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The map label for this gene is codB [H]

Identifier: 126446307

GI number: 126446307

Start: 1764428

End: 1765753

Strand: Reverse

Name: codB [H]

Synonym: BMA10247_A1833

Alternate gene names: 126446307

Gene position: 1765753-1764428 (Counterclockwise)

Preceding gene: 126447209

Following gene: 126447330

Centisome position: 75.05

GC content: 66.59

Gene sequence:

>1326_bases
ATGCGGCGGCTTTATTGGCCGGGCATCATCCGTTCACGCTGGAATGCTGGAGATCAAAAGACGATGGCAACACGGGGCGA
ATTTTCATTGAGCGAGGTGCCCGCGCACGAGCGCAAAGGCGCACTGTCGATCACGATGGTGCTGCTCACCTTCACGTTCT
TCACGGGTACGATGTTCGCGGGCGGCAAGATCGGCGTCGCGTTTCGCGTCGTCGACATGCTGTGGGTCGCGGTCGTCCGC
AATCTGCTGCTTGCCGCCTATGCGGCCGCGCTCGCGTTCGTCGCGTCGCGCAGCGGGCTCAATTCGGTGCTGATGGGGCG
TTTCTGTTTCGGCGAGGTCGGCAGCAAGCTGTCCGATTTCCTGCTCGGCTTCGCCGAACTCGGCTGGTATGCGTGGGGCA
CCGCGACGGTGGCGATTGTGCTCGTCAAGCTGCTCGGCTGGCCCGCGTCGGTGACGACGCCGCTGATGGTGCTGTTCGGG
TTCGGCTTCTCGATTACCGCGATCGTCGGCTATCGCGGGATGGACGCGCTCTCGCGCGTGTCGGTGCCGCTGATGTTCGC
GCTGCTCGTCGTGTCGATGTGGATCGCCACGCGCGACGTCGGCGGCTGGCCGGGCCTCGCGAAGATCGCGCCGACGCAGC
CGATGAGCTTCGCCGCCGCGGTCACGATGGTGTTCGGCACGTTCGCGAGCGGCGCGACGCAGGCGACGAACTGGACGCGG
CTCGCGAAGAGCGGCCGCGCGGCCGTCGCGGCGAGCATGATCGGCTTTTTCGTCGGCAATGGGCTGATGATCGTCGCGGG
CGCGTATTGCGCGATCGTCTATCAGCAGTCCGACATCGTCGAAGTGATGATGCTGCAAGGGCTGTCGATCGCGGCCGTCG
TGATGCTCTGCCTGAACCTGTGGACGATTCAGGGGCCGACGATCTACAACGTGTCGGCGGCCGCGTGCCATCTGTTGCGC
AGCGAACGCCGCCGCACGCTGACGCTCGTCGGCGCGGCGGTCGGCATCGTGCTCGCGATCGGCGGCATGTACGAGATGCT
GATCCCGTTCCTGATCCTGCTCGGCTCGATCATTCCGCCCGTCGGCGGCGTGATTCTCGCCGATTTCTGGTATCGGCACC
GCGGCCGCTATCCGGCGATCGCGAGCGCCCGGCTGCCGCGCTTCAATATCGCCGGGCTCGCCGCATATGCGATCGGCGCG
GCGCTCGCGTACGCATCGCCGTGGATCGCGCCGCTCGTCGGCATCGCCGCGTCGTCGTTCTGCTACATCGTGTTCGTGCA
GATCGCGGGCCGCGCGGTGCGCGCGCCGTCGGTCCAGGGAGAGTGA

Upstream 100 bases:

>100_bases
GGTAGCGGCAAGGTGCACGTGCCTTGTGCAGGATGAACCGCGCGAATTGTCCGCTTTGCCATGCCCGAGTTCGATTTCGG
TATTAATTGTCCGAATCGGG

Downstream 100 bases:

>100_bases
AGCGATGAGTCTGACCATCAGCGAGATCCTGCAACTGCCCGGTCTCGAAGAGCTCCAGCTGCGCGCGGGCGAGCGCAGCG
TGCAGCGGCCGGTGCGCTGG

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRRLYWPGIIRSRWNAGDQKTMATRGEFSLSEVPAHERKGALSITMVLLTFTFFTGTMFAGGKIGVAFRVVDMLWVAVVR
NLLLAAYAAALAFVASRSGLNSVLMGRFCFGEVGSKLSDFLLGFAELGWYAWGTATVAIVLVKLLGWPASVTTPLMVLFG
FGFSITAIVGYRGMDALSRVSVPLMFALLVVSMWIATRDVGGWPGLAKIAPTQPMSFAAAVTMVFGTFASGATQATNWTR
LAKSGRAAVAASMIGFFVGNGLMIVAGAYCAIVYQQSDIVEVMMLQGLSIAAVVMLCLNLWTIQGPTIYNVSAAACHLLR
SERRRTLTLVGAAVGIVLAIGGMYEMLIPFLILLGSIIPPVGGVILADFWYRHRGRYPAIASARLPRFNIAGLAAYAIGA
ALAYASPWIAPLVGIAASSFCYIVFVQIAGRAVRAPSVQGE

Sequences:

>Translated_441_residues
MRRLYWPGIIRSRWNAGDQKTMATRGEFSLSEVPAHERKGALSITMVLLTFTFFTGTMFAGGKIGVAFRVVDMLWVAVVR
NLLLAAYAAALAFVASRSGLNSVLMGRFCFGEVGSKLSDFLLGFAELGWYAWGTATVAIVLVKLLGWPASVTTPLMVLFG
FGFSITAIVGYRGMDALSRVSVPLMFALLVVSMWIATRDVGGWPGLAKIAPTQPMSFAAAVTMVFGTFASGATQATNWTR
LAKSGRAAVAASMIGFFVGNGLMIVAGAYCAIVYQQSDIVEVMMLQGLSIAAVVMLCLNLWTIQGPTIYNVSAAACHLLR
SERRRTLTLVGAAVGIVLAIGGMYEMLIPFLILLGSIIPPVGGVILADFWYRHRGRYPAIASARLPRFNIAGLAAYAIGA
ALAYASPWIAPLVGIAASSFCYIVFVQIAGRAVRAPSVQGE
>Mature_441_residues
MRRLYWPGIIRSRWNAGDQKTMATRGEFSLSEVPAHERKGALSITMVLLTFTFFTGTMFAGGKIGVAFRVVDMLWVAVVR
NLLLAAYAAALAFVASRSGLNSVLMGRFCFGEVGSKLSDFLLGFAELGWYAWGTATVAIVLVKLLGWPASVTTPLMVLFG
FGFSITAIVGYRGMDALSRVSVPLMFALLVVSMWIATRDVGGWPGLAKIAPTQPMSFAAAVTMVFGTFASGATQATNWTR
LAKSGRAAVAASMIGFFVGNGLMIVAGAYCAIVYQQSDIVEVMMLQGLSIAAVVMLCLNLWTIQGPTIYNVSAAACHLLR
SERRRTLTLVGAAVGIVLAIGGMYEMLIPFLILLGSIIPPVGGVILADFWYRHRGRYPAIASARLPRFNIAGLAAYAIGA
ALAYASPWIAPLVGIAASSFCYIVFVQIAGRAVRAPSVQGE

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=420, Percent_Identity=32.6190476190476, Blast_Score=215, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 47043; Mature: 47043

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]