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The map label for this gene is hmuV [H]

Identifier: 126445291

GI number: 126445291

Start: 398837

End: 399655

Strand: Reverse

Name: hmuV [H]

Synonym: BURPS668_A0434

Alternate gene names: 126445291

Gene position: 399655-398837 (Counterclockwise)

Preceding gene: 126444518

Following gene: 126444547

Centisome position: 12.78

GC content: 75.34

Gene sequence:

>819_bases
ATGTTGAATGCCGACCATCTTCACGTCGCGCGCGACGGCCGCGCGATCCTGAACGACCTGTCGATCCGGATCGCGCCCGG
CTGCGTCACCGCGCTGCTCGGCCGCAACGGCGCGGGCAAGAGCACGCTGCTCGGCGTGCTCGCGGGCGACCTGCCGGCCG
GCGGCCTCGCGCGCGGCGCGACGGTGCGCGGCGGCGTCGCGCTGAACGGCGAGCCGCTTCACGCGATCGACGCGCCGCGC
CTCGCACGGCTGCGGGCGGTGCTGCCGCAGGCGTCGCGGCCCGCGTTCGCGTTCAGCGCGCGCGAGATCGTGCTGCTCGG
GCGCTACCCGCACGCGCGCCGCGCGGGCGCGCTCACGTATGCGGACGGCGAGATCGCGTCGCAGGCGCTCGCGCTCGCCG
GCGCAACGGCGCTCGATGCGCGCGACGTGACGACGCTCTCGGGCGGCGAGCTTGCCCGCGTGCAATTCGCGCGCGTGCTC
GCGCAGCTCTGGCCGCCGCCCGGCGCGGCGCAGCCGCCGCGCTACCTGCTGCTCGACGAGCCGACCGCCGCGCTCGACCT
CGCGCATCAGCATCAATTGCTCGACACGGTTCGACGCCTGTCGCGCGACTGGAACCTCGGCGTGCTGACGATCGTCCACG
ATCCGAATCTCGCCGCGCGCCACGCGGATCGCATCGCGATGCTCGCGGACGGCGCGATCGTCGCGCAAGGCGCGCCCGCC
GACGTGCTGCGCCCCGAGCCGATCGCGCGGTGCTACGGCTTTCGCGTGCGGCTCGTCGACGCGGGCGACGGCGTCGCACC
CGTCATCGTGCCCGCGTGA

Upstream 100 bases:

>100_bases
TGACTCATCGAGTTCATCGAGTTCATCGAACCCGAACCCGAACCCATCGAGAGCCTCATCGAAAACCCATCGATAGTCCA
CCCATAGCCCATCGAACGCC

Downstream 100 bases:

>100_bases
ACGACGCGCGAGCGGCACATGAGCGGCCGCCGCGCCCGCGGCGACGTGTCACCCGGCGTCGGCCGCCTGAAACGCCTTCA
GCCGCCAGCCGCGCCGCACG

Product: hemin importer ATP-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPR
LARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTYADGEIASQALALAGATALDARDVTTLSGGELARVQFARVL
AQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA

Sequences:

>Translated_272_residues
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPR
LARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTYADGEIASQALALAGATALDARDVTTLSGGELARVQFARVL
AQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
>Mature_272_residues
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGATVRGGVALNGEPLHAIDAPR
LARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTYADGEIASQALALAGATALDARDVTTLSGGELARVQFARVL
AQLWPPPGAAQPPRYLLLDEPTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system [H]

COG id: COG4559

COG function: function code P; ABC-type hemin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI11967969, Length=234, Percent_Identity=28.6324786324786, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786345, Length=256, Percent_Identity=39.453125, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1786803, Length=271, Percent_Identity=33.9483394833948, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790739, Length=244, Percent_Identity=33.6065573770492, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788002, Length=247, Percent_Identity=35.2226720647773, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789891, Length=243, Percent_Identity=29.2181069958848, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081791, Length=271, Percent_Identity=28.7822878228782, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081834, Length=233, Percent_Identity=30.9012875536481, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786563, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994997, Length=247, Percent_Identity=29.1497975708502, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787712, Length=240, Percent_Identity=27.9166666666667, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787029, Length=240, Percent_Identity=27.9166666666667, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790544, Length=228, Percent_Identity=30.2631578947368, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786398, Length=245, Percent_Identity=25.3061224489796, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=224, Percent_Identity=31.25, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789864, Length=268, Percent_Identity=23.134328358209, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994883, Length=232, Percent_Identity=25, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789890, Length=233, Percent_Identity=29.1845493562232, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788506, Length=237, Percent_Identity=24.8945147679325, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786253, Length=225, Percent_Identity=31.1111111111111, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787759, Length=236, Percent_Identity=26.6949152542373, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786872, Length=243, Percent_Identity=26.7489711934156, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788450, Length=257, Percent_Identity=25.2918287937743, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI48995001, Length=220, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787112, Length=246, Percent_Identity=29.6747967479675, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI145693107, Length=257, Percent_Identity=26.0700389105058, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=243, Percent_Identity=29.2181069958848, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193211017, Length=243, Percent_Identity=28.8065843621399, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=243, Percent_Identity=28.8065843621399, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322640, Length=253, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI23397593, Length=240, Percent_Identity=30.8333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136592, Length=247, Percent_Identity=27.5303643724696, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR015863
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 28427; Mature: 28427

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGA
CCCCCCEEEECCCHHHHHCCEEEECCHHHHHHHCCCCCCHHHHHEEHCCCCCCCCCCCCC
TVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTY
EEECCEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEEEECCCCCHHCCEEEE
ADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDE
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
PTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCEEEEEECCEEEECCCCC
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
CCCCCCHHHHHCCEEEEEEECCCCCCEEEECC
>Mature Secondary Structure
MLNADHLHVARDGRAILNDLSIRIAPGCVTALLGRNGAGKSTLLGVLAGDLPAGGLARGA
CCCCCCEEEECCCHHHHHCCEEEECCHHHHHHHCCCCCCHHHHHEEHCCCCCCCCCCCCC
TVRGGVALNGEPLHAIDAPRLARLRAVLPQASRPAFAFSAREIVLLGRYPHARRAGALTY
EEECCEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEEEEECCCCCHHCCEEEE
ADGEIASQALALAGATALDARDVTTLSGGELARVQFARVLAQLWPPPGAAQPPRYLLLDE
CCHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
PTAALDLAHQHQLLDTVRRLSRDWNLGVLTIVHDPNLAARHADRIAMLADGAIVAQGAPA
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCEEEEEECCEEEECCCCC
DVLRPEPIARCYGFRVRLVDAGDGVAPVIVPA
CCCCCCHHHHHCCEEEEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA