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The map label for this gene is pcaK-1 [H]

Identifier: 126446443

GI number: 126446443

Start: 49358

End: 50713

Strand: Direct

Name: pcaK-1 [H]

Synonym: BMA10247_A0061

Alternate gene names: 126446443

Gene position: 49358-50713 (Clockwise)

Preceding gene: 126446920

Following gene: 126446252

Centisome position: 2.1

GC content: 69.17

Gene sequence:

>1356_bases
ATGACCGATCTCGCGCGCCAGCTCGATGTGCAGCAGTTCATCGACGAACGGCGCTTTTCGCCCTATCAGTGGCTGATTCT
GATCCTGTGTTTTCTGATCGTCGCGGCGGACGGCTTCGACACCGCCGCGATCGGTTTCGTCGCGCCCGCGCTCGCCCAGC
AATGGCACGTGACGAAGGCCGCGCTGGGGCCGGTGATGAGCGCGGCGCTCGTCGGCCTCGCGCTCGGCGCGCTCGCGGCG
GGCCCGCTTGCCGACCGGATCGGCCGCAAGCGCGTGCTGGTGGGCTCGGTCGTGCTGTTCGGACTCTTCAGCATCGGCTG
CGCTTTCACGCAGTCGGTCACCGAGCTCGCGGTGCTGCGGCTGCTGACGGGGCTCGGGTTGGGCGCGGCGATGCCGAACG
CGACGACGCTGATGGCCGAGTATGCGCCGCACGCGAAACGCTCGTTTCTCGTCAACACGATGTTCTGCGGCTTTACGCTG
GGCTCGTCCGCGGGCGGCCTCGTCGCCGCCGCGCTGATTCCCGAGCACGGGTGGCGCAGCGTGTTCATCGTCGGCGGTAT
CGTGCCGCTTGCGCTCGGCGCGCTGCTGATCGCGCTGCCCGAATCGATCCGCTTCATGGTGCTGCGCGGCGCGCCGCACG
AGCGCATCGCCGCGGTGTTGCGCAGGATCGCGCCCGATGCGGCGTTCGACGGCGTGCGCTTCGTGCTGCCCGACGATCGC
GGCGAGCAACGGCGCTCGGGCGCGGCCGTCGTGTTGTCGCCGCGCTATCGTGCGGGCACCGCGATGCTGTGGCTCACCTA
TTTCATGGGGCTGCTCGTCTACTATCTGATGACGAGCTGGCTGCCCACGCTGATTCGCGACACGGGATTCACCGTACGCG
ACGCGGCGCTCGTCACCGCGCTGTTTCCGCTCGGCGGCGGCATCGGCGCGATTGCTTGCGGCTGGCTGATGGACCGCATC
GAGCCGCATCGCGTGATTGCGTTTGCCTATGCGCTGACGGCGTTGTTCGTCTGGATGATCGGACTGCAGGCCGGGCACCT
CGCGTTGCTGGCGACCGTCGTGTTCGTCGCGGGCGTTTGCATGAACGGCGCGCAGTCGTCGCTGCCGGCGCTCGCGGCGG
CGTTCTATCCGACGAGCGGGCGCGCGACGGGCGTCGCATGGATGCTCGGCGTCGGGCGCTTTGGCGGCATTCTGGGCGCG
TTTTCGGGCGGCTTGCTGCTGCAGGCGCAGCTGGGATTCGGCACGATTTTCTCGATGCTCGCGGTGCCGGCGCTGATTGC
GGCGGGGGCGCTGATGGTCAAGCGTTCGGCGGCGTCGCGCGAGACGCAGCCGGATGCGCCGACACGAGCGGCGTGA

Upstream 100 bases:

>100_bases
CGGCGCGCCGGACGGCCGCCGCCCGTGCGCGACGACACGCGCCGGCATCGCATCGGCGCAGGACGCGAATGCGTCGACGA
CAACCCCAACGGAGACAGCA

Downstream 100 bases:

>100_bases
TCGGCGTGGTCGGCGGCGCGGGAATGCGCCGTCGCGGCGGCTGACGGGGCGCTCCGTTCAGGCCCCGTCATTCCTCGGCG
TCGTGGACTTTCGCGAAGTG

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKAALGPVMSAALVGLALGALAA
GPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLRLLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTL
GSSAGGLVAAALIPEHGWRSVFIVGGIVPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLPDDR
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTALFPLGGGIGAIACGWLMDRI
EPHRVIAFAYALTALFVWMIGLQAGHLALLATVVFVAGVCMNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGA
FSGGLLLQAQLGFGTIFSMLAVPALIAAGALMVKRSAASRETQPDAPTRAA

Sequences:

>Translated_451_residues
MTDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKAALGPVMSAALVGLALGALAA
GPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLRLLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTL
GSSAGGLVAAALIPEHGWRSVFIVGGIVPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLPDDR
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTALFPLGGGIGAIACGWLMDRI
EPHRVIAFAYALTALFVWMIGLQAGHLALLATVVFVAGVCMNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGA
FSGGLLLQAQLGFGTIFSMLAVPALIAAGALMVKRSAASRETQPDAPTRAA
>Mature_450_residues
TDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKAALGPVMSAALVGLALGALAAG
PLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLRLLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTLG
SSAGGLVAAALIPEHGWRSVFIVGGIVPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLPDDRG
EQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTALFPLGGGIGAIACGWLMDRIE
PHRVIAFAYALTALFVWMIGLQAGHLALLATVVFVAGVCMNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGAF
SGGLLLQAQLGFGTIFSMLAVPALIAAGALMVKRSAASRETQPDAPTRAA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=431, Percent_Identity=24.8259860788863, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI7662270, Length=330, Percent_Identity=23.9393939393939, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI216548223, Length=329, Percent_Identity=24.9240121580547, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI73695465, Length=330, Percent_Identity=23.9393939393939, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI166064021, Length=363, Percent_Identity=25.6198347107438, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262399383, Length=263, Percent_Identity=24.7148288973384, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI8923870, Length=405, Percent_Identity=23.2098765432099, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081723, Length=430, Percent_Identity=36.9767441860465, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082231, Length=438, Percent_Identity=24.4292237442922, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082159, Length=397, Percent_Identity=25.9445843828715, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786229, Length=210, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789152, Length=418, Percent_Identity=21.7703349282297, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789207, Length=276, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082404, Length=395, Percent_Identity=21.2658227848101, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789515, Length=332, Percent_Identity=21.6867469879518, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=458, Percent_Identity=23.7991266375546, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640198, Length=450, Percent_Identity=23.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640196, Length=450, Percent_Identity=23.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640200, Length=450, Percent_Identity=23.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922874, Length=270, Percent_Identity=28.1481481481481, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573097, Length=519, Percent_Identity=22.3506743737958, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47447; Mature: 47316

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ALGPVMSAALVGLALGALAAGPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLR
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTLGSSAGGLVAAALIPEHGWRS
HHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCE
VFIVGGIVPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLPDDR
EEEHHHHHHHHHHHHHHHCCHHHEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCC
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTA
CCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LFPLGGGIGAIACGWLMDRIEPHRVIAFAYALTALFVWMIGLQAGHLALLATVVFVAGVC
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGAFSGGLLLQAQLGFGTIFSML
HCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AVPALIAAGALMVKRSAASRETQPDAPTRAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLARQLDVQQFIDERRFSPYQWLILILCFLIVAADGFDTAAIGFVAPALAQQWHVTKA
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ALGPVMSAALVGLALGALAAGPLADRIGRKRVLVGSVVLFGLFSIGCAFTQSVTELAVLR
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTGLGLGAAMPNATTLMAEYAPHAKRSFLVNTMFCGFTLGSSAGGLVAAALIPEHGWRS
HHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCE
VFIVGGIVPLALGALLIALPESIRFMVLRGAPHERIAAVLRRIAPDAAFDGVRFVLPDDR
EEEHHHHHHHHHHHHHHHCCHHHEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCC
GEQRRSGAAVVLSPRYRAGTAMLWLTYFMGLLVYYLMTSWLPTLIRDTGFTVRDAALVTA
CCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LFPLGGGIGAIACGWLMDRIEPHRVIAFAYALTALFVWMIGLQAGHLALLATVVFVAGVC
HHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MNGAQSSLPALAAAFYPTSGRATGVAWMLGVGRFGGILGAFSGGLLLQAQLGFGTIFSML
HCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
AVPALIAAGALMVKRSAASRETQPDAPTRAA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]