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The map label for this gene is clcB [H]

Identifier: 126446237

GI number: 126446237

Start: 1756033

End: 1757463

Strand: Reverse

Name: clcB [H]

Synonym: BMA10247_A1825

Alternate gene names: 126446237

Gene position: 1757463-1756033 (Counterclockwise)

Preceding gene: 126446142

Following gene: 126446388

Centisome position: 74.7

GC content: 73.86

Gene sequence:

>1431_bases
ATGATTTCCCGGCGCATACGATGGCGCCATTCGTTCGCGTCGCGCACCCGCTCGGCCGTTCGCCCATTCGATTCGCCATC
GCCCATGCCCAACCCGATCGCCTGCGCTTCGCCTGTTTCGCCGATTCGATCCGCGCCCGCGGCCGCACGGGGGCCGCTCG
CGAGGATCGCGGCCGTCACGCTGTTGACCGGCGCCGGCGCGGGCCTGGGCGGCATGCTGCTCGCGCTGCTGCTGCACGCG
ATCCAGCACCTCGCGTACGGGTACGACGTCGCGCGCGCGATCGGCGATGAGGGCTTTCTCGAAGGCGTGACGGCCGCGTC
GCCGCTGCGGCGGTTCATCGTGCTGACCGGTTGCGGCGTGCTCGCGGGCGGCGGCTGGTGGGCGCTGTACCGGTTCGGGG
CGCCGCTCGTCGGCATTCGCCGCGCGGTGCGCGCCGAGGACCCGCGAATGCCCGTCGCGAGCACGACCGCGCATGCGTTG
CTGCAGATCGCCACCGTCGCGCTCGGTTCGCCGCTCGGCCGCGAGGTCGCGCCGCGCGAGATCGGTGCGATGTGGGCCGG
CTGGCTCGCGCATCGCGCGGGGCTGCCGGTGGCCGACGCACGGATGATGGTCGCGTGCGGCGCGGGCGCCGGGCTGGCGG
CCGTCTACAACGTGCCGCTCGGCGGCGCGCTGTTCGTGCTCGAGGGGCTGCTCGGCACGTTCGCGTGGCGCGCGCTCGTG
CCGGCCGTCGCGACGTCCGCGATCGCGGCGCTCGTCGCCCGGATCGGGCTGGGCGACGCGCAGCAGTACCATGTCGCGCC
GATCGCGGCCGGCGCGCCGCTGTTCGCGTGGTCGGCGGTGTGCGGGCCGCTCTTCGGCGTCGCCGCACACGGCTTCGTGC
GGCTCACCGCGCATGCGCGGGCGCGCGCGCCGAAGGACGGGCGCTTGCCGGCGCTCGCGCTCGTCAACTTCGCGATCGTC
GGCGCGCTCGCGACGGTGTTTCCGCAATTGCTCGGCAACGGCAAGGGCCCGGCCGCGCTCGGTTTCGACGGGCAGCTCGC
GATCGGGCTCGCGGCGACGCTGCTCGTGCTGAAGATCGCGATCACATGGAGCAGCCTGCGCGCGGGCGCGGAGGGCGGGC
TGCTGACGCCGGGGCTCGCCCATGGCGCGCTGCTCGCGATCGTGCTCGGCGGGCTATGGCGCGCGGCATGGCCGGGCGAG
CCGCTCGGCGCGTTCGCGGTCGTCGGCGCGTCGGCGTTTCTCGCGGCTTCGATGCGGATGCCGCTCACCGCGATCGTGCT
CGTCGTCGAGTTCACGCGCGTCGGGCACGATGTGCTGATTCCGATGCTGATCGCGATGGTGGGGGCGGTGGCGGTGTTCC
GGCTGCTCGAGCGGAGGAGGGAGAGGAAACAGAGCCGGCTGCATGAGGCAATCGGCGAGGTCGCGAGGTGA

Upstream 100 bases:

>100_bases
GCGCAGTTCGGGCGGCATGCGCGCGGCACGGGCACGGTTCGCGCGATCGCGCAGTGAATGCATTGAACTCATCGATGAAG
AAGAAAAATCCATTTGTTTC

Downstream 100 bases:

>100_bases
CACGGGAAGCGGTGCGTTGATGGGTGGGGGGCCATTGCGTTTCGCCGCATCGCATTCGTGACGATGCATCGCGGTTTGCG
CAGCACGCCGCTTGCGGATG

Product: voltage gated chloride channel family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MISRRIRWRHSFASRTRSAVRPFDSPSPMPNPIACASPVSPIRSAPAAARGPLARIAAVTLLTGAGAGLGGMLLALLLHA
IQHLAYGYDVARAIGDEGFLEGVTAASPLRRFIVLTGCGVLAGGGWWALYRFGAPLVGIRRAVRAEDPRMPVASTTAHAL
LQIATVALGSPLGREVAPREIGAMWAGWLAHRAGLPVADARMMVACGAGAGLAAVYNVPLGGALFVLEGLLGTFAWRALV
PAVATSAIAALVARIGLGDAQQYHVAPIAAGAPLFAWSAVCGPLFGVAAHGFVRLTAHARARAPKDGRLPALALVNFAIV
GALATVFPQLLGNGKGPAALGFDGQLAIGLAATLLVLKIAITWSSLRAGAEGGLLTPGLAHGALLAIVLGGLWRAAWPGE
PLGAFAVVGASAFLAASMRMPLTAIVLVVEFTRVGHDVLIPMLIAMVGAVAVFRLLERRRERKQSRLHEAIGEVAR

Sequences:

>Translated_476_residues
MISRRIRWRHSFASRTRSAVRPFDSPSPMPNPIACASPVSPIRSAPAAARGPLARIAAVTLLTGAGAGLGGMLLALLLHA
IQHLAYGYDVARAIGDEGFLEGVTAASPLRRFIVLTGCGVLAGGGWWALYRFGAPLVGIRRAVRAEDPRMPVASTTAHAL
LQIATVALGSPLGREVAPREIGAMWAGWLAHRAGLPVADARMMVACGAGAGLAAVYNVPLGGALFVLEGLLGTFAWRALV
PAVATSAIAALVARIGLGDAQQYHVAPIAAGAPLFAWSAVCGPLFGVAAHGFVRLTAHARARAPKDGRLPALALVNFAIV
GALATVFPQLLGNGKGPAALGFDGQLAIGLAATLLVLKIAITWSSLRAGAEGGLLTPGLAHGALLAIVLGGLWRAAWPGE
PLGAFAVVGASAFLAASMRMPLTAIVLVVEFTRVGHDVLIPMLIAMVGAVAVFRLLERRRERKQSRLHEAIGEVAR
>Mature_476_residues
MISRRIRWRHSFASRTRSAVRPFDSPSPMPNPIACASPVSPIRSAPAAARGPLARIAAVTLLTGAGAGLGGMLLALLLHA
IQHLAYGYDVARAIGDEGFLEGVTAASPLRRFIVLTGCGVLAGGGWWALYRFGAPLVGIRRAVRAEDPRMPVASTTAHAL
LQIATVALGSPLGREVAPREIGAMWAGWLAHRAGLPVADARMMVACGAGAGLAAVYNVPLGGALFVLEGLLGTFAWRALV
PAVATSAIAALVARIGLGDAQQYHVAPIAAGAPLFAWSAVCGPLFGVAAHGFVRLTAHARARAPKDGRLPALALVNFAIV
GALATVFPQLLGNGKGPAALGFDGQLAIGLAATLLVLKIAITWSSLRAGAEGGLLTPGLAHGALLAIVLGGLWRAAWPGE
PLGAFAVVGASAFLAASMRMPLTAIVLVVEFTRVGHDVLIPMLIAMVGAVAVFRLLERRRERKQSRLHEAIGEVAR

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=249, Percent_Identity=30.1204819277108, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 49095; Mature: 49095

Theoretical pI: Translated: 11.87; Mature: 11.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRRIRWRHSFASRTRSAVRPFDSPSPMPNPIACASPVSPIRSAPAAARGPLARIAAVT
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHCCHHHHHHHHH
LLTGAGAGLGGMLLALLLHAIQHLAYGYDVARAIGDEGFLEGVTAASPLRRFIVLTGCGV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
LAGGGWWALYRFGAPLVGIRRAVRAEDPRMPVASTTAHALLQIATVALGSPLGREVAPRE
HCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IGAMWAGWLAHRAGLPVADARMMVACGAGAGLAAVYNVPLGGALFVLEGLLGTFAWRALV
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHH
PAVATSAIAALVARIGLGDAQQYHVAPIAAGAPLFAWSAVCGPLFGVAAHGFVRLTAHAR
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHH
ARAPKDGRLPALALVNFAIVGALATVFPQLLGNGKGPAALGFDGQLAIGLAATLLVLKIA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ITWSSLRAGAEGGLLTPGLAHGALLAIVLGGLWRAAWPGEPLGAFAVVGASAFLAASMRM
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
PLTAIVLVVEFTRVGHDVLIPMLIAMVGAVAVFRLLERRRERKQSRLHEAIGEVAR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MISRRIRWRHSFASRTRSAVRPFDSPSPMPNPIACASPVSPIRSAPAAARGPLARIAAVT
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHCCHHHHHHHHH
LLTGAGAGLGGMLLALLLHAIQHLAYGYDVARAIGDEGFLEGVTAASPLRRFIVLTGCGV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
LAGGGWWALYRFGAPLVGIRRAVRAEDPRMPVASTTAHALLQIATVALGSPLGREVAPRE
HCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IGAMWAGWLAHRAGLPVADARMMVACGAGAGLAAVYNVPLGGALFVLEGLLGTFAWRALV
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHH
PAVATSAIAALVARIGLGDAQQYHVAPIAAGAPLFAWSAVCGPLFGVAAHGFVRLTAHAR
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHH
ARAPKDGRLPALALVNFAIVGALATVFPQLLGNGKGPAALGFDGQLAIGLAATLLVLKIA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ITWSSLRAGAEGGLLTPGLAHGALLAIVLGGLWRAAWPGEPLGAFAVVGASAFLAASMRM
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
PLTAIVLVVEFTRVGHDVLIPMLIAMVGAVAVFRLLERRRERKQSRLHEAIGEVAR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA