPSGLAHRLVRLKNVLLTMYFYNLARRRPDATKKFIVRAAG
CEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KQLGPQFDVNKHLTPRYKPWDQRVCLVPNGDLFKAIRAGRASIATDEIERFTPGGLRLKS
HHCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEECC
GQRLEADVIVTATGLKLKMLGGAAVTVDGKPVDLSQTVSYKGMMYSGVPNLASSFGYTNA
CCCEEEEEEEEECCEEEEEECCEEEEECCCCCCHHHHHCCCCEEECCCCHHHHHCCCCCC
SWTLKAELIAQYVCRLLEHMRTHGYDVCVPRLAPGSMELEPVVDLTSGYIQRAAGVLPKQ
CEEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GTKKPWKSYQNYARDFATFRFGPLADGAMQFERRRPALAERDDTRQPAYEGR
CCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSTTDWNAARALDERAPQAAAGGHARAKTDFDVLIVGAGLSGIGAAYYLRERCPDATYA
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
ILEGRETMGGTWDLFRYPGVRSDSDMFTLGFSFRPWHSDKAISDGQTILDYIRDTARAYG
EEECCCCCCCCEEHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
IDKTIRFGHKVTAASWDSTSARWTVRVQRATGDARHDEAVYTCRFLYMCSGYYDYEEGHA
CCHHHHCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PSWPDMDAYQGRIVHPQHWPSDLDYKDKRVVVIGSGATAVTLVPSMAADARHVTMLQRSP
CCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCEEEEEECHHHCCCHHEEEEECCC
TYIVSLPARDAIANALRRWLPSGLAHRLVRLKNVLLTMYFYNLARRRPDATKKFIVRAAG
CEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KQLGPQFDVNKHLTPRYKPWDQRVCLVPNGDLFKAIRAGRASIATDEIERFTPGGLRLKS
HHCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEECC
GQRLEADVIVTATGLKLKMLGGAAVTVDGKPVDLSQTVSYKGMMYSGVPNLASSFGYTNA
CCCEEEEEEEEECCEEEEEECCEEEEECCCCCCHHHHHCCCCEEECCCCHHHHHCCCCCC
SWTLKAELIAQYVCRLLEHMRTHGYDVCVPRLAPGSMELEPVVDLTSGYIQRAAGVLPKQ
CEEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GTKKPWKSYQNYARDFATFRFGPLADGAMQFERRRPALAERDDTRQPAYEGR
CCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]