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The map label for this gene is tetA [H]

Identifier: 126446343

GI number: 126446343

Start: 1253399

End: 1254688

Strand: Reverse

Name: tetA [H]

Synonym: BMA10247_A1290

Alternate gene names: 126446343

Gene position: 1254688-1253399 (Counterclockwise)

Preceding gene: 126446905

Following gene: 126445858

Centisome position: 53.33

GC content: 73.64

Gene sequence:

>1290_bases
ATGGATCTCCACGAACGCACGCTCGACGCGCCGGGCGCACCGGCGGCCGCGGCGCACGGCGCCGGCTCGCGTCTGTCGCG
CGAGGTCTGGATCATTCTGCTCACGCTCGCCGTGGATGCCGTCGGGCTCGGCGTCGCGACTCCCGTGCTGCCCGATCTGC
TGCGCGCGGTGGGCGAGCGGCCCGCGCACGTGCCCGTGATGCTCGGCAGCCTGATCACGTGCTTCTACTTCATGCAGTTC
GTGTTCGGCCCGATCGTCGGCGCGCTGAGCGATGCGTGGGGGCGCCGCCCGATATTGCTGATCGCGCTCGGCGGCGGCGC
GCTCAGCTATGCGATCGGCGCGACCGCGCGCAGCTACGGCGGGCTGCTCGCGGCGCACATGCTCGCCGGCATCGCGGCGT
CGAGCGCGGCCGTCGCGACCGCGTATCTGGCCGACGTGACGCCGCCCGCGCTGCGCGCGCGCCGCTTCGCGCTCGCGAGC
AGCGTGCTCGGCCTGGGCTTGATCGCGGGCCCCGCGTTCGGCGGCGTGCTGGGCGCGCTCGGGCCGCGCGTGCCGTTCGT
CGCGGCGGGCGCGATCGCCGCGCTCAACTTCGTGAGCGCCGCGTGCTTCCTGCGCGAAAGCCTGCCGGCGCGGCGGCGCG
TGCCCGTCTCATGGGCGCGGGCGAACCTGTTCGGCAGCCTGCGGCTCGTGCGCGAGGACCGCGTGTTTCGCGATCTGCTC
GCCGCCGTGTGCCTCGGCATGCTTGCCTACGGCATTTATCTGTCGTGCTTCGTGCTCGCCAACGCCGCGCGCCTCGGCTG
GGGGCCGCGCGAGAACGGCCTGGCGCTCGCGGGCCTCGGGCTCGGCATCACGCTCACGCAGACGCTGCTGCTGCCGCGCT
TGGTCGCACGGCTCGGCGAGCATCGCACCGCGCTCGTCGGCTTCGGCGCGTTCGTGCTCGCGTATGGCCTCTACAGCCGC
GCCGATTCCGTCGCGCTCGTCGCCGCCGCGCTGGCGGTGCATGCGTTGTCGCTGATCAGCGATCCGAGCGTGCGCAGCCT
GATCTCCGTGCACGCGGGGCCGCAGCGGCAGGGCGAGTATCAGGGCGCGCTGGTTTGCCTGACGGGGCTGGCCTCGTCGA
TCGCGCCGCTCGTCGGCGGCAATCTGTTCGCGTTCTTCACGCGCGCCGGCGCGTCGACGTATTTTCCCGGCGCGCCGTTT
CTGGCGGCCGCGGTGCTCTACGCGCTCGCGATGCTGGCCGTCTGGCGCGCGATGGCGGGCGCGGCTCGCCGACGATCGGC
TTCCCACTGA

Upstream 100 bases:

>100_bases
AACCATTACAGTTGCCTGATGGACGGCTACGTCGAGCGCATCGCCGATGCGCTGCGCGATGCGCTGGCGTCGGCGCGGCA
AGCGATCGAGGCGTGACGCG

Downstream 100 bases:

>100_bases
CATTTCGAGGACTTTCGCATGACTCATTTGCTCGACGATCCCGATGGCTCGTTTCAGGTGCTGGTGAACGAAGAAGGGCA
GCATTCGCTGTGGCCGGCCG

Product: multidrug resistance protein

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MDLHERTLDAPGAPAAAAHGAGSRLSREVWIILLTLAVDAVGLGVATPVLPDLLRAVGERPAHVPVMLGSLITCFYFMQF
VFGPIVGALSDAWGRRPILLIALGGGALSYAIGATARSYGGLLAAHMLAGIAASSAAVATAYLADVTPPALRARRFALAS
SVLGLGLIAGPAFGGVLGALGPRVPFVAAGAIAALNFVSAACFLRESLPARRRVPVSWARANLFGSLRLVREDRVFRDLL
AAVCLGMLAYGIYLSCFVLANAARLGWGPRENGLALAGLGLGITLTQTLLLPRLVARLGEHRTALVGFGAFVLAYGLYSR
ADSVALVAAALAVHALSLISDPSVRSLISVHAGPQRQGEYQGALVCLTGLASSIAPLVGGNLFAFFTRAGASTYFPGAPF
LAAAVLYALAMLAVWRAMAGAARRRSASH

Sequences:

>Translated_429_residues
MDLHERTLDAPGAPAAAAHGAGSRLSREVWIILLTLAVDAVGLGVATPVLPDLLRAVGERPAHVPVMLGSLITCFYFMQF
VFGPIVGALSDAWGRRPILLIALGGGALSYAIGATARSYGGLLAAHMLAGIAASSAAVATAYLADVTPPALRARRFALAS
SVLGLGLIAGPAFGGVLGALGPRVPFVAAGAIAALNFVSAACFLRESLPARRRVPVSWARANLFGSLRLVREDRVFRDLL
AAVCLGMLAYGIYLSCFVLANAARLGWGPRENGLALAGLGLGITLTQTLLLPRLVARLGEHRTALVGFGAFVLAYGLYSR
ADSVALVAAALAVHALSLISDPSVRSLISVHAGPQRQGEYQGALVCLTGLASSIAPLVGGNLFAFFTRAGASTYFPGAPF
LAAAVLYALAMLAVWRAMAGAARRRSASH
>Mature_429_residues
MDLHERTLDAPGAPAAAAHGAGSRLSREVWIILLTLAVDAVGLGVATPVLPDLLRAVGERPAHVPVMLGSLITCFYFMQF
VFGPIVGALSDAWGRRPILLIALGGGALSYAIGATARSYGGLLAAHMLAGIAASSAAVATAYLADVTPPALRARRFALAS
SVLGLGLIAGPAFGGVLGALGPRVPFVAAGAIAALNFVSAACFLRESLPARRRVPVSWARANLFGSLRLVREDRVFRDLL
AAVCLGMLAYGIYLSCFVLANAARLGWGPRENGLALAGLGLGITLTQTLLLPRLVARLGEHRTALVGFGAFVLAYGLYSR
ADSVALVAAALAVHALSLISDPSVRSLISVHAGPQRQGEYQGALVCLTGLASSIAPLVGGNLFAFFTRAGASTYFPGAPF
LAAAVLYALAMLAVWRAMAGAARRRSASH

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=362, Percent_Identity=29.2817679558011, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI94721311, Length=443, Percent_Identity=27.0880361173815, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI225703104, Length=152, Percent_Identity=36.1842105263158, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI225703102, Length=152, Percent_Identity=36.1842105263158, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996331, Length=320, Percent_Identity=26.25, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357569, Length=333, Percent_Identity=27.6276276276276, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161080926, Length=333, Percent_Identity=27.6276276276276, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161080924, Length=333, Percent_Identity=27.6276276276276, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24656463, Length=333, Percent_Identity=27.6276276276276, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24656468, Length=333, Percent_Identity=27.6276276276276, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17738085, Length=384, Percent_Identity=27.34375, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221513297, Length=337, Percent_Identity=25.8160237388724, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44194; Mature: 44194

Theoretical pI: Translated: 10.84; Mature: 10.84

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHERTLDAPGAPAAAAHGAGSRLSREVWIILLTLAVDAVGLGVATPVLPDLLRAVGER
CCCCHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAHVPVMLGSLITCFYFMQFVFGPIVGALSDAWGRRPILLIALGGGALSYAIGATARSYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHH
GLLAAHMLAGIAASSAAVATAYLADVTPPALRARRFALASSVLGLGLIAGPAFGGVLGAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GPRVPFVAAGAIAALNFVSAACFLRESLPARRRVPVSWARANLFGSLRLVREDRVFRDLL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAVCLGMLAYGIYLSCFVLANAARLGWGPRENGLALAGLGLGITLTQTLLLPRLVARLGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
HRTALVGFGAFVLAYGLYSRADSVALVAAALAVHALSLISDPSVRSLISVHAGPQRQGEY
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
QGALVCLTGLASSIAPLVGGNLFAFFTRAGASTYFPGAPFLAAAVLYALAMLAVWRAMAG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AARRRSASH
HHHHCCCCC
>Mature Secondary Structure
MDLHERTLDAPGAPAAAAHGAGSRLSREVWIILLTLAVDAVGLGVATPVLPDLLRAVGER
CCCCHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAHVPVMLGSLITCFYFMQFVFGPIVGALSDAWGRRPILLIALGGGALSYAIGATARSYG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHH
GLLAAHMLAGIAASSAAVATAYLADVTPPALRARRFALASSVLGLGLIAGPAFGGVLGAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GPRVPFVAAGAIAALNFVSAACFLRESLPARRRVPVSWARANLFGSLRLVREDRVFRDLL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAVCLGMLAYGIYLSCFVLANAARLGWGPRENGLALAGLGLGITLTQTLLLPRLVARLGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
HRTALVGFGAFVLAYGLYSRADSVALVAAALAVHALSLISDPSVRSLISVHAGPQRQGEY
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
QGALVCLTGLASSIAPLVGGNLFAFFTRAGASTYFPGAPFLAAAVLYALAMLAVWRAMAG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AARRRSASH
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]