Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 126446181

GI number: 126446181

Start: 1313464

End: 1314132

Strand: Reverse

Name: mdmC [H]

Synonym: BMA10247_A1343

Alternate gene names: 126446181

Gene position: 1314132-1313464 (Counterclockwise)

Preceding gene: 126447311

Following gene: 126447643

Centisome position: 55.86

GC content: 71.0

Gene sequence:

>669_bases
ATGAACGAACGGCAATGGAGCGCGGTCGATGATTTCTTCTGCAGTCAGCTCGCGCCGTCCGATCCGGTGCTGGATGCGGC
GCTCGCGTCGAGCCGGGCGGCCGGCCTGCCCGCGATCAACGTCACCGCGAATCAGGGCAAGTTCCTGAACCTGCTCGCGA
CGATTCGCGGCGCGCGCCGGATTCTCGAGCTCGGCACGCTGGGCGGCTACAGCGCGATCTGGCTCGCGCGGGCGCTGCCG
CCGGGCGGCGTGCTGATCACGCTCGAGGCGAACGCCGACCACGCGGCGCTCGCGCGCGAGAACCTCGGGCGCGCCGGGCT
GGGCGGCGTCGCGTCGGTCGTCGTCGGCCGCGCGAAGGACAGCCTGGAGCGGCTGATCGCCGAGCGCGCCGAGCCGTTCG
ACCTGATCTTCCTCGATGCCGACAAGGACAGCTACCCGGCCTATTTGCCGCTGATGGTCGCGCTGTCGCGGCCGGGCACC
GTGATCGTCGCCGACAACGTCGTGCGGCAGGGGCGCGTCGCCGACCGGCGGAACCAGGATCCGGACGCGCTCGGCGTGCG
CGAATATTTCCGTCTGATCGCCGCGCACCCGCGCCTGACGACGACCGCGCTGCAGACCGTCGGCTCGAAAGGCTGGGACG
GATTCGCGCTGACGATCGTGACGGCGTAG

Upstream 100 bases:

>100_bases
TCCGCCTGAGGTTCGGTCAGGCAAATCCGGCGGATATCGGCCCGACGCGCGCCCGCGCGCCGCCATAGAATGACTTTCTC
CGACATGACAAAGGTGTGCG

Downstream 100 bases:

>100_bases
GCGCCGCGTGTCGGGCTCCGGCGCCGCGCGGCGCGTCTCGCCGGCCCGGACGCTCGCCCGCGCGCCGGTTCAATCGGCCC
GGATGCGATGGATCACGACG

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNERQWSAVDDFFCSQLAPSDPVLDAALASSRAAGLPAINVTANQGKFLNLLATIRGARRILELGTLGGYSAIWLARALP
PGGVLITLEANADHAALARENLGRAGLGGVASVVVGRAKDSLERLIAERAEPFDLIFLDADKDSYPAYLPLMVALSRPGT
VIVADNVVRQGRVADRRNQDPDALGVREYFRLIAAHPRLTTTALQTVGSKGWDGFALTIVTA

Sequences:

>Translated_222_residues
MNERQWSAVDDFFCSQLAPSDPVLDAALASSRAAGLPAINVTANQGKFLNLLATIRGARRILELGTLGGYSAIWLARALP
PGGVLITLEANADHAALARENLGRAGLGGVASVVVGRAKDSLERLIAERAEPFDLIFLDADKDSYPAYLPLMVALSRPGT
VIVADNVVRQGRVADRRNQDPDALGVREYFRLIAAHPRLTTTALQTVGSKGWDGFALTIVTA
>Mature_222_residues
MNERQWSAVDDFFCSQLAPSDPVLDAALASSRAAGLPAINVTANQGKFLNLLATIRGARRILELGTLGGYSAIWLARALP
PGGVLITLEANADHAALARENLGRAGLGGVASVVVGRAKDSLERLIAERAEPFDLIFLDADKDSYPAYLPLMVALSRPGT
VIVADNVVRQGRVADRRNQDPDALGVREYFRLIAAHPRLTTTALQTVGSKGWDGFALTIVTA

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI6466450, Length=137, Percent_Identity=38.6861313868613, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI205830453, Length=137, Percent_Identity=38.6861313868613, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI205830451, Length=137, Percent_Identity=38.6861313868613, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI4502969, Length=137, Percent_Identity=38.6861313868613, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI25148771, Length=163, Percent_Identity=36.1963190184049, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565612, Length=160, Percent_Identity=34.375, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI72001127, Length=163, Percent_Identity=31.9018404907975, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23629; Mature: 23629

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERQWSAVDDFFCSQLAPSDPVLDAALASSRAAGLPAINVTANQGKFLNLLATIRGARR
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
ILELGTLGGYSAIWLARALPPGGVLITLEANADHAALARENLGRAGLGGVASVVVGRAKD
HHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
SLERLIAERAEPFDLIFLDADKDSYPAYLPLMVALSRPGTVIVADNVVRQGRVADRRNQD
HHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHEECCCCEEEEECCHHHCCCCHHCCCCC
PDALGVREYFRLIAAHPRLTTTALQTVGSKGWDGFALTIVTA
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure
MNERQWSAVDDFFCSQLAPSDPVLDAALASSRAAGLPAINVTANQGKFLNLLATIRGARR
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
ILELGTLGGYSAIWLARALPPGGVLITLEANADHAALARENLGRAGLGGVASVVVGRAKD
HHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
SLERLIAERAEPFDLIFLDADKDSYPAYLPLMVALSRPGTVIVADNVVRQGRVADRRNQD
HHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHEECCCCEEEEECCHHHCCCCHHCCCCC
PDALGVREYFRLIAAHPRLTTTALQTVGSKGWDGFALTIVTA
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]