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The map label for this gene is mrcA [H]

Identifier: 126445996

GI number: 126445996

Start: 2277532

End: 2280066

Strand: Reverse

Name: mrcA [H]

Synonym: BMA10247_A2346

Alternate gene names: 126445996

Gene position: 2280066-2277532 (Counterclockwise)

Preceding gene: 126446583

Following gene: 126447116

Centisome position: 96.91

GC content: 71.72

Gene sequence:

>2535_bases
GTGAACCGCCGAATCGTGTCGTCCTTCCTCGAGCGTTGCGCGGCCTGGCTCGCCGCCGCGAAGCCGCACGCCGTCGCCGT
CCTGCACCGCCTGCGCCACCCGACGCGGCGCGGCGTGCTGCTCGCCGTCGCCGCTCTCCCCGCGCTGTGCGTGCTCTACG
TGCTCGCGCTGATCCCGTTCACGCCGAGCATCGGCGACATCCGCAAGGCGCGCGTCGACGCGCCCGCGCAGATCCTGTCC
GCCGACGGCAAGCTGCTCGCCGAGTTCAAGCCGTCGAACCGCGAATGGGTGCCGCTCGCCGACATCTCGCCGAAGATGGT
CGACGCGCTGATCTCGACCGAGGACCATCGCTTCTACGAGCACCACGGCCTCGACTGGCGGCGCACCGCGGGCGCCGCGC
TGCGCACGTTCTCCGGCGACCGGCAGGGCGGCTCGACGATCACGCAGCAGCTCGCGCGCAACCTGTATCCGGACGAGATC
GGCCGCGCGCCGACGCTCACGCGCAAGCTGAAGGAAGCGATCACCGCGCTGAAGATCGAGGCGGTCTACAGCAAGGCGCA
GATCCTCGAGACGTATCTGAACACGGTGCCGTTCCTGTACAACGCGTACGGCGTCGAGATGGCCGCGCGCACGTACTTCG
ACAAATCGGCCGACCAGCTCGACGCGCTCGACGCGGCGACGCTCGTCGGCATGCTCAAGGGCAACAGCTATTACAACCCG
GTGCTAAACCCCGAGCGCGCGCTCGCGCGCCGCAACACGGTGCTCGCGCAGATGGTGAAGTACGGCAGGCTCTCGCCCGC
CGCGTATGCGTCGCTGCAGAAGAAGCCGCTGCGCATCGATTTCGAGCGGCAGAAGGAGCCGCCCGGCCCCGCGCCGCATT
TCGCGCAGCAACTGCGCAAGTGGCTGATCGCGTGGGCCGACCGCAACGATTACAACATCTACTCCGACGGCCTCGTCGTG
CGCACGACGATCGATTCGCGGCTGCAGACGTATGCGACGCAGGCGCTCGCGCGTCAGACCAACCAGCTGCAGGGCGTCGC
GAACGGGATGTGGAACGCCGGCAGCGGCTGCGCCCCCGGCAATCCGCTGTTTCGCGCATTCGTGCGCGAGACGCCGGAGT
TCCGCGCGGCGCTCGACGGCGGCGCGACCGGGGACGCCGCGCTCAAGCGCCTGCTCGCCGACCGCGGCTTCGCGCGCGCG
CTCTGCAAGGCGAAGGCCGACGTGCAGGCGGGCTTTCTCGCGATCGATCCGCGCAACGGGCAGATCAAGGCGTGGGTCGG
CAGCCGCGATTTCACGGCCGAGCCGTTCGATCACGTGCAGCAGGCGCGCCGGCAGCCGGGCTCGACGTTCAAGCCGTTCG
TCTACGGCGCGGCGTTCGCGGCGGGCGCGACGCCCGACGATACGTTCGTCGATCAGCCGGTCGAGATCCCGCTCGCGGGC
GGCGAGATCTGGCGGCCCGACGACGACGCGCCGCCCACGAACAAGCCGATGACGCTGCGCGACGCGATCGCGTACTCGCG
CAACCGGATCACCGCGCAACTGATGATGAAGGTCGGCCCGCAGAAGGTGGCGCGCCTCGCGCGCGCGATGGGCGTGCGCG
ACAGCGCGCTCGATGCGGTGCCGTCGCTCGCGCTCGGCACGAGCCCCGTGACGCTCAAGGAGATGGTGTCCGCCTACGCG
ACGATCGCGAACGTCGGCGAATACGTCGAGCCGCGGATGGTCACGCGCATCGAGGGCCGCAACGGCGAGGTGCTCGCCGA
GTTCGCGAGCGCGACGCCCGAGCGCGCGCTCGACGCGGCGGCGGCGCGCACGCTGATCGACGTGATGCGCGGCGTCGTCG
AGCGCGGCACCGGCGCGGCGATCCGCTCGCGCTACGGGATTCGCGCGGACGTCGCCGGCAAGACCGGCACGACGCAGGGC
GACACCGACGGCTGGTTCATCCTGATGCAGCCCGAGCTTGTCGCGGGCGCGTGGGTCGGCTTCGACGACGGCCGCGTGAC
GCTAGGCGGCGATTGGGGGCAAGGCGCGCGCAGCGCGCTGCCGATCGTCGGCGATTTCTATCAGCGGGCGATTCGCGCGC
GGCTCGTCGATACGCGCGAACGCTTCGCGACCGAAGCGCCGCCGAGCGCGTTCGACACGTTCCGCAACAAGCTCGGCGAC
TGGTATCGCTACCTGTTCGAGAAGCCCGAGCCGCCGCGCAAGGCCGCGCCGCCGAAAGCGCCGCGCGCGCCGCTCGAGGA
GGTGATGCCGGCTTCCGAGGTCGAGGCGGCGTCGGCGGCGGTCGCGCGCGCCGCGTCGGAAGCGGCTGCAGTGGCATCGG
CCGCGTCGACCGCATCGGCCGCACCGCCGGCGAGCGGCGTGCCGTTCGCGCCGGGCGGCGCGTCGGCGCCGGCGCTGCCG
CCGCTGTTGCCGCCGATGCCACAGTCTGCTCCGTTGCCGCCTGCCGCGCAGCCGGGCAGCAGCCTGCCGAACGACAACGC
GCCGATGTCGCCGACGCCGACGCCCGATGCGCCGGCCGCGGGCGGCAGCAATTAG

Upstream 100 bases:

>100_bases
ACCCGAACCCACATCCACGCGCCGAATCCGCCCTCCCGCCGCGCCCTGGCCGCCGCGTTTGGTACGATTCACGCTTTCCC
ATCCCCATTCGCCTCACCGC

Downstream 100 bases:

>100_bases
CGAAGACCGGCGGCGACGGTTCGTTCGCGGCGCGCGTTGCGTTGCCCCGTCGCTTTGGCCGCCGCCGCCGCCCGCCTCGG
CCCGCGTCGACCCGCTTCGC

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 844; Mature: 844

Protein sequence:

>844_residues
MNRRIVSSFLERCAAWLAAAKPHAVAVLHRLRHPTRRGVLLAVAALPALCVLYVLALIPFTPSIGDIRKARVDAPAQILS
ADGKLLAEFKPSNREWVPLADISPKMVDALISTEDHRFYEHHGLDWRRTAGAALRTFSGDRQGGSTITQQLARNLYPDEI
GRAPTLTRKLKEAITALKIEAVYSKAQILETYLNTVPFLYNAYGVEMAARTYFDKSADQLDALDAATLVGMLKGNSYYNP
VLNPERALARRNTVLAQMVKYGRLSPAAYASLQKKPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDGLVV
RTTIDSRLQTYATQALARQTNQLQGVANGMWNAGSGCAPGNPLFRAFVRETPEFRAALDGGATGDAALKRLLADRGFARA
LCKAKADVQAGFLAIDPRNGQIKAWVGSRDFTAEPFDHVQQARRQPGSTFKPFVYGAAFAAGATPDDTFVDQPVEIPLAG
GEIWRPDDDAPPTNKPMTLRDAIAYSRNRITAQLMMKVGPQKVARLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYA
TIANVGEYVEPRMVTRIEGRNGEVLAEFASATPERALDAAAARTLIDVMRGVVERGTGAAIRSRYGIRADVAGKTGTTQG
DTDGWFILMQPELVAGAWVGFDDGRVTLGGDWGQGARSALPIVGDFYQRAIRARLVDTRERFATEAPPSAFDTFRNKLGD
WYRYLFEKPEPPRKAAPPKAPRAPLEEVMPASEVEAASAAVARAASEAAAVASAASTASAAPPASGVPFAPGGASAPALP
PLLPPMPQSAPLPPAAQPGSSLPNDNAPMSPTPTPDAPAAGGSN

Sequences:

>Translated_844_residues
MNRRIVSSFLERCAAWLAAAKPHAVAVLHRLRHPTRRGVLLAVAALPALCVLYVLALIPFTPSIGDIRKARVDAPAQILS
ADGKLLAEFKPSNREWVPLADISPKMVDALISTEDHRFYEHHGLDWRRTAGAALRTFSGDRQGGSTITQQLARNLYPDEI
GRAPTLTRKLKEAITALKIEAVYSKAQILETYLNTVPFLYNAYGVEMAARTYFDKSADQLDALDAATLVGMLKGNSYYNP
VLNPERALARRNTVLAQMVKYGRLSPAAYASLQKKPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDGLVV
RTTIDSRLQTYATQALARQTNQLQGVANGMWNAGSGCAPGNPLFRAFVRETPEFRAALDGGATGDAALKRLLADRGFARA
LCKAKADVQAGFLAIDPRNGQIKAWVGSRDFTAEPFDHVQQARRQPGSTFKPFVYGAAFAAGATPDDTFVDQPVEIPLAG
GEIWRPDDDAPPTNKPMTLRDAIAYSRNRITAQLMMKVGPQKVARLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYA
TIANVGEYVEPRMVTRIEGRNGEVLAEFASATPERALDAAAARTLIDVMRGVVERGTGAAIRSRYGIRADVAGKTGTTQG
DTDGWFILMQPELVAGAWVGFDDGRVTLGGDWGQGARSALPIVGDFYQRAIRARLVDTRERFATEAPPSAFDTFRNKLGD
WYRYLFEKPEPPRKAAPPKAPRAPLEEVMPASEVEAASAAVARAASEAAAVASAASTASAAPPASGVPFAPGGASAPALP
PLLPPMPQSAPLPPAAQPGSSLPNDNAPMSPTPTPDAPAAGGSN
>Mature_844_residues
MNRRIVSSFLERCAAWLAAAKPHAVAVLHRLRHPTRRGVLLAVAALPALCVLYVLALIPFTPSIGDIRKARVDAPAQILS
ADGKLLAEFKPSNREWVPLADISPKMVDALISTEDHRFYEHHGLDWRRTAGAALRTFSGDRQGGSTITQQLARNLYPDEI
GRAPTLTRKLKEAITALKIEAVYSKAQILETYLNTVPFLYNAYGVEMAARTYFDKSADQLDALDAATLVGMLKGNSYYNP
VLNPERALARRNTVLAQMVKYGRLSPAAYASLQKKPLRIDFERQKEPPGPAPHFAQQLRKWLIAWADRNDYNIYSDGLVV
RTTIDSRLQTYATQALARQTNQLQGVANGMWNAGSGCAPGNPLFRAFVRETPEFRAALDGGATGDAALKRLLADRGFARA
LCKAKADVQAGFLAIDPRNGQIKAWVGSRDFTAEPFDHVQQARRQPGSTFKPFVYGAAFAAGATPDDTFVDQPVEIPLAG
GEIWRPDDDAPPTNKPMTLRDAIAYSRNRITAQLMMKVGPQKVARLARAMGVRDSALDAVPSLALGTSPVTLKEMVSAYA
TIANVGEYVEPRMVTRIEGRNGEVLAEFASATPERALDAAAARTLIDVMRGVVERGTGAAIRSRYGIRADVAGKTGTTQG
DTDGWFILMQPELVAGAWVGFDDGRVTLGGDWGQGARSALPIVGDFYQRAIRARLVDTRERFATEAPPSAFDTFRNKLGD
WYRYLFEKPEPPRKAAPPKAPRAPLEEVMPASEVEAASAAVARAASEAAAVASAASTASAAPPASGVPFAPGGASAPALP
PLLPPMPQSAPLPPAAQPGSSLPNDNAPMSPTPTPDAPAAGGSN

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=588, Percent_Identity=31.4625850340136, Blast_Score=262, Evalue=9e-71,
Organism=Escherichia coli, GI1786343, Length=589, Percent_Identity=29.8811544991511, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI1788867, Length=270, Percent_Identity=31.4814814814815, Blast_Score=103, Evalue=6e-23,
Organism=Escherichia coli, GI1789601, Length=174, Percent_Identity=37.3563218390805, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 90751; Mature: 90751

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRIVSSFLERCAAWLAAAKPHAVAVLHRLRHPTRRGVLLAVAALPALCVLYVLALIPF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPSIGDIRKARVDAPAQILSADGKLLAEFKPSNREWVPLADISPKMVDALISTEDHRFYE
CCCHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCCHHHHH
HHGLDWRRTAGAALRTFSGDRQGGSTITQQLARNLYPDEIGRAPTLTRKLKEAITALKIE
HCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHH
AVYSKAQILETYLNTVPFLYNAYGVEMAARTYFDKSADQLDALDAATLVGMLKGNSYYNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
VLNPERALARRNTVLAQMVKYGRLSPAAYASLQKKPLRIDFERQKEPPGPAPHFAQQLRK
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEECHHHCCCCCCCCHHHHHHHHH
WLIAWADRNDYNIYSDGLVVRTTIDSRLQTYATQALARQTNQLQGVANGMWNAGSGCAPG
HHHHHCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NPLFRAFVRETPEFRAALDGGATGDAALKRLLADRGFARALCKAKADVQAGFLAIDPRNG
CHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCC
QIKAWVGSRDFTAEPFDHVQQARRQPGSTFKPFVYGAAFAAGATPDDTFVDQPVEIPLAG
EEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECC
GEIWRPDDDAPPTNKPMTLRDAIAYSRNRITAQLMMKVGPQKVARLARAMGVRDSALDAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
PSLALGTSPVTLKEMVSAYATIANVGEYVEPRMVTRIEGRNGEVLAEFASATPERALDAA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCHHHHHHHH
AARTLIDVMRGVVERGTGAAIRSRYGIRADVAGKTGTTQGDTDGWFILMQPELVAGAWVG
HHHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCCCCCCCEEEEECCCHHHHEEEE
FDDGRVTLGGDWGQGARSALPIVGDFYQRAIRARLVDTRERFATEAPPSAFDTFRNKLGD
CCCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
WYRYLFEKPEPPRKAAPPKAPRAPLEEVMPASEVEAASAAVARAASEAAAVASAASTASA
HHHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
APPASGVPFAPGGASAPALPPLLPPMPQSAPLPPAAQPGSSLPNDNAPMSPTPTPDAPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGSN
CCCC
>Mature Secondary Structure
MNRRIVSSFLERCAAWLAAAKPHAVAVLHRLRHPTRRGVLLAVAALPALCVLYVLALIPF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPSIGDIRKARVDAPAQILSADGKLLAEFKPSNREWVPLADISPKMVDALISTEDHRFYE
CCCHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCCHHHHH
HHGLDWRRTAGAALRTFSGDRQGGSTITQQLARNLYPDEIGRAPTLTRKLKEAITALKIE
HCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHH
AVYSKAQILETYLNTVPFLYNAYGVEMAARTYFDKSADQLDALDAATLVGMLKGNSYYNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
VLNPERALARRNTVLAQMVKYGRLSPAAYASLQKKPLRIDFERQKEPPGPAPHFAQQLRK
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEECHHHCCCCCCCCHHHHHHHHH
WLIAWADRNDYNIYSDGLVVRTTIDSRLQTYATQALARQTNQLQGVANGMWNAGSGCAPG
HHHHHCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NPLFRAFVRETPEFRAALDGGATGDAALKRLLADRGFARALCKAKADVQAGFLAIDPRNG
CHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCC
QIKAWVGSRDFTAEPFDHVQQARRQPGSTFKPFVYGAAFAAGATPDDTFVDQPVEIPLAG
EEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECC
GEIWRPDDDAPPTNKPMTLRDAIAYSRNRITAQLMMKVGPQKVARLARAMGVRDSALDAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
PSLALGTSPVTLKEMVSAYATIANVGEYVEPRMVTRIEGRNGEVLAEFASATPERALDAA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCHHHHHHHH
AARTLIDVMRGVVERGTGAAIRSRYGIRADVAGKTGTTQGDTDGWFILMQPELVAGAWVG
HHHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCCCCCCCEEEEECCCHHHHEEEE
FDDGRVTLGGDWGQGARSALPIVGDFYQRAIRARLVDTRERFATEAPPSAFDTFRNKLGD
CCCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
WYRYLFEKPEPPRKAAPPKAPRAPLEEVMPASEVEAASAAVARAASEAAAVASAASTASA
HHHHHHCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
APPASGVPFAPGGASAPALPPLLPPMPQSAPLPPAAQPGSSLPNDNAPMSPTPTPDAPAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GGSN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA