Click here to switch to the map view.

The map label for this gene is nprS [H]

Identifier: 126446284

GI number: 126446284

Start: 672649

End: 674346

Strand: Reverse

Name: nprS [H]

Synonym: BMA10247_A0724

Alternate gene names: 126446284

Gene position: 674346-672649 (Counterclockwise)

Preceding gene: 126447316

Following gene: 126447424

Centisome position: 28.66

GC content: 68.96

Gene sequence:

>1698_bases
ATGAAGAAACTGTCCTGCCTGCTGTCGGTCACCGCGATTTCCCTTGCATGCCTCAGCGCGTTCGCGCAAGCCGACGATCC
GCCGGCCGCGGCCGACCGCGCGCTGCAACTGATCCGACAGAACCCGTCCGCCTTCCACCTCGCCGCCGGCAGCGCCGCGC
GCACGCTGAAGTTCGCCGGCGCGCAAGCGAAGGCGCCGGCGGACGGCGACCAGTTCCAGGTGCGCGACGTGATCGTCGAC
GCCGACGGCACCGAGCACGTGCGCTTCGATCGCTTCTACGCGGGGCTGCCCGTGATCGGCGGCGACGTCGTCGTCCATTC
GAACCAGGGGCAACTGAAGCAGGCGAGCCTCACGCAGCCCGCGCCGATCGATCTCGCGGGCAAGATCGGCAAGGTGGGCG
AGCGCTTCGTCGTGCGCAACGCGCCCGACGTGGGCGCGGACGCGGCAAGACGCGTCGCGTCGAAGCGCTTCGGCGCGGAC
GTGCGCCGCGTCGACGGCGCGGATCTCGTCGTGTTCGCGCGCGACGCCGCGCCGACGCTCGCCTACGCGGTGCGCGTGTA
CGGCAAGGCGACCGACGCGCACGGCGAGGCCGTGATCTACTACGTCGACGCGCGCACGGGCAACGTGCTGGACGCGCAGG
ACCTGATCAAGACCGCCTCCGTGACGGGCACCGGCCGCTCGCTGTACTACGGCAACCTGTCGCTCACGACCGATCAGACC
GGCACGAACGCGTACCGGATGCTCGATCCGACGCGCGGCAGCGGCTCGGTCTACGACGGGCGCGGCCTGAGCTCGGACGA
AGTCGAGCAGGCGAGCGACCTGCCGATCTTCACGAGCAGCACGAACGTGTGGGGCAACAACACGACGAGCGACCGGCAGA
CCGTCGCCGCCGACATCGACTACGGCCTCGCGCTGACGTGGGATTACTACAAGACCACGCACAACCGCAACGGCATCTTC
AACGACGGCCGCGGCGTGCGCAGCTACGCGCACGTGGTGTTCGACACCGGCAGCGGCACGACGGGCGCGAACGCCGCGTG
GCTGTCGTCGCGCGTGATGGTGTACGGCGACGGCGAGCCGGGCACGCGGCTGCCGAAGCCCGTCGTGTCGGTCGACGTGG
CCGGGCACGAGATGAGCCACGGCGTGACCGAGGCCACCTCGAACCTGTATTATTCGGGCGACGCGGGCGGCCTGAACGAA
TCGACGTCGGACATCTTCGGCACGCTCGTCAAGTACTACGCGAACAATCCGAACGACCCGGGCAACTACGTGATCGGCGC
GCGGATCACGAGCGGCGGCCTGCGCAAGATGTACAAGCAGGATCTCGACGGCCGCTCATACAGTTGCTACCCGTCCGGCG
GCTTCTCGTGGGCGAATCCGCGCCACGATCCGCACTACACGTCGGGCGTCGGCAACCGGTTCTTCTATCTGCTCGCGGAA
GGCCCGGTCGCGCCGTCGACCGATACCGGACTGTCGAGGAGCCAGCTCGTCTGCAACGGCGACACCGGCTTCAGCGGCCT
CGGCCGCGACAAGGCGGGCAAGATCTGGTATCGCACGCTCACCGTGTACCTGACCACCAACTCCAGCTACCCGGGCGCGC
GTCGCGCGTCGATCCAGGCGGCGAACGATCTGTACGGCGTGAATTCGCTCGAGAGCGCAACGGTCGCGCGCGCGTGGAGC
GCCGCCGGCGTGAACTGA

Upstream 100 bases:

>100_bases
CTAGCATGCCTCTGCAGTTCGAAGGTACCTCTCACGTTTAATGCTTGCTGTTAATGCGTTTTCAATAATCAACGCAGTCA
TCCATTATCTGGGGGATTAC

Downstream 100 bases:

>100_bases
CGGCGCGGCGCATGCGCTTCGCGGGCCCGCGGGCTTGACGGTCGAGGCGATCGCCCGGCGGCATGCCGATGCCGGCGAGC
GCCGCCGAACGGGCCGGGTG

Product: thermolysin metallopeptidase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MKKLSCLLSVTAISLACLSAFAQADDPPAAADRALQLIRQNPSAFHLAAGSAARTLKFAGAQAKAPADGDQFQVRDVIVD
ADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGAD
VRRVDGADLVVFARDAAPTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQT
GTNAYRMLDPTRGSGSVYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIF
NDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNE
STSDIFGTLVKYYANNPNDPGNYVIGARITSGGLRKMYKQDLDGRSYSCYPSGGFSWANPRHDPHYTSGVGNRFFYLLAE
GPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGVNSLESATVARAWS
AAGVN

Sequences:

>Translated_565_residues
MKKLSCLLSVTAISLACLSAFAQADDPPAAADRALQLIRQNPSAFHLAAGSAARTLKFAGAQAKAPADGDQFQVRDVIVD
ADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGAD
VRRVDGADLVVFARDAAPTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQT
GTNAYRMLDPTRGSGSVYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIF
NDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNE
STSDIFGTLVKYYANNPNDPGNYVIGARITSGGLRKMYKQDLDGRSYSCYPSGGFSWANPRHDPHYTSGVGNRFFYLLAE
GPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGVNSLESATVARAWS
AAGVN
>Mature_565_residues
MKKLSCLLSVTAISLACLSAFAQADDPPAAADRALQLIRQNPSAFHLAAGSAARTLKFAGAQAKAPADGDQFQVRDVIVD
ADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQPAPIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGAD
VRRVDGADLVVFARDAAPTLAYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQT
GTNAYRMLDPTRGSGSVYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADIDYGLALTWDYYKTTHNRNGIF
NDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYGDGEPGTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNE
STSDIFGTLVKYYANNPNDPGNYVIGARITSGGLRKMYKQDLDGRSYSCYPSGGFSWANPRHDPHYTSGVGNRFFYLLAE
GPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQAANDLYGVNSLESATVARAWS
AAGVN

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 60015; Mature: 60015

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00142 ZINC_PROTEASE ; PS00201 FLAVODOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLSCLLSVTAISLACLSAFAQADDPPAAADRALQLIRQNPSAFHLAAGSAARTLKFAG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEECC
AQAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQP
CCCCCCCCCCCEEEEEEEEECCCCCCEEEHHHHCCCCEECCCEEEECCCCCCCCCCCCCC
APIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADVRRVDGADLVVFARDAAPTL
CCCCCCCCHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCHH
AYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQT
EEEEEEEECCCCCCCCEEEEEEECCCCCEECHHHHHHHHCCCCCCCEEEEECEEEEECCC
GTNAYRMLDPTRGSGSVYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADID
CCCEEEEECCCCCCCCEECCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCEEEEEECC
YGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYGDGEP
CCEEEEEEHHEECCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEECEEEEEECCCC
GTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDP
CCCCCCCEEEEEECCCHHHCCHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
GNYVIGARITSGGLRKMYKQDLDGRSYSCYPSGGFSWANPRHDPHYTSGVGNRFFYLLAE
CCEEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
GPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQA
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCEEEH
ANDLYGVNSLESATVARAWSAAGVN
HHHHCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKLSCLLSVTAISLACLSAFAQADDPPAAADRALQLIRQNPSAFHLAAGSAARTLKFAG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEECC
AQAKAPADGDQFQVRDVIVDADGTEHVRFDRFYAGLPVIGGDVVVHSNQGQLKQASLTQP
CCCCCCCCCCCEEEEEEEEECCCCCCEEEHHHHCCCCEECCCEEEECCCCCCCCCCCCCC
APIDLAGKIGKVGERFVVRNAPDVGADAARRVASKRFGADVRRVDGADLVVFARDAAPTL
CCCCCCCCHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCEEEEEECCCCCHH
AYAVRVYGKATDAHGEAVIYYVDARTGNVLDAQDLIKTASVTGTGRSLYYGNLSLTTDQT
EEEEEEEECCCCCCCCEEEEEEECCCCCEECHHHHHHHHCCCCCCCEEEEECEEEEECCC
GTNAYRMLDPTRGSGSVYDGRGLSSDEVEQASDLPIFTSSTNVWGNNTTSDRQTVAADID
CCCEEEEECCCCCCCCEECCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCEEEEEECC
YGLALTWDYYKTTHNRNGIFNDGRGVRSYAHVVFDTGSGTTGANAAWLSSRVMVYGDGEP
CCEEEEEEHHEECCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEECEEEEEECCCC
GTRLPKPVVSVDVAGHEMSHGVTEATSNLYYSGDAGGLNESTSDIFGTLVKYYANNPNDP
CCCCCCCEEEEEECCCHHHCCHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
GNYVIGARITSGGLRKMYKQDLDGRSYSCYPSGGFSWANPRHDPHYTSGVGNRFFYLLAE
CCEEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
GPVAPSTDTGLSRSQLVCNGDTGFSGLGRDKAGKIWYRTLTVYLTTNSSYPGARRASIQA
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCEEEH
ANDLYGVNSLESATVARAWSAAGVN
HHHHCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2203733; 3149972 [H]