Click here to switch to the map view.

The map label for this gene is dsbC [H]

Identifier: 126446081

GI number: 126446081

Start: 1850285

End: 1851013

Strand: Reverse

Name: dsbC [H]

Synonym: BMA10247_A1918

Alternate gene names: 126446081

Gene position: 1851013-1850285 (Counterclockwise)

Preceding gene: 126446975

Following gene: 126445719

Centisome position: 78.68

GC content: 64.61

Gene sequence:

>729_bases
ATGAAAAAAACGATTCGTATCGCCGCGCTCGCCCTGGCTGCCGCGACGGCGACGCTCGGCTGCACCGCGCAGGCCGACCA
GTCCACCGACAAGCTGAAGGCCGCGCTGCAATCGCGCCTCGGCGCCGACGCGCCGATCAAGAGCGTGACGAAGTCGCCGA
TTGCGGGTTTGTACGAGGTCAATCTCGGCTCGCAGATCGTCTATAGCGACGCATCGGGCGATTACGTGCTGCTCGGCGAG
CTCGTCAACACGAAGACGCACAAGAACCTCACGGCCGAGCGCCTCGCCGAGATCAACAAGATCGATTTCGCGAGCCTGCC
GCTGTCGAACGCGATCAAGGTCGTGAAGGGCAACGGCGCGCGCAAGATCGCGGTGTTCTCCGATCCGAACTGCCCGTACT
GCAAGAAGCTCGAGACGACGCTGCAATCGGTCGACAACGTGACCGTCTACACGTTCCTGTATCCGGTGCTGTCGCCCGAT
TCGACGGTGAAGTCGAAGTCGATCTGGTGCGCGAGCGACCGCGTGAAGAGCTGGCAGTCGTGGATGCTCGAGCATCGCGC
GCCCACGAGCGCGGCGAACTGCGACACGACCGCGCTCGACAAGAACCTCGCGCTCGGCCGCGGAATGAACGTGACGGGCA
CGCCGACCGTATTCCTCGCCGACGGCACGCGCCTGCCGGGCGCCGTATCCGCCGACGAACTGAATCAGGCGCTCGCCGGC
GTCAAGTGA

Upstream 100 bases:

>100_bases
GCGCGGCGCGAACCTTCGCGCGGCGCGGCGGTCGGACACTGCTCGGCCACAGTCAGTCGTACACTGTGGCGATGCACGCA
CGCTTTGAAGGATGATTTGC

Downstream 100 bases:

>100_bases
CGCGGCGTTTCCTGCATCGCGAAGGAGGCGTCGGCGCGTAGCCGACGCCTCTTTTCGTATCCGCATCCCTACCCCGTTCC
CGCCTGACCGATTCCGACGA

Product: putative thiol:disulfide interchange protein DsbC

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MKKTIRIAALALAAATATLGCTAQADQSTDKLKAALQSRLGADAPIKSVTKSPIAGLYEVNLGSQIVYSDASGDYVLLGE
LVNTKTHKNLTAERLAEINKIDFASLPLSNAIKVVKGNGARKIAVFSDPNCPYCKKLETTLQSVDNVTVYTFLYPVLSPD
STVKSKSIWCASDRVKSWQSWMLEHRAPTSAANCDTTALDKNLALGRGMNVTGTPTVFLADGTRLPGAVSADELNQALAG
VK

Sequences:

>Translated_242_residues
MKKTIRIAALALAAATATLGCTAQADQSTDKLKAALQSRLGADAPIKSVTKSPIAGLYEVNLGSQIVYSDASGDYVLLGE
LVNTKTHKNLTAERLAEINKIDFASLPLSNAIKVVKGNGARKIAVFSDPNCPYCKKLETTLQSVDNVTVYTFLYPVLSPD
STVKSKSIWCASDRVKSWQSWMLEHRAPTSAANCDTTALDKNLALGRGMNVTGTPTVFLADGTRLPGAVSADELNQALAG
VK
>Mature_242_residues
MKKTIRIAALALAAATATLGCTAQADQSTDKLKAALQSRLGADAPIKSVTKSPIAGLYEVNLGSQIVYSDASGDYVLLGE
LVNTKTHKNLTAERLAEINKIDFASLPLSNAIKVVKGNGARKIAVFSDPNCPYCKKLETTLQSVDNVTVYTFLYPVLSPD
STVKSKSIWCASDRVKSWQSWMLEHRAPTSAANCDTTALDKNLALGRGMNVTGTPTVFLADGTRLPGAVSADELNQALAG
VK

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=248, Percent_Identity=31.0483870967742, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 25675; Mature: 25675

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTIRIAALALAAATATLGCTAQADQSTDKLKAALQSRLGADAPIKSVTKSPIAGLYEV
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEE
NLGSQIVYSDASGDYVLLGELVNTKTHKNLTAERLAEINKIDFASLPLSNAIKVVKGNGA
CCCCEEEEECCCCCEEEEEEHHCCHHHCCCCHHHHHHHCCCCCCCCCHHHCEEEEECCCC
RKIAVFSDPNCPYCKKLETTLQSVDNVTVYTFLYPVLSPDSTVKSKSIWCASDRVKSWQS
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEEHHCCCCCCCCCCEEEECHHHHHHHHH
WMLEHRAPTSAANCDTTALDKNLALGRGMNVTGTPTVFLADGTRLPGAVSADELNQALAG
HHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
VK
CC
>Mature Secondary Structure
MKKTIRIAALALAAATATLGCTAQADQSTDKLKAALQSRLGADAPIKSVTKSPIAGLYEV
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEE
NLGSQIVYSDASGDYVLLGELVNTKTHKNLTAERLAEINKIDFASLPLSNAIKVVKGNGA
CCCCEEEEECCCCCEEEEEEHHCCHHHCCCCHHHHHHHCCCCCCCCCHHHCEEEEECCCC
RKIAVFSDPNCPYCKKLETTLQSVDNVTVYTFLYPVLSPDSTVKSKSIWCASDRVKSWQS
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEEEEEHHCCCCCCCCCCEEEECHHHHHHHHH
WMLEHRAPTSAANCDTTALDKNLALGRGMNVTGTPTVFLADGTRLPGAVSADELNQALAG
HHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]