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The map label for this gene is paaF [C]

Identifier: 126446283

GI number: 126446283

Start: 1542224

End: 1543009

Strand: Reverse

Name: paaF [C]

Synonym: BMA10247_A1606

Alternate gene names: 126446283

Gene position: 1543009-1542224 (Counterclockwise)

Preceding gene: 126446921

Following gene: 126447559

Centisome position: 65.58

GC content: 73.28

Gene sequence:

>786_bases
ATGCGCTACGAAACGATCGAAGTGACCGACGACGGCCGCGTCGCGACCGTCACGCTCGCGCGCCCCGACGTGCGCAACGC
GTTCAACGAGACGATGATCGCCGAGCTCACGACCGCGTTCGACCGCATCGACGCGCAGCCGTCGCTGCGCGCGGTCGTGC
TCGCCGCGCGCGGCCCCGCGTTCTGCGCGGGCGCGGATCTGAACTGGATGAAGAAGATGGCGGGCTTCTCCGACGACGAG
AACCGCGCCGACGCGCGCCGGCTCGCGCGCATGCTCGACGCGATCTATCGCTGCGCGAAGCCCGTGATCGCGCGCGTGCA
CGGCGACGCGTACGCGGGCGGCGTCGGGCTCGTCGCCGCGTGCGACATCGCGCTTGCCGCCGAGGACGTGAAATTCTGCC
TGTCCGAGGCGCGCCTCGGGCTGATACCGGCGACGATCGCGCCGTACGTCGTGCGCGCGATGGGCGAGCGCGCGGCGCGC
CGCTATTTCGCGACGGCCGAGGCGTTCGACTGCGCGAAGGCCGCGCAGCTCGGCTTCGTGCACGAGCGCGTGCCGGCCGA
TGCGCTCGACGCGAGCGTCGCGAAGCTCGCCGATGCGCTGTGCGCGAACGGCCCGCAGGCGGTGCGTGCATGCAAGGCGC
TCGTGCGCGACGTCGCGGGGCGCGCGCTCGACGCCGCGCTGATCGAGCAGACCGCCGACTGGATCGCGAAGGCGCGCGCG
GGCGCGGAGGCGCGCGAGGGCGTCGCGTCGTTCCTGGAAAAGCGCACGCCGTCGTGGCGCGCGTGA

Upstream 100 bases:

>100_bases
GCGACGTGCTGGGCCTCGCGCTTGCCGCCGCGCGAAACGCGCCGATCGAGGACACGCGGTTCGGCGTGTTCCGGATGTGA
TGCCTGCCTAGGAGCCGACG

Downstream 100 bases:

>100_bases
CTTCGTCGCCGGCCGCCCGCATCGCCGTCGCCGCCCGTCGCCGCCCGTCGCCGCGTTTCCCGACGTTCGCGACCTTCGCG
ACCTTCGCGGCGGCGCGCGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MRYETIEVTDDGRVATVTLARPDVRNAFNETMIAELTTAFDRIDAQPSLRAVVLAARGPAFCAGADLNWMKKMAGFSDDE
NRADARRLARMLDAIYRCAKPVIARVHGDAYAGGVGLVAACDIALAAEDVKFCLSEARLGLIPATIAPYVVRAMGERAAR
RYFATAEAFDCAKAAQLGFVHERVPADALDASVAKLADALCANGPQAVRACKALVRDVAGRALDAALIEQTADWIAKARA
GAEAREGVASFLEKRTPSWRA

Sequences:

>Translated_261_residues
MRYETIEVTDDGRVATVTLARPDVRNAFNETMIAELTTAFDRIDAQPSLRAVVLAARGPAFCAGADLNWMKKMAGFSDDE
NRADARRLARMLDAIYRCAKPVIARVHGDAYAGGVGLVAACDIALAAEDVKFCLSEARLGLIPATIAPYVVRAMGERAAR
RYFATAEAFDCAKAAQLGFVHERVPADALDASVAKLADALCANGPQAVRACKALVRDVAGRALDAALIEQTADWIAKARA
GAEAREGVASFLEKRTPSWRA
>Mature_261_residues
MRYETIEVTDDGRVATVTLARPDVRNAFNETMIAELTTAFDRIDAQPSLRAVVLAARGPAFCAGADLNWMKKMAGFSDDE
NRADARRLARMLDAIYRCAKPVIARVHGDAYAGGVGLVAACDIALAAEDVKFCLSEARLGLIPATIAPYVVRAMGERAAR
RYFATAEAFDCAKAAQLGFVHERVPADALDASVAKLADALCANGPQAVRACKALVRDVAGRALDAALIEQTADWIAKARA
GAEAREGVASFLEKRTPSWRA

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=254, Percent_Identity=27.9527559055118, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI70995211, Length=148, Percent_Identity=38.5135135135135, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=26.5060240963855, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4502327, Length=273, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62530384, Length=183, Percent_Identity=26.2295081967213, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787659, Length=256, Percent_Identity=30.46875, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1788597, Length=267, Percent_Identity=29.2134831460674, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787660, Length=248, Percent_Identity=28.6290322580645, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI221142681, Length=271, Percent_Identity=26.5682656826568, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082183, Length=268, Percent_Identity=23.8805970149254, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=251, Percent_Identity=29.4820717131474, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=28.90625, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=205, Percent_Identity=31.219512195122, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=256, Percent_Identity=26.953125, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540306, Length=193, Percent_Identity=30.5699481865285, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=230, Percent_Identity=28.2608695652174, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=216, Percent_Identity=24.537037037037, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=202, Percent_Identity=25.7425742574257, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=254, Percent_Identity=25.1968503937008, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144276, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24653139, Length=257, Percent_Identity=33.0739299610895, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129971, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653477, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922422, Length=257, Percent_Identity=26.8482490272374, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19920382, Length=212, Percent_Identity=31.1320754716981, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583165, Length=182, Percent_Identity=26.3736263736264, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921018, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24654903, Length=192, Percent_Identity=23.9583333333333, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27914; Mature: 27914

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYETIEVTDDGRVATVTLARPDVRNAFNETMIAELTTAFDRIDAQPSLRAVVLAARGPA
CCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCC
FCAGADLNWMKKMAGFSDDENRADARRLARMLDAIYRCAKPVIARVHGDAYAGGVGLVAA
EECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHH
CDIALAAEDVKFCLSEARLGLIPATIAPYVVRAMGERAARRYFATAEAFDCAKAAQLGFV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HERVPADALDASVAKLADALCANGPQAVRACKALVRDVAGRALDAALIEQTADWIAKARA
HHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEAREGVASFLEKRTPSWRA
CCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRYETIEVTDDGRVATVTLARPDVRNAFNETMIAELTTAFDRIDAQPSLRAVVLAARGPA
CCCEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCC
FCAGADLNWMKKMAGFSDDENRADARRLARMLDAIYRCAKPVIARVHGDAYAGGVGLVAA
EECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHH
CDIALAAEDVKFCLSEARLGLIPATIAPYVVRAMGERAARRYFATAEAFDCAKAAQLGFV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HERVPADALDASVAKLADALCANGPQAVRACKALVRDVAGRALDAALIEQTADWIAKARA
HHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAEAREGVASFLEKRTPSWRA
CCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA