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The map label for this gene is tycC [H]

Identifier: 126445949

GI number: 126445949

Start: 561605

End: 566056

Strand: Direct

Name: tycC [H]

Synonym: BMA10247_A0618

Alternate gene names: 126445949

Gene position: 561605-566056 (Clockwise)

Preceding gene: 126445987

Following gene: 126447046

Centisome position: 23.87

GC content: 64.78

Gene sequence:

>4452_bases
ATGACTGACATGCTCGATTCTTCGGAAATTTCGGTCCGCGACGATATCGATCCCGTTCCGGGCGCCGCGCCCGAACGCGT
CCTTGCGCTGACGGCCGGCCAGTACGGCATCTGGCTCGATCAAATGCTCAATCCGGATCTGCCGTGTTACATCCTCGGCG
CGATTCTTCGAATCGACGGTACGTTCGACGAGGCGTTGCTGACGTCGGTCGTCAACGAAGTCGTCAATGCGAACGATTCC
CTGCGCGCGGTGCTGGTGAGCGAAGGCGGTTCGGTGCGGCAGCGTGTCCTGTCCGACGTGGAGCTGGAGATTGCGCATAT
CGATTTTTCCGGCTCCGCGCACCCGCACGACAGCGCGTGGCGATACATGCGAACGGCGTTCGATACGGCGTTCGCGCTCG
ACGGACTGCTGTGCGATTTCCGCATCGTACGCGAGAGCCCGTCTCGCACGTACTGGATGTATCGCTGCCATCATCTGGTT
GCGGACGGTCAGAGCGTGTCGATGATCTGCCGGATGATCGTCGATCTCTATAACCGCCGTGCGAGCGCGGACATGGCGCG
CATCGAGCCTACGCCCTCCTATTTCGATTCGCTCGACGACGACCGCAAGTATGCCGAGTCGTCCCGTTACGAGCGCGACG
CGCAGTTCTGGCAGGACAAATTTTCGTCGCTTCCGCCGCCGTTGCTTTCGTCGCGCTCGAGCGAGGCGGCCGCACGCCCC
GCGTCGTTTCCCGACGGCCAGGTGAATCTGACGATCGAGCGCGCGAAGTACGATCGGCTCGGGCGGATCGCCGAGGCGAG
CGGATGTACGATCGTCCACGTGATGTTCGGCGTGCTCGCGCTCTACTTCTCGCGAGCGTTTCAGGTCGACGAGGTGGTGA
TCGGCATGCCGGTGCACAACCGAAGCACCGCACAGCAGAAGCGCGCGATCGGCATGTTCGCTTCGGTGGTGCCGATTCGC
ATCCCGGTCGACGGGAACGAGCGTTTCGTATCATTGCTGAACGGCGTGTCGGCCGAGTTGCGGCATTGCTATCGCCATCA
GCGTTTTCCGATCGCGGAGTTGAACCGGCGTCTGGGGCTCGTGCGAACCGGTCGCAGGCAGCTTTTCGATCTCACGCTGT
CGTTCGAGAAGTTCCCGCTCGATTTCTACATCGGCGACGTCAAGCTAGGGCTGACATCGATGCGGCACCGTTTCGAGCAG
ACGCCGATCACGGTCAACGTCCAGGATTATCACGAGGACCAAGACCTCGTCATGCAGTTCAATTACGACGTCAATGCGTT
CTCTCATGCGGAGGTCGACAACATTGGCACGCGCATCGGCGGGTTGCTCGATGCATTGATCGAGCATCACGACGATATGC
CGGTGGGCATGCTGCCGTTGCTAGACGAAGCCGAACGCAAGCAGGTGGTGTACGAGTGGAACGCAACGGAGCGTGACTAT
CCGATCGAGCAATGCATTCATCAGTTGTTCGAAGCGCAGGTGGATCGGAAGCCGGAGGCGATTGCGCTGACGTTCGACGG
GCGGCGACTGAGCTACGCGGAACTCAACGCCCGAGCGAACCGGCTTGCGCACTATCTGCAGGGGCGCGGCGTGGGCCCGG
ACCGACTGGTTGCGCTTTGCGCCGAACGCGGAATCGAGATGGTGGTGGGGCTGCTGGCGATCCTGAAGGCGGGCGGCGCG
TATGTGCCGCTGGATCCGAGCCATCCGCCCGAGCGTTTGCGCCGGATGCTGGACGATACGAACCCGGTGGCGGTGCTCGT
CGACGACATCGGCGCGGACGCGCTCGCATCGTTCGAATCACATGTCGCGGCCCGTTCGCCCCGTGTGCACCTGTCGCGCG
ACATCGCGCAATGGCGGGCATGCAGCCCAGCGAATCCGCCTACCCCGCGGGAGCGCGCCGCGCGGCGTCTCGCATACGTG
ATCTACACGTCGGGCTCGAGCGGCGAGCCGAAGGGAGTGATGAACGAGCATCGCGGGGTGGTGAACCGGCTGTGGTGGAT
GCAACAGACGTACGCGCTGGACGAGCGCGACGCGGTATTGCAAAAGACGCCGTTCAGCTTCGACGTATCGGTGTGGGAGT
TCTTCTGGCCGCTGATGTCGGGCGCGCGGCTGGTGATCGCGAAGCCGGAGGGGCACAAGGATCCGGCGTACCTGTCGGAG
TTGATCGATCGCGAACGCGTGACGACGCTGCACTTCGTACCGTCGATGCTGCAGGCGTTCCTGGAGGATGAGGGCGCGGC
TCGGGGCTGCGGGAGCGTGAAGCGGGTGATGTGCAGCGGAGAGGCGCTGCCGCCGTCGCTGGTGAAGCGCTTCTATCGTT
GCTTGCCGGATGCGCGCTTGCACAATCTGTACGGTCCGACGGAAGCGGCGGTGGACGTGACGGCGTGGGCGTGCGATGCG
GAAGAAGGGGGCGCGTCGGTGCCGATCGGTCGGCCGATCGCGAACACGCGGATCTACGTATTGGACGAGTATGGCCAGCC
GGTGCCGCGAGGGGTGGCGGGGGAACTGTATATCGGCGGCGTGCAGGTGGCGCGAGGGTATCTGAACCGGCCGGAGCTGA
CGCGGGAGCGGTTCGTCGACGATCCGTTCGTGGCGGGCGGTCGACTCTATAAGACGGGAGATTTGGCGCGTTGGCGCACG
GACGGGAGTCTGGAGTATCTGGGTCGAAACGATTTCCAGGTGAAGATACGCGGTTTCCGGATCGAGTTGGGGGAGATCGA
GGCGCAACTGGCGAAGGTGGCGGGCGTGCGCGAGACGGTGGTGTTGGCGCGCGACTCGGGTTCGCCTGTCGGCGAGAAAC
GCCTCGTCGCGTACTACACGGGGAATGCCGATGTTGCGGCGTTGAGGGAACAGGCAACACGACATCTGCCGGCCTACATG
GTGCCATCGGCGTACGTGCGGCTGGACGCGTGGCCGCTGACGCCGAACGGCAAGCTGGACCGGCGCGCACTGCCCGCGCC
GGCGGACGACGCGTACGCCCGCGCCGAATACGAAGCGCCGCAGGGCGCAAAGGAAGAAGCACTGGCCGCGATCTGGAAGG
ACCTGCTGCCCGTGGAGCGCATCAGCCGCCATGACAATTTCTTCGAACTCGGCGGGCATTCACTGCTCGTGATCGGCTTG
AGCGAGAAGCTTCGGGCGGCGGGCTTGCATGCCGACGTGCGTGTCGTCTACCGGGCGTCGACGCTGGCCGATCTCGCCGC
GCATCTGGGGACCGACAATCAGGACATCCGGATACCGCCGAATCTGATTGCCGACGGCGACGAGCACATTACGCCGGCCC
AACTGACGCTGGTGGCGCTGAGCCAGGAGTCGATCGACGCGTTGGTGGCGAAGGTGGAAGGCGGTGCGGCGAACGTGCAG
GACATCTATCCGTTGGCGCCGTTGCAGGAAGGCATTCTGTTTCATCACCTGATGTCGGGGGAAAGCGATCCGTACGTGCT
GTCGGGCGTGCTGGCGTTCCGCAGCCGCGAGGTGATGGAGCGGTTTGTGTCGGCATTGCAGCAGGTGATCGATCGGCACG
ACATCCTGCGCACCGGCTTCTTCTGGGAGGGACTCGAGCAACCGGTGCAGGTCGTGCAGCGCCGGGCGACGTTGCCGGTT
AGCGTCGTCGAGCTCGATGCACGCGAAGGCGACATCGTGCGGCAACTGGAGACCCGCTTCGATTCGCGCGGCTATCGGAT
GGACGTGAGCCGCGCGCCGTTGATGCACGTTCACGCGGCTTGCGACGGCGAGCACGAACGCTGGGTGGCGCGCGTGCTGT
TTCACCATCTGTCGATCGATCATACGACGCTCGAGCGTGTGATCGAGGAGGCGCGCGCGATCGGGCAGGGCCGAGCGGAG
GACTTGCCGCAGCCGGTGCCGTTCCGGAATTTCGTCGCGCAGGCGAGGCTGGGGGTGAGCGAGGCGGACCACGAGGCGTA
CTTCAGGGCGAAGCTGGGGGACATCGATGAGCCGACGGCGCCGTTCGGTCTGCTGAGCGTTCAGGGAGACGGGCGTGAGA
TAGCGGAGGCGGCGCGGACGTTGAAGCCGGAGCTGTCGGGGGCGCTTCGCGGACATGCGCGCCGGCTGGGGGTGAGCGCG
GCGAGCATGATGCATGTGGCGTGGGGGCTGGTGCTGTCGCGCACGACGGGGCGGCAGGACGTGGTGTTCGGCACGGTGCT
GTTCGGGCGGATGCAGGGAGGCGCGCAATCGGATCGAGCGCTGGGCTTGTTCATCAACACGTTGCCGGTGCGGATGAGGG
TAGCGCAGACGGGCGTGGAGGCGAGCGTGAAGGGGGCGCATGCGCAGCTGGCGGAATTGATGCGTCACGAGCATGCGCCG
CTGGTGCTGGCGCAGCGTTGCAGCGGGGTGCCGGCGCAGACGCCGTTGTTCACGTCGCTGCTGAACTATCGGTACAGCAA
GCCGAAGGTCGCGGCCGCGCATATTGCCGACGGCATCGAATTGCTCGACTGA

Upstream 100 bases:

>100_bases
GGCGTTTCATTCGGTGATATCGCCGTATCACATTCGCCTTCCGTTGCGGCGCATTCGAATCATTCGTGAATACGTGAACA
CGACTCAGGAGTATGGCGTC

Downstream 100 bases:

>100_bases
CCTGCCCCCTACAAACAGGGCCAGCCGGAGTCTAGTAAAGTTCGTTTTCGGAGAAGAAGACGAACATGAAGAAGCGCTTT
ACGGAACAGCAAATCATCGG

Product: putative peptide synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1483; Mature: 1482

Protein sequence:

>1483_residues
MTDMLDSSEISVRDDIDPVPGAAPERVLALTAGQYGIWLDQMLNPDLPCYILGAILRIDGTFDEALLTSVVNEVVNANDS
LRAVLVSEGGSVRQRVLSDVELEIAHIDFSGSAHPHDSAWRYMRTAFDTAFALDGLLCDFRIVRESPSRTYWMYRCHHLV
ADGQSVSMICRMIVDLYNRRASADMARIEPTPSYFDSLDDDRKYAESSRYERDAQFWQDKFSSLPPPLLSSRSSEAAARP
ASFPDGQVNLTIERAKYDRLGRIAEASGCTIVHVMFGVLALYFSRAFQVDEVVIGMPVHNRSTAQQKRAIGMFASVVPIR
IPVDGNERFVSLLNGVSAELRHCYRHQRFPIAELNRRLGLVRTGRRQLFDLTLSFEKFPLDFYIGDVKLGLTSMRHRFEQ
TPITVNVQDYHEDQDLVMQFNYDVNAFSHAEVDNIGTRIGGLLDALIEHHDDMPVGMLPLLDEAERKQVVYEWNATERDY
PIEQCIHQLFEAQVDRKPEAIALTFDGRRLSYAELNARANRLAHYLQGRGVGPDRLVALCAERGIEMVVGLLAILKAGGA
YVPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFESHVAARSPRVHLSRDIAQWRACSPANPPTPRERAARRLAYV
IYTSGSSGEPKGVMNEHRGVVNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSE
LIDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARLHNLYGPTEAAVDVTAWACDA
EEGGASVPIGRPIANTRIYVLDEYGQPVPRGVAGELYIGGVQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRT
DGSLEYLGRNDFQVKIRGFRIELGEIEAQLAKVAGVRETVVLARDSGSPVGEKRLVAYYTGNADVAALREQATRHLPAYM
VPSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVERISRHDNFFELGGHSLLVIGL
SEKLRAAGLHADVRVVYRASTLADLAAHLGTDNQDIRIPPNLIADGDEHITPAQLTLVALSQESIDALVAKVEGGAANVQ
DIYPLAPLQEGILFHHLMSGESDPYVLSGVLAFRSREVMERFVSALQQVIDRHDILRTGFFWEGLEQPVQVVQRRATLPV
SVVELDAREGDIVRQLETRFDSRGYRMDVSRAPLMHVHAACDGEHERWVARVLFHHLSIDHTTLERVIEEARAIGQGRAE
DLPQPVPFRNFVAQARLGVSEADHEAYFRAKLGDIDEPTAPFGLLSVQGDGREIAEAARTLKPELSGALRGHARRLGVSA
ASMMHVAWGLVLSRTTGRQDVVFGTVLFGRMQGGAQSDRALGLFINTLPVRMRVAQTGVEASVKGAHAQLAELMRHEHAP
LVLAQRCSGVPAQTPLFTSLLNYRYSKPKVAAAHIADGIELLD

Sequences:

>Translated_1483_residues
MTDMLDSSEISVRDDIDPVPGAAPERVLALTAGQYGIWLDQMLNPDLPCYILGAILRIDGTFDEALLTSVVNEVVNANDS
LRAVLVSEGGSVRQRVLSDVELEIAHIDFSGSAHPHDSAWRYMRTAFDTAFALDGLLCDFRIVRESPSRTYWMYRCHHLV
ADGQSVSMICRMIVDLYNRRASADMARIEPTPSYFDSLDDDRKYAESSRYERDAQFWQDKFSSLPPPLLSSRSSEAAARP
ASFPDGQVNLTIERAKYDRLGRIAEASGCTIVHVMFGVLALYFSRAFQVDEVVIGMPVHNRSTAQQKRAIGMFASVVPIR
IPVDGNERFVSLLNGVSAELRHCYRHQRFPIAELNRRLGLVRTGRRQLFDLTLSFEKFPLDFYIGDVKLGLTSMRHRFEQ
TPITVNVQDYHEDQDLVMQFNYDVNAFSHAEVDNIGTRIGGLLDALIEHHDDMPVGMLPLLDEAERKQVVYEWNATERDY
PIEQCIHQLFEAQVDRKPEAIALTFDGRRLSYAELNARANRLAHYLQGRGVGPDRLVALCAERGIEMVVGLLAILKAGGA
YVPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFESHVAARSPRVHLSRDIAQWRACSPANPPTPRERAARRLAYV
IYTSGSSGEPKGVMNEHRGVVNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSE
LIDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARLHNLYGPTEAAVDVTAWACDA
EEGGASVPIGRPIANTRIYVLDEYGQPVPRGVAGELYIGGVQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRT
DGSLEYLGRNDFQVKIRGFRIELGEIEAQLAKVAGVRETVVLARDSGSPVGEKRLVAYYTGNADVAALREQATRHLPAYM
VPSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVERISRHDNFFELGGHSLLVIGL
SEKLRAAGLHADVRVVYRASTLADLAAHLGTDNQDIRIPPNLIADGDEHITPAQLTLVALSQESIDALVAKVEGGAANVQ
DIYPLAPLQEGILFHHLMSGESDPYVLSGVLAFRSREVMERFVSALQQVIDRHDILRTGFFWEGLEQPVQVVQRRATLPV
SVVELDAREGDIVRQLETRFDSRGYRMDVSRAPLMHVHAACDGEHERWVARVLFHHLSIDHTTLERVIEEARAIGQGRAE
DLPQPVPFRNFVAQARLGVSEADHEAYFRAKLGDIDEPTAPFGLLSVQGDGREIAEAARTLKPELSGALRGHARRLGVSA
ASMMHVAWGLVLSRTTGRQDVVFGTVLFGRMQGGAQSDRALGLFINTLPVRMRVAQTGVEASVKGAHAQLAELMRHEHAP
LVLAQRCSGVPAQTPLFTSLLNYRYSKPKVAAAHIADGIELLD
>Mature_1482_residues
TDMLDSSEISVRDDIDPVPGAAPERVLALTAGQYGIWLDQMLNPDLPCYILGAILRIDGTFDEALLTSVVNEVVNANDSL
RAVLVSEGGSVRQRVLSDVELEIAHIDFSGSAHPHDSAWRYMRTAFDTAFALDGLLCDFRIVRESPSRTYWMYRCHHLVA
DGQSVSMICRMIVDLYNRRASADMARIEPTPSYFDSLDDDRKYAESSRYERDAQFWQDKFSSLPPPLLSSRSSEAAARPA
SFPDGQVNLTIERAKYDRLGRIAEASGCTIVHVMFGVLALYFSRAFQVDEVVIGMPVHNRSTAQQKRAIGMFASVVPIRI
PVDGNERFVSLLNGVSAELRHCYRHQRFPIAELNRRLGLVRTGRRQLFDLTLSFEKFPLDFYIGDVKLGLTSMRHRFEQT
PITVNVQDYHEDQDLVMQFNYDVNAFSHAEVDNIGTRIGGLLDALIEHHDDMPVGMLPLLDEAERKQVVYEWNATERDYP
IEQCIHQLFEAQVDRKPEAIALTFDGRRLSYAELNARANRLAHYLQGRGVGPDRLVALCAERGIEMVVGLLAILKAGGAY
VPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFESHVAARSPRVHLSRDIAQWRACSPANPPTPRERAARRLAYVI
YTSGSSGEPKGVMNEHRGVVNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSEL
IDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARLHNLYGPTEAAVDVTAWACDAE
EGGASVPIGRPIANTRIYVLDEYGQPVPRGVAGELYIGGVQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRTD
GSLEYLGRNDFQVKIRGFRIELGEIEAQLAKVAGVRETVVLARDSGSPVGEKRLVAYYTGNADVAALREQATRHLPAYMV
PSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVERISRHDNFFELGGHSLLVIGLS
EKLRAAGLHADVRVVYRASTLADLAAHLGTDNQDIRIPPNLIADGDEHITPAQLTLVALSQESIDALVAKVEGGAANVQD
IYPLAPLQEGILFHHLMSGESDPYVLSGVLAFRSREVMERFVSALQQVIDRHDILRTGFFWEGLEQPVQVVQRRATLPVS
VVELDAREGDIVRQLETRFDSRGYRMDVSRAPLMHVHAACDGEHERWVARVLFHHLSIDHTTLERVIEEARAIGQGRAED
LPQPVPFRNFVAQARLGVSEADHEAYFRAKLGDIDEPTAPFGLLSVQGDGREIAEAARTLKPELSGALRGHARRLGVSAA
SMMHVAWGLVLSRTTGRQDVVFGTVLFGRMQGGAQSDRALGLFINTLPVRMRVAQTGVEASVKGAHAQLAELMRHEHAPL
VLAQRCSGVPAQTPLFTSLLNYRYSKPKVAAAHIADGIELLD

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=645, Percent_Identity=24.6511627906977, Blast_Score=144, Evalue=5e-34,
Organism=Homo sapiens, GI187761345, Length=528, Percent_Identity=26.1363636363636, Blast_Score=106, Evalue=2e-22,
Organism=Homo sapiens, GI187761343, Length=528, Percent_Identity=26.1363636363636, Blast_Score=106, Evalue=2e-22,
Organism=Homo sapiens, GI42544132, Length=531, Percent_Identity=21.4689265536723, Blast_Score=84, Evalue=1e-15,
Organism=Homo sapiens, GI156151445, Length=564, Percent_Identity=23.5815602836879, Blast_Score=83, Evalue=3e-15,
Organism=Homo sapiens, GI38505220, Length=520, Percent_Identity=23.2692307692308, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1786801, Length=1089, Percent_Identity=34.8943985307622, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=25.3141831238779, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=26.2042389210019, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI145693145, Length=523, Percent_Identity=24.282982791587, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17556356, Length=566, Percent_Identity=27.5618374558304, Blast_Score=158, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=419, Percent_Identity=24.3436754176611, Blast_Score=107, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32564422, Length=412, Percent_Identity=25, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32564420, Length=412, Percent_Identity=25, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=308, Percent_Identity=23.0519480519481, Blast_Score=84, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=355, Percent_Identity=24.5070422535211, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994694, Length=477, Percent_Identity=22.4318658280922, Blast_Score=77, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71994690, Length=475, Percent_Identity=22.5263157894737, Blast_Score=77, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994703, Length=477, Percent_Identity=22.4318658280922, Blast_Score=77, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319591, Length=688, Percent_Identity=25.4360465116279, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24648676, Length=707, Percent_Identity=31.2588401697313, Blast_Score=268, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24656500, Length=511, Percent_Identity=24.6575342465753, Blast_Score=105, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19922652, Length=531, Percent_Identity=23.728813559322, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24582852, Length=367, Percent_Identity=25.8855585831063, Blast_Score=87, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24581924, Length=530, Percent_Identity=23.3962264150943, Blast_Score=83, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161076582, Length=557, Percent_Identity=19.2100538599641, Blast_Score=80, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859661, Length=468, Percent_Identity=22.8632478632479, Blast_Score=78, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356947, Length=483, Percent_Identity=18.8405797101449, Blast_Score=76, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 164847; Mature: 164716

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMLDSSEISVRDDIDPVPGAAPERVLALTAGQYGIWLDQMLNPDLPCYILGAILRIDG
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHCCC
TFDEALLTSVVNEVVNANDSLRAVLVSEGGSVRQRVLSDVELEIAHIDFSGSAHPHDSAW
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCEEEEEEEECCCCCCCCHHHH
RYMRTAFDTAFALDGLLCDFRIVRESPSRTYWMYRCHHLVADGQSVSMICRMIVDLYNRR
HHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
ASADMARIEPTPSYFDSLDDDRKYAESSRYERDAQFWQDKFSSLPPPLLSSRSSEAAARP
CCCCHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHCCC
ASFPDGQVNLTIERAKYDRLGRIAEASGCTIVHVMFGVLALYFSRAFQVDEVVIGMPVHN
CCCCCCEEEEEEEHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
RSTAQQKRAIGMFASVVPIRIPVDGNERFVSLLNGVSAELRHCYRHQRFPIAELNRRLGL
CCHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCH
VRTGRRQLFDLTLSFEKFPLDFYIGDVKLGLTSMRHRFEQTPITVNVQDYHEDQDLVMQF
HHCCCHHHEEEEEEHHHCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
NYDVNAFSHAEVDNIGTRIGGLLDALIEHHDDMPVGMLPLLDEAERKQVVYEWNATERDY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEECCCCCCC
PIEQCIHQLFEAQVDRKPEAIALTFDGRRLSYAELNARANRLAHYLQGRGVGPDRLVALC
CHHHHHHHHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AERGIEMVVGLLAILKAGGAYVPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFES
HHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
HVAARSPRVHLSRDIAQWRACSPANPPTPRERAARRLAYVIYTSGSSGEPKGVMNEHRGV
HHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCEEEEEEEECCCCCCCCCHHHHHHHH
VNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSE
HHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
LIDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHH
HNLYGPTEAAVDVTAWACDAEEGGASVPIGRPIANTRIYVLDEYGQPVPRGVAGELYIGG
HHCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEECH
VQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRTDGSLEYLGRNDFQVKIRGFR
HHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCEEECCCCCEEEEEEEEE
IELGEIEAQLAKVAGVRETVVLARDSGSPVGEKRLVAYYTGNADVAALREQATRHLPAYM
EEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEE
VPSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVER
CCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHH
ISRHDNFFELGGHSLLVIGLSEKLRAAGLHADVRVVYRASTLADLAAHLGTDNQDIRIPP
HHCCCCEEEECCCEEEEEECCHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCCEECCC
NLIADGDEHITPAQLTLVALSQESIDALVAKVEGGAANVQDIYPLAPLQEGILFHHLMSG
CCCCCCCCCCCHHHEEEEEECHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHCC
ESDPYVLSGVLAFRSREVMERFVSALQQVIDRHDILRTGFFWEGLEQPVQVVQRRATLPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCE
SVVELDAREGDIVRQLETRFDSRGYRMDVSRAPLMHVHAACDGEHERWVARVLFHHLSID
EEEEECCCCCHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
HTTLERVIEEARAIGQGRAEDLPQPVPFRNFVAQARLGVSEADHEAYFRAKLGDIDEPTA
HHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
PFGLLSVQGDGREIAEAARTLKPELSGALRGHARRLGVSAASMMHVAWGLVLSRTTGRQD
CEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
VVFGTVLFGRMQGGAQSDRALGLFINTLPVRMRVAQTGVEASVKGAHAQLAELMRHEHAP
HHHHHHHHHHCCCCCCCCCEEEEEEECCCHHEEHHHCCCCHHHCHHHHHHHHHHHHCCCC
LVLAQRCSGVPAQTPLFTSLLNYRYSKPKVAAAHIADGIELLD
CHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHCC
>Mature Secondary Structure 
TDMLDSSEISVRDDIDPVPGAAPERVLALTAGQYGIWLDQMLNPDLPCYILGAILRIDG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHCCC
TFDEALLTSVVNEVVNANDSLRAVLVSEGGSVRQRVLSDVELEIAHIDFSGSAHPHDSAW
CHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCEEEEEEEECCCCCCCCHHHH
RYMRTAFDTAFALDGLLCDFRIVRESPSRTYWMYRCHHLVADGQSVSMICRMIVDLYNRR
HHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
ASADMARIEPTPSYFDSLDDDRKYAESSRYERDAQFWQDKFSSLPPPLLSSRSSEAAARP
CCCCHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHCCC
ASFPDGQVNLTIERAKYDRLGRIAEASGCTIVHVMFGVLALYFSRAFQVDEVVIGMPVHN
CCCCCCEEEEEEEHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
RSTAQQKRAIGMFASVVPIRIPVDGNERFVSLLNGVSAELRHCYRHQRFPIAELNRRLGL
CCHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCH
VRTGRRQLFDLTLSFEKFPLDFYIGDVKLGLTSMRHRFEQTPITVNVQDYHEDQDLVMQF
HHCCCHHHEEEEEEHHHCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
NYDVNAFSHAEVDNIGTRIGGLLDALIEHHDDMPVGMLPLLDEAERKQVVYEWNATERDY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCEEEEEECCCCCCC
PIEQCIHQLFEAQVDRKPEAIALTFDGRRLSYAELNARANRLAHYLQGRGVGPDRLVALC
CHHHHHHHHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AERGIEMVVGLLAILKAGGAYVPLDPSHPPERLRRMLDDTNPVAVLVDDIGADALASFES
HHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
HVAARSPRVHLSRDIAQWRACSPANPPTPRERAARRLAYVIYTSGSSGEPKGVMNEHRGV
HHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCEEEEEEEECCCCCCCCCHHHHHHHH
VNRLWWMQQTYALDERDAVLQKTPFSFDVSVWEFFWPLMSGARLVIAKPEGHKDPAYLSE
HHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
LIDRERVTTLHFVPSMLQAFLEDEGAARGCGSVKRVMCSGEALPPSLVKRFYRCLPDARL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHHH
HNLYGPTEAAVDVTAWACDAEEGGASVPIGRPIANTRIYVLDEYGQPVPRGVAGELYIGG
HHCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEECH
VQVARGYLNRPELTRERFVDDPFVAGGRLYKTGDLARWRTDGSLEYLGRNDFQVKIRGFR
HHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCEEECCCCCEEEEEEEEE
IELGEIEAQLAKVAGVRETVVLARDSGSPVGEKRLVAYYTGNADVAALREQATRHLPAYM
EEHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCEE
VPSAYVRLDAWPLTPNGKLDRRALPAPADDAYARAEYEAPQGAKEEALAAIWKDLLPVER
CCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHH
ISRHDNFFELGGHSLLVIGLSEKLRAAGLHADVRVVYRASTLADLAAHLGTDNQDIRIPP
HHCCCCEEEECCCEEEEEECCHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCCEECCC
NLIADGDEHITPAQLTLVALSQESIDALVAKVEGGAANVQDIYPLAPLQEGILFHHLMSG
CCCCCCCCCCCHHHEEEEEECHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHCC
ESDPYVLSGVLAFRSREVMERFVSALQQVIDRHDILRTGFFWEGLEQPVQVVQRRATLPV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCE
SVVELDAREGDIVRQLETRFDSRGYRMDVSRAPLMHVHAACDGEHERWVARVLFHHLSID
EEEEECCCCCHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
HTTLERVIEEARAIGQGRAEDLPQPVPFRNFVAQARLGVSEADHEAYFRAKLGDIDEPTA
HHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
PFGLLSVQGDGREIAEAARTLKPELSGALRGHARRLGVSAASMMHVAWGLVLSRTTGRQD
CEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
VVFGTVLFGRMQGGAQSDRALGLFINTLPVRMRVAQTGVEASVKGAHAQLAELMRHEHAP
HHHHHHHHHHCCCCCCCCCEEEEEEECCCHHEEHHHCCCCHHHCHHHHHHHHHHHHCCCC
LVLAQRCSGVPAQTPLFTSLLNYRYSKPKVAAAHIADGIELLD
CHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]